Publications
Comprehensive database of Alpha-gal Syndrome research from PubMed, automatically updated weekly. Filter by year, topic, or search by keyword.
Institution Map
2232 institutions linked to Alpha-gal Syndrome publications
Publications Over Time
Annual Alpha-gal Syndrome publication counts matching the filters below
Select topics to match all of them. Counts show results with that topic and the other active filters.
Allergenicity of α-Gal-Containing Products.
Mangaard FB, Eller E, Skov PS, et al.·Allergy·
View on PubMed →Implications of Alpha-gal Syndrome in Urologic Management.
Ghenbot RG, Newman I, Leung A, et al.·Urology·
Alpha-gal syndrome (AGS) is a tick-borne allergy to mammalian products with significant anaphylactic potential. Despite increasing prevalence, with an estimated 450,000 Americans affected, no resource...
View on PubMed →Occupational Primary Red Meat Allergy With Sensitization to Serum Albumins, Sus s 1, and Bos d 6.
Aoyama M, Hagihara E, Furuya Y, et al.·The Journal of dermatology·
To date, occupational primary red meat allergies have not been reported. A 42-year-old man visited our clinic with allergic symptoms after ingesting red meat. For the past 5 years, he has developed a...
View on PubMed →Correction to: Alpha-Gal syndrome unveiled: decoding the glycan-driven red meat allergy.
Sobala ŁF, Szymczak-Kulus K, Kasper Ł, et al.·Glycoconjugate journal·
View on PubMed →Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.
Jacobs JW, Kaufman RM, Schwartz JY, et al.·American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity to the oligosaccharide galactose-α-1,3-galactose, acquired through tick bites and increasingly recognized as a cause of allergic reactions...
View on PubMed →Alpha-gal Immunoglobulin E Seroprevalence Among Blood Donors - 10 States, 2024-2025.
Saunders EF, Taylor ML, Jones ES, et al.·MMWR. Morbidity and mortality weekly report·
Alpha-gal syndrome (AGS) is an emerging, noninfectious tickborne disease characterized by an allergic reaction to galactose-α-1,3-galactose (alpha-gal), an oligosaccharide found in red (mammalian) mea...
Unusual Causes of Food-Induced Anaphylaxis - A Review.
Santhosh P, Abraham A, Khan S·Indian dermatology online journal·
Anaphylaxis is a potentially fatal, acute, multisystemic hypersensitivity reaction. Food-induced anaphylaxis (FIA) is typically an IgE-mediated reaction. Although any food has the potential to cause F...
View on PubMed →The alpha-gal syndrome: Understanding the role of tick bites, and the delays in severe anaphylaxis.
Platts-Mills TAE, Dunaway CA, Gangwar RS, et al.·Allergy and asthma proceedings·
The presence of serum immunoglobulin E (IgE) antibodies to the oligosaccharide galactose-alpha-1,3-galactose (α-gal) was first recognized during the investigation of allergic reactions to the monoclon...
When Dinner Becomes Dangerous-Alpha-Gal Syndrome as a Diagnostic Pitfall in the Emergency Department: An Illustrative Case Presentation.
Vitko HA, Edlow JA·Journal of emergency nursing·
Alpha-gal syndrome is an underrecognized, tick-associated allergic reaction that can cause delayed anaphylaxis, posing a growing diagnostic challenge in the emergency department. Transmitted most comm...
Why It Is Wrong to Promote Alpha-Gal Syndrome: A Response to Crutchfield and Hereth.
Ebert R, Koeder C·Bioethics·
Crutchfield and Hereth have proposed the deliberate promotion of tick-borne alpha-gal syndrome (AGS)-a condition typically causing red meat allergy-as a strategy to reduce meat consumption and hence a...
Emerging Clinical Complications of Alpha-Gal Syndrome: A Scoping Review.
Vundamati VS, Patel SR, Patel R, et al.·Cureus·
Alpha-gal syndrome (AGS) is characterized by an IgE-mediated immune response against galactose-α-1,3-galactose (α-gal). In the United States, the principal vector is the lone star tick, whose range ha...
View on PubMed →Natural antibodies induced by host gut microbiota modulate tick microbiota, inhibiting Borrelia colonization.
Mateos-Hernandez L, Wu-Chuang A, Maitre A, et al.·Ticks and tick-borne diseases·
The gut microbiome undergoes natural selection pressure, likely because it can affect infection resistance by stimulating natural antibody (NAb) production, notably against the glycan Galα1-3Galβ1-4Gl...
Alpha-Gal Syndrome-A Case Series of Successful Transcatheter Mammalian-Derived Aortic Valve Replacements.
Lari K, Leghari S, Smeltz AM, et al.·Seminars in cardiothoracic and vascular anesthesia·
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity to galactose-α-1,3-galactose, an oligosaccharide found in mammalian tissues, including bovine or porcine-derived bioprosthetic valves and h...
View on PubMed →Tick-Borne Disease Prevention in Long-Distance Appalachian Trail Hikers: A Health Belief Model Approach.
Getz E, Christiana RW, Seagle SW·Wilderness & environmental medicine·
Tick-borne-disease (TBD) risk is high along the Appalachian Trail (AT), yet little is known about how long-distance hikers practice recommended prevention behaviors. Because their prolonged outdoor ex...
View on PubMed →Disrupted barriers, evolved risks: toward precision One Health in arthropod allergy.
Li D, Zhang WF, Deng YP, et al.·Trends in parasitology·
Arthropod-induced allergic diseases are increasingly recognized as a major global health challenge in the Anthropocene. Climate change, urbanization, and ecological disruption are expanding human expo...
View on PubMed →Severe allergic transfusion reactions to group B/AB plasma or platelets in group O recipients are linked to α-Gal sensitization.
de Chaisemartin L, de la Taille V, Nicaise-Roland P, et al.·Blood·
Allergic transfusion reactions (ATR) are potentially lethal adverse events that occur in ∼0.3% to 6% of plasma or platelet transfusions. The main mechanism described is an immunoglobulin E (IgE)-media...
Anti-α-Gal IgG antibodies promote macrophage uptake of α-Gal-bearing lipoproteins and foam cell formation.
Román-Carrasco P, Ridlmaier N, Martínez-Martos S, et al.·The Journal of allergy and clinical immunology·
View on PubMed →Tick-Borne Diseases in Orthopaedic Practice: Lyme Arthritis and Alpha-gal Syndrome.
Zikria B, Murali S·The Journal of the American Academy of Orthopaedic Surgeons·
The prevalence of tick-borne disease continues to rise in the United States. Lyme disease is the most prevalent, classically presenting as monoarthralgia or polyarthralgia and effusions. Although most...
View on PubMed →α-Gal Syndrome in the South: Why We Need Treatment Trials, Not Just Tick Prevention.
Casterline BW, Franzese C, Park Y, et al.·Southern medical journal·
α-Gal syndrome (AGS), a tick bite-associated allergy to mammalian meat, affects an estimated 450,000 Americans, with the highest prevalence concentrated in the US South and Southeast. The lone star ti...
Immunogenic and cross-reactive carbohydrate determinants in ticks and other arthropods.
Sterbova J, Grubhoffer L, Sterba J·Journal of applied biomedicine·
Ticks are parasites that feed on the blood of humans and animals, using it as their sole source of food. Due to their lifestyle, ticks at each life stage transmit various tick-borne pathogens while fe...
MEAT PIES: Mammalian Meat Allergy in Patients Investigated for Gastrointestinal Symptoms: Detection of Mammalian Meat Allergy in the Gastroenterology Outpatient Department, Cairns Hospital, Queensland, Australia.
Bitzer E, Bourke P, Hussain S·JGH open : an open access journal of gastroenterology and hepatology·
Alpha-gal syndrome (AGS), an IgE-mediated allergy to galactose-α-1,3-galactose acquired via tick bites, often presents with a delayed gastrointestinal (GI) phenotype without anaphylaxis. We evaluated...
View on PubMed →Transfusion-related alpha-gal syndrome: Two new cases expanding the demographic and geographic spectrum, and evidence of a diagnostic gap in allergic transfusion reaction evaluation.
Foster M, Brown M, Mueller A, et al.·Transfusion·
Transfusion-related alpha-gal syndrome (TRAGS) has recently been proposed as a cause of allergic transfusion reactions (ATRs) in which alpha-gal-specific IgE in sensitized group O (or potentially grou...
Contact Urticaria to Chamois ( Rupicapra rupicapra ) Raw Muscle Meat in a Non-Occupational Hunter: First Documented Case.
Noori M, Brüggen MC, Schmid-Grendelmeier P, et al.·Contact dermatitis·
View on PubMed →Acute Diverticulitis as an Atypical Presentation of Alpha-Gal Syndrome.
Salam E, DelaRosa VS, Trivedi M·Cureus·
Alpha-gal syndrome (AGS) is an immunoglobulin E (IgE) mediated hypersensitivity reaction caused by tick bites. The body's immune response to tick bites can lead to the production of anti-alpha-gal IgE...
View on PubMed →Heparin-Induced Anaphylaxis With Cardiac Arrest in a Patient With Alpha-Gal Syndrome: A Case Report.
Khanipour R, Bera RK, Suarez I, et al.·Cureus·
Alpha-gal syndrome (AGS) is a delayed allergic reaction to red meat linked to bites of various species of ticks around the world, with the common culprits in North America identified as the Ixodes and...
View on PubMed →Monitoring Inflammatory Markers and Anti-α-Gal Antibodies in Liver Transplant Recipients: Implications for Infection and Rejection.
Karaca G, Karaca ZM, Kayhan B, et al.·Diagnostics (Basel, Switzerland)·
Living donor liver transplantation is a multifactorial process, and non-invasive serological parameters that may provide information about graft and patient status are still under investigation. Howev...
View on PubMed →CRISPR-mediated engineering of bovine satellite cells for Alpha-Gal Syndrome-compatible cultivated meat.
D'Costa S, Choudhary SK, Kenney GE, et al.·bioRxiv : the preprint server for biology·
Alpha-gal Syndrome (AGS) is a potentially life-threatening allergy caused by an IgE-mediated immune response to galactose-α-1,3-galactose (alpha-gal), a carbohydrate epitope present in most mammalian...
View on PubMed →Comparative in vitro and in vivo assessment of three experimental extracellular matrix meshes for soft tissue remodeling.
Ruan W, Wang G, Qu Q, et al.·Scientific reports·
The development of standardized cross-species evaluation frameworks is urgently needed for absorbable extracellular matrix (ECM) meshes, due to significant variations in safety and efficacy across tis...
View on PubMed →American College of Allergy, Asthma and Immunology (ACAAI)/American Academy of Pediatrics (AAP) symposium-What was served in the past year: Food allergy nontreatment.
Bingemann TA·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Food allergies are increasing, with 1 of 13 children in the United States affected. This article discusses articles chosen by the author for inclusion in the American College of Allergy, Asthma and Im...
View on PubMed →Alpha-Gal syndrome unveiled: decoding the glycan-driven red meat allergy.
Sobala ŁF, Szymczak-Kulus K, Kasper Ł, et al.·Glycoconjugate journal·
α-Gal syndrome (AGS) is a type of allergy to red meat and other mammalian products that develops after a tick bite. Symptoms may include urticaria, angioedema, gastrointestinal and respiratory symptom...
Accelerating Progress on Ticks and Tick-Borne Diseases in Southeast Asia: Regional Challenges, Evidence Gaps, and Priorities (2023-2025).
Malleret B, Kwak ML, Chavatte JM·Pathogens (Basel, Switzerland)·
Southeast Asia (SEA) faces persistent gaps in regional understanding and control of ticks and tick-borne diseases (TBDs) despite recent advances (2023-2025). The second international symposium on tick...
Acute Coronary Syndrome in Alpha-Gal Syndrome: A Rare Immune-Cardiac Intersection.
Zerihun W, Tewodros B, Fahed J, et al.·Cureus·
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity reaction to galactose-α-1,3-galactose (alpha-gal) following exposure to lone star tick bites. While classically associated with anaphylacti...
View on PubMed →Alpha-gal Syndrome Surveillance in Rhode Island.
Garrett J, Gosciminski M, Quilliam DN, et al.·Rhode Island medical journal (2013)·
View on PubMed →Tick-borne pathogen diversity and clinical impact of tick-infestation in Serbia and North Macedonia.
Jakimovski D, Banović P, Mateska S, et al.·Ticks and tick-borne diseases·
Ticks and tick-borne pathogens (TBPs) pose an expanding health threat across Europe, yet few studies link tick infection data directly to human clinical outcomes. We conducted a prospective, cross-bor...
The Prevalence of Alpha-Gal IgE among Patients with Confirmed Lyme Serology Result.
Kadkhoda K, Schwaben A, Dee M·International archives of allergy and immunology·
Given the significant rise in the incidence of alpha-gal syndrome alongside the geographical expansion of ticks in recent years, it is crucial to conduct studies aimed at raising awareness particularl...
View on PubMed →Alpha-gal Syndrome Symptom Profiles and Diagnostic Experiences Among Farmer and Ranchers.
Welch AM, Beseler CL, Cross ST·medRxiv : the preprint server for health sciences·
Alpha-gal syndrome (AGS) is an emerging health issue. This syndrome, caused by the bites of ticks, induces allergic reactions to the sugar molecule galactose-α-1,3-galactose after exposure to non-prim...
View on PubMed →IgE And IgG Antibody Responses to α-Gal and Association With Carotid Stenosis in Swedish Patients.
Perusko M, Apostolovic D, Grundström J, et al.·Allergy·
View on PubMed →Chemically Defined Non-human Glycans Comprising Galactose-α1-3-Galactose (α-Gal) Epitopes Glycoengineered into the Fragment Antigen-Binding (Fab) Domain of Cetuximab Differentially Affect Human Anti-α-Gal Immunoglobulin E (IgE) Binding.
Hatfield G, Tepliakova L, Tam RY·ACS pharmacology & translational science·
Glycosylation of monoclonal antibodies (mAbs) critically affects their effector function, stability, pharmacokinetics, and immunogenicity. Glycan structures can vary with cell type and culture conditi...
View on PubMed →Anaphylactic transfusion reaction to group B platelets related to alpha-gal syndrome: A case report.
Hinojosa OA, Dasgupta A, Ye Z·Transfusion·
Alpha-gal syndrome (AGS), a distinct form of IgE-mediated hypersensitivity to the carbohydrate galactose-α-1,3-galactose (α-Gal), typically occurs after repeated tick bites and leads to allergic react...
View on PubMed →Beyond the Bite: Shedding Light on Alpha-Gal Syndrome.
Vitko HA, Keyrouze KA, Miller SA, et al.·The American journal of nursing·
Alpha-gal syndrome (AGS) is an emerging tick-borne allergic condition associated with bites from the lone star tick (Amblyomma americanum). Unlike typical tick-borne diseases caused by bacteria or vir...
Alpha-gal-specific human IgE promotes both alpha-gal-induced and antigen-independent allergic effector cell activation.
Wang Y, Zhang Y, Dudley C, et al.·The Journal of allergy and clinical immunology·
In alpha-gal syndrome (AGS), IgE antibodies form against the glycan galactose-α-1,3-galactose (alpha-gal) in mammal products rather than food proteins. Alpha-gal glycolipids and glycoproteins activate...
Reply to "Fatal reactions to alpha-gal might be due to comorbid mast cell diseases".
Platts-Mills TAE, Workman LJ, Richards NE, et al.·The journal of allergy and clinical immunology. In practice·
View on PubMed →Fatal reactions to alpha-gal might be due to comorbid mast cell diseases.
Moraczewski J, Stone CA·The journal of allergy and clinical immunology. In practice·
View on PubMed →Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria.
Cuamba I, Santano R, Grau-Pujol B, et al.·BMC medicine·
Clearance of Plasmodium falciparum infection requires a T1 immune response with production of pro-inflammatory cytokines, IgG1, and IgG3 responses. In contrast, infections with helminths are dominated...
A Health-Economic Analysis of Alpha-Gal Screening in the Asymptomatic Patient to Prevent Fatal Anaphylaxis.
Shaker M, Wang J, Chu D, et al.·The journal of allergy and clinical immunology. In practice·
Sensitization to galactose-α-1,3-galactose (alpha-gal) can present with variable signs and symptoms. Although sensitization may be asymptomatic in a large proportion of individuals, in some it may pre...
View on PubMed →Beefing Up Awareness: Navigating Alpha-Gal Syndrome.
Davis MJ, Topol D, Davis ME·Clinical journal of oncology nursing·
Alpha-gal syndrome (AGS) is an acquired allergy caused by an immunoglobulin E-mediated reaction to alpha-gal, or galactose-alpha-1,3-galactose, a sugar molecule found in mammalian meat. Clinicians can...
Further insights into the sialome switch of Amblyomma americanum adult females.
Lu S, Ribeiro JMC, Tirloni L·BMC genomics·
BACKGROUND: The lone star tick, Amblyomma americanum, is a three-host species widely distributed across North America and a vector for multiple human pathogens. Bites from this tick is also associated...
Tick to table: a scoping review on the global impact of alpha-gal syndrome.
Owens Pickle E, Dye-Braumuller K, Self S, et al.·Journal of medical entomology·
Alpha-gal syndrome (AGS) is a tick-associated, IgE-mediated allergy to galactose-α-1,3-galactose (alpha-gal), an oligosaccharide found on non-primate mammalian cells expressed by various bacteria and...
Altered Levels of Known Allergens in Cultured Primary Bovine Myoblasts for Cultivated Meat.
Trlin HJF, Bennie RZ, Ogilvie OJ, et al.·Journal of agricultural and food chemistry·
Cellular agriculture combines cell culture and tissue engineering techniques to produce animal-derived food products. While cell culture is routinely reported in the medical literature to affect prote...
Alpha-Gal Syndrome in a Pediatric Patient From Northeast Florida.
Rahalkar NJ, Sanders MR, Joshi SN, et al.·Cureus·
Alpha-gal syndrome (AGS) is a rare, tick-borne condition that is characterized by a delayed hypersensitivity reaction to galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in mammalian meat p...
View on PubMed →Differential alpha-gal expression during and tick feeding and development: A driver for the development of alpha-gal syndrome in South Africa.
Murangi T, Mans B, Pienaar R, et al.·The journal of allergy and clinical immunology. Global·
The presence of galactose-α-1,3-galactose (alpha-gal) in tick salivary antigens has been implicated to initiate host IgE responses resulting in sensitization to alpha-gal. We sought to investigate the...
View on PubMed →Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha-Gal Sensitization.
Emerson AG, Mundy L, Murphy BA, et al.·Head & neck·
Alpha-gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galacto...
Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab') and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area.
Filip AB, Mahmood L, Tilly C, et al.·Annals of emergency medicine·
North American pit viper antivenoms, CroFab® and ANAVIP®, contain galactose-α-1,3-galactose (α-GAL) oligosaccharide. We compared adverse drug reactions, including presumed anaphylaxis, following admin...
Snake Antivenom Reactions: A New Finding and Continued Controversy.
Dart RC·Annals of emergency medicine·
View on PubMed →Alpha-gal sensitization and allergic transfusion reactions: a scoping review protocol.
Miller MJ, Price C, Shields TC, et al.·Systematic reviews·
Tick bites may expose individuals to a carbohydrate not found in humans, galactose-alpha-1,3-galactose (alpha-gal). A spectrum of disorders may result from IgE-mediated hypersensitivity reactions to a...
Alpha-gal syndrome: under-recognized food allergy in dermatology practice.
Tanrıbilir ME·Clinical and experimental dermatology·
View on PubMed →The Lyme Disease Vaccine Paradox.
Siegel EL, Rich SM·Journal of clinical medicine·
Lyme disease causes a significant financial and health burden. Recent advances in developing new Lyme disease vaccines have renewed optimism that vaccination may serve as an additional strategy to red...
View on PubMed →The Alpha-Gal Syndrome and Hypersensitivity to Biomaterials: Understanding Xenoimmunity.
Sami N, Parikh MA, Mihatov N, et al.·Cardiology in review·
Biomaterials derived from nonhuman mammals are increasingly used in cardiovascular interventions, yet xenoimmune responses to these materials can complicate these procedures. Xenoimmunity describes th...
View on PubMed →Lessons of Macrophage-Associated Heart Regeneration in Fish, Amphibians, and Neonatal Mice, Applied to Adult Mice: A Perspective on α-Gal Nanoparticles.
Galili U, Schaer GL·International journal of molecular sciences·
An ancient evolutionary regenerative mechanism of injured myocardium in vertebrates has been conserved in zebrafish, urodeles (salamander, newt, and axolotl) and neonatal mice. This innate regenerativ...
A Human Monoclonal Antibody Targeting α-Gal Ameliorates Experimental Cutaneous Leishmaniasis.
Cho H, Paun A, Seo Y, et al.·The Journal of infectious diseases·
Leishmaniasis is a vector-borne disease transmitted by female sand flies infected with Leishmania parasites. Cutaneous leishmaniasis is primarily caused by Leishmania major in the Old World and typica...
Linear Epitope-Mediated Immunological Cross-Reactivity in Livestock Product Allergens.
An P, Cong Y·International journal of molecular sciences·
Linear epitopes, comprising continuous amino acid sequences, are critically implicated in the immunological cross-reactivity of livestock products owing to their stability during food processing. This...
Alpha-gal sensitization and allergic blood transfusion reactions: a scoping review.
Miller MJ, Zarpak R, Lee P, et al.·Journal of translational medicine·
BACKGROUND: Tick bites may expose individuals to a carbohydrate not found in humans, galactose-alpha-1,3-galactose (alpha-gal), including allergy to mammalian red meat or red meat-derived products pre...
IgE to Galactose-α-1,3-Galactose (α-Gal) and Relevance to Ustekinumab First-Dose Infusion Reactions and Allergenicity.
Venkat PG, Nehrbas JF, Bortz PS, et al.·JGH open : an open access journal of gastroenterology and hepatology·
Ustekinumab, a monoclonal antibody (mAb) used to treat inflammatory bowel disease, has been associated with immediate hypersensitivity reactions during first intravenous infusion. While rare, the mech...
View on PubMed →Mammalian meat allergy and beyond: overview of alpha-gal syndrome.
Browning RL, Iweala OI, Jerath MR·Current opinion in allergy and clinical immunology·
Alpha-gal syndrome (AGS) is a unique allergy to the carbohydrate galactose-alpha-1,3-galactose, which is found in mammalian products, excluding humans and Old World primates. As its prevalence increas...
Successful home reintroduction of mammalian meat in patients with alpha-gal syndrome.
Owusu-Asare C, Browning RL, Jerath MR·The journal of allergy and clinical immunology. In practice·
View on PubMed →Meat allergy: Specific reactions to chicken, beef, pork, and alternative protein sources.
Lisiecka MZ·Asia Pacific allergy·
Meat allergies, though less common than other food allergies, can be difficult to diagnose due to cross-reactivity among different types of meat and varying immunological responses. Alternative protei...
View on PubMed →Maculopapular-Type Drug Eruption Caused by Cetuximab.
Ikegawa N, Saito-Sasaki N, Sawada Y·Cureus·
Cetuximab, a chimeric immunoglobulin G1 (IgG1) monoclonal antibody targeting the epidermal growth factor receptor, is well known to cause immediate hypersensitivity reactions mediated by pre-existing...
View on PubMed →Pediatric Allergy to Poultry Meat: A Case of Egg-Bird Syndrome.
Dias MI, Pereira RS, Santos PR, et al.·Cureus·
Poultry meat allergy is a rare condition that can present as a primary allergy or a secondary syndrome, such as the egg-bird syndrome. This syndrome involves primary sensitization to egg yolk (alpha-l...
View on PubMed →Conjugates of α-d-Galp-(1→3)-β-d-Galp for the serological diagnosis of Chagas disease.
Balouz V, Lopez R, Conte N, et al.·PLoS neglected tropical diseases·
Chagas disease (ChD), caused by the parasitic protozoan Trypanosoma cruzi, is a lifelong, neglected tropical disease with substantial medical and socioeconomic impact. Despite this situation, currentl...
Cross-ancestry meta-analysis identifies a GSTP1 variant in the polycyclic aromatic hydrocarbons metabolism-related pathway contributing to colorectal cancer susceptibility.
Wang W, Li H, Gao L, et al.·Archives of toxicology·
Unhealthy diets (e.g., higher red meat consumption) and tobacco exposure are major risk factors for colorectal cancer (CRC), contributing the toxic substances exposure of polycyclic aromatic hydrocarb...
