Lin Z

Chinese Academy of Agricultural Sciences

OpenAlex Profile
2
Publications
12
h-index
(440 citations, 33 total works)

Research Topics

Microbial Natural Products and Biosynthesis (23)Plant biochemistry and biosynthesis (7)Alkaloids: synthesis and pharmacology (6)Microbial Metabolism and Applications (6)Carbohydrate Chemistry and Synthesis (4)

Alpha-gal Syndrome Publications

Integrative approaches unravelling tea drought alleviation mechanisms primed by carbonyl volatiles and signal peptide.

Bassiony A, Sun S, Yan K, Peng Q, Zhou M, et al.
Plant physiology and biochemistry : PPB •

Drought stress (DS) significantly hampers the growth and productivity of tea plants, necessitating effective strategies to enhance their resilience. This study comprehensively investigated the mechanisms of carbonyl volatiles-methyl jasmonate (MeJA) and cis-3-hexenyl acetate (cis-3-HAC) and signal peptide CLAVATA3/EMBRYO-SURROUNDING REGION-RELATED 25 (CLE25) promotion DS resistance using integrative metabolomics and proteomics strategy. Total pigment content decreased, while soluble sugar and proteins increased significantly under DS and further increased after foliar inducement of CLE25, MeJA, and cis-3-HAC. Gallated catechins and amino acids exhibited apparent decreased under DS, especially EGCG (24.6-13.4 mg g) and theanine (10.66-3.78 mg g), but significantly mitigated by CLE25 inducement. Antioxidant enzymes activity, such as catalase (CAT), jumped from 23.1 to 48.2 and further boosted to 118.8 Ugmin FW with CLE25. Proteomic analysis revealed massive increased in stress tolerance proteins, particularly dehydrins and heat shock proteins, rising by >50.0 % with CLE25 inducement and the expression levels of peroxidase (POX), superoxide dismutase (SOD), α-galactosidase (α-GAL), carboxypeptidases (CPs), and transaldolase (TAL) exhibited higher after inducement. Furthermore, stress signaling-related proteins were in-depth explored, especially thioredoxin proteins; sucrose non-fermenting 1-related protein kinase 2 (SnRK2) was novelly verified in activating abscisic acid (ABA) responding. Differences among drought resistance mechanisms after carbonyl volatile and CLE25 treatments were comprehensively studied. The integration of metabolite and protein levels provided a comprehensive illustration of tea DS tolerance mechanisms and offered promising promotion strategies through foliar application of MeJA, cis-3-HAC, and CLE25.

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Safety and tissue remodeling assay of small intestinal submucosa meshes using a modified porcine surgical hernia model.

Liu C, Lin Z, Ruan W, Gai X, Qu Q, et al.
Scientific reports •

In studies to date, meshes based on extracellular matrix (ECM) have been extensively used in clinical applications. Unfortunately, little is known about the function of the immunogenic residual, absorbable profile during the tissue repair process. Moreover, there needs to be a recognized preclinical animal model to investigate the safety and efficacy of extracellular matrix meshes. Herein, we designed and fabricated a kind of SIS mesh followed by a scanned electron micrograph characterization and tested α-Gal antigen clearance rate and DNA residual. In order to prove the biocompatibility of the SIS mesh, cell viability, chemotaxis assay and local tissue reaction were assessed by MTT and RTCA cytotoxicity test in vitro as well as implantation and degradation experiments in vivo. Furthermore, we developed a stable preclinical animal model in the porcine ventral hernia repair investigation, which using laparoscopic plus open hybridization method to evaluate tissue adhesion, explant mechanical performance, and histologic analysis after mesh implantation. More importantly, we established a semi-quantitative scoring system to examine the ECM degradation, tissue remodeling and regeneration in the modified porcine surgical hernia model for the first time. Our results highlight the application prospect of the improved porcine ventral hernia model for the safety and efficacy investigation of hernia repair meshes.

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