Adherence to Mediterranean Diet During Pregnancy, Breastfeeding, and Development of Food Allergy in the Offspring: Results From the MEDALLION Cohort Study.
Vassilopoulou E, Karastogiannidou C, Comotti A, et al.·Allergy·
Prevention is a key strategy for reducing the burden of food allergies (FA). The maternal diet during pregnancy and breastfeeding is increasingly recognized as a factor contributing to FA risk. We ana...
Fish swim bladders as valve leaflets enhance the durability of transcatheter aortic valve replacement devices.
Jiang H, Li J, Kong Y, et al.·Acta biomaterialia·
Transcatheter aortic valve replacement (TAVR) has emerged as an effective therapy for inoperable patients with severe aortic stenosis (AS). However, calcification-induced limited durability restricts...
Misdiagnosis of alpha-gal syndrome as non-celiac gluten sensitivity or lactose intolerance: A diagnostic blind spot for clinicians.
Awosika A, Balaji P·World journal of gastroenterology·
Alpha-gal syndrome (AGS), an emerging tick-borne carbohydrate hypersensitivity, has gained increasing recognition for its atypical presentation and delayed food-related allergic reactions. While urtic...
Isohemagglutinins exhibit synergistic polyreactivity toward Streptococcus pneumoniae surface antigens: implications for broad-spectrum reactivity of human antibodies.
Bernth Jensen JM, Søgaard OS, Petersen MS, et al.·Medical microbiology and immunology·
Synergistic polyreactivity of antibodies—where distinct oligo- or polyreactive clones combine to enable broad-spectrum antigen binding—was recently demonstrated for human anti-galactose-α-1,3-galactos...
Intraoperative Anaphylaxis in the Setting of Undiagnosed Alpha-Gal Syndrome: A Heart Team Clinical Conundrum.
Henderson JJ, Saleem D, George E, et al.·JACC. Case reports·
Alpha-gal syndrome (AGS) is a delayed allergic reaction to galactose-α-1,3-galactose, a carbohydrate in nonprimate mammalian tissue. Reactions can occur in individuals exposed to lone star ticks after...
View on PubMed →Alpha-Gal Syndrome Managed With Omalizumab for Perioperative Optimization of Total Hip Arthroplasty: A Case Report.
Kohli-Pamnani A, Rodenas M, Duah BA, et al.·JBJS case connector·
A 65-year-old woman with alpha-gal syndrome (AGS) required total hip arthroplasty. Laboratories revealed galactose-alpha-1,3-galactose immunoglobulin E 0.4 kU/L (abnormal ≥ 0.1 kU/L). In the absence o...
Risk factors for α-Gal syndrome: A case-control study exploring the role of tick bites in French Guiana.
Valois A, Le Forestier J, Baduel E, et al.·Ticks and tick-borne diseases·
α-Gal Syndrome (AGS) is an IgE-mediated allergy to galactose-α-1,3-galactose (α-Gal), a carbohydrate found in non-primate mammalian tissues. AGS manifests as delayed anaphylactic reactions following t...
Understanding Alpha-Gal Syndrome: A Systematic Review and Meta-Analysis of Clinical Manifestations and Outcomes.
Rao S, Rathore SS, Goyal RM, et al.·Neurogastroenterology and motility·
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity to galactose-α-1,3-galactose, triggered by tick bites. It typically presents with delayed onset allergic or gastrointestinal symptoms after...
Complex Spine Surgery in the Setting of Alpha-Gal Syndrome.
Razzaq BW, Passman JN, DiMaria S, et al.·World neurosurgery·
Alpha-gal syndrome (AGS) is an immunoglobulin E -mediated allergy to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) that can trigger delayed anaphylaxis after exposure to nonprimate m...
Association between group B major ABO-incompatible platelet or plasma transfusion and severe allergic reactions: A nationwide haemovigilance analysis suggesting a role for α-gal syndrome. A Biomedical Excellence for Safer Transfusion Collaborative study.
Malard L, Beuscart C, de Chaisemartin L, et al.·Vox sanguinis·
Severe transfusion reactions to group B-incompatible platelets and plasma possibly related to the α-gal syndrome (AGS) have been recently described. AGS is a potentially severe Immunoglobulin E mediat...
Structure-activity relationships of acid-hydrolyzed Carrageenans: Molecular modifications and anticancer activity in colorectal Cancer cells.
Lacerda ECM, Pedrosa LF, Bezerra FF, et al.·International journal of biological macromolecules·
Carrageenans are sulfated polysaccharides found in algae and certain plants, and are widely used in the food industry. By modifying their chemical structures through sulfation, polysaccharides can enh...
From vector to allergen: exploring the immunology of tick-triggered α-Gal syndrome.
Petry J, Swiontek K, Hilger C·Frontiers in immunology·
The α-Gal syndrome (AGS) is an emerging form of food allergy characterized by delayed hypersensitivity reactions to mammalian meat products and mediated by IgE antibodies specific to the carbohydrate...
Managing Alpha-Gal Allergy in a Case of Bioprosthetic TAVR.
Patel R, Patel A, Biswas R, et al.·Case reports in immunology·
Alpha-gal syndrome (AGS) is an uncommon IgE-mediated allergy to mammalian-derived products, caused by sensitization to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) after tick exposure. Al...
View on PubMed →Beyond Side Effect: Immuno-Ethical Risk Analysis of Animal-Derived Ingredients in Pharmaceuticals.
Herdiana Y, Gozali D, Putriana NA, et al.·Risk management and healthcare policy·
Animal-derived ingredients (ADIs) account for up to 75% of prescription drugs, triggering clinical risks such as alpha-gal syndrome (AGS), ethical-religious conflicts, and supply transparency issues....
View on PubMed →Digital Health Solutions for Alpha-Gal Syndrome: A Scoping Review of Telemedicine Evidence and Applications.
Abadi AEZS, Becevic M, Dunaway L, et al.·Missouri medicine·
Alpha-gal syndrome (AGS) is an emerging allergy initiated by tick bites that leads to delayed IgE-mediated hypersensitivity reactions to galactose-α-1,3-galactose (α-gal), a carbohydrate present in ma...
Case Report: A case of carbapenem hypersensitivity and tigecycline-associated coagulopathy after immunotherapy for advanced oral cancer.
Peng Y, Peng R·Frontiers in medicine·
Managing complex infections after immunotherapy in patients with advanced head and neck cancer is clinically challenging, especially when severe adverse drug reactions like carbapenem hypersensitivity...
View on PubMed →Leishmaniasis: pathogenesis, host immunity, and the evolving landscape of immunotherapy and immunochemotherapy.
Okeke GN, Oduwe UK, Kenkebashvili G, et al.·Frontiers in microbiology·
Leishmaniasis is a group of neglected tropical diseases caused by protozoan parasites of the genus , transmitted by the bite of infected female phlebotomine sandflies. Manifesting as cutaneous (CL), m...
View on PubMed →Deciphering Protein Interaction Dynamics Using the Yeast Three-Hybrid System.
Liu Q, Ponnu J·Methods in molecular biology (Clifton, N.J.)·
Proteins often act together with other proteins to regulate crucial biological processes. Beyond binary interactions, they often operate within multi-protein assemblies, where alterations in binding a...
Can food allergy trigger acute pancreatitis? Exploring an unusual etiology.
Balaban YA, Inan MI, Kalkan F, et al.·Allergologia et immunopathologia·
Food allergy (FA) is an immune-mediated hypersensitivity reaction to specific dietary antigens. While FA typically manifests with skin, respiratory, or gastrointestinal symptoms, its role in acute pan...
Alpha-Gal Syndrome Allergy to Intravitreal Administration of Anti-Vascular Endothelial Growth Factor Agents.
Zhang E, Bylund R, Zhang A, et al.·Journal of vitreoretinal diseases·
To describe a case of allergic reaction to intravitreal (IVT) injection of antivascular endothelial growth factor (anti-VEGF) medications in patients with alpha-gal syndrome. A single case was evalua...
View on PubMed →α‑Gal Causes Tick-Related Meat AllergiesIt Could Also Be a Therapeutic.
Zaraska M·ACS central science·
As people with α-gal syndrome seek to boost awareness, researchers are looking to harness the molecule for new therapies.
View on PubMed →A Case of Severe Skin Adverse Reactions Caused by Cetuximab.
Yan YT, Jiang CH, Wang L, et al.·Journal of visualized experiments : JoVE·
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), is associated with various adverse reactions, among which skin-related adverse events (AEs) are common. This cas...
Childhood-onset alpha-gal syndrome in the central black sea region: real-world data on diagnostic delays, age-specific clinical patterns, environmental risk factors, and anaphylaxis predictors.
Kökcü Karadağ Şİ, Kutlu A, Kutluğ Ş, et al.·European journal of pediatrics·
Alpha-gal syndrome (AGS) remains underdiagnosed in the pediatric population despite increasing awareness. This study comprehensively evaluates diagnostic delays, age-specific clinical presentations, e...
Naturally acquired immune responses to alpha-gal in malaria endemic settings and pre-clinical efficacy testing with R21/MM.
Mukhopadhyay ES, Bellamy DG, Tinto H, et al.·Vaccine·
Malaria sporozoite surface glycan alpha-gal (α-gal), which is absent in humans has been shown to elicit an antibody response that can confer protection against malaria in alpha- gal transferase knock-...
Global trend of food-induced anaphylaxis: Up to date.
Leung AS, Estrada-Reyes E, Goto K, et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
This review examines the evolving global landscape of food-induced anaphylaxis (FIA), revealing critical epidemiological shifts that challenge traditional allergen management paradigms. As the leading...
Alpha-gal syndrome across the lifespan: Distinct pediatric clinical patterns and rural predominance in Midwestern patients.
Patrick B, Salathe V, Casterline BW·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
View on PubMed →Could alpha-gal syndrome be the cause of southern tick-associated rash illness (STARI)? : A simple study could answer that question.
Wormser GP, Shishido A·Wiener klinische Wochenschrift·
View on PubMed →Allergic reactions associated with tsetse fly bites.
Vaz-Rodrigues R, P Odyek Abila P, Kasaija PD, et al.·Annals of medicine·
Allergic reactions in response to arthropod bites are a growing concern worldwide. Alpha-Gal syndrome (AGS) is a red meat allergy associated with IgE antibodies against galactose-alpha-1,3-galactose (...
Public perspectives on tick bite exposure, healthcare visits and associated allergies in iberia.
Vaz-Rodrigues R, Rafael M, Carniato D, et al.·Annals of medicine·
Tick bites and tick-borne diseases (TBDs) are a worldwide concern, with growing evidence of an ongoing spread and emergence of new cases. This study applied a participatory citizen science across Spai...
Associations Between the Maternal Diet Index and Childhood Asthma: The NorthPop and Healthy Start Cohorts.
Bodén S, Venter C, Pickett-Nairne K, et al.·Clinical and translational allergy·
A novel maternal diet index (MDI), characterizing offspring asthma- and allergy-associated maternal intake during pregnancy was constructed and validated in Healthy Start, USA. This study aims to (1)...
View on PubMed →A systematic review of tick removal techniques: Relationship to outcomes of tick-induced allergic reactions and tick-borne illnesses.
Owen A, Duong K, Symons J, et al.·Asia Pacific allergy·
Australia has the highest prevalence worldwide of tick-induced allergies (mammalian meat and tick allergy/anaphylaxis). Inappropriate tick removal techniques are known to trigger tick anaphylaxis. Thi...
View on PubMed →Unambiguous identification and quantification of galactose-α-1,3-galactose as a critical quality attribute with mass spectrometry and exoglycosidases.
Gan Y, Johnson EJ, Tran V, et al.·mAbs·
Alpha-galactosylation, galactose-α-1,3-galactose (α-Gal), is always regarded as a critical quality attribute due to its potential to provoke immunogenic responses in patients. Consequently, monitoring...
Implications of a fatal anaphylactic reaction occurring 4 hours after eating beef in a young man with IgE antibodies to galactose-α-1,3-galactose.
Platts-Mills TAE, Workman LJ, Richards NE, et al.·The journal of allergy and clinical immunology. In practice·
View on PubMed →Idiopathic Anaphylaxis.
Ben-Shoshan M, Cem A, Cook VE, et al.·The journal of allergy and clinical immunology. In practice·
Idiopathic anaphylaxis (IA) refers to recurrent, life-threatening hypersensitivity reactions without identifiable triggers, representing a diagnostic and therapeutic challenge. We describe a 17-year-o...
Development and evaluation of a new protocol for the management of immediate hypersensitivity reactions in an oncology outpatient department.
Cren PY, Rosier G, Penel N, et al.·Bulletin du cancer·
Management of immediate hypersensitivity reactions (HSRs) is an everyday practice issue in oncology. Our primary objective aimed to harmonize the management of HSRs. The second aim was to evaluate the...
Ticked Off: Allergic Effector Cells in the Pathogenesis of Alpha-gal Syndrome.
Kepley CL, Wang Y, Yelton A, et al.·Current allergy and asthma reports·
Alpha-gal syndrome (AGS) is a novel allergic disease characterized by hypersensitivity responses following exposure to the glycan galactose-alpha-1,3-galactose (alpha-gal or α-Gal) attached to mammali...
Evaluation of lactoferrin administration as an antibiotic alternative growth promoter: impacts on rabbit's growth, meat quality, blood biochemical parameters, immune status, antioxidant status, and tissue histology.
Imbabi TA, Amer SA, Halawa EH, et al.·Tropical animal health and production·
Antibiotic-resistant microbes have emerged because of the widespread misuse of antibiotics in modern animal production. To overcome antibiotic resistance, the name lactoferrin (Lf) is promising since...
Monosaccharide Binding to Synthetic Carbohydrate Receptor Microarrays.
Shlain MA, Erzoah Ndede K, Thakur K, et al.·The journal of physical chemistry. C, Nanomaterials and interfaces·
A glycan detection platform, comprised of synthetic carbohydrate receptors (SCRs) immobilized onto polymer brushes, was prepared. , an alkene-containing SCR, was incorporated into grafted-from polymer...
View on PubMed →Assessing the potential risk of lone star tick, Amblyomma americanum, establishment in California.
Foley J, Rubino F, Kam D, et al.·Ticks and tick-borne diseases·
The lone star tick (LST), Amblyomma americanum, is an aggressive human biter and important vector of the causative agents of tick-borne diseases. As geographic ranges of multiple Amblyomma species rap...
UB-221, an antibody that neutralizes IgE and downregulates the CD23 receptor: a potential treatment for the alpha-gal syndrome.
Reznik SE, Tiwari AK, Ashby CR·Ticks and tick-borne diseases·
View on PubMed →Food Anaphylaxis: Eight Food Allergens Without Mandatory Labelling Highlighted by the French Allergy-Vigilance Network.
Sabouraud-Leclerc D, Mariotte D, Bradatan E, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
The European Regulation list on mandatory labelling of foods includes 14 allergenic foods; however, other foods are also frequently implicated in food-induced anaphylaxis (FIA). We analysed FIA cases...
Alpha-Gal Syndrome and Aortic Valve Replacement.
Sami N, Ravishankar B, Worku B, et al.·JACC. Case reports·
Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity response to galactose-alpha-1,3-galactose (alpha-gal), an oligosaccharide present in beef and pork. This complicates bioprosthetic heart va...
View on PubMed →Immunologic investigation of an allergic transfusion reaction suspected due to alpha-gal syndrome.
Jones VM, Nakahara H, Choudhary SK, et al.·Transfusion·
The bites of certain tick species can induce galactose-α-1,3-galactose (alpha-gal) IgE formation. Individuals with alpha-gal IgE can become allergic to meat, a condition termed alpha-gal syndrome. Alp...
Beneficial Bloodsucking.
Crutchfield P, Hereth B·Bioethics·
The bite of the lone star tick spreads alpha-gal syndrome (AGS), a condition whose only effect is the creation of a severe but nonfatal red meat allergy. Public health departments warn against lone st...
Unraveling the Effect of the C-terminal Tail of Mannose-Binding Protein and Discovery of a Second Functional Sugar-Binding Site.
Rahayu AP, Akhwan ZR, Karsono AH, et al.·Biochemistry. Biokhimiia·
The effect of the C-terminal tail on the bioactivity of mannose-binding protein (Abmb) was investigated. Based on the earlier obtained crystal structure of Abmb, it was suggested that the additional...
Severe asthma and new-onset meat allergy in a child: Could a new puppy be to blame?
Misra G, Grohman R, Kazachkov M, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
View on PubMed →[Genuine awareness of mammalian meat such as beef and pork: Myth or reality?].
Flores-Montiel A, Hernández-Ojeda M, O Farril-Romanillos PM, et al.·Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·
Genuine sensitization to beef and pork is rare, with the best-characterized allergens being beef and pork (Bos d 6 and Sus s1). There are different presentations of mammalian meat allergy: cat-pork sy...
A methylation-assisted gas chromatography-mass spectrometry strategy for comprehensive monosaccharide profiling in Polygonatum polysaccharides: Overcoming limitations of conventional chromatographic techniques.
Xu L, Yao J, Wang Z, et al.·Journal of chromatography. A·
Conventional methods for analyzing monosaccharides, such as 1-Phenyl-3-methyl-5-pyrazolone (PMP) derivatization coupled with high-performance liquid chromatography (HPLC), struggle to detect ketoses a...
Alpha-Gal Syndrome in the Heartland: Dietary Restrictions, Public Awareness, and Systemic Barriers in Rural Kansas.
Sempa J, Brenes P, Tegeler A, et al.·Nutrients·
: Alpha-gal syndrome (AGS) is a tick-borne allergic condition increasingly prevalent in the Southern, Eastern and Mid-western regions of the United States. This study aims to assess the awareness and...
Alpha-Gal Syndrome-A Series of Cases with Different Clinical Pictures.
Branicka O, Rozłucka L, Gawlik R, et al.·International journal of molecular sciences·
Alpha-gal syndrome (AGS) is an IgE-mediated allergy, triggered by a carbohydrate-galactose-α-1,3-galactose (α-Gal). AGS is marked by a delayed onset of symptoms, typically occurring 3-8 h after the in...
Opinion: Ecologists and entomologists wanted! An open invitation to alpha-gal syndrome research.
Barnett KM, Maki CK, Nicholson WL, et al.·Ticks and tick-borne diseases·
In this Opinion, the authors investigated peer-reviewed publications on alpha-gal syndrome (AGS), also known as red meat allergy, since its first description in the literature in 2009 to October 2024...
Association between tick-bite history and safety of gelatin-containing vaccines: Analysis of a large database of the United States.
Chiu CY, Henao-Martínez AF, Agudelo Higuita NI·Ticks and tick-borne diseases·
Alpha-gal syndrome (AGS) is an allergic reaction caused by sensitization to alpha-gal, a sugar molecule in gelatin-containing vaccines. Tick bites can induce alpha-gal IgE sensitization, as ticks inje...
ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study.
Dunbar NM, Kaufman RM, Bary KS, et al.·Transfusion·
Alpha-gal syndrome (AGS) is caused by IgE antibodies against the alpha-gal oligosaccharide, which is structurally similar to the Group B antigen. Recent case reports of severe allergic transfusion rea...
Perioperative Considerations for a Patient with Alpha-Gal Syndrome Undergoing Cardiac Surgery.
Rinehart CD, Wang K, LoBue C, et al.·Journal of cardiothoracic and vascular anesthesia·
View on PubMed →Isolation and structural identification of the homogeneous polysaccharide CGPA1 from Calvatia gigantea with wound healing effects.
Meng X, Zhao W, Zhao Y, et al.·Carbohydrate polymers·
Calvatia gigantea is a traditional Chinese medicinal fungus known for its diverse pharmacological effects, with polysaccharides being one of its main bioactive components. In this study, a novel homog...
The Role of sp. in α-Gal Sensitization: Implications for Parasitic-Induced Meat Allergy.
Rodero M, Romero S, Valcárcel Á, et al.·Pathogens (Basel, Switzerland)·
This study investigates the potential of sp. as a novel source of α-Gal (Galα1-3Galβ1-4GlcNAc-R) epitopes capable of inducing allergic sensitization in humans. While α-Gal is classically associated w...
A Review of Alpha-Gal Syndrome for the Infectious Diseases Practitioner.
Shishido AA, Wormser GP·Open forum infectious diseases·
Alpha-gal syndrome (AGS) is an emerging allergic disease caused by an immunoglobulin E (IgE) response to galactose-α-1,3-galactose (alpha-gal), a sugar found in mammalian meat. The initial IgE sensiti...
View on PubMed →Living close to the forest is a risk factor for galactose-α-1,3-galactose sensitization.
Leth-Møller KB, Hansen FR, van Hage M, et al.·The journal of allergy and clinical immunology. Global·
The α-gal syndrome is a food allergy to galactose-α-1,3-galactose present in mammalian meat; it usually develops after tick bites. Despite being considered an emerging health problem, little is known...
View on PubMed →Longitudinal Follow-up Reveals Peripheral Immunological Changes Upon Tick Bite in α-Gal-Sensitized Individuals.
Swiontek K, Fischer J, Hedin F, et al.·Journal of investigational allergology & clinical immunology·
α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion of mammalian meat. While...
Diet Diversity and Adherence to a Mediterranean Diet Pattern in Pregnancy Is Protective Against the Development of Early-Childhood Atopic Dermatitis.
Heye KN, Bogl LH, Sasaki M, et al.·Nutrients·
The role of maternal diet in atopic dermatitis (AD) requires better understanding, as AD often manifests early in life and precedes other allergic diseases. We evaluated the association between matern...
Alpha-Gal on the Rise: The Alarming Growth of Alpha-Gal Syndrome in High-Risk Regions.
Ross M, Daley G, Burnard ML, et al.·Cureus·
Background Mammalian meat allergy (MMA), increasingly linked to delayed hypersensitivity reactions such as alpha-gal syndrome, is a growing public health concern. This study evaluates the incidence, p...
View on PubMed →Serum albumin sensitization in children with cow's milk allergy: Clinical relevance to red meat reactions.
Özdemiral C, Konuralp I, Sekerel BE·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
Sensitization to serum albumins (SAs) in cow's milk allergy (CMA) may contribute to red meat (RM) allergy. This study evaluated the prevalence of SA sensitization, patterns of cross-sensitization, and...
The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat.
Platts-Mills TAE, Gangwar RS, Workman L, et al.·Immunological reviews·
The primary features of the alpha-gal syndrome (AGS) are (i) The IgE ab that are causally related to anaphylaxis with infusions of Cetuximab are specific for galactose alpha-1,3-galactose. (ii) In the...
Alpha-gal syndrome: potential for a hypersensitivity reaction after the use of dental products: Literature review and case report.
Brooks JK, Hoch NI, Hoch ER, et al.·Journal of the American Dental Association (1939)·
Alpha-gal syndrome (AGS) is associated with a potentially severe delayed immunoglobulin E-based hypersensitivity reaction produced via transmission of a salivary oligosaccharide (galactose-⍺-1,3-galac...
Analysis of Acute Hypersensitivity Reactions by Antivenom Type and Geographic Location in the North American Snake Bite Registry (NASBR).
Glaser T, Culbreth R, Liebelt EL, et al.·Journal of medical toxicology : official journal of the American College of Medical Toxicology·
Evidence regarding acute hypersensitivity reactions (AHRs) to the snakebite antivenoms Crotalidae Polyvalent Immune Fab (ovine) (Fab) and Crotalidae Immune F(ab') (equine) (Fab2) supports no differenc...
Food allergy endotypes revisited.
Baker MG, Wong LSY, Konstantinou GN, et al.·The Journal of allergy and clinical immunology·
In the last century, food allergy has become recognized as an increasingly prevalent and heterogeneous condition. Advances in biomedical technology have revealed complex genetic, environmental, immune...
Pre-clinical strategies and emerging technologies driving advances in the alpha-gal syndrome.
Erickson LD, Wilson JM, Cramton K, et al.·Allergology international : official journal of the Japanese Society of Allergology·
Alpha-gal syndrome (AGS) is a unique allergic condition triggered by IgE antibody production against the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal). The syndrome, acquired by bites fr...
Lectin microarray analysis of salivary gland glycoproteins from arboviral vector Aedes aegypti and malaria vector Anopheles stephensi.
Ramasamy R, Chen X, Zhang J, et al.·Journal of vector borne diseases·
Salivary gland proteins but not glycoconjugates have been previously studied in mosquito vectors of human diseases. Glycoconjugates from salivary gland-derived proteins from human-feeding tick vectors...
Is gastrointestinal epithelial barrier dysfunction the only responsible for sensitization to food allergens?
Asero R, Pravettoni V, Villalta D, et al.·European annals of allergy and clinical immunology·
Epithelial barriers are crucial defenses against pathogens and allergens, and recent theories suggest that environmental factors may compromise them, leading to type 2 inflammation and conditions such...
Effects of Polypropylene and Polyethylene Terephthalate Microplastics on Trypsin Structure and Function.
Lujic T, Gligorijevic N, Stanic-Vucinic D, et al.·International journal of molecular sciences·
Ingestion is one of the main exposure routes of humans and animals to microplastics (MPs). During digestion, MPs can interact with both gastrointestinal enzymes and food proteins. This study investiga...
Publisher Correction: Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection.
Vaz-Rodrigues R, Mazuecos L, Contreras M, et al.·Scientific reports·
View on PubMed →Integrative approaches unravelling tea drought alleviation mechanisms primed by carbonyl volatiles and signal peptide.
Bassiony A, Sun S, Yan K, et al.·Plant physiology and biochemistry : PPB·
Drought stress (DS) significantly hampers the growth and productivity of tea plants, necessitating effective strategies to enhance their resilience. This study comprehensively investigated the mechani...
Diagnostic cat and dog allergenic products contain galactose-α-1,3-galactose.
Merritt TK, Bermingham MD, Agah S, et al.·The journal of allergy and clinical immunology. In practice·
View on PubMed →IgG to Galactose-Alpha-1,3-Galactose: Impact of Alpha-Gal IgE Sensitization, Blood Type, and Tick Bites.
Ailsworth SM, MacCallum M, Richards NE, et al.·Antibodies (Basel, Switzerland)·
Antibodies to galactose-alpha-1,3-galactose (alpha-gal), particularly the IgM and IgG isotypes, are abundant in human sera. These antibodies are known to be an important xenotransplantation barrier, b...
View on PubMed →Alpha-gal allergy in a South Asian country.
Dasanayake D, Karunatilake C, Karunaratne C, et al.·BMC immunology·
Alpha gal syndrome (AGS) is a delayed allergy to red meat, due to IgE to galactose-alpha-1,3-galactose (alpha-gal). Sensitization occurs via tick bites. It has been described in the US, Europe, Austra...
Is Zebrafish a Good Model for the Alpha-Gal Syndrome?
Vaz-Rodrigues R, de la Fuente J·FASEB journal : official publication of the Federation of American Societies for Experimental Biology·
The alpha-Gal syndrome (AGS) is an underdiagnosed tick-borne allergy characterized by both immediate and delayed IgE-mediated anaphylactic reactions to the galactose-alpha-1,3-galactose (alpha-Gal) ep...
Impact of Staphylococcus aureus colonization and skin abscesses on formation of human anti-αGal antibodies.
Bernth Jensen JM, Dinh KM, Hindhede L, et al.·Medical microbiology and immunology·
IgG antibodies against terminal galactose-α-1,3-galactose (anti-αGal antibodies) are naturally occurring in humans, but their origins remain poorly understood. These antibodies target various microorg...
Alpha-gal syndrome: Recognizing and managing a tick-bite-related meat allergy.
Naseem Z, Muhammad A, Chatterjee A, et al.·Cleveland Clinic journal of medicine·
Alpha-gal syndrome is an emerging condition characterized by an immunoglobulin (Ig) E-mediated reaction to galactose-alpha-1,3-galactose (alpha-gal) after consumption of mammalian-derived food product...
An eczematous eruption with features of prurigo nodularis: An unexpected presentation of alpha-gal syndrome.
Wu S, Nadelmann ER, Koschitzky M, et al.·JAAD case reports·
View on PubMed →Connecting Diagnostics and Clinical Relevance of the α-Gal Syndrome-Individual Sensitization Patterns of Patients with Suspected α-Gal-Associated Allergy.
Jappe U, Kolaly T, de Vries MS, et al.·Nutrients·
Sensitization to the carbohydrate antigen α-Gal is associated with allergic reactions against different types of food that contain α-Gal (e.g., mammalian meat). This form of allergy is termed α-Gal sy...
Big Data-Driven Evolution of a Diagnostic Multiplex IgE-Test: Enhancing Accuracy and Efficacy in Allergy Diagnostics.
Lupinek C, Forstenlechner P, Ringauf A, et al.·International journal of molecular sciences·
The ALEX-test (MacroArray Diagnostics, Vienna, Austria) is a diagnostic multiplex IgE-test for the simultaneous detection of IgE to 178 allergens and 117 extracts, in addition to total IgE. Test resul...
Conformational Profile of Galactose-α-1,3-Galactose (α-Gal) and Structural Basis of Its Immunological Response.
Santra G, Pantazis DA·Chemistry (Weinheim an der Bergstrasse, Germany)·
Small carbohydrates present a rich and complex conformational landscape whose accurate description is a significant challenge for computational molecular science, yet essential for understanding their...
Alpha-gal syndrome in general practice: red meat food allergy caused by UK ticks.
Douglas JD, Furrie E, Jones S·The British journal of general practice : the journal of the Royal College of General Practitioners·
View on PubMed →Onset of Alpha-Gal Syndrome after Tick Bite, Washington, USA.
Butler WK, Oltean HN, Dykstra EA, et al.·Emerging infectious diseases·
We describe a case of alpha-gal syndrome (AGS) in a resident of Washington, USA, after local Ixodes pacificus tick bites, which were associated with IgE increases after diagnosis. AGS should be consid...
Alpha-Gal Syndrome after Ixodes scapularis Tick Bite and Statewide Surveillance, Maine, USA, 2014-2023.
Saunders EF, Sohail H, Myles DJ, et al.·Emerging infectious diseases·
In the United States, alpha-gal syndrome (AGS) is primarily associated with lone star tick (Amblyomma americanum) bites. We describe AGS onset after an Ixodes scapularis tick bite and present AGS surv...
Alpha-Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans.
van Gorkom T, Heron M, Hofhuis A, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
α-Gal syndrome (AGS) is an emerging tick-borne disease characterised by the development of specific immunoglobulin E (sIgE) antibodies against galactose-α-1,3-galactose (α-gal), a carbohydrate found i...
French Guiana and AGS: a path to uncovering hidden clues.
Baduel E, Smilov M, Epelboin L·Expert review of clinical immunology·
This article is a narrative review exploring how research in French Guiana could unlock the mysteries surrounding Alpha-Gal Syndrome (AGS), a recently identified IgE-mediated allergy with delayed reac...
Desensitization with telemedicine: A novel protocol using remote monitoring for oral immunotherapy for alpha-gal syndrome.
Wu AG, Patel MC, Ramesh M·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
View on PubMed →Mutations Inactivating Biosynthesis of Dispensable Carbohydrate-Antigens Prevented Extinctions in Primate/Human Lineage Evolution.
Galili U·Journal of molecular evolution·
The human natural anti-carbohydrate antibodies anti-Gal, anti-Neu5Gc, and anti-Forssman are "living-fossils" that appeared in ancestral apes, monkeys and hominins millions of years ago. These antibodi...
Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection.
Vaz-Rodrigues R, Mazuecos L, Contreras M, et al.·Scientific reports·
The alpha-Gal syndrome (AGS) evolved as a catastrophic selection associated with anti-α-Gal IgM/IgG protective response against pathogen infection and tick-borne food allergy caused by IgE-type antibo...
Time From Onset to Diagnosis of Alpha-Gal Syndrome.
Maki CK, Saunders EF, Taylor ML, et al.·JAMA network open·
View on PubMed →Perioperative Outcomes After Bioprosthetic Valve Replacement in Patients Sensitized to Alpha-Gal.
Aykut B, Lim HK, Ngeve SM, et al.·Annals of thoracic surgery short reports·
Alpha-gal syndrome from tick bites, due to sensitivity to alpha-gal, can cause severe allergies. Heart valve implants contain alpha-gal, yet alpha-gal syndrome screening is not standard before valve r...
View on PubMed →α-Galactose Syndrome Cases within the Prisma Health System, South Carolina.
Waltz H, Kaminski L, Dye-Braumuller K, et al.·Southern medical journal·
Humans can develop a vector-associated allergy to galactose-α-1,3-galactose (α-gal) a polysaccharide found in mammalian meats and by-products, resulting in α-gal syndrome (AGS). tick bites have been...
Alpha-Gal Syndrome: A Review for the General Internist.
Peterson CJ, Mohankumar P, Tarbox JA, et al.·The American journal of the medical sciences·
Alpha-gal syndrome develops in some individuals who have had tick bites which result in IgE responses to alpha-gal, a carbohydrate not found in humans. Patients with alpha-gal syndrome develop symptom...
Clinical usefulness of anti-α3Gal immunoglobulin E assays for cetuximab-mediated anaphylaxis in head and neck cancer.
Pointreau Y, Freneaux C, Bejan-Angoulvant T, et al.·Immuno-oncology technology·
Fatal anaphylactic reactions to cetuximab remain a clinical issue, although they are associated with preexisting immunoglobulin E (IgE) directed against the galactose-α1,3-galactose epitope (α3Gal). W...
View on PubMed →Sensitization to common foods and early vascular aging: associations and the mitigating effects of health behaviors.
Shen R, Chen S, Zhou Z, et al.·BMC public health·
Sensitization to common foods is typically considered clinically irrelevant in individuals without symptomatic food allergies. However, recent studies found an association between IgE specific to the...
Flounder Roe Triggering α-Gal Syndrome: Hyosophorin as a Possible Allergen.
Hashizume H, Matsuura A, Ishikawa Y, et al.·Acta dermato-venereologica·
View on PubMed →Alpha-Gal Syndrome: An Emerging Tick-Borne Allergy to Red Meat.
McCladdie T, Herman M·Cureus·
Alpha-gal syndrome (AGS) is a delayed-onset food allergy triggered by an immune response to galactose-α-1,3-galactose (alpha-gal), a carbohydrate associated with Lone Star tick bites. A 45-year-old fe...
View on PubMed →Incidence of anaphylaxis in patients with alpha-gal syndrome receiving gelatin-containing vaccines: A large database analysis.
Chiu CY, Henao-Martínez AF, Agudelo Higuita NI·The journal of allergy and clinical immunology. In practice·
View on PubMed →Safety and Low Incidence of Anaphylaxis in Performing Oral Drug and Food Challenges in Mastocytosis.
Bent RK, Varsanova I, Faihs V, et al.·The journal of allergy and clinical immunology. In practice·
Patients with mastocytosis (MC) have an increased risk of severe anaphylaxis. They report hypersensitivity reactions to drugs and food, but causality often remains questionable. Most allergy centers a...
Genetic and Immunological Insights into Tick-Bite Hypersensitivity and Alpha-Gal Syndrome: A Case Study Approach.
Banović P, Jakimovski D, Mijatović D, et al.·International journal of molecular sciences·
Tick-bite hypersensitivity encompasses a range of clinical manifestations, from localized allergic reactions to systemic conditions like alpha-gal syndrome (AGS), an IgE-mediated allergy to galactose-...
Multiple Allergen Simultaneous Test for Food Allergens Cannot Screen Wheat-Dependent, Exercise-Induced Anaphylaxis and α-Gal Syndrome.
Park JS, Yoo Y, Kwon JW·Yonsei medical journal·
Screening tests for specific immunoglobulin E (sIgE) to food allergens, such as the multiple allergen simultaneous test (MAST), are widely used in patients with suspected food allergies in South Korea...
Case Report: Alpha-Gal Diagnosis in an Adolescent With Cystic Fibrosis.
Coyne S, Condren M·Pediatric pulmonology·
A 17-year-old female with cystic fibrosis was diagnosed with alpha-gal syndrome after 6 months of progressively worsening abdominal pain. Alpha-gal is an acquired allergy to mammalian products that ca...
Alpha Guy? No, Alpha Gal-Important to Remember in Patients with IBD in Endemic Areas.
Muratore A, Barnes EL, Long MD, et al.·Digestive diseases and sciences·
View on PubMed →Increasing prevalence of galactose-α-1,3-galactose sensitization in the Danish general adult population.
Leth-Møller KB, van Hage M, Apostolovic D, et al.·Allergy·
Alpha-gal syndrome is a novel food allergy to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) present in mammalian meat. Tick bites are considered an important route of sensitization to alph...
Clinical Presentation and Outcomes of Alpha-Gal Syndrome.
Lesmana E, Rao S, Keehn A, et al.·Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·
Alpha-gal syndrome (AGS) is an IgE-mediated allergic reaction to galactose-α-1,3-galactose, primarily linked with Lone Star tick bites in the United States. It presents with symptoms ranging from urti...
Allergenic potency of various foods of mammalian origin in patients with α-Gal syndrome.
Perusko M, Grundström J, Eldh M, et al.·Allergy·
The α-Gal syndrome (AGS) is an emerging allergy to mammalian food caused by IgE-mediated reactions to the carbohydrate galactose-α-1,3-galactose (α-Gal). Mammalian food sources contain α-Gal, but the...
Structural characterization and in vitro hepatoprotective activity of an acidic polysaccharide from Dendrobium nobile Lindl. flower.
Li Y, Duan X, Wang Y, et al.·International journal of biological macromolecules·
This study aimed to investigate the structural characterization, conformational properties, and hepatoprotectiveactivity of acidic polysaccharide (DNLPS-3) from Dendrobium nobile flower. DNLPS-3 with...
Transcriptomics insights into the functional role of tick Ixodes ricinus proteins metalloprotease and antigen p23.
Vaz-Rodrigues R, Duru VC, Nijhof AM, et al.·PloS one·
Ixodes ricinus ticks (Acari: Ixodidae) are hematophagous ectoparasites and a major European vector of zoonotic diseases affecting global health. Tick salivary and midgut proteins antigen p23 (A0A0K8RK...
Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome.
Choudhary SK, Commins SP·Frontiers in immunology·
Alpha-gal syndrome (AGS) is an IgE-mediated allergy to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Alpha-gal is found in the tissues of non-catarrhine mammals, and the characteristi...
Alpha gal syndrome - A rare case report in South India.
Sribalaji S, S A, J M·Bioinformation·
A 31-year-old female presented with complaints of itching with previous history of 5-6 anaphylactic reactions since last one month. Her symptoms were preceded (3-6 hours) with intake of red meat. She...
View on PubMed →Alpha-Gal Syndrome: Often Hidden, Under-Recognized, and in Need of Attention-A Rapid Review.
Thompson CC, Saracco B, Pruthi A, et al.·International journal of general medicine·
Alpha-gal syndrome (AGS), a tick-borne allergy, is increasing as its vectors migrate throughout the US and the world. There were an estimated 450,000 cases in the US. AGS reactions to mammalian foods...
View on PubMed →Perioperative management of alpha-gal syndrome in bariatric surgery: A case study of venous thromboembolism prophylaxis.
Glaze K, Ancayan S, Dodge S·Journal of the American Pharmacists Association : JAPhA·
Alpha-gal syndrome (AGS) is a tick-borne allergic condition triggered by galactose-alpha-1,3-galactose, a carbohydrate found in mammalian products. This case report highlights the perioperative challe...
Alpha-gal syndrome and the gastrointestinal reaction: a narrative review.
Propst SBH, Thompson DK·Frontiers in allergy·
Gastrointestinal (GI) disturbances such as abdominal pain, nausea, and diarrhea are infrequently attributed to food allergies as an initial diagnosis in the absence of more traditional allergic reacti...
View on PubMed →Eosinophils in inflammatory bowel disease pathogenesis: an ROS-centric view.
Tomii T, Kano G·Frontiers in allergy·
Eosinophils (Eos), long recognized for their roles in allergy and helminth defense, are now emerging as key players in gastrointestinal immune regulation. In inflammatory bowel disease (IBD), eosinoph...
View on PubMed →A protocol for pre-treatment testing for antibodies to galactose-alpha-1,3-galactose to mitigate the risk of cetuximab hypersensitivity reactions - a retrospective cohort review.
Della Marta N, Yuile A, Mok C, et al.·Cancer treatment and research communications·
Cetuximab improves survival in KRAS wildtype metastatic colorectal cancer. However, high rates of hypersensitivity reactions (HSRs) limit its use, with HSR rates up to 10-20 %. A major driver of cetux...
Microorganism changes in the gut of surviving for the long term in forests.
Chen L, Li Z, Yuan D, et al.·Frontiers in cellular and infection microbiology·
Alpha-galactosides (oligosaccharides) in nectar and pollen cause honey bee larval rot and worker bloats. Honey bee colonies surviving in forests for a long period have low rates of larval rot and wo...
Fewer injections, less pain: Successful cyanocobalamin desensitization.
Katran ZY, Bulut İ·Allergologia et immunopathologia·
Vitamin B12 (cobalamin) is a water-soluble vitamin that is derived from animal products such as red meat, dairy, and eggs. Cobalamin deficiency can be frequently seen in people all around the world. D...
Characterization of HOL-30: a novel tandem-repeat galectin from the marine sponge .
Ohkawa M, Kamata K, Kawsar SMA, et al.·BBA advances·
We here report the novel primary structure of a new member in the galectin family, the β-galactoside-binding lectin HOL-30, from the marine sponge , whose full-length sequence was determined thanks to...
View on PubMed →[PORK-CAT SYNDROME WITH ALLERGIC SYMPTOMS DUE TO THE INGESTION OF COW'S MILK].
Takewa R, Chinuki Y, Harada Y, et al.·Arerugi = [Allergy]·
We present a case of a 9-year-old girl with pork-cat syndrome (PCS) who experienced repeated episodes of urticaria and gastrointestinal symptoms after ingesting pork, beef, and milk since she was 7 ye...
[Preparation of decellularized bone graft material with supercritical carbon dioxide extraction technique].
Hao F, Pan K, Huang L, et al.·Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·
To evaluate the immunogenicity and osteogenic ability of animal-derived bone graft material decellularized with supercritical carbon dioxide. Porcine femurs were randomly divided into two groups after...
Application of an α-galactosidase from Bacteroides fragilis on structural analysis of raffinose family oligosaccharides.
Zu H, Yan X, Wu J, et al.·Carbohydrate polymers·
Raffinose family oligosaccharides (RFOs) have diverse structures and exhibit various biological activities. When using RFOs as prebiotics, their structures need to be identified. If we first knew whet...
Extending discussion on alpha-gal syndrome: research needs, clinical significance, and more broad consequences.
Chinnakannu Marimuthu MM, Agaran Sundaram V, Emran TB·Annals of medicine and surgery (2012)·
View on PubMed →Glycosylation in Canine Placentas.
Zanuzzi CN, Gomez Castro G, Hernández R, et al.·Reproduction in domestic animals = Zuchthygiene·
This article describes the carbohydrate composition of early and mature placentas from bitches, detected by lectin histochemistry. Formalin-fixed placental samples from 11 mixed-breed bitches have bee...
Characterization of antibodies induced by immunization of mice with isoglobotrihexosylceramide (iGb3).
Okuda T·Biochemistry and biophysics reports·
Isoglobotrihexosylceramide (iGb3), a well-characterized natural killer T cell ligand found in mammalian tissues, is also known as a glycosphingolipid that contains the human IgE epitope α-Gal (Galα1,3...
View on PubMed →The Tick Microbiome: The "Other Bacterial Players" in Tick Biocontrol.
Maldonado-Ruiz P·Microorganisms·
Hard ticks (family Ixodidae) are one of the most predominant arthropod disease vectors worldwide, second only to mosquitoes. In addition to harboring animal and human pathogens, ticks are known to car...
View on PubMed →Incidence of Alpha-Gal IgE Sensitization in 3000 Military Personnel, Assessing Sex, Race, Installation, and Occupational Impacts.
Ching SJ, Susi A, Ailsworth SM, et al.·Journal of clinical medicine·
: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with (lone star tick) bites, accounting for the regional distribution of the alpha-gal syndrome (AGS). Longitudinal studies describing...
View on PubMed →Algorithms in allergy: An algorithm for alpha-Gal syndrome diagnosis and treatment, 2024 update.
Darsow U, Gelincik A, Jappe U, et al.·Allergy·
View on PubMed →Alpha-Gal Syndrome and Cardiac Surgery.
Zvara J, Smith AL, Mazzeffi MA, et al.·Journal of cardiothoracic and vascular anesthesia·
Galactose-alpha-1,3-galactose (alpha-gal) is a carbohydrate expressed by all mammals except for humans and certain old-world primates. It can be found in a plethora of products derived from mammals, i...
Identification of Alpha-Gal glycolipids in saliva of Lone-Star Tick (Amblyomma americanum).
Sharma SR, Hussain S, Choudhary SK, et al.·Ticks and tick-borne diseases·
Alpha-Gal Syndrome (AGS) is a delayed allergic reaction triggered by IgE antibodies targeting galactose-α-1,3-galactose (α-gal), prevalent in red meat. Its global significance has increased, with over...
Statistical optimization and sequential scale-up of α-galactosidase production B1 from shake flask to pilot scale.
John Babu D, Balumahendra K, Venkateswarulu TC, et al.·Preparative biochemistry & biotechnology·
α-Galactosidase (α-GAL) is a class of hydrolase that releases galactose from galacto-oligosaccharides and synthetic substrates such as pNPG. In this study, the production of α-GAL by B1 in submerged...
Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy.
J N C, Guvench O, MacKerell AD, et al.·Journal of chemical theory and computation·
We present a revised version of the Drude polarizable carbohydrate force field (FF), focusing on refining the ring and exocyclic torsional parameters for hexopyranose monosaccharides. This refinement...
Successful administration of cetuximab using dose escalation method: a case report.
Li S, Zhang Y, Zha J, et al.·Journal of medical case reports·
Cetuximab, used to treat head and neck squamous cell carcinoma and metastatic colorectal cancer, can cause severe infusion reactions. We report an 87-year-old East Asian woman with stage IV ileocecal...
Mysterious Allergy Caused by Tick Bite: Alpha-Gal Syndrome.
Nalçacı M·Turkiye parazitolojii dergisi·
Alpha-Gal syndrome (AGS) manifests as an intricate allergic response characterised by the formation of specific immunoglobulin E (IgE) antibodies targeting a carbohydrate termed galactose-a-1.3-galact...
Alpha-Gal Syndrome in a Military Member.
Howell JL, Neaves B, Coop C·Cureus·
Alpha-gal syndrome is an acquired disease ranging from gastrointestinal discomfort to anaphylaxis, an acute, life-threatening allergic reaction. Susceptible individuals have high-risk vocations or hob...
View on PubMed →Recurrent tick bites induce high IgG1 antibody responses to α-Gal in sensitized and non-sensitized forestry employees in Luxembourg.
Chakrapani N, Swiontek K, Hübschen JM, et al.·Clinical and translational allergy·
The α-Gal syndrome (AGS) is characterized by the presence of specific IgE-antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal). Sensitization to α-Gal has been associated with tick bites a...
View on PubMed →Food-triggered anaphylaxis in adults.
Chong T, Olivieri B, Skypala IJ·Current opinion in allergy and clinical immunology·
Adult food allergy, either unresolved from childhood, or new-onset in adult-life, is known to be increasingly prevalent. Although much of the reported anaphylaxis in adults is due to drug reactions, f...
Tick salivary proteome and lipidome with low glycan content correlate with allergic type reactions in the zebrafish model.
Vaz-Rodrigues R, Mazuecos L, Villar M, et al.·International journal for parasitology·
Ticks, as hematophagous ectoparasites, can manipulate host immune and metabolic processes, causing tick-borne allergies such as α-Gal syndrome (AGS). Glycolipids with bound galactose-alpha-1-3-galacto...
Mammalian Meat Allergy and IgE to Alpha-Gal in Central Virginia: Findings From a COVID-19 Vaccine and Patient Cohort.
Richards NE, Ailsworth SM, Workman LJ, et al.·The journal of allergy and clinical immunology. In practice·
IgE to galactose-alpha-1,3-galactose (alpha-gal) is linked to tick bites and an important cause of anaphylaxis and urticarial reactions to mammalian meat. The alpha-gal syndrome (AGS) is recognized as...
Reply to corresponcence: "Oral immunotherapy in alpha-gal red meat allergy: Could specific IgE be a potential biomarker in monitoring management?".
Ünal D, Eyice-Karabacak D, Kutlu A, et al.·Allergy·
Sensitization to α-gal and omega-5-gliadin in patients with chronic urticaria: clinical implications and need for targeted testing.
Lazarević VV, Božan M, Lokner I, et al.·Postepy dermatologii i alergologii·
Chronic urticaria (CU) is defined as the presence of recurring hives and/or angioedema lasting more than 6 weeks. The precise impact of food allergies, particularly to galactose-α-1,3-galactose (α-gal...
View on PubMed →Retrospective analysis of rapid drug desensitization with biologic agents: A single center experience.
Unutmaz Erkaya DG, Bayrak Durmaz MS, Görgülü Akın B, et al.·Clinical and translational allergy·
Following the increased use of biological agents, a subset of patients experiences hypersensitivity reaction (HSR). We reported our experience with rapid drug desensitization (RDD) to nine biologics (...
View on PubMed →Synthesis of alpha-Gal C-disaccharides.
Ann A, Truong S, Peters J, et al.·Bioorganic & medicinal chemistry·
The synthesis of C-disaccharides of α-d-galactopyranosyl-(1 → 3)-d-galactopyranose (α-Gal), potential tools for studying the biology of α-Gal glycans, is described. The synthetic strategy, centers on...
Safe Implantation of a Bovine Bioprosthetic Aortic Valve in a Patient With Galactose-α-1,3-Galactose Allergy.
Chen S, Zeigler S·The Annals of thoracic surgery·
Allergy to galactose-α-1,3-galactose (alpha-gal) is associated with immediate allergic manifestations and premature degeneration of the prosthesis in patients who receive bovine- or porcine-derived bi...
The Spread of Lone Star Ticks () and Persistence of Blacklegged Ticks () on a Coastal Island in Massachusetts, USA.
Johnson RW, Roden-Reynolds P, Snow AA, et al.·Insects·
In the northeastern USA, the distribution of lone star ticks () has expanded northward in recent decades, overlapping with the range of blacklegged ticks (). Blacklegged ticks carry pathogens for dise...
View on PubMed →Surveillance of ticks (Acari: Ixodidae) and tick-borne pathogens in Eastern Central Alabama.
Wang X, Mathias DK·Journal of medical entomology·
Similar to other states in the southeastern United States, human cases of tick-borne diseases in Alabama have risen steadily over the last 2 decades. Nevertheless, limited data have been published on...
Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum.
Valcárcel Á, Montero AB, Rodero M, et al.·Medical and veterinary entomology·
Alpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphy...
Understanding American tegumentary leishmaniasis in urban Montes Claros, Brazil: insights from clinical, immunological and therapeutic investigations.
Lopes DMS, Lima JMS, Ribeiro KSM, et al.·Parasitology·
The challenge of American tegumentary leishmaniasis (ATL) continues in Brazil, presenting a persistent public health issue despite initiatives aimed at public outreach, vector control and health educa...
Tick-Borne Illnesses in Emergency and Wilderness Medicine.
Sullivan MD, Glose K, Sward D·Emergency medicine clinics of North America·
This review highlights the causative organisms, clinical features, diagnosis, and treatment of the most common tick-borne illnesses in the United States, including Lyme disease, Rocky Mountain spotted...
A case of alpha-gal syndrome: Recall urticaria and 10 years of measurements of IgE to galactose-α-1,3-galactose.
Leth-Møller KB, van Hage M, Linneberg A, et al.·The journal of allergy and clinical immunology. Global·
Alpha-gal IgE level can change rapidly. Reassessment of a patient's alpha-gal IgE level may be helpful in the patient's clinical follow-up. Pruritus related to the site of a previous tick bite strengt...
View on PubMed →Zebrafish gut microbiota composition in response to tick saliva biomolecules correlates with allergic reactions to mammalian meat consumption.
Díaz-Sánchez S, Vaz-Rodrigues R, Contreras M, et al.·Microbiological research·
The α-Gal syndrome (AGS) is an IgE-mediated tick borne-allergy that results in delayed anaphylaxis to the consumption of mammalian meat and products containing α-Gal. Considering that α-Gal-containing...
Management of Acute Hemorrhage without the Use of Mammalian Products in a Patient with Alpha-Gal Syndrome.
Jensen L, Ushinsky A·Journal of vascular and interventional radiology : JVIR·
Thyroglobulin specific IgE and a possible link to suspected penicillin induced allergic skin manifestations - cross sectional study.
Trivić T, Blagojević G, Živančević-Simonović S, et al.·Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·
Porcine thyroglobulin was important in the discovery of alpha-Gal allergy. Here, the linkage of porcine thyroglobulin-specific IgE with IgE positivity to routinely assessed allergens and to the incomi...
A Macrocyclic Tweezers-Shaped Receptor for the Biomimetic Recognition of the Gal(α1-3)Gal Disaccharide of the α-Gal Antigen.
Milanesi F, Burrini N, Corti G, et al.·Chemistry (Weinheim an der Bergstrasse, Germany)·
The Gal(α1-3)Gal is the terminal disaccharide unit of the α-Gal epitope [Gal(α1-3)Gal(β1-4)GlcNAc], an exogenous antigenic determinant with several clinical implications, found in all non-primate mamm...
Chicken meat allergy in children: Complex sensitization profiles with newly described allergen candidates.
Guiddir T, Sénéchal H, Selva MA, et al.·Allergy·
Alpha-gal-related bilateral orbital inflammatory syndrome in a strict vegan.
Wong CW, Laylani NAR, Davila-Siliezar P, et al.·Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·
bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice.
Leyva-Castillo JM, Strakosha M, Smith SEM, et al.·bioRxiv : the preprint server for biology·
Tick bites often promote local allergic reactions in the skin and predispose to red meat allergy. The mechanisms involved in these processes are not fully understood. Here we investigated the local ch...
View on PubMed →Unraveling Alpha-Gal Syndrome: A Case Study of a Rare Meat Allergy.
Patel R, Jaglan A, Aguileraserna C, et al.·Cureus·
Allergies are a very common pathology and their manifestations consist of a spectrum of presentations, ranging from minimal discomfort like a runny nose to lethal reactions like anaphylaxis and death....
View on PubMed →Alpha-Gal Syndrome: An Underrated Serious Disease and a Potential Future Challenge.
Zhan M, Yin J, Xu T, et al.·Global challenges (Hoboken, NJ)·
Over the past decades, red meat allergy, also known as mammalian meat allergy, which manifests differently from classic food allergies, has been reported in different countries and regions, including...
View on PubMed →Neurosurgical Management of Patients with Alpha-Gal Syndrome.
Carlstrom LP, Akhter A, Macielak RJ, et al.·Journal of neurological surgery reports·
Alpha-gal syndrome (AGS) is an immunoglobulin E-mediated hypersensitivity to galatcose-alpha-1,3-galactose (alpha-gal), a carbohydrate compound present in nonprimate mammalian products. Initial exposu...
View on PubMed →Basophil Activation Test Predicts Cetuximab Anaphylaxis Severity in Alpha-Gal IgE-Positive Patients.
Kopač P, Koren A, Bidovec-Stojkovič U, et al.·Diagnostics (Basel, Switzerland)·
Upon first exposure to cetuximab, hypersensitivity reactions can occur. We aimed to assess the utility of the basophil activation test (BAT) to alpha-gal and cetuximab for predicting severe reactions....
View on PubMed →Structure of the type 38 Streptococcus pneumoniae capsular polysaccharide.
Li X, Puvanesarajah V, Berti F·Carbohydrate research·
Streptococcus pneumoniae is one of the globally important encapsulated human pathogens and more than 100 different serotypes have been identified. Despite very extensive genetic and immune-serological...
Single cell glycan-linkages profiling for hepatocellular carcinoma early diagnosis using lanthanide encoded bacteriophage MS2 based ICP-MS.
Liang Y, Liu Z, Zuo D, et al.·Talanta·
Early diagnosis is paramount for enhancing survival rates and prognosis in the context of malignant diseases. Hepatocellular carcinoma (HCC), the second leading cause of cancer-related deaths worldwid...
Expression and predictive value of serum core fucosylated low molecular weight kininogen and alpha-galactosylated antibodies in patients with hepatic fibrosis.
Zhang X, Dai Z, Xiao X, et al.·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·
Hepatic fibrosis is a common pathological basis for many chronic liver diseases and can progress to cirrhosis, a leading cause of mortality in liver diseases. Early identification and reversal of hepa...
Anaphylaxis triggered by alpha-gal allergy.
Rørvik SD, Alnæs MB, Vikenes BC, et al.·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·
Alpha-gal allergy or red meat allergy is a rare yet potentially severe allergy. Sensitisation usually occurs when alpha-gal present in the tick's saliva is transferred to humans during a tick bite, pr...
[Preparation and osteogenesis of acellular dermal matrix/dicalcium phosphate composite scaffold for bone repair].
Lan Y, Zhang J, Ran Y, et al.·Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery·
To investigate the physicochemical properties, osteogenic properties, and osteogenic ability in rabbit model of femoral condylar defect of acellular dermal matrix (ADM)/dicalcium phosphate (DCP) compo...
Alpha-Gal syndrome as a novel food allergy: a case report study.
Ghelichi-Ghojogh M, Ghezeljeh E, Delavari S, et al.·Annals of medicine and surgery (2012)·
Alpha-Gal syndrome (AGS), a distinct form of mammalian meat allergy, presents unique characteristics that set it apart from typical IgE-mediated food hypersensitivities. AGS induces an allergic respon...
View on PubMed →Electrochemical bioplatform to manage alpha-gal syndrome by tracking the carbohydrate allergen in meat.
Ruiz-Valdepeñas Montiel V, Gamella M, Blázquez-García M, et al.·Talanta·
This work presents the first bioplatform described to date for the determination of galactose-α-1,3-galactose (α-Gal), a non-primate mammalian oligosaccharide responsible for almost all cases of red m...
Characterization of alpha-gal syndrome and sensitization on Eastern Long Island.
Heffes-Doon A, McGintee E, Akerman M, et al.·The journal of allergy and clinical immunology. In practice·
Intrinsic risk factors for alpha-gal syndrome in a case-control study, 2019 to 2020.
Taylor ML, Kersh GJ, Salzer JS, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Alpha-gal syndrome (AGS) is an allergy to galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in most mammals. Evidence indicates that AGS develops after a tick bite, and in the United States,...
Tick bites, IgE to galactose-alpha-1,3-galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha-gal syndrome.
Wilson JM, Erickson L, Levin M, et al.·Allergy·
The recent recognition of a syndrome of tick-acquired mammalian meat allergy has transformed the previously held view that mammalian meat is an uncommon allergen. The syndrome, mediated by IgE antibod...
A Case of Transient Pediatric Pork-Cat Syndrome Caused by Sensitization to Albumin.
Ramírez-Mateo E, Fernández-Lozano C, De-Andrés-Martín A, et al.·Journal of investigational allergology & clinical immunology·
Food for thought: Making the case for food produced via regenerative agriculture in the battle against non-communicable chronic diseases (NCDs).
Ramkumar D, Marty A, Ramkumar J, et al.·One health (Amsterdam, Netherlands)·
Non-communicable diseases (NCDs) pose a global health challenge, leading to substantial morbidity, mortality, and economic strain. Our review underscores the escalating incidence of NCDs worldwide and...
View on PubMed →Structure and properties of the acellular porcine cornea irradiated with Co-γ and electron beam and its histocompatibility.
Li Q, Sun Y, Zhao H, et al.·Journal of biomedical materials research. Part A·
Acellular porcine cornea (APC) has been used in corneal transplantation and treatment of the corneal diseases. Sterilization is a key step before the application of graft, and irradiation is one of th...
Alpha-gal syndrome.
Zhan M, Chen S, Xu T, et al.·Chinese medical journal·
Emerging Trends in Information-Seeking Behavior for Alpha-Gal Syndrome: Infodemiology Study Using Time Series and Content Analysis.
Romeiser JL, Jusko N, Williams AA·Journal of medical Internet research·
Alpha-gal syndrome is an emerging allergy characterized by an immune reaction to the carbohydrate molecule alpha-gal found in red meat. This unique food allergy is likely triggered by a tick bite. Cas...
Stereoselective Synthesis of the Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc Trisaccharide: a new Ligand for DCAR and Mincle C-Type Lectin Receptors.
Tricomi J, Aoun M, Xu B, et al.·Chembiochem : a European journal of chemical biology·
In this work, we have discovered that the Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc trisaccharide, a fragment of the B antigen Type-1, is a new ligand of two C-type lectin receptors (CLRs) i. e. DCAR and Mincle...
[Not Available].
Aiuto B, Cirrincione S, Giuffrida MG, et al.·Molecular nutrition & food research·
Alpha-gal syndrome (AGS) is a mammalian meat allergy associated with tick bites and specific IgE to the oligosaccharide galactose-α-1,3-galactose (α-gal). Recent studies have shown that 10-20% of AGS...
Consideration for alpha-gal syndrome in two critically ill persons with group O blood who received group B plasma.
Miller MJ, Lee P, Lee BG, et al.·Transfusion·
The U.S. Centers for Disease Control and Prevention (CDC) has reported increasing rates of alpha-gal syndrome, an allergic response after meat ingestion (AGS). AGS has been associated with prior expos...
Decellularized kidney extracellular matrix-based hydrogels for renal tissue engineering.
Quinteira R, Gimondi S, Monteiro NO, et al.·Acta biomaterialia·
Kidney regeneration is hindered by the limited pool of intrinsic reparative cells. Advanced therapies targeting renal regeneration have the potential to alleviate the clinical and financial burdens as...
Regeneration in Mice of Injured Skin, Heart, and Spinal Cord by α-Gal Nanoparticles Recapitulates Regeneration in Amphibians.
Galili U, Li J, Schaer GL·Nanomaterials (Basel, Switzerland)·
The healing of skin wounds, myocardial, and spinal cord injuries in salamander, newt, and axolotl amphibians, and in mouse neonates, results in scar-free regeneration, whereas injuries in adult mice h...
View on PubMed →Alpha gal syndrome, a relative not absolute contraindication to the use of bovine pericardium to close an intracardiac septal defect: a case report.
Taira K, Kanade R, Yammine M, et al.·Journal of cardiothoracic surgery·
Alpha-gal syndrome is an allergic condition in which individuals develop an immune-mediated hypersensitivity response when consuming red meat and its derived products. Its diagnosis is important in in...
Recurrent Ogilvie Syndrome as a Possible Manifestation of Alpha-Gal Syndrome (AGS) Requiring Surgical Management: A Case Report.
Dai J, Obokhare I·Cureus·
We present a case of a male in his 60s with a history of alpha-gal syndrome (AGS) who presented with recurrent acute colonic pseudo-obstruction, also known as Ogilvie syndrome, and underwent surgical...
View on PubMed →Approaches to Alpha-Gal Syndrome in Japan.
Okumura H, Inaba S, Kawashima A·Annals of emergency medicine·
Correspondence to "Oral immunotherapy in alpha-gal red meat allergy: Could specific IgE be a potential biomarker in monitoring management?".
Chen YC, Lin YH, Lu CT, et al.·Allergy·
IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.
Hils M, Hoffard N, Iuliano C, et al.·The Journal of allergy and clinical immunology·
Alpha-gal (Galα1-3Galβ1-4GlcNAc) is a carbohydrate with the potential to elicit fatal allergic reactions to mammalian meat and drugs of mammalian origin. This type of allergy is induced by tick bites,...
Alpha-Gal Syndrome: A Novel and Increasingly Common Cause of Anaphylaxis.
Edlow JA·Annals of emergency medicine·
The alpha-gal syndrome is a recently described cause of anaphylaxis to red meat that has been increasing in frequency over time. It is related to Lone Star tick bites in the United States and occurs i...
Modulation of Inflammatory Responses to Enhance Nerve Recovery after Spinal Cord Injury.
Seo YK·Tissue engineering and regenerative medicine·
Inflammation can occur at the wound site, and immune cells are necessary to trigger wound healing and tissue regeneration after injury. It is partly initiated by the rapid migration of immune cells su...
α-Gal Nanoparticles in CNS Trauma: II. Immunomodulation Following Spinal Cord Injury (SCI) Improves Functional Outcomes.
Gopalakrishnan B, Galili U, Saenger M, et al.·Tissue engineering and regenerative medicine·
Previous investigations have shown that local application of nanoparticles presenting the carbohydrate moiety galactose-α-1,3-galactose (α-gal epitopes) enhance wound healing by activating the complem...
α-Gal Nanoparticles in CNS Trauma: I. In Vitro Activation of Microglia Towards a Pro-Healing State.
Gopalakrishnan B, Galili U, Dunbar A, et al.·Tissue engineering and regenerative medicine·
Macrophages and microglia play critical roles after spinal cord injury (SCI), with the pro-healing, anti-inflammatory (M2) subtype being implicated in tissue repair. We hypothesize that promoting this...
Significance of Raffinose Family Oligosaccharides (RFOs) metabolism in plants.
Liu H, Wang F, Liu B, et al.·Advanced biotechnology·
Raffinose Family Oligosaccharides (RFOs) are a kind of polysaccharide containing D-galactose, and they widely exist in higher plants. Synthesis of RFOs begins with galactinol synthase (GolS; EC 2.4.1....
View on PubMed →The Role of Cytokines and Molecular Pathways in Lung Fibrosis Following SARS-CoV-2 Infection: A Physiopathologic (Re)view.
Lazar M, Sandulescu M, Barbu EC, et al.·Biomedicines·
SARS-CoV-2 infection is a significant health concern that needs to be addressed not only during the initial phase of infection but also after hospitalization. This is the consequence of the various pa...
View on PubMed →Red Meat Hypersensitivity and Probable Alpha-Gal Syndrome: Prevalence Among Adolescents.
Bedolla-Barajas M, Morales-Romero J, Meza-Lopez C, et al.·Cureus·
It is unknown whether late adolescents represent a particular risk group for the development of red meat hypersensitivity (RMH) and alpha-gal syndrome (AGS). This age group's physiological changes and...
View on PubMed →Immunoassay Testing of Alpha-Gal Specific Immunoglobulin-E: Data from a National Reference Laboratory.
Saadalla A, Jacela J, Poll R, et al.·The journal of applied laboratory medicine·
Immunoassay measurements of serum alpha-gal (AG) specific IgE (sIgE) enable antibody detection and quantification with high sensitivity and specificity and are essential for AG syndrome diagnosis and...
Epidemiology and the Growing Epidemic of Food Allergy in Children and Adults Across the Globe.
Warren CM, Sehgal S, Sicherer SH, et al.·Current allergy and asthma reports·
Food allergies are immune-mediated, complex disorders, which are the source of increasing health concern worldwide. The goal of this review is to present an updated summary of the food allergy (FA) bu...
Use of antithymocyte globulin (rabbit) in a patient with known alpha-gal syndrome undergoing allogenic stem cell transplantation.
Peterson H, Wells DA, Marjoncu D, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Alpha-gal syndrome (AGS) is a hypersensitivity disorder in which tick bites-most commonly from the lone star tick ()-trigger immunoglobulin E-mediated hypersensitivity reaction upon exposure to oligos...
Premedication strategy in cetuximab rechallenge after Grade 2 hypersensitivity reactions.
Lofy M, Jung L, Dow-Hillgartner E·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Cetuximab, an IgG1 monoclonal antibody, is utilized in the treatment of metastatic colorectal cancer and squamous cell head and neck cancers. Due to the risk of hypersensitivity reactions, standard pr...
Management of Food Allergies and Food-Related Anaphylaxis.
Iglesia EGA, Kwan M, Virkud YV, et al.·JAMA·
An estimated 7.6% of children and 10.8% of adults have IgE-mediated food-protein allergies in the US. IgE-mediated food allergies may cause anaphylaxis and death. A delayed, IgE-mediated allergic resp...
Development of anti-PEG IgG/IgM/IgE ELISA assays for profiling anti-PEG immunoglobulin response in PEG-sensitized individuals and patients with alpha-gal allergy.
Li Z, Ma A, Miller I, et al.·Journal of controlled release : official journal of the Controlled Release Society·
Polyethylene glycol (PEG) is frequently used in various protein and nanomedicine therapeutics. However, various studies have shown that select PEGylated therapeutics can induce production of anti-PEG...
Big is not better: Comparing two alpha-Gal-bearing glycotopes in neoglycoproteins as biomarkers for Leishmania (Viannia) braziliensis infection.
Montoya AL, Gil ER, Vinales I, et al.·Carbohydrate research·
The protozoan parasite Leishmania (Viannia) braziliensis is among Latin America's most widespread Leishmania species and is responsible for tegumentary leishmaniasis (TL). This disease has multiple cl...
IgE to common food allergens is associated with cardiovascular mortality in the National Health and Examination Survey and the Multi-Ethnic Study of Atherosclerosis.
Keet C, McGowan EC, Jacobs D, et al.·The Journal of allergy and clinical immunology·
In individuals without symptomatic food allergy, food-specific IgE is considered clinically irrelevant. However, recent studies have suggested that galactose-α-1,3-galactose (alpha-gal) IgE is associa...
Enzymatically-derived oligo-carrageenans interact with α-Gal antibodies and Galectin-3.
Sokolova E, Jouanneau D, Chevenier A, et al.·Carbohydrate polymers·
Carrageenans are linear sulfated galactans synthesized in the Gigartinales, Rhodophyceae species with a varied range of biological properties that are of value to the pharmaceutical and cosmetic secto...
Safety and tissue remodeling assay of small intestinal submucosa meshes using a modified porcine surgical hernia model.
Liu C, Lin Z, Ruan W, et al.·Scientific reports·
In studies to date, meshes based on extracellular matrix (ECM) have been extensively used in clinical applications. Unfortunately, little is known about the function of the immunogenic residual, absor...
Tick-Borne Disease Infections and Chronic Musculoskeletal Pain.
Zychowski DL, Alvarez C, Abernathy H, et al.·JAMA network open·
Tick-borne diseases (TBDs) other than Lyme disease, such as spotted fever group rickettsiosis, ehrlichiosis, and galactose-α-1,3-galactose (α-gal) syndrome, are an emerging public health issue. Long-t...
What Is Alpha-Gal Syndrome?
Mollah F, Zacharek MA, Benjamin MR·JAMA·
Perioperative Considerations in Alpha-Gal Syndrome: A Review.
Leder J, Diederich A, Patel B, et al.·Cureus·
Galactose-⍺-1, 3-galactose (alpha-gal) is an oligosaccharide found in mammalian tissues that causes allergic reactions in patients with alpha-gal syndrome (AGS). AGS is a hypersensitivity reaction not...
View on PubMed →Palindromic rheumatism as a feature of alpha-gal syndrome: Initial observation on 18 patients from the capital of the Cherokee Nation.
Kaushik P, Kaushik AA·International journal of rheumatic diseases·
Alpha-Gal IgE Prevalence Patterns in the United States: An Investigation of 3,000 Military Recruits.
Ailsworth SM, Susi A, Workman LJ, et al.·The journal of allergy and clinical immunology. In practice·
IgE to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal) is an important cause of allergic reactions to mammalian meat. The "alpha-gal syndrome" is strongly associated with a preceding his...
The alpha-Gal Syndrome is Underdiagnosed.
de la Fuente J·Actas dermo-sifiliograficas·
Gastrointestinal-isolated Distress is Common in Alpha-gal Allergic Patients on Mammalian Meat Challenge.
McGill SK, Levin ME, Shaheen NJ, et al.·Journal of clinical gastroenterology·
Alpha-gal allergy causes a delayed reaction to mammalian meats and has been reported worldwide. Patients with the allergy may present with isolated gastrointestinal (GI) symptoms, but this phenotype i...
An α-Gal antigenic surrogate as a biomarker of treatment evaluation in Trypanosoma cruzi-infected children. A retrospective cohort study.
Abal M, Balouz V, Lopez R, et al.·PLoS neglected tropical diseases·
Proper evaluation of therapeutic responses in Chagas disease is hampered by the prolonged persistence of antibodies to Trypanosoma cruzi measured by conventional serological tests and by the lack of s...
Isotype diversity of antibodies specific for component allergens in the context of allergic diseases: eosinophilic esophagitis (EoE), asthma, and the alpha-gal syndrome (AGS).
Platts-Mills TAE, MacCallum MH, Wilson JM, et al.·Frontiers in allergy·
From the earliest days of studying the reagins in allergic sera that give rise to the Prausnitz-Kuestner reaction, there was evidence that there were other types of antibodies (Ab) specific for allerg...
View on PubMed →Editorial: Animal models of allergic diseases: from basic to preclinical research.
Jönsson F, Pazos-Castro D, Castell M, et al.·Frontiers in allergy·
View on PubMed →Alpha-gal syndrome.
Nalin F, Scarmozzino R, Arcolaci A, et al.·Allergologia et immunopathologia·
View on PubMed →Alpha-gal syndrome and treatment of hypovolemic shock.
Özdemir Ö·Allergologia et immunopathologia·
View on PubMed →Netosis and trained immunity in tick-borne diseases: a possible pathogenetic role.
Badami GD, Tamburini B, Mohammadnezhad L, et al.·Cellular immunology·
Various types of pathogens transmitted by ticks elicit distinct immune responses just like the emerging α-Gal syndrome that is associated with allergic reactions to tick bites. The mechanisms of Neutr...
[TWO CASES OF α-GAL SYNDROME CAUSED BY INGESTION OF WILD BOAR MEAT].
Hattori N, Matsumoto M, Chinuki Y, et al.·Arerugi = [Allergy]·
α-Gal syndrome (AGS) is an allergic reaction to galactose-α-1,3-galactose (α-gal) found in the salivary glands of ticks, mammalian meat excluding primates, and some antibody preparations, such as cetu...
Immunotherapy with biodegradable nanoparticles encapsulating the oligosaccharide galactose-alpha-1,3-galactose enhance immune tolerance against alpha-gal sensitization in a murine model of alpha-gal syndrome.
Saunders MN, Rival CM, Mandal M, et al.·Frontiers in allergy·
IgE antibodies against the mammalian oligosaccharide allergen galactose-α-1,3-galactose (αGal) can result in a severe allergic disease known as alpha-gal syndrome (AGS). This syndrome, acquired by tic...
View on PubMed →The Acari Hypothesis, IV: revisiting the role of hygiene in allergy.
Retzinger AC, Retzinger GS·Frontiers in allergy·
Allergy and its manifestations were first appreciated in the 1870 s. Today, the mechanism by which specific substances elicit allergic reactions remains poorly understood. This is problematic from a h...
View on PubMed →Trending ticks: using Google Trends data to understand tickborne disease prevention.
Yang CX, Baker LM, McLeod-Morin A·Frontiers in public health·
Ticks and pathogens they carry seriously impact human and animal health, with some diseases like Lyme and Alpha-gal syndrome posing risks. Searching for health information online can change people's h...
Alpha-gal syndrome: when treatment of hypovolemic shock can lead to anaphylaxis.
Nalin F, Scarmozzino R, Arcolaci A, et al.·Allergologia et immunopathologia·
Delayed anaphylaxis after ingestion of red meat because of galactose-alpha-1,3-galactose (alpha-gal) syndrome has increased in recent years. The mechanism involves an immunoglobulin E reaction to alph...
A Rare Case of Persistent Multifocal Cribriform-Morular Thyroid Carcinoma.
Kuenstner W, Zhao P, Lee W, et al.·AACE clinical case reports·
Cribriform-morular thyroid carcinoma (CMTC) was considered a variant of papillary thyroid carcinoma (PTC) but is a separate entity in the 2022 World Health Organization classification. CMTC has an ass...
View on PubMed →Gene-edited pigs: a translational model for human food allergy against alpha-Gal and anaphylaxis.
Wang Y, Hils M, Fischer A, et al.·Frontiers in immunology·
The prevalence of food allergy is rising and is estimated to approach 10%. Red meat allergy is the first known food allergy elicited by immunoglobulin E (IgE) antibodies recognizing a carbohydrate. Du...
The α-Gal epitope - the cause of a global allergic disease.
Perusko M, Grundström J, Eldh M, et al.·Frontiers in immunology·
The galactose-α-1,3-galactose (α-Gal) epitope is the cause of a global allergic disease, the α-Gal syndrome (AGS). It is a severe form of allergy to food and products of mammalian origin where IgE aga...
Systematic evaluation and meta-analysis of the prognosis of down-staging human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma using cetuximab combined with radiotherapy instead of cisplatin combined with radiotherapy.
Hu Q, Li F, Yang K·PeerJ·
To evaluate the efficacy and safety of cetuximab instead of cisplatin in combination with downstaging radiotherapy for papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV OPSCC)....
Influence of microbiota-driven natural antibodies on dengue transmission.
Wu-Chuang A, Rojas A, Bernal C, et al.·Frontiers in immunology·
Dengue has had a significant global health impact, with a dramatic increase in incidence over the past 50 years, affecting more than 100 countries. The absence of a specific treatment or widely applic...
New l-Rhamnose-Binding Lectin from the Bivalve : Purification, Partial Structural Characterization and Antibacterial Activity.
Mizgina TO, Chikalovets IV, Bulanova TA, et al.·Marine drugs·
In this study, a new l-rhamnose-binding lectin (GYL-R) from the hemolymph of bivalve was purified using affinity and ion-exchange chromatography and functionally characterized. Lectin antimicrobial a...
Leucovorin-induced Hypersensitivity Reaction in a Patient with Metastatic Colorectal Cancer Treated with Cetuximab Plus FOLFOX Chemotherapy: A Case Report.
Kim M, Kim DH, Lee JY, et al.·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·
The FOLFOX regimen (combination of leucovorin, 5-fluorouracil, and oxaliplatin) is the first-line treatment for high-risk stage 2 and 3 colorectal cancer patients. While hypersensitivity reactions (HS...
A platform for qualitative and quantitative characterization of α-Gal and NeuGc at the oligosaccharide level.
Ren W, Yang L, Feng J, et al.·Analytical biochemistry·
Glycosylation modification serves as a pivotal quality attribute in glycoprotein-based therapeutics, emphasizing its role in drug safety and efficacy. Prior studies have underscored the potential immu...
High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood.
Maldonado-Ruiz LP, Reif KE, Ghosh A, et al.·Scientific reports·
Tick bites, associated with the secretion of tick saliva containing the xenoglycan galactose-alpha-1, 3-galactose (alpha-gal or aGal), are recognized as the causal factors of alpha-Gal syndrome (AGS;...
Importance of alpha-gal syndrome in patients undergoing catheter ablation.
Hasegawa K, Powers EM, Yoneda ZT, et al.·HeartRhythm case reports·
View on PubMed →Multi-omics analysis of zebrafish response to tick saliva reveals biological processes associated with alpha-Gal syndrome.
Vaz-Rodrigues R, Mazuecos L, Villar M, et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·
The alpha-Gal syndrome (AGS) is a tick-borne allergy. A multi-omics approach was used to determine the effect of tick saliva and mammalian meat consumption on zebrafish gut transcriptome and proteome....
Tick salivary glycans - a sugar-coated tick bite.
Karim S, Leyva-Castillo JM, Narasimhan S·Trends in parasitology·
Ticks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure suc...
Oral immunotherapy in alpha-gal red meat allergy: Could specific IgE be a potential biomarker in monitoring management?
Ünal D, Eyice-Karabacak D, Kutlu A, et al.·Allergy·
Oral immunotherapy (OIT) is a promising treatment for food allergies. Our aim was to establish the long-term safety and efficacy of a novel red meat (RM) OIT in galactose-alpha-1,3-galactose (alpha-ga...
sialidase interaction with Neu5Ac α-Gal sialic acid receptors by observation and its impact on monolayers cellular behavior structure.
Kurnia RS, Soebandrio A, Harun VH, et al.·Journal of advanced veterinary and animal research·
This study aims to evaluate the effect of sialidase treatment on monolayer cell behavior using computational screening and an approach to demonstrate interaction between enzyme-based drugs and ligan...
View on PubMed →Sensitization to alpha-gal as a cause of idiopathic anaphylaxis.
Ranasinghe T, Aberathna IS, Jayamali J, et al.·Clinical and translational allergy·
View on PubMed →Structure and properties of the acellular porcine cornea irradiated with electron beam and its in-situ implantation.
Li Q, Sun Y, Zhao H, et al.·Journal of biomedical materials research. Part B, Applied biomaterials·
Different sterilization doses of the electron beam (E-beam) will change the properties of biomaterials and affect their clinical application. Acellular porcine cornea (APC) is a promising corneal subs...
Diagnostic validity of specific immunoglobulin E levels to alpha-gal in alpha-gal syndrome: a cross-sectional analysis.
Germán-Sánchez A, Alonso-Llamazares A, García-González F, et al.·Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·
The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values of specific IgE (sIgE) to alpha-gal ≥ 0.1 kU...
View on PubMed →Tick bite-induced Alpha-Gal Syndrome and Immunologic Responses in an Alpha-Gal Deficient Murine Model.
Sharma SR, Choudhary SK, Vorobiov J, et al.·bioRxiv : the preprint server for biology·
Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE antibodies targeting galactose-α-1,3-galactose (α-gal), a carbohydrate found in red meat. This condition has gained signific...
View on PubMed →Case report of a child who may have developed anaphylaxis after ingesting raw horse meat by cross-reactivity of horse and cat pelt.
Shingaki T, Hiraguchi Y, Tokuda R, et al.·The journal of allergy and clinical immunology. Global·
Pork-cat syndrome can occur in children younger than 10 years. A history of contact with animals since infancy and history of severe atopic dermatitis, which can promote epicutaneous sensitization to...
View on PubMed →α-Galactosidase interacts with persistent organic pollutants to induce oxidative stresses in rice (Oryza sativa L.).
Sun Y, Chen J, Wang W, et al.·Environmental pollution (Barking, Essex : 1987)·
Persistent organic pollutants (POPs) in agricultural soil often triggered metabolic alterations and phytotoxicity in plants, ultimately threatening crop quality. Unraveling the phytotoxic mechanisms o...
Accelerated Burn Healing in a Mouse Experimental Model Using α-Gal Nanoparticles.
Galili U·Bioengineering (Basel, Switzerland)·
Macrophages play a pivotal role in the process of healing burns. One of the major risks in the course of burn healing, in the absence of regenerating epidermis, is infections, which greatly contribute...
View on PubMed →Tick-borne red meat allergy (α-gal syndrome).
Jeimy S, Zhu R·CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·
An outbreak of anaphylactic transfusion reactions to group B plasma and platelets and its possible relationship to Alpha-Gal syndrome.
Gilstad CW, Conry-Cantilena K, Zarpak R, et al.·Transfusion·
Alpha-gal syndrome (AGS) is a potentially life-threatening acquired meat allergy associated with tick bites. The allergen Galactose-α-1,3-Galactose is antigenically similar to the B blood group antige...
Incorrect laboratory test selection is common in the evaluation of alpha-gal syndrome and Fabry disease.
Bentz Pino G, Piazza A, Schultz M, et al.·The journal of allergy and clinical immunology. In practice·
Alpha-gal syndrome: A review for the dermatologist.
Reddy S, Yi L, Shields B, et al.·Journal of the American Academy of Dermatology·
Alpha-gal syndrome (AGS) is an allergy to "red meat" and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is...
Structure-function analysis of bacterial GH31 α-galactosidases specific for α-(1→4)-galactobiose.
Ikegaya M, Park EY, Miyazaki T·The FEBS journal·
Glycoside hydrolase family 31 (GH31) contains α-glycoside hydrolases with different substrate specificities involved in various physiological functions. This family has recently been classified into 2...
Treatment of idiopathic anaphylaxis with dupilumab: a case report.
Pepper E, Pittman L·Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·
Anaphylaxis is an acute, potentially life-threatening allergic reaction that typically occurs after exposure to a trigger, while idiopathic anaphylaxis (IA) occurs in the absence of a trigger. Acute m...
View on PubMed →Delayed anaphylaxis due to Alpha-gal allergy: A modified desensitization protocol with red meat in an adult patient.
Tepetam FM, Yegin Katran Z, Bayraktar Barın R, et al.·Tuberkuloz ve toraks·
Alpha-gal allergy is the sensitization to Alpha-gal present in saliva when a tick bites and the development of an IgE-mediated reaction to Alpha-gal also present in red meat by cross-reactivity. In co...
Alpha-gal syndrome-Food or drug allergy: A case report.
Božan M, Vukičević Lazarević V, Marković I, et al.·Clinical case reports·
Alpha-gal syndrome is an immunoglobulin E-mediated hypersensitivity characterized by delayed allergic reactions to ingested products containing alpha-gal carbohydrate. We present a patient with recurr...
View on PubMed →Citizen Science on Lyme Borreliosis in Spain Reveals Disease-Associated Risk Factors and Control Interventions.
de la Fuente J, Estrada-Peña A, Gortázar C, et al.·Vector borne and zoonotic diseases (Larchmont, N.Y.)·
Lyme borreliosis (LB) caused by lato complex spirochetes is one of the tick-borne diseases with high prevalence and social/economic burden in the United States, Spain, and other European countries. T...
The Feline and the Swine: A Peculiar Case in an Allergy Clinic.
Kile MR, Lucas MD, Ganguli MP, et al.·Cureus·
Cross-reactivity between mammalian proteins, such as that in Pork Cat Syndrome, remains a topic of great interest. This syndrome, characterized by an immunoglobulin E (IgE)-mediated response to porcin...
View on PubMed →Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic bacterium.
Ta HP, Clarisse C, Maes E, et al.·Chemistry and physics of lipids·
The growing consumption of fermented products has led to an increasing demand for lactic acid bacteria (LAB), especially for LAB tolerant to freezing/thawing conditions. Carnobacterium maltaromaticum...
Cell wall composition and enzyme-related activities in eggplant as affected by hot water, 1-MCP and calcium chloride treatments.
Alkan ON, Önder D, Önder S, et al.·Food science and technology international = Ciencia y tecnologia de los alimentos internacional·
The effects of postharvest applications of hot water (HWT) (45, 50, and 55 °C), 1-MCP (1, 5, and 10 μL/L), and CaCl (1, 2, and 3%) on polygalacturonase (PG), pectin methylesterase (PME), -galactosidas...
Nonanaphylactic Variant of Alpha-Gal Syndrome as an Etiology for Chronic Gastrointestinal Symptoms in Children.
Glynn D, Halma J, Welch H, et al.·The Journal of pediatrics·
We report 3 pediatric patients who presented with only nonanaphylactic symptoms of alpha-gal syndrome. This report highlights the necessity of not discounting alpha-gal syndrome from a differential di...
Delayed Hypersensitivity Reaction to Infliximab Due to Mammalian Meat Allergy.
González Polanco E, Borowitz S·JPGN reports·
Mammalian meat allergy is a delayed immunoglobulin E (IgE) mediated hypersensitivity reaction to galactose-alpha-1,3-galactose (alpha-gal). Alpha-gal is an oligosaccharide present on glycoproteins and...
View on PubMed →Bos d 13, A Novel Heat-Stable Beef Allergen.
Román-Carrasco P, Klug C, Hemmer W, et al.·Molecular nutrition & food research·
Red meat, a staple food of Western diets, can also induce IgE-mediated allergic reactions. Yet, apart from the heat-labile protein serum albumin and the carbohydrate α-Gal, the molecules causing aller...
Health Care Provider Knowledge Regarding Alpha-gal Syndrome - United States, March-May 2022.
Carpenter A, Drexler NA, McCormick DW, et al.·MMWR. Morbidity and mortality weekly report·
Alpha-gal syndrome (AGS) is an emerging, tick bite-associated immunoglobulin E-mediated allergic condition characterized by a reaction to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal),...
Geographic Distribution of Suspected Alpha-gal Syndrome Cases - United States, January 2017-December 2022.
Thompson JM, Carpenter A, Kersh GJ, et al.·MMWR. Morbidity and mortality weekly report·
Alpha-gal syndrome (AGS) is an emerging, tick bite-associated allergic condition characterized by a potentially life-threatening immunoglobulin E (IgE)-mediated hypersensitivity to galactose-alpha-1,3...
Allergic reactions to tick saliva components in zebrafish model.
Contreras M, Vaz-Rodrigues R, Mazuecos L, et al.·Parasites & vectors·
Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose (α-Gal) present in glycoproteins and glycolipids from mammalian meat. To...
Tick Densities and Infection Prevalence on Coastal Islands in Massachusetts, USA: Establishing a Baseline.
Snow AA, Pearson P, Xu G, et al.·Insects·
Tick-borne diseases and a tick-induced red meat allergy have become increasingly common in the northeastern USA and elsewhere. At the scale of local communities, few studies have documented tick densi...
View on PubMed →Extrinsic and Intrinsic Modulators of Anaphylaxis.
Carter MC, Park J, Vadas P, et al.·The journal of allergy and clinical immunology. In practice·
The severity of anaphylaxis is determined by many factors. The allergenic source as well as the age of the affected individual and the route of allergen exposure encompass the major contributors of th...
Clinical Presentation of Alpha-Gal Syndrome in Pediatric Gastroenterology and Response to Mammalian Dietary Elimination.
Busing JD, Stone CA, Nicholson MR·The American journal of gastroenterology·
Alpha-gal syndrome is an immunoglobulin E (IgE)-mediated delayed hypersensitivity reaction to nonprimate mammalian products, which has a newly established gastrointestinal (GI) phenotype in adults. We...
Alpha-Gal Sensitization in a US Screening Population Is Not Associated With a Decreased Meat Intake or Gastrointestinal Symptoms.
McGill SK, Commins SP, Peery AF, et al.·The American journal of gastroenterology·
Patients with alpha-gal syndrome, a delayed reaction to mammalian meat, can present with isolated gastrointestinal (GI) symptoms. We aimed to estimate the frequency of alpha-gal sensitization in a Sou...
Immobilization of α-galactosidase in polyvinyl alcohol-chitosan-glycidyl methacrylate hydrogels based on directional freezing-assisted salting-out strategy for hydrolysis of RFOs.
Bai X, Sun X, Yu Y, et al.·International journal of biological macromolecules·
Raffinose family oligosaccharides (RFOs) in food are the main factors causing flatulence in Irritable Bowel Syndrome (IBS) patients and the development of effective approaches for reducing food-derive...
Active surveillance of alpha-gal (galactose-alpha-1,3-galactose) syndrome in Middle Tennessee.
Liu K, Wofford RN, Newcomb DC, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains.
Hartrampf N, Leitao SM, Winter N, et al.·Biophysical journal·
Sphingolipids are a structurally diverse class of lipids predominantly found in the plasma membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and cholesterol in...
-Gal Syndrome: Busting Paradigms in Food Allergy.
Iweala OI·Annals of internal medicine. Clinical cases·
-Gal syndrome, also known as red or mammalian meat allergy, results from immunoglobulin E-mediated hypersensitivity responses to the carbohydrate galactose--1,3-galactose (-gal). Patients with -gal sy...
View on PubMed →Perioperative implications of patients with alpha gal allergies.
Nourian MM, Stone CA, Siegrist KK, et al.·Journal of clinical anesthesia·
Alpha Gal Syndrome (AGS) is an emerging immune response to mammalian products (MP) containing the oligosaccharide galactose-α-1,3 galactose (α-Gal) which includes meats and inactive ingredients in cer...
The effect of decellularization protocols on characterizations of thermoresponsive and light-curable corneal extracellular matrix hydrogels.
Yazdanpanah G, Jalilian E, Shen X, et al.·Scientific reports·
To compare the effects of two decellularization protocols on the characteristics of fabricated COrnea Matrix (COMatrix) hydrogels. Porcine corneas were decellularized with Detergent (De) or Freeze-Tha...
Cross-reactive epitopes and their role in food allergy.
Kamath SD, Bublin M, Kitamura K, et al.·The Journal of allergy and clinical immunology·
Allergenic cross-reactivity among food allergens complicates the diagnosis and management of food allergy. This can result in many patients being sensitized (having allergen-specific IgE) to foods wit...
Alpha-gal syndrome is an immunoparasitologic disease.
Carlson JC·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
AGA Clinical Practice Update on Alpha-Gal Syndrome for the GI Clinician: Commentary.
McGill SK, Hashash JG, Platts-Mills TA·Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·
Alpha-gal syndrome is an emerging allergy first described in the early 2000s. The allergy can cause anaphylaxis, gastrointestinal (GI) symptoms, and skin changes one to several hours after ingestion o...
Tick bite as a risk factor for alpha-gal-specific immunoglobulin E antibodies and development of alpha-gal syndrome.
Kersh GJ, Salzer J, Jones ES, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
The disaccharide galactose-α-1,3-galactose (alpha-gal) is expressed in mammals other than humans, apes, and old-world monkeys. In humans, elevated immunoglobulin E (IgE) antibodies specific for alpha-...
Hemocompatibility tuning of an innovative glutaraldehyde-free preparation strategy using riboflavin/UV crosslinking and electron irradiation of bovine pericardium for cardiac substitutes.
Dittfeld C, Welzel C, König U, et al.·Biomaterials advances·
Hemocompatibility tuning was adopted to explore and refine an innovative, GA-free preparation strategy combining decellularization, riboflavin/UV crosslinking, and low-energy electron irradiation (SUL...
Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome.
Apostolovic D, Grundström J, Kiewiet MBG, et al.·The Journal of clinical investigation·
Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not be...
Development and In Vitro/In Vivo Comparative Characterization of Cryopreserved and Decellularized Tracheal Grafts.
Stocco E, Barbon S, Mammana M, et al.·Cells·
Tracheal reconstruction represents a challenge when primary anastomosis is not feasible. Within this scenario, the study aim was to develop a new pig-derived decellularized trachea (DecellT) to be com...
Analysis of Immunogenic Galactose-α-1,3-galactose-Containing -Glycans in Beef, Mutton, and Pork Tenderloin by Combining Matrix-Assisted Laser Desorption/Ionization-Mass Spectroscopy and Capillary Electrophoresis Hyphenated with Mass Spectrometry via Electrospray Ionization.
Guo RR, Lageveen-Kammeijer GSM, Wang W, et al.·Journal of agricultural and food chemistry·
Severe allergic reactions to certain types of meat following tick bites have been reported in geographic regions which are endemic with ticks. This immune response is directed to a carbohydrate antige...
[The advances of allergen component detection in IgE-mediated food allergy].
Chen H, Zhu RF, Liao XT, et al.·Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·
There are many types in food allergy, and the most common is mediated by IgE. Currently, the diagnosis of food allergy mainly relied on skin prick test and serum specific IgE of allergen extract, whic...
Clinical Use of the ImmunoCAP Inhibition Test in the Diagnosis of Meat Allergy Caused by a Tick Bite in an Adult Male with No Previous Atopic History.
Lis K, Ukleja-Sokołowska N, Karwowska K, et al.·Life (Basel, Switzerland)·
(1) Background: alpha-gal syndrome (AGS) is a serious, potentially life-threatening allergic reaction. This is a type of food allergy to red meat and other mammalian products (e.g., gelatin). In Polan...
View on PubMed →Alpha-gal syndrome (AGS) in a glaucoma suspect with narrow iridocorneal angles.
Tejan-Kamara AZ, Murhammer JM, Fingert JH·American journal of ophthalmology case reports·
Alpha-gal syndrome (AGS) is an allergy to non-primate mammalian carbohydrate (galactose-alpha-1,3-galactose) which may cause anaphylaxis. Allergic patients must avoid ophthalmic drugs containing anima...
View on PubMed →The epidemiology of food allergy in adults.
Warren C, Nimmagadda SR, Gupta R, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
The prevalence and awareness of food allergy (FA) among US adults is arguably at a historical high, both with respect to primary immunoglobulin E-mediated food hypersensitivity and other food-triggere...
The Two-Sided Experimental Model of ImmunoCAP Inhibition Test as a Useful Tool for the Examination of Allergens Cross-Reactivity on the Example of α-Gal and Mammalian Meat Sensitization-A Preliminary Study.
Lis K, Ukleja-Sokołowska N, Karwowska K, et al.·Current issues in molecular biology·
Cross-reactivity of allergens is the cause of various, sometimes unexpected, clinical reactions. There are no standard methods to investigate cross-reactivity. We present an experimental model of a tw...
View on PubMed →Food Allergies and Alpha-gal Syndrome for the Gastroenterologist.
Lee CJ, McGill SK·Current gastroenterology reports·
Food allergies are typically not considered as a cause of gastrointestinal (GI) distress without additional allergic symptoms, apart from celiac disease and eosinophilic esophagitis. However, recent r...
Clinical and laboratory features of patients diagnosed with alpha-gal syndrome-2010-2019.
Binder AM, Cherry-Brown D, Biggerstaff BJ, et al.·Allergy·
Alpha-gal syndrome (AGS) is an IgE-mediated allergy to galactose-alpha-1,3-galactose. Clinical presentation ranges from hives to anaphylaxis; episodes typically occur 2-6 h after exposure to alpha-gal...
[Frequency of food allergy in students of human medicine of a private university].
Rojas-Puell MJ, Salazar-Gastelu D, Runzer-Colmenares FM, et al.·Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·
Determine the frequency of total food allergy, and to Peruvian products, in Human Medicine students. A study design is observational, descriptive and retrospective was made. Human medicine students, a...
Serum biomarkers for nutritional status as predictors in COVID-19 patients before and after vaccination.
Vaz-Rodrigues R, Mazuecos L, Villar M, et al.·Journal of functional foods·
The aim of this study was to characterize serum protein biomarkers for nutritional status that may be used as predictors for disease symptomatology in COVID-19 patients before and after vaccination. I...
View on PubMed →Validation of an anti-α-Gal IgE fluoroenzyme-immunoassay for the screening of patients at risk of severe anaphylaxis to cetuximab.
Serrier J, Davy JB, Dupont B, et al.·BMC cancer·
The link between immediate hypersensitivity reactions (HSR) following the first cetuximab infusion and the IgE sensitization against anti-galactose-α-1,3-galactose (α-Gal) is now well-established. An...
Impact of Polarization on the Ring Puckering Dynamics of Hexose Monosaccharides.
J N C, Mallajosyula SS·Journal of chemical information and modeling·
Analysis of crystal structures of hexose monosaccharides α-d-mannose (α-MAN), β-d-mannose (β-MAN), α-d-glucose (α-GLC), β-d-glucose (β-GLC), α-d-galactose (α-GAL), β-d-galactose (β-GAL), α-d-altrose (...
Alpha-gal syndrome initially misdiagnosed as chronic spontaneous urticaria in a pediatric patient: a case report and review of the literature.
Bellutti Enders F, Elkuch M, Wörner A, et al.·Journal of medical case reports·
Delayed allergy to red meat, also termed alpha-gal syndrome, is increasingly reported in adults and African communities, while pediatric cases remain rare. Here, we report on a 7-year-old Caucasian bo...
Complete chemical structure of the K135 capsular polysaccharide produced by Acinetobacter baumannii RES-546 that contains 5,7-di-N-acetyl-8-epipseudaminic acid.
Shashkov AS, Kasimova AA, Arbatsky NP, et al.·Carbohydrate research·
A structurally diverse capsular polysaccharide (CPS) in the outer cell envelope plays an important role in the virulence of the important bacterial pathogen, Acinetobacter baumannii. More than 75 diff...
Anaphylaxis: Advances in the Past 10 Years.
Weiler CR, Schrijvers R, Golden DBK·The journal of allergy and clinical immunology. In practice·
In the past 10 years, anaphylaxis has grown into its own special area of study within Allergy-Immunology, both at the bench and at the bedside. This review focuses on some of the most clinically relev...
Paleo-immunology of human anti-carbohydrate antibodies preventing primate extinctions.
Galili U·Immunology·
Two human natural anti-carbohydrate antibodies appeared in critical evolutionary events that brought primates and hominins to brink of extinction. The first is the anti-Gal antibody, produced in Old-W...
Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model.
Sharma SR, Choudhary SK, Vorobiov J, et al.·Frontiers in immunology·
Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE antibodies targeting galactose-α-1,3-galactose (α-gal), a carbohydrate found in red meat. This condition has gained signific...
Allergic reactions associated with medically relevant arthropods.
Vaz-Rodrigues R, Feo Brito F, Guzmán Rodríguez R, et al.·Annals of medicine·
Vector-borne diseases are a growing burden worldwide. In particular, the risks of allergic reactions to bites are associated with growing arthropod populations in contact with the public. The diversit...
Unique allergen-specific human IgE monoclonal antibodies derived from patients with allergic disease.
Smith BRE, Reid Black K, Bermingham M, et al.·Frontiers in allergy·
Allergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate...
View on PubMed →High-risk groups for alpha-gal sensitization.
Benders-Guedj M, Köberle M, Hofmann H, et al.·Allergologie select·
Tick bite-induced IgE-mediated reactions to the oligosaccharide galactose α-1,3-galactose (alpha-gal) are increasingly recognized. This study investigated alpha-gal sensitization in three groups with...
View on PubMed →A retrospective review of α-gal syndrome complicating the management of suspected pancreatic exocrine insufficiency in one gastroenterology clinic in central Virginia.
Richards NE, Wilson JM, Platts-Mills TAE, et al.·Frontiers in gastroenterology (Lausanne, Switzerland)·
The galactose-α-1,3-galactose (α-gal) mammalian meat allergy, α-gal syndrome, often includes diarrhea, abdominal pain, and other gastrointestinal (GI) symptoms. Pancreatic exocrine insufficiency cause...
View on PubMed →Alpha-gal Syndrome - A Case Report of Tick-Borne Anaphylactic Shock.
Müller J, Radej J, Kriz M, et al.·European journal of case reports in internal medicine·
The most common cause of vasoplegic shock in critical care is sepsis. However, although rarely and only in specifically sensitised individuals previously bitten by a tick, red meat may provoke a delay...
View on PubMed →Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies.
Hatfield G, Tepliakova L, Tran J, et al.·mAbs·
Monoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes including terminal galactosyl-α1-3-galactose (α1-3-Gal) moieties. Cetuximab is a commercial mAb assoc...
Engineering protein glycosylation in CHO cells to be highly similar to murine host cells.
Gupta S, Shah B, Fung CS, et al.·Frontiers in bioengineering and biotechnology·
Since 2015 more than 34 biosimilars have been approved by the FDA. This new era of biosimilar competition has stimulated renewed technology development focused on therapeutic protein or biologic manuf...
View on PubMed →Production, purification, characterization, and applications of -galactosidase from JS27 isolated from Manikaran hot springs.
Bhatia S, Batra N, Singh J·Preparative biochemistry & biotechnology·
α-Galactosidase hydrolyzes the α-1,6-linkage present at the non-reducing end of the sugars and results in the release of galactosyl residue from oligosaccharides like melibiose, raffinose, stachyose,...
Idiopathic Anaphylaxis? Analysis of Data from the Anaphylaxis Registry for West Pomerania Province, Poland.
Poziomkowska-Gęsicka I·International journal of environmental research and public health·
The most common causes of anaphylaxis, according to various authors and depending on the age of the studied groups, are: Hymenoptera venom, food, and medications. Unfortunately, we are not always able...
Alpha-Gal Syndrome in the Infectious Diseases Clinic: A Series of 5 Cases in Central North Carolina.
Boyce RM, Schulz A, Mansour O, et al.·Open forum infectious diseases·
Alpha-gal syndrome (AGS) is a recently described allergy to galactose-α-1,3-galactose, an oligosaccharide present in mammalian meat. AGS can present with angioedema, urticaria, and anaphylaxis arising...
View on PubMed →Food allergy in Sri Lanka - A comparative study.
de Silva R, Karunatilake C, Iddagoda J, et al.·The World Allergy Organization journal·
The incidence of IgE mediated food allergy (FA) is increasing in the west. Cow's milk (CM), hen's egg, wheat, soy, peanut, tree nut, fish, and shellfish are responsible for 90% of food allergy in the...
View on PubMed →Knowledge, attitudes, and practices of Illinois medical professionals related to ticks and tick-borne disease.
Carson DA, Kopsco H, Gronemeyer P, et al.·One health (Amsterdam, Netherlands)·
The rising incidence of tick-borne disease (TBD) underscores the importance of proficiency in TBD diagnosis. Clinicians' knowledge about vector ticks and TBDs in their area may influence whether patie...
View on PubMed →Cohort study of subclinical sensitization against galactose-α-1,3-galactose in Japan: Prevalence and regional variations.
Nakagawa Y, Chinuki Y, Ogino R, et al.·The Journal of dermatology·
Sensitization to galactose-α-1,3-galactose (α-Gal) leads to the development of α-Gal syndrome, which includes red meat allergy and cetuximab-induced anaphylaxis. Since tick bites represent the main ca...
Commentary: Alpha-gal syndrome and cardiac implant durability.
Kilmarx SE, Balsam LB·The Journal of thoracic and cardiovascular surgery·
Allergic response to medical products in patients with alpha-gal syndrome.
Kuravi KV, Sorrells LT, Nellis JR, et al.·The Journal of thoracic and cardiovascular surgery·
Galactose-α-1,3-galactose (alpha-gal) is a carbohydrate that is ubiquitously expressed in all mammals except for primates and humans. Patients can become sensitized to this antigen and develop alpha-g...
Structural and biomechanical characterizations of acellular porcine mitral valve scaffolds: anterior leaflets, posterior leaflets, and chordae tendineae.
Wang B, Sierad LN, Mercuri JJ, et al.·Engineered regeneration·
Mitral valve (MV) tissue engineering is still in its early stage, and one major challenge in MV tissue engineering is to identify appropriate scaffold materials. With the potential of acellular MV sca...
View on PubMed →Serodiagnosis and therapeutic monitoring of New-World tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins.
Viana SM, Montoya AL, Carvalho AM, et al.·Emerging microbes & infections·
American tegumentary leishmaniasis (TL) caused by is characterized by a spectrum of clinical presentations, ranging from localized cutaneous ulcers (CL), mucosal (ML), or disseminated (DL) disease, t...
Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: a possible association with Lyme disease?
Dupont M, Carlier C, Gower-Rousseau C, et al.·BMC cancer·
Previous studies have observed an increased incidence of Cetuximab-induced hypersensitivity infusion reactions (CI-IRs) in the southeastern states of the USA. Tick's bites were suspected of generating...
Biology, Systematics, Microbiome, Pathogen Transmission and Control of Chiggers (Acari: Trombiculidae, Leeuwenhoekiidae) with Emphasis on the United States.
Chen K, Roe RM, Ponnusamy L·International journal of environmental research and public health·
Chiggers are the larval stage of Trombiculidae and Leeuwenhoekiidae mites of medical and veterinary importance. Some species in the genus and vector species, the bacteria that causes scrub typhus d...
The α-Galactosyl Carbohydrate Epitope in Pathogenic Protozoa.
de Lederkremer RM, Giorgi ME, Marino C·ACS infectious diseases·
The α-gal epitope, which refers to the carbohydrate α-d-Gal-(1 → 3)-β-d-Gal-(1 → 4)-d-GlcNAc-R, was first described in the glycoconjugates of mammals other than humans. Evolution caused a mutation tha...
[Mediation effect of inflammatory biomarkers on the association between blood lead levels and blood pressure changes in Chinese adults].
Qu YL, Zhao F, Ji SS, et al.·Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·
To investigate the role of inflammatory biomarkers in the relationship between blood lead levels and blood pressure changes. A total of 9 910 people aged 18-79 years who participated in the China Nat...
Administration of nicotinamide mononucleotide improves oocyte quality of obese mice.
Wang L, Chen Y, Wei J, et al.·Cell proliferation·
Obesity has become a common health concern around the world. Maternal obesity could cause poor reproductive outcomes due to chronic ovarian inflammation and decreased oocyte quality. However, the stra...
Prevalence, predictors, and clinical relevance of α-gal sensitization in patients with chronic urticaria.
Pedersen HST, Sørensen JA, Madsen F, et al.·Clinical and translational allergy·
Little is known about α-gal (galactose-α-1,3-galactose) sensitization in patients with chronic urticaria (CU). The aim of this study was to examine the prevalence, predictors and clinical relevance of...
View on PubMed →Reactivity to heparin in patients with alpha-gal allergy: A potential role for skin testing?
Koo G, Plager J, Fahrenholz JM, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model.
Juste RA, Ferreras-Colino E, de la Fuente J, et al.·Immunology·
Trained immunity (TRAIM) may be defined as a form of memory where innate immune cells such as monocytes, macrophages, dendritic and natural killer (NK) cells undergo an epigenetic reprogramming that e...
α-Gal Nanoparticles Mediated Homing of Endogenous Stem Cells for Repair and Regeneration of External and Internal Injuries by Localized Complement Activation and Macrophage Recruitment.
Galili U, Goldufsky JW, Schaer GL·International journal of molecular sciences·
This review discusses a novel experimental approach for the regeneration of original tissue structure by recruitment of endogenous stem-cells to injured sites following administration of α-gal nanopar...
Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules.
Contreras M, González-García A, de la Fuente J·Journal of visualized experiments : JoVE·
Ticks are arthropod vectors that cause disease by pathogen transmission and whose bites could be related to allergic reactions impacting human health worldwide. In some individuals, high levels of imm...
Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study.
Milosevic J, Jurisevic M, Grbovic V, et al.·International journal of environmental research and public health·
Gonarthrosis and diabetes mellitus are two diseases that are increasingly being linked. The aim of this study was to quantify serum levels of Gal-3, pro- and anti-inflammatory cytokines (including the...
Effect of Dried Apple Pomace (DAP) as a Feed Additive on Antioxidant System in the Rumen Fluid.
Bartel I, Koszarska M, Wysocki K, et al.·International journal of molecular sciences·
The study aimed to evaluate the effect of dried apple pomace (DAP) as a feed additive on the enzymatic activity and non-enzymatic compounds belonging to the antioxidant system in cattle rumen fluid. T...
A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease.
Montoya AL, Carvajal EG, Ortega-Rodriguez U, et al.·Molecules (Basel, Switzerland)·
Chagas disease (CD) is caused by the parasite and affects 6-7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity encompassing seven genotypes (TcI-VI an...
Newly Recognized α-Gal Syndrome in the Upper Midwestern United States.
Chacon Osorio GR, Palraj R, van Nunen S, et al.·Mayo Clinic proceedings·
ENDURAGen graft durability in α-Gal disease.
Ruland KL, Kirzhner M·American journal of ophthalmology case reports·
We present a case of eyelid reconstruction using ENDURAGen, a porcine-derived acellular collagen graft, complicated by dissolution of the graft in a patient recently diagnosed with α-Gal disease. A 33...
View on PubMed →Correlation between Endometriosis and Selected Allergic and Autoimmune Diseases and Eating Habits.
Nowakowska A, Kwas K, Fornalczyk A, et al.·Medicina (Kaunas, Lithuania)·
: Endometriosis is a hormone-dependent chronic inflammatory disease with serious reproductive and general health consequences. It is viewed as a multifactorial problem, consisting of matters related t...
Initiating Psychotropic Treatment in a Patient With Alpha-Gal Syndrome.
Narlesky MR, Palting A, Sukpraprut-Braaten S, et al.·Cureus·
Alpha-gal syndrome, which is typically acquired by a tick bite, is an IgE-mediated immune response to galactose-alpha-1,3-galactose (alpha-gal), an oligosaccharide in most mammalian tissue. This repor...
View on PubMed →α-Gal present on both glycolipids and glycoproteins contributes to immune response in meat-allergic patients.
Chakrapani N, Fischer J, Swiontek K, et al.·The Journal of allergy and clinical immunology·
The α-Gal syndrome is associated with the presence of IgE directed to the carbohydrate galactose-α-1,3-galactose (α-Gal) and is characterized by a delayed allergic reaction occurring 2 to 6 hours afte...
Sensitisation and allergic reactions to alpha-1,3-galactose in Podlasie, Poland, an area endemic for tick-borne infections.
Rutkowski K, Sowa P, Mroczko B, et al.·Infectious diseases (London, England)·
Ticks transmit several pathogens and seem implicated in the production of specific IgE antibodies to alpha-1,3-galactose (α-gal sIgE). They cause delayed and immediate allergy to mammalian meat and me...
A low level of naturally occurring antibodies associates with functional antibody deficiency.
Bernth Jensen JM, Hansen AT, Söderström A, et al.·Clinical immunology (Orlando, Fla.)·
Functional antibody deficiency is clinically assessed from antibody responses to vaccination. However, diagnostic vaccination is complex and may fail in practice. We hypothesized that the levels of na...
Sensitisation of Forest workers to the oligosaccharide galactose alpha-1, 3-galactose (alpha-gal) is strongly associated with tick bites but not with evidence of tick borne infections.
Platts-Mills T·Infectious diseases (London, England)·
IgE Antibodies to Galactose-α-1,3-galactose, an Epitope of Red Meat Allergen, Cross-react With a Novel Flounder Roe Allergen.
Chinuki Y, Takahashi H, Morita E·Journal of investigational allergology & clinical immunology·
Genetic and structural basis of the human anti-α-galactosyl antibody response.
Langley DB, Schofield P, Nevoltris D, et al.·Proceedings of the National Academy of Sciences of the United States of America·
Humans lack the capacity to produce the Galα1-3Galβ1-4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut...
Meat Allergy: A Ticking Time Bomb.
Shah R, Schwartz RA·American journal of clinical dermatology·
Food allergies are relatively prevalent, but mammalian meat allergy remains uncommon and represents an important, potentially acute healthcare risk. This risk is partly because both clinicians and the...
Management of allergic reactions and anaphylaxis in the emergency department.
Zeke A, Sudhir A·Emergency medicine practice·
An acute allergic reaction is a rapid-onset, IgE-mediated hypersensitivity reaction. Although it is most commonly caused by food, insect stings, and medications, there are many additional causes. Symp...
A glucomannogalactan from Pleurotus geesteranus: Structural characterization, chain conformation and immunological effect.
Liang Z, Yin Z, Liu X, et al.·Carbohydrate polymers·
A water-soluble glucomannogalactan was isolated from P. geesteranus fruit bodies by hot water extraction and column chromatography method. The structure, chain conformation and immune effect of PGP-1c...
Alkaline α-galactosidase 2 (CsAGA2) plays a pivotal role in mediating source-sink communication in cucumber.
Liu H, Liu X, Zhao Y, et al.·Plant physiology·
Sugars are necessary for plant growth and fruit development. Cucumber (Cucumis sativus L.) transports sugars, mainly raffinose family oligosaccharides (RFOs), in the vascular bundle. As the dominant s...
Alpha-Gal-specific humoral immune response and reported clinical consequence for cardiac valve replacement in patients below 65 years: moving beyond conjecture.
Copic D, Bormann D, Direder M, et al.·European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·
Cardiac Arrest Induced by an Anaphylactic Reaction Associated With the First Dose of Cetuximab.
Hane A, Ito A, Ishikura K, et al.·Cureus·
Cetuximab is a chimeric mouse-human monoclonal antibody biologic used for the treatment of epidermal growth factor receptor-positive colorectal cancer and head and neck cancer. The incidence of severe...
View on PubMed →Suddenly Steakless: A Gastroenterologist's Guide to Managing Alpha-Gal Allergy.
McGill SK, Richards RD, Commins SP·The American journal of gastroenterology·
Functional characterization of α-Gal producing lactic acid bacteria with potential probiotic properties.
Bamgbose T, Alberdi P, Abdullahi IO, et al.·Scientific reports·
The possibility of exploiting the human immune response to glycan α-Gal for the control of multiple infectious diseases has been the objective of recent investigations. In this field of research, the...
[Alpha-gal Syndrome].
Mülleneisen NK, Bergenroth T, Salge S·Pneumologie (Stuttgart, Germany)·
The quality of life in urticaria strongly corresponds with the subjective perception and the localization of the wheals. Guidelines should take impairment of health-related quality of life much strong...
First conjugation directed traverse of gene cassettes harboring α1,3GT from fast-growing Mycobacterium smegmatis mc 155 to slow-growing pathogen Mycobacterium tuberculosis H37Rv, presumably opening up new scopes in tuberculosis treatment.
Golichenari B, Yari S, Tasbiti AH, et al.·Enzyme and microbial technology·
Mycobacterium smegmatis strain mc 155 is a fast-growing and non-pathogenic mycobacteria and widely used in genetic studies of mycobacteria. It has been shown that this species of mycobacterium can tra...
Structure and activity of an anti-epidermal growth factor receptor antibody without galactose-α-1,3-galactose residues.
Ren K, Gong H, Ma Z, et al.·Drug development research·
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein, which has been considered as one of the key targets for cancer therapy. However, currently approved therapeutic anti-EGFR antib...
Anti-Inflammatory and Pro-Regenerative Effects of Hyaluronan-Chitlac Mixture in Human Dermal Fibroblasts: A Skin Ageing Perspective.
Donato A, Belluzzi E, Mattiuzzo E, et al.·Polymers·
Inflammation and the accumulation of reactive oxygen species (ROS) play an important role in the structural and functional modifications leading to skin ageing. The reduction of inflammation, cellular...
View on PubMed →Novel Case Presentation of Abulia After Lone Star Tick Bite As Evidenced by Raised Titers of Alpha-Gal Specific IgM Immunoglobulin and a Possibility of Alpha-Gal Driven Hypothalamic Dysfunction As the Pathomechanism.
Daripa B, Lucchese S·Cureus·
Galactose-α-1,3-galactose, an oligosaccharide epitope better acknowledged as α-Gal, is present in non-primate mammal meat, tick bites, microorganisms, and vaccines as a glycoprotein or glycolipid moie...
View on PubMed →Clinical Issues-April 2022.
Wood A·AORN journal·
Perioperative care of the patient with alpha-gal syndrome Key words: alpha-gal syndrome (AGS), red meat allergy, allergic reaction, mammalian-derived ingredients, gelatin. Overnight storage of sterile...
View on PubMed →Alpha-Gal (Mammalian Meat) Allergy: Implications for Dermatologic Surgeons.
Raji K, Baucom M·Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·
Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, et al.·Journal of the European Academy of Dermatology and Venereology : JEADV·
Long eyelashes have been popularized and many commercially available products exist to achieve eyelash growth as a desired cosmetic effect. Eyelash trichomegaly may be induced by medications, procedur...
An approach to a patient with suspected meat allergy due to underlying alpha-Gal syndrome in a resource-limited setting.
Vanegas E, Felix M, Farfán Bajaña MJ, et al.·JAAD case reports·
View on PubMed →[Alpha-gal syndrome : Overview of clinical presentation and pathophysiology].
Fischer J, Reepschläger T, Schricker T, et al.·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
In the world of allergology, alpha-gal syndrome remains one of the most fascinating discoveries over the last 15 years as it is triggered by specific IgE directed against the immunogenic sugar galacto...
Immunoglobulin E Sensitization to Mammalian Oligosaccharide Galactose-α-1,3 (α-Gal) Is Associated With Noncalcified Plaque, Obstructive Coronary Artery Disease, and ST-Segment-Elevated Myocardial Infarction.
Vernon ST, Kott KA, Hansen T, et al.·Arteriosclerosis, thrombosis, and vascular biology·
Treating known risk factors for coronary artery disease (CAD) has substantially reduced CAD morbidity and mortality. However, a significant burden of CAD remains unexplained. Immunoglobulin E sensitiz...
Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties.
Piening LM, Lillyman DJ, Lee FS, et al.·JOR spine·
Chronic low back pain (LBP) is a leading cause of disability, but treatments for LBP are limited. Degeneration of the intervertebral disc due to loss of neuroinhibitory sulfated glycosaminoglycans (sG...
View on PubMed →The Quantification of IgG Specific to α-Gal Could Be Used as a Risk Marker for Suffering Mammalian Meat Allergy.
Joral A, Azketa N, Sanchez P, et al.·Foods (Basel, Switzerland)·
The alpha-Gal Syndrome is a delayed meat allergy characterized by the presence of sIgE against α-Gal epitope. It is known that the α-Gal present in tick saliva induces the sensitization to this epitop...
View on PubMed →Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome.
Murangi T, Prakash P, Moreira BP, et al.·The Journal of allergy and clinical immunology·
IgE to galactose alpha-1,3 galactose (alpha-gal) causes alpha-gal syndrome (delayed anaphylaxis after ingestion of mammalian meat). Development of sensitization has been attributed to tick bites; howe...
Anaphylaxis: Epidemiology and Differential Diagnosis.
Motosue MS, Li JT, Campbell RL·Immunology and allergy clinics of North America·
Anaphylaxis-related emergency department (ED) visits and hospitalizations are increasing. Triggers for anaphylaxis include food, medications, and stinging insects. Idiopathic anaphylaxis accounts for...
Effects of Emulsifiers on an In vitro Model of Intestinal Epithelial Tight Junctions and the Transport of Food Allergens.
Khuda SE, Nguyen AV, Sharma GM, et al.·Molecular nutrition & food research·
Certain food emulsifiers may interfere with gut barrier function in ways correlating to increased exposure to allergens. Understanding the consequences of interactions between these food ingredients a...
Where's the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome.
Carson AS, Gardner A, Iweala OI·Journal of immunology (Baltimore, Md. : 1950)·
Alpha-gal syndrome (AGS) describes a collection of symptoms associated with IgE-mediated hypersensitivity responses to the glycan galactose-alpha-1,3-galactose (alpha-gal). Individuals with AGS develo...
Engineering an Enhanced EGFR Engager: Humanization of Cetuximab for Improved Developability.
Goulet DR, Chatterjee S, Lee WP, et al.·Antibodies (Basel, Switzerland)·
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase whose proliferative effects can contribute to the development of many types of solid tumors when overexpressed. For this reaso...
View on PubMed →Specific Recognition of β-Galactofuranose-Containing Glycans of Synthetic Neoglycoproteins by Sera of Chronic Chagas Disease Patients.
Montoya AL, Gil ER, Heydemann EL, et al.·Molecules (Basel, Switzerland)·
Chagas disease (CD) can be accurately diagnosed by detecting in patients' blood using polymerase chain reaction (PCR). However, parasite-derived biomarkers are of great interest for the serological d...
Cross-reactivity between tick and wasp venom can contribute to frequent wasp sensitization in patients with the α-Gal syndrome.
Kiewiet MBG, Perusko M, Grundström J, et al.·Clinical and translational allergy·
α-Gal syndrome (AGS) is a food allergy with severe delayed allergic reactions, mediated by IgE-reactivity to galactose-α1,3-galactose (α-Gal). AGS is strongly associated with tick bites. An increased...
View on PubMed →Tick bite induced α-gal syndrome highlights anticancer effect of allergy.
Apari P, Földvári G·BioEssays : news and reviews in molecular, cellular and developmental biology·
Tick bite induced α-gal syndrome (AGS) following consumption of mammalian meat is a recently described intriguing disease occurring worldwide. Here we argue that AGS and delayed allergy in general is...
A retrospective evaluation of heparin product reactions in patients with alpha-gal allergies.
Nwamara U, Kaplan MC, Mason N, et al.·Ticks and tick-borne diseases·
Alpha-gal allergy, also known as red meat allergy or alpha-gal syndrome, can present after bites of certain tick species that contain galactose-alpha-1,3-galactose (alpha-gal) carbohydrate. Following...
Delayed reaction in alpha-gal allergy is reflected in serum levels after ingestion of pork kidney, and absorption is dependent on food processing.
Eller E, Stahl Skov P, Baumann K, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
Alpha-gal sensitization among young adults is associated with male sex and polysensitization.
Westman M, Asarnoj A, Ballardini N, et al.·The journal of allergy and clinical immunology. In practice·
Update on idiopathic anaphylaxis.
Calvani M·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
Idiopathic anaphylaxis (AI) refers to anaphylaxis without a recognizable cause after a comprehensive allergic workup. The diagnostic approach usually includes an accurate clinical history aimed at exc...
Of mice and men, MMXXI: Anaphylaxis.
Platts-Mills TAE, Eid RC, Keshavarz B·The Journal of allergy and clinical immunology·
Fabrication and characterization of an acellular annulus fibrosus scaffold with aligned porous construct for tissue engineering.
Jin X, Kang R, Deng R, et al.·Journal of biomaterials applications·
Scaffolds mimicking the native annulus fibrosus (AF) extracellular matrix (ECM) structure are crucial to guide the seeding cells to regenerate aligned tissue, while fabricating such a scaffold by synt...
Alpha-gal syndrome and delayed anaphylaxis after ingestion of red meat: A case report.
Caron L, Ortolani VGR, Bono E, et al.·Allergologie select·
α-gal syndrome (AGS) is caused by the intake of products containing α-gal (galactose-α-1,3-galactose) like mammalian meat. Over the last decade, scientific literature about AGS has been increasing, bu...
View on PubMed →Editorial: Novel horizons in pediatric food allergy.
Barni S, Buyuktiryaki B·Frontiers in pediatrics·
View on PubMed →The α-Gal mammalian meat allergy as a cause of isolated gastrointestinal symptoms.
Richards NE, Makin TA, Smith AR, et al.·Frontiers in gastroenterology (Lausanne, Switzerland)·
The α-Gal mammalian meat allergy classically presents with urticaria, with or without gastrointestinal (GI) symptoms or anaphylaxis, but increasingly we are aware of patients with only GI symptoms. He...
View on PubMed →The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome.
Macdougall JD, Thomas KO, Iweala OI·ImmunoTargets and therapy·
Alpha-gal syndrome is an unconventional food allergy, characterized by IgE-mediated hypersensitivity responses to the glycan galactose-alpha-1,3-galactose (alpha-gal) and not to a food-protein. In thi...
View on PubMed →Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS).
Vaz-Rodrigues R, Mazuecos L, de la Fuente J·Journal of asthma and allergy·
The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dair...
View on PubMed →Recently Evolved -Like Endosymbiont Outcompetes an Ancient and Evolutionarily Associated -Like Endosymbiont in the Lone Star Tick () Linked to the Alpha-Gal Syndrome.
Kumar D, Sharma SR, Adegoke A, et al.·Frontiers in cellular and infection microbiology·
Ticks are hematophagous arthropods that transmit various bacterial, viral, and protozoan pathogens of public health significance. The lone star tick () is an aggressive human-biting tick that transmit...
Editorial: Characterization, Biosynthesis and Biological Functions of Novel Glyco-Epitopes.
Yan S, Hodžić A, Bandini G, et al.·Frontiers in molecular biosciences·
View on PubMed →Tick Intrastadial Feeding and Its Role on IgE Production in the Murine Model of Alpha-gal Syndrome: The Tick "Transmission" Hypothesis.
Maldonado-Ruiz LP, Boorgula GD, Kim D, et al.·Frontiers in immunology·
Recent studies have provided strong evidence indicating that lone star tick bites are a cause of AGS (alpha-gal syndrome, also known as red meat allergy RMA) in humans. AGS is characterized by an incr...
Alpha-gal syndrome. Allergy to red meat and gelatin.
Zurbano-Azqueta L, Antón-Casas E, Duque-Gómez S, et al.·Revista clinica espanola·
Alpha-gal syndrome is a potentially severe food allergy caused by the presence of alpha-gal-specific IgE. The aim of this study is to describe our series of 13 patients. This work is a retrospective s...
Tumor treatment by pHLIP-targeted antigen delivery.
DuPont M, Visca H, Moshnikova A, et al.·Frontiers in bioengineering and biotechnology·
Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a sugar, to...
View on PubMed →Heparin desensitisation prior to cardiopulmonary bypass in a patient with alpha-gal allergy.
McRae AS, Tidwell WP, Patel S, et al.·Anaesthesia reports·
This case report describes the implementation of a heparin desensitisation strategy for a patient with confirmed galactose-alpha-1,3-galactose (alpha-gal) allergy, prior to cardiac surgery. We describ...
View on PubMed →Association of dengue infection with anti-alpha-gal antibodies, IgM, IgG, IgG1, and IgG2.
Olajiga OM, Maldonado-Ruiz LP, Fatehi S, et al.·Frontiers in immunology·
Dengue virus (DENV) transmitted by the mosquitoes is the etiological agent of dengue fever, one of the fastest-growing reemerging mosquito-borne diseases on the planet with a 30-fold surge in the las...
Red meat consumption and risk for dyslipidaemia and inflammation: A systematic review and meta-analysis.
Sun L, Yuan JL, Chen QC, et al.·Frontiers in cardiovascular medicine·
The study (PROSPERO: CRD42021240905) aims to reveal the relationships among red meat, serum lipids and inflammatory biomarkers. PubMed, EMBASE and the Cochrane databases were explored through December...
View on PubMed →New Challenges in Drug Allergy: the Resurgence of Excipients.
Venturini Díaz M, Vidal Oribe I, D'Elia Torrence D, et al.·Current treatment options in allergy·
Allergy to excipients is a cause of multidrug allergy and if it is not taken into account, it can lead to unexpected severe reactions. If an excipient allergy is suspected, an accurate examination fol...
View on PubMed →Assessment of the Safety and Efficacy of an Oral Probiotic-Based Vaccine Against Aspergillus Infection in Captive-Bred Humboldt Penguins ().
Thorel M, Mateos-Hernandez L, Mulot B, et al.·Frontiers in immunology·
Aspergillosis is a fungal infection caused mainly by that often results in respiratory disease in birds. Aspergillosis is a major cause of morbidity and mortality in captive-bred penguin species. Cur...
Comparing the Characteristics of Amniotic Membrane-, Endometrium-, and Urinary-Derived ECMs and Their Effects on Endometrial Regeneration in a Rat Uterine Injury Model.
Ji W, Wen J, Lin W, et al.·Frontiers in bioengineering and biotechnology·
The decellularized extracellular matrices (d-ECMs) currently utilized to repair endometrial injuries are derived from three tissue sources, the endometrium (dE-ECM), placental amniotic membrane (dA-EC...
View on PubMed →A phase II study of chemotherapy in combination with telomerase peptide vaccine (GV1001) as second-line treatment in patients with metastatic colorectal cancer.
Kim S, Kim BJ, Kim I, et al.·Journal of Cancer·
GV1001 is a human telomerase peptide vaccine that induces a CD4/CD8 T-cell response against cancer cells, thereby affording an immunological anti-tumor effect. Here, we evaluated the efficacy and safe...
View on PubMed →Exploring the Ecological Implications of Microbiota Diversity in Birds: Natural Barriers Against Avian Malaria.
Palinauskas V, Mateos-Hernandez L, Wu-Chuang A, et al.·Frontiers in immunology·
Natural antibodies (Abs), produced in response to bacterial gut microbiota, drive resistance to infection in vertebrates. In natural systems, gut microbiota diversity is expected to shape the spectrum...
CsAGA1 and CsAGA2 Mediate RFO Hydrolysis in Partially Distinct Manner in Cucumber Fruits.
Hua B, Zhang M, Zhang J, et al.·International journal of molecular sciences·
A Raffinose family oligosaccharides (RFOs) is one of the major translocated sugars in the vascular bundle of cucumber, but little RFOs can be detected in fruits. Alpha-galactosidases (α-Gals) catalyze...
Course of IgE to α-Gal in a Swedish population of α-Gal syndrome patients.
Apostolovic D, Grundström J, Perusko M, et al.·Clinical and translational allergy·
View on PubMed →Characterization of tick salivary gland and saliva alphagalactome reveals candidate alpha-gal syndrome disease biomarkers.
Villar M, Pacheco I, Mateos-Hernández L, et al.·Expert review of proteomics·
Ticks are obligate hematophagous arthropods that synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) associated with the alpha-gal syndrome (AGS) or allergy to mammalian meat consumption. In this...
Testing virtual nursing education on alpha-gal allergy.
Farmer LM, Monroe M, Davies CC·Nursing management·
Demystifying α-gal syndrome: identification and risk management in the perioperative setting.
Wolaver W, Thakrar S, Thomas K, et al.·Current opinion in anaesthesiology·
α-Gal syndrome is among a vexing perioperative consideration for anesthesiologists. Commonly referred to as 'red meat allergy', α-Gal syndrome is precipitated by a lone star tick bite resulting in the...
Bovine γ-globulin, lactoferrin, and lactoperoxidase are relevant bovine milk allergens in patients with α-Gal syndrome.
Perusko M, Apostolovic D, Kiewiet MBG, et al.·Allergy·
Mammalian meat is the most common trigger of the allergic reactions in patients with α-Gal syndrome (AGS). Milk and dairy, although less often, also cause a significant number of allergic manifestatio...
Increased rates of cetuximab reactions in tick prevalent regions and a proposed protocol for risk mitigation.
Yuile A, Fanuli C, van Nunen S, et al.·Asia-Pacific journal of clinical oncology·
Cetuximab is an anti-epidermal growth factor receptor mouse-human chimeric monoclonal antibody used to treat advanced colorectal cancers. Initial data suggest that severe infusion reactions occurred i...
Mammalian meat allergy emerges after tick bite: the alpha-gal syndrome.
Altshuler E, Krikpatrick J, Aryan M, et al.·BMJ case reports·
Alpha-gal syndrome (AGS) is a hypersensitivity reaction to mammalian meat that develops after tick bite exposure. AGS was first described in 2009 and testing for the allergy has become available in th...
Potential Effects of Climate Change on Tick-borne Diseases in Rhode Island.
Ginsberg HS, Couret J, Garrett J, et al.·Rhode Island medical journal (2013)·
Human cases of tick-borne diseases have been increasing in the United States. In particular, the incidence of Lyme disease, the major vector-borne disease in Rhode Island, has risen, along with cases...
Aortic homograft for aortic valve replacement in patient with Alpha-Gal allergy.
Dang Van S, Fouquet O, Jeanneteau A, et al.·General thoracic and cardiovascular surgery·
Allergy to Galactose-Alpha-1,3-Galactose is an allergy to mammalian proteins, that are present on the surface of standard bioprosthestic valves, and could result in a catastrophic allergic reaction or...
A bio-inductive collagen scaffold that supports human primary tendon-derived cell growth for rotator cuff repair.
Chen P, Wang A, Haynes W, et al.·Journal of orthopaedic translation·
Rotator Cuff (RC) tendon tearing is a common clinical problem and there is a high incidence of revision surgery due to re-tearing. In an effort to improve patient outcome and reduce surgical revision,...
View on PubMed →Idiopathic anaphylaxis: Diagnosis and management.
Burrows AG, Ellis AK·Allergy and asthma proceedings·
Idiopathic anaphylaxis (IA) is a diagnosis of exclusion and is based on the inability to identify a causal relationship between a trigger and an anaphylactic event, despite a detailed patient history...
Structural and functional characterization of bovine G1P[5] rotavirus VP8* protein.
Dang L, Su Y, Qi J, et al.·Virology·
The widely used rotavirus (RV) vaccine, Rotateq, contained reassortment strains of human and bovine G1/2/3/4P[5] RVs. The functional and structural features of bovine G1P[5] VP8* were investigated. Bo...
Mid-term outcomes of the Pulsta transcatheter pulmonary valve for the native right ventricular outflow tract.
Lee SY, Kim GB, Kim SH, et al.·Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·
The aim of this study is to present the mid-term outcomes of Pulsta valve. The Pulsta valve is a Self-expandable knitted nitinol-wire stent mounted with a treated tri-leaflet α-Gal-free porcine perica...
Emergency medicine updates: Anaphylaxis.
Long B, Gottlieb M·The American journal of emergency medicine·
Anaphylaxis is a potentially deadly condition that requires emergent therapy. While frequently treated in the emergency department (ED), recent evidence updates may improve the diagnosis and managemen...
Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series.
Bernal M, Huecker M, Shreffler J, et al.·Medical acupuncture·
Alpha gal syndrome (AGS) is an acquired allergy to mammalian products correlates with a tick bite(s) that appears to cause immune sensitization to an oligosaccharide in meat. Most publications on AGS...
View on PubMed →Severe anaphylaxis caused by intravenous anti-cancer drugs.
Horita N, Miyagi E, Mizushima T, et al.·Cancer medicine·
The incidence and risk factors of severe anaphylaxis by intravenous anti-cancer drugs are unclear, whereas those of milder reactions have been reported. Electronic medical charts of cancer patients wh...
Functional Food for the Stimulation of the Immune System Against Malaria.
Bamgbose T, Anvikar AR, Alberdi P, et al.·Probiotics and antimicrobial proteins·
Drug resistance has become a threat to global health, and new interventions are needed to control major infectious diseases. The composition of gut microbiota has been linked to human health and has b...
Review of topical gelatin-based haemostatic agents; an insidious culprit of intraoperative anaphylaxis?
White RZ, Kerr L, White TJ, et al.·ANZ journal of surgery·
An under-recognized complication of gelatin-based haemostatic agents is their potential to cause anaphylactic reactions. This review aims to collate and analyse case in the literature of intraoperativ...
The Role of Carrageenan in Inflammatory Bowel Diseases and Allergic Reactions: Where Do We Stand?
Borsani B, De Santis R, Perico V, et al.·Nutrients·
Carrageenan (CGN) is a high molecular weight polysaccharide extracted from red seaweeds, composed of D-galactose residues linked in β-1,4 and α-1,3 galactose-galactose bond, widely used as a food addi...
Food Taste, Dietary Consumption, and Food Preference Perception of Changes Following Bariatric Surgery in the Saudi Population: A Cross-Sectional Study.
Althumiri NA, Basyouni MH, Al-Qahtani FS, et al.·Nutrients·
Bariatric surgery is known as the most effective treatment resulting in long-term weight loss for obesity. However, behavioral changes, including food preference, food allergies, and consumption, betw...
The Acari Hypothesis, II: Interspecies Operability of Pattern Recognition Receptors.
Retzinger AC, Retzinger GS·Pathogens (Basel, Switzerland)·
Hypersensitivity to galactose-α-1,3-galactose (α-gal) is an informative example of a pathologic IgE-mediated process. By way of their saliva, ticks are able to sensitize humans to tick dietary element...
View on PubMed →Allergy to Mammalian Meat Linked to Alpha-Gal Syndrome Potentially After Tick Bite in the Amazon: A Case Series.
Epelboin L, Roche F, Dueymes M, et al.·The American journal of tropical medicine and hygiene·
The past decade has seen the emergence of a new type of food allergy occurring after ingestion of mammalian meat. This allergy is related to immunoglobulin (Ig)E specific for galactose-alpha-1,3 galac...
Anti-EGFR Single-Chain Fv Antibody Fragment Displayed on the Surface of Ferritin H-Chain Protein Nanoparticle for Asthma Therapy.
Zhang T, Wang R, Li Z, et al.·ACS applied bio materials·
Epidermal growth factor receptor (EGFR)-dependent signaling contributes to the pathophysiology of asthma. However, these findings have not been translated into a clinical application. We recently gene...
Substrate specificities of α1,2- and α1,3-galactosyltransferases and characterization of Gmh1p and Otg1p in Schizosaccharomyces pombe.
Fukunaga T, Tanaka N, Furumoto T, et al.·Glycobiology·
In the fission yeast Schizosaccharomyces pombe, α1,2- and α1,3-linked D-galactose (Gal) residues are transferred to N- and O-linked oligosaccharides of glycoproteins by galactosyltransferases. Althoug...
A pediatric case of tick-bite-Induced meat allergy and recall urticaria.
Saleem M, Nilsson C·Clinical case reports·
Alpha-gal syndrome should be suspected also in children in case of typical allergic symptoms in the evening or night during tick seasons and the event of recall urticaria. It is, however, still a chal...
View on PubMed →Corrigendum to "Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report" [Legal Med. 51 (2021) 101878].
Wen S, Unuma K, Chinuki Y, et al.·Legal medicine (Tokyo, Japan)·
View on PubMed →Tick salivary gland extract induces alpha-gal syndrome in alpha-gal deficient mice.
Choudhary SK, Karim S, Iweala OI, et al.·Immunity, inflammation and disease·
Alpha-gal syndrome (AGS) is characterized by delayed hypersensitivity to non-primate mammalian meat in people having specific immunoglobulin E (sIgE) to the oligosaccharide galactose-alpha-1,3-galacto...
Reply to: The antibody response to the glycan α-Gal correlates with COVID-19 symptoms.
Wilson JM, Platts-Mills TAE, Keshavarz B·Journal of medical virology·
Reversed Immunoglycomics Identifies α-Galactosyl-Bearing Glycotopes Specific for Infection.
Montoya AL, Austin VM, Portillo S, et al.·JACS Au·
All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited by yet uncharacterized glycotopes), which may play important roles in immunoglycomics: (a) potential prote...
View on PubMed →Diseases Transmitted by the Black-Legged Ticks in the United States: A Comprehensive Review of the Literature.
Sosa JP, Ferreira Caceres MM, Agadi K, et al.·Cureus·
The black-legged tick is endemic to the midwestern, northeastern, western, south-eastern, and southern regions of the United States. There has been an increased burden of black-legged ticks in humans...
View on PubMed →Perioperative Considerations for the Emerging Alpha-gal Allergy.
Wolfe RC, Blunt J·Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses·
Proteomic insights into protostane triterpene biosynthesis regulatory mechanism after MeJA treatment in Alisma orientale (Sam.) Juz.
Rong T, Chunchun Z, Wei G, et al.·Biochimica et biophysica acta. Proteins and proteomics·
Protostane triterpenes in Alisma orientale (Sam.) Juz. have unique structural features with distinct pharmacological activities. Previously we have demonstrated that protostane triterpene biosynthesis...
Hidden Dangers: Recognizing Excipients as Potential Causes of Drug and Vaccine Hypersensitivity Reactions.
Caballero ML, Krantz MS, Quirce S, et al.·The journal of allergy and clinical immunology. In practice·
Excipients are necessary as a support to the active ingredients in drugs, vaccines, and other products, and they contribute to their stability, preservation, pharmacokinetics, bioavailability, appeara...
Carbohydrate epitopes currently recognized as targets for IgE antibodies.
Platts-Mills TA, Hilger C, Jappe U, et al.·Allergy·
Until recently, glycan epitopes have not been documented by the WHO/IUIS Allergen Nomenclature Sub-Committee. This was in part due to scarce or incomplete information on these oligosaccharides, but al...
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Nguyen SMT, Rupprecht CP, Haque A, et al.·International journal of molecular sciences·
Anaphylaxis is a severe, acute, life-threatening multisystem allergic reaction resulting from the release of a plethora of mediators from mast cells culminating in serious respiratory, cardiovascular...
Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report.
Wen S, Unuma K, Chinuki Y, et al.·Legal medicine (Tokyo, Japan)·
Cetuximab is mainly used for the treatment of advanced and metastatic colorectal cancer. Owing to the oligosaccharide galactose-α-1,3-galactose (α-gal) in its heavy chain, cetuximab can induce severe...
Speculations on red meat allergy due to alpha-Gal; its connection to coronary artery disease, suggested dietary guidance and allergy testing.
Pitsios C, Dimitriou A, Vassilopoulou E·European annals of allergy and clinical immunology·
Nationwide pharmacovigilance data for cetuximab-induced anaphylaxis and predictive model validation using prospective specific IgE detection.
Park KH, Lee J, Beom SH, et al.·The World Allergy Organization journal·
Cetuximab (chimeric monoclonal antibody to human epidermal growth factor receptor) is used to treat colorectal and head and neck cancers. Due to cross-reactivity with galactose-α-1,3-galactose (alpha-...
View on PubMed →Probiotic Bacteria with High Alpha-Gal Content Protect Zebrafish against Mycobacteriosis.
Pacheco I, Díaz-Sánchez S, Contreras M, et al.·Pharmaceuticals (Basel, Switzerland)·
Mycobacteriosis affects wild fish and aquaculture worldwide, and alternatives to antibiotics are needed for an effective and environmentally sound control of infectious diseases. Probiotics have shown...
View on PubMed →Altered Blood Levels of Anti-Gal Antibodies in Alzheimer's Disease: A New Clue to Pathogenesis?
Angiolillo A, Gandaglia A, Arcaro A, et al.·Life (Basel, Switzerland)·
Alzheimer's disease is a neurodegenerative disorder whose pathological mechanisms, despite recent advances, are not fully understood. However, the deposition of beta amyloid -peptide and neuroinflamma...
View on PubMed →Synthesis of -linked α-Gal and α-GalNAc-1'-hydroxyalkanes by way of C2 functionality transfer.
Nolen EG, Hornik ES, Jeans KB, et al.·Tetrahedron letters·
Inspired by reports of water sculpted Tn antigen (α-GalNAc--Ser/Thr) epitopes and our interest in producing metabolically more stable -linked analogs of Tn, we explored the utility of C2 functionality...
View on PubMed →Mosquito vector proteins homologous to α1-3 galactosyl transferases of tick vectors in the context of protective immunity against malaria and hypersensitivity to vector bites.
Ramasamy R·Parasites & vectors·
An epitope, Galα1-3Galβ1-4GlcNAc-R, termed α-gal, is present in glycoconjugates of New World monkeys (platyrrhines) and other mammals but not in hominoids and Old World monkeys (catarrhines). The diff...
Safety of Intravenous Heparin for Cardiac Surgery in Patients With Alpha-Gal Syndrome.
Hawkins RB, Wilson JM, Mehaffey JH, et al.·The Annals of thoracic surgery·
Alpha-gal syndrome is a tick-acquired disease caused by immunoglobulin E (IgE) to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), causing allergic reactions to meat and products sourced...
[Exceptional occupational allergies due to food of animal origin].
Dickel H·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
The food industry is a high-risk area for work-related allergic immediate skin reactions (contact urticaria, contact urticaria syndrome, protein contact dermatitis) with or without respiratory symptom...
Recurrent anaphylaxis to a gelatin-based colloid plasma substitute and to cetuximab following sensitisation to galactose-alpha-1,3-galactose.
Serrier J, Khoy K, Ollivier Y, et al.·British journal of anaesthesia·
Inflammatory immune response in recipients of transcatheter aortic valves.
Veraar C, Koschutnik M, Nitsche C, et al.·JTCVS open·
Transcatheter aortic valve implantation (TAVI) is rapidly replacing cardiac surgery due to its minimal invasiveness and practicality. Midterm immunological studies on the biocompatibility of galactose...
View on PubMed →Glycan-based shaping of the microbiota during primate evolution.
Singh S, Bastos-Amador P, Thompson JA, et al.·eLife·
Genes encoding glycosyltransferases can be under relatively high selection pressure, likely due to the involvement of the glycans synthesized in host-microbe interactions. Here, we used mice as an exp...
Cetuximab plus irinotecan administered biweekly with reduced infusion time to heavily pretreated patients with metastatic colorectal cancer and related RAS and BRAF mutation status.
Jensen BV, Schou JV, Yilmaz M, et al.·International journal of cancer·
Metastatic colorectal cancer (mCRC) is treated with cetuximab 250 mg/m administered weekly over 1 hour or biweekly (q2w) over 3.5 hours when combined with irinotecan. This prospective study investigat...
View on PubMed →Tick-human interactions: from allergic klendusity to the α-Gal syndrome.
Cabezas-Cruz A, Hodžić A, Mateos-Hernández L, et al.·The Biochemical journal·
Ticks and the pathogens they transmit, including bacteria, viruses, protozoa, and helminths, constitute a growing burden for human and animal health worldwide. The ability of some animal species to ac...
Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice.
Pontrelli P, Conserva F, Menghini R, et al.·International journal of molecular sciences·
Diabetic nephropathy (DN) is the most frequent cause of end-stage renal disease. Tubulointerstitial accumulation of lysine 63 (K63)-ubiquitinated (Ub) proteins is involved in the progression of DN fib...
Probing -Octyl α-d-Glycosides Using Deuterated Water in the Lyotropic Phase by Deuterium NMR.
Wan Iskandar WFN, Salim M, Patrick M, et al.·The journal of physical chemistry. B·
The lyotropic phase behavior of four common and easily accessible glycosides, -octyl α-d-glycosides, namely, α-Glc-OC, α-Man-OC, α-Gal-OC, and α-Xyl-OC, was investigated. The presence of normal hexago...
View on PubMed →Tick exposures and alpha-gal syndrome: A systematic review of the evidence.
Young I, Prematunge C, Pussegoda K, et al.·Ticks and tick-borne diseases·
Alpha-gal syndrome (AGS) refers to a delayed allergic reaction to galactose-α-1,3-galactose (α-Gal) that occurs following the consumption of mammalian meat or exposure to other animal-based foods and...
Isolated Gastrointestinal Alpha-gal Meat Allergy Is a Cause for Gastrointestinal Distress Without Anaphylaxis.
Croglio MP, Commins SP, McGill SK·Gastroenterology·
Characterization of the anti-α-Gal antibody profile in association with Guillain-Barré syndrome, implications for tick-related allergic reactions.
Pacheco I, Fernández de Mera IG, Feo Brito F, et al.·Ticks and tick-borne diseases·
Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the capacity to develop a protective response mediated by anti-α-Gal IgM/IgG antibod...
Prevalence of alpha-gal sensitization among Kentucky timber harvesters and forestry and wildlife practitioners.
Bellamy P, Sanderson WT, Winter K, et al.·The journal of allergy and clinical immunology. In practice·
Elucidating the α-Gal syndrome at the molecular allergen level.
Kiewiet MBG, Grundström J, Apostolovic D, et al.·Allergy·
Phase II study of an oxaliplatin-based regimen for relapsed colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy (INSPIRE study).
Ishibashi K, Aoyama T, Kotaka M, et al.·Cancer chemotherapy and pharmacology·
The aim of this study was to evaluate the efficacy and safety of first-line chemotherapy with re-introduction of oxaliplatin (OX) more than 6 months after adjuvant chemotherapy including OX. Stage II/...
The first reported cases of meat allergy following tick bites in the UK.
Bansal RA, Bahal S, O'Brien R, et al.·JRSM open·
Allergic reactions frequently involve the production of immunoglobulin E (IgE) antibodies to proteins. However, reactions directed against carbohydrate moieties are increasingly being recognised. Tick...
View on PubMed →α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG.
Wilson JM, Keshavarz B, James HR, et al.·The Journal of allergy and clinical immunology·
IgE to α-Gal is a cause of mammalian meat allergy and has been linked to tick bites in North America, Australia, and Eurasia. Reports from the developing world indicate that α-Gal sensitization is pre...
Diagnostic testing for galactose-alpha-1,3-galactose, United States, 2010 to 2018.
Binder AM, Commins SP, Altrich ML, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Alpha-gal syndrome (AGS) is an emerging immunoglobulin E (IgE)-mediated allergy to galactose-alpha-1,3-galactose (alpha-gal). The geographic distribution and burden of AGS in the United States are unk...
The human natural anti-αGal antibody targets common pathogens by broad-spectrum polyreactivity.
Bernth Jensen JM, Skeldal S, Petersen MS, et al.·Immunology·
Naturally occurring antibodies are abundant in human plasma, but their importance in the defence against bacterial pathogens is unclear. We studied the role of the most abundant of such antibodies, th...
The antibody response to the glycan α-Gal correlates with COVID-19 disease symptoms.
Urra JM, Ferreras-Colino E, Contreras M, et al.·Journal of medical virology·
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide. Characterization of the immunological...
[Establishment of animal models of epidermal growth factor receptor inhibitor-related rashes].
Zhang X, Xue C, Li J, et al.·Nan fang yi ke da xue xue bao = Journal of Southern Medical University·
To establish animal models epidermal growth factor receptor inhibitor-related skin rashes using cetuximab, gefitinib or erlotinib. Female SCID mice were randomly divided into blank control group and h...
T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome.
Iweala OI, Choudhary SK, Addison CT, et al.·International journal of molecular sciences·
The mechanisms of pathogenesis driving alpha-gal syndrome (AGS) are not fully understood. Differences in immune gene expression between AGS individuals and non-allergic controls may illuminate molecul...
Intra-Laboratory Validation of Alpha-Galactosidase Activity Measurement in Dietary Supplements.
Fabris E, Bulfoni M, Nencioni A, et al.·Molecules (Basel, Switzerland)·
Alpha-galactosidase (α-Gal) is an enzyme responsible for the hydrolyzation of glycolipids and glycoprotein commonly found in dietary sources. More than 20% of the general population suffers from abdom...
My Old World chap, this α-gal is not for you.
Barreiro LB, Chervonsky A·Cell host & microbe·
30 million years ago, ancestors of Old World primates lost the ability to produce α-gal. In this issue of Cell Host & Microbe, Singh et al. (2021) show that the loss is associated with increased resis...
Considerations for cataract surgery: alpha-gal allergy.
Weaver M, Thevarajah T, Shah H·Journal of cataract and refractive surgery·
Alpha-Gal Allergy as a Cause of Intestinal Symptoms in a Gastroenterology Community Practice.
Richards NE, Richards RD·Southern medical journal·
Immunoglobulin E (IgE) to galactose-α-1,3-galactose (alpha-gal) is a recently appreciated cause of allergic reactions to mammalian meat and dairy. In eastern North America Lone Star tick bites are the...
Climatic requirements of the eastern paralysis tick, Ixodes holocyclus, with a consideration of its possible geographic range up to 2090.
Teo EJM, Vial MN, Hailu S, et al.·International journal for parasitology·
The eastern paralysis tick, Ixodes holocyclus, is an ectoparasite of medical and veterinary importance in Australia. The feeding of I. holocyclus is associated with an ascending flaccid paralysis whic...
Effects of laparoscopic and traditional open surgery on the levels of IL-6, TNF-α, and Gal-3 in patients with thyroid cancer.
He L, Qing F, Li M, et al.·Gland surgery·
Traditional open surgery and laparoscopic surgery are common treatments for thyroid cancer patients, this paper aims to explore their effects on the levels of interleukin-6 (IL-6), tumor necrosis fact...
View on PubMed →IgE-mediated food allergy throughout life.
Çelebioğlu E, Akarsu A, Şahiner ÜM·Turkish journal of medical sciences·
Food allergy (FA) has become an increasing problem throughout the world. Over the last 2 decades, the frequency of FA has increased in both children and adults. The prevalence differs according to the...
Idiopathic Anaphylaxis: a Perplexing Diagnostic Challenge for Allergists.
Gulen T, Akin C·Current allergy and asthma reports·
The aim of this systematic review is to present the proposed theories of pathogenesis for idiopathic anaphylaxis (IA), to discuss its classification, its diagnostic approach, and management. IA repres...
Hunting for a Diagnosis.
Houchens N, Hartley S, Commins SP, et al.·The New England journal of medicine·
Immunity to glycan α-Gal and possibilities for the control of COVID-19.
la Fuente J, Gortázar C, Cabezas-Cruz A·Immunotherapy·
A dynamic relationship between two regional causes of IgE-mediated anaphylaxis: α-Gal syndrome and imported fire ant.
Wilson JM, Keshavarz B, Retterer M, et al.·The Journal of allergy and clinical immunology·
A syndrome of mammalian meat allergy relating to IgE specific for galactose-α-1,3-galactose (α-Gal) was first reported 10 years ago in the southeastern United States and has been related to bites of t...
α-Gal on Crotalidae-polyvalent Fab antivenom (CroFab): Investigating the relevance to immediate hypersensitivity reactions.
Straesser M, Keshavarz B, Borish L, et al.·The journal of allergy and clinical immunology. In practice·
Molecular IgE sensitization profiles of urban and rural children in South Africa.
Mittermann I, Dzoro S, Gattinger P, et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
Allergens can act as disease-triggering factors in atopic dermatitis (AD) patients. The aim of the study was to elucidate the molecular IgE sensitization profile in children with and without AD living...
In Situ "Humanization" of Porcine Bioprostheses: Demonstration of Tendon Bioprostheses Conversion into Human ACL and Possible Implications for Heart Valve Bioprostheses.
Galili U, Stone KR·Bioengineering (Basel, Switzerland)·
This review describes the first studies on successful conversion of porcine soft-tissue bioprostheses into viable permanently functional tissue in humans. This process includes gradual degradation of...
View on PubMed →Lone Star Ticks ():: An Emerging Threat in Delaware.
Kennedy AC, Marshall E·Delaware journal of public health·
Public health messaging in the eastern United States has historically underemphasized the risks posed by lone star ticks (), focusing instead on blacklegged ticks (). This gap persists despite mountin...
View on PubMed →Alpha-Gal Syndrome in Ophthalmology and Medicine: Erratum.
·International ophthalmology clinics·
View on PubMed →The α-Gal Syndrome and Potential Mechanisms.
Román-Carrasco P, Hemmer W, Cabezas-Cruz A, et al.·Frontiers in allergy·
The α-Gal syndrome is a complex allergic disease characterized by the development of specific IgE antibodies against the carbohydrate galactose-α-1,3-galactose (α-Gal), an oligosaccharide present in c...
View on PubMed →Alpha-Gal Syndrome in Children: Peculiarities of a "Tick-Borne" Allergic Disease.
Saretta F, Giovannini M, Mori F, et al.·Frontiers in pediatrics·
The alpha-gal syndrome is an allergic syndrome that comprises two clinical pictures: an immediate hypersensitivity to drugs containing alpha-gal and a delayed hypersensitivity to the ingestion of red...
View on PubMed →Alpha-Gal Syndrome: Involvement of α-D-Galactosidase and β-1,4 Galactosyltransferase Enzymes in α-Gal Metabolism.
Sharma SR, Crispell G, Mohamed A, et al.·Frontiers in cellular and infection microbiology·
Alpha-Gal Syndrome (AGS) is an IgE-mediated delayed-type hypersensitivity reaction to the oligosaccharide galactose-α-1, 3-galactose (α-gal) injected into humans from the lone-star tick () bite. Indee...
Alpha-gal syndrome: the first report in Poland.
Brzozowska M, Mokrzycka N, Porebski G·Central-European journal of immunology·
Alpha-gal syndrome is an immunoglobulin E (IgE)-dependent allergy to galactose-α-1,3-galactose, resulting in a delayed anaphylactic reaction to red meat. The syndrome is causally linked to bites from...
View on PubMed →Evaluation of red meat allergy patients and review of the literature.
Kutluğ Ş, Hancıoğlu G, Karadağ-Kökçü Şİ, et al.·The Turkish journal of pediatrics·
It was reported that prevalence of red meat allergy in children was higher in our country than in western populations. However, the diagnosis of these patients is often delayed. The aim of the study w...
A Case of α-Gal-Unrelated Red Meat-Induced Urticaria Treated by Omalizumab.
Kondo M, Matsushima Y, Iida S, et al.·Case reports in dermatology·
A 70-year-old healthy woman was referred to our hospital for chronic urticaria. She did not have a history of allergy, asthma, and rhinitis. She was initially diagnosed with α-gal-related urticaria ba...
View on PubMed →Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack.
Sharma SR, Karim S·Frontiers in cellular and infection microbiology·
Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the vertebrate h...
Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics.
Konradsen JR, Borres MP, Nilsson C·International archives of allergy and immunology·
The fifth class of immunoglobulin, immunoglobulin E (IgE) was discovered in 1967 and has had immense importance for the understanding, diagnosis, and treatment of allergic disease. More than 50 years...
Gelatin-Containing Vaccines for Varicella, Zoster, Measles, Mumps, and Rubella Induce Basophil Activation in Patients with Alpha-Gal Syndrome.
Schmidle P, Mehlich J, Brockow K, et al.·International archives of allergy and immunology·
The alpha-gal syndrome (AGS) describes a new type I allergy entity to the carbohydrate epitope galactose-α-1,3-galactose (alpha-gal), which is mainly found in mammalian food products (e.g., beef, pork...
Lessons in Innate and Allergic Immunity From Dust Mite Feces and Tick Bites.
Keshavarz B, Erickson LD, Platts-Mills TAE, et al.·Frontiers in allergy·
Allergic diseases represent a major cause of morbidity in modern industrialized and developing countries. The origins and development of allergic immune responses have proven difficult to unravel and...
View on PubMed →The Nordic Nutrition Recommendations 2022 - prioritisation of topics for systematic reviews.
Høyer A, Christensen JJ, Arnesen EK, et al.·Food & nutrition research·
As part of the process of updating national dietary reference values (DRVs) and food-based dietary guidelines (FBDGs), the Nordic Nutrition Recommendations 2022 project (NNR2022) will select a limited...
View on PubMed →Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease.
Pattarabanjird T, Wilson JM, Erickson LD, et al.·Frontiers in cardiovascular medicine·
Recent studies have suggested that IgE sensitization to α-gal is associated with coronary artery disease (CAD). However, the B cell subtype(s) responsible for production of IgE to α-gal and mechanisms...
View on PubMed →Near Complete Repair After Myocardial Infarction in Adult Mice by Altering the Inflammatory Response With Intramyocardial Injection of α-Gal Nanoparticles.
Galili U, Zhu Z, Chen J, et al.·Frontiers in cardiovascular medicine·
Neonatal mice, but not older mice, can regenerate their hearts after myocardial-infarction (MI), a process mediated by pro-reparative macrophages. α-Gal nanoparticles applied to skin wounds in adult-m...
View on PubMed →Veggie burgers in the EU market: a nutritional challenge?
Boukid F, Castellari M·European food research and technology = Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. A·
Nutritional information of burgers launched in the EU market during 2020 was retrieved from their labels. Products were initially classified into four types: i.e., veggie, red meat-, fish- and poultry...
View on PubMed →Maternal Dietary Protein Patterns During Pregnancy and the Risk of Infant Eczema: A Cohort Study.
Zeng J, Wu W, Tang N, et al.·Frontiers in nutrition·
Previous studies have suggested that maternal dietary protein was associated with allergic diseases in offspring, but few studies have evaluated the influence of dietary protein patterns. This study a...
View on PubMed →Characteristics and expression patterns of six α-galactosidases in cucumber (Cucumis sativus L.).
Zhang ZP, Liu YC, Dai HB, et al.·PloS one·
Six putative α-galactosidase genes (α-Gals), three acid forms (CsGAL1, CsGAL2, CsGAL3) and three alkaline forms (CsAGA1, CsAGA2, CsAGAL3), were found in the cucumber genome. It is interesting to know...
Delayed urticaria or anaphylaxis after consumption of red meat with evidence of alpha-gal sensitisation.
Garcia MB, Gomez-Samper AF, Garcia E, et al.·BMJ case reports·
Food allergies to red meat, specifically to galactose-alpha-1,3-galactose (alpha-gal), a mammalian oligosaccharide, are considered to be very rare, especially in Asia and Latin America. Most of the ca...
The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens.
McGuire BE, Hettle AG, Vickers C, et al.·The Journal of biological chemistry·
α-Linked galactose is a common carbohydrate motif in nature that is processed by a variety of glycoside hydrolases from different families. Terminal Galα1-3Gal motifs are found as a defining feature o...
COVID-19 in the Developing World: Is the Immune Response to α-Gal an Overlooked Factor Mitigating the Severity of Infection?
Hodžić A, de la Fuente J, Cabezas-Cruz A·ACS infectious diseases·
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has affected millions of people worldwide. Considerably lower prevalen...
The role of IgE specific for galactose-α-1,3-galactose in predicting cetuximab induced hypersensitivity reaction: a systematic review and a diagnostic meta-analysis.
Lungulescu CV, Ungureanu BS, Turcu-Stiolica A, et al.·Scientific reports·
Recombinant monoclonal antibodies are used for treating various diseases, from asthma, rheumatoid arthritis, and inflammatory bowel disease to cancer. Although monoclonal antibodies are known to have...
Cracking the meat-allergy mystery with the tick-bite link.
Nogrady B·Nature·
'Doc, will I ever eat steak again?': diagnosis and management of alpha-gal syndrome.
Patel C, Iweala OI·Current opinion in pediatrics·
Alpha-gal syndrome encompasses a constellation of symptoms associated with immune-mediated hypersensitivity responses to galactose-alpha-1,3-galactose (alpha-gal). The purpose of this review is to dis...
The chemical properties and hygroscopic activity of the exopolysaccharide lubcan from Paenibacillus sp. ZX1905.
Sun X, Wang L, Fu R, et al.·International journal of biological macromolecules·
This study aims to explore the production and physicochemical properties of an exopolysaccharide (EPS) produced from soil isolate, Paenibacillus sp. ZX1905 in submerged culture. The highest EPS produc...
Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species.
Zhao D, Liu Y, Huang P, et al.·Emerging microbes & infections·
Histo-blood group antigens (HBGAs) have been found to be important host susceptibility factors or receptors for human rotavirus (RVs) with genotype-specific host ranges, impacting the disease patterns...
Anti-Tick Microbiota Vaccine Impacts Performance during Feeding.
Mateos-Hernández L, Obregón D, Maye J, et al.·Vaccines·
The tick microbiota is a highly complex ensemble of interacting microorganisms. Keystone taxa, with a central role in the microbial networks, support the stability and fitness of the microbial communi...
View on PubMed →Mites, ticks, anaphylaxis and allergy: The Acari hypothesis.
Retzinger AC, Retzinger GS·Medical hypotheses·
Anaphylaxis is a poorly understood immune process in which a Th2-/IgE-mediated adaptive response commandeers cellular machinery, typically reserved for defense against multicellular ectoparasites, to...
Does maternal diet during pregnancy influence clinical and laboratory characteristics of infantile-onset atopic dermatitis?
Milewska-Wróbel D, Lis-Święty A·European annals of allergy and clinical immunology·
Prenatal environmental factors are suggested to be implicated in the dramatic increase in Atopic Dermatitis (AD) in recent years. The aim of this study was to investigate the possible associations bet...
Bioprosthetic heart valves with reduced immunogenic residuals using vacuum-assisted decellularization treatment.
Luo Y, Ma L·Biomedical materials (Bristol, England)·
Despite the good hemodynamic characteristics of bioprosthetic heart valves, it is inevitable that they will suffer from calcification and tissue deterioration. Decellularization has been utilized to r...
EGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells.
Eloy JO, Ruiz A, de Lima FT, et al.·Colloids and surfaces. B, Biointerfaces·
Prostate cancer is the second cause of cancer death in men worldwide. Docetaxel (DTX), an antimitotic drug, is widely used for the treatment of metastatic prostate cancer patients. Taxotere® is a comm...
Food allergy: epidemiology, pathogenesis, diagnosis, prevention, and treatment.
Lopes JP, Sicherer S·Current opinion in immunology·
Food allergy affects up to 10% of the population. The identification of modifiable risk factors including skin barrier dysfunction, vitamin D deficiency, microbiome, and route and timing of allergen e...
Unique repertoire of anti-carbohydrate antibodies in individual human serum.
Luetscher RND, McKitrick TR, Gao C, et al.·Scientific reports·
Humoral immunity to pathogens and other environmental challenges is paramount to maintain normal health, and individuals lacking or unable to make antibodies are at risk. Recent studies indicate that...
Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers.
Mitchell CL, Lin FC, Vaughn M, et al.·Parasites & vectors·
Alpha-gal is an oligosaccharide implicated in delayed anaphylaxis following red meat consumption. Exposure to tick bites has been correlated with development of an allergic response to alpha-gal. Howe...
Host Synthesized Carbohydrate Antigens on Viral Glycoproteins as "Achilles' Heel" of Viruses Contributing to Anti-Viral Immune Protection.
Galili U·International journal of molecular sciences·
The glycans on enveloped viruses are synthesized by host-cell machinery. Some of these glycans on zoonotic viruses of mammalian reservoirs are recognized by human natural antibodies that may protect a...
Galactose-alpha-1,3-galactose syndrome.
Nguyen M, Heath J·Journal of food allergy·
The galactose-alpha-1,3-galactose (alpha-Gal) syndrome is a newly recognized and unique form of food allergy, characterized by delayed reactions to mammalian meats. This form of allergy occurs in indi...
View on PubMed →Spatial distribution of alpha-gal in Ixodes ricinus - A histological study.
Fischer J, Riel S, Fehrenbacher B, et al.·Ticks and tick-borne diseases·
Alpha-gal syndrome is a complex allergic disease in humans that is caused by specific IgE (sIgE) against the carbohydrate galactose-α-1,3-galactose (alpha-gal). Tick saliva contains alpha-gal, and tic...
Alpha-gal syndrome: challenges to understanding sensitization and clinical reactions to alpha-gal.
de la Fuente J, Cabezas-Cruz A, Pacheco I·Expert review of molecular diagnostics·
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal). Tick bites are recognized as the most important cause o...
Serum IgE against galactose-alpha-1,3-galactose is common in Laotian patients with snakebite envenoming but not the major trigger for early anaphylactic reactions to antivenom.
Blessmann J, Hanlodsomphou S, Santisouk B, et al.·Toxicon: X·
Snake antivenom is the only specific treatment for snakebite envenoming, but life-threatening anaphylaxis is a severe side effect and drawback for the use of these typically mammalian serum products....
View on PubMed →Reproductive tissues-specific meta-QTLs and candidate genes for development of heat-tolerant rice cultivars.
Raza Q, Riaz A, Bashir K, et al.·Plant molecular biology·
By integrating genetics and genomics data, reproductive tissues-specific and heat stress responsive 35 meta-QTLs and 45 candidate genes were identified, which could be exploited through marker-assiste...
Complement activation by human IgG antibodies to galactose-α-1,3-galactose.
Bernth Jensen JM, Laursen NS, Jensen RK, et al.·Immunology·
Some human antibodies may paradoxically inhibit complement activation on bacteria and enhance pathogen survival in humans. This property was also claimed for IgG antibodies reacting with terminal gala...
Individuals with IgE antibodies to α-Gal and CCD show specific IgG subclass responses different from subjects non-sensitized to oligosaccharides.
Román-Carrasco P, Hemmer W, Klug C, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
Radiochemotherapy with or without cetuximab for unresectable esophageal cancer: final results of a randomized phase 2 trial (LEOPARD-2).
Rades D, Bartscht T, Hunold P, et al.·Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·
To investigate the efficacy and toxicity of cetuximab when added to radiochemotherapy for unresectable esophageal cancer. This randomized phase 2 trial (clinicaltrials.gov, identifier NCT01787006) com...
Rapid desensitization to antineoplastic drugs in an outpatient immunoallergology clinic: Outcomes and risk factors.
Caiado J, Brás R, Paulino M, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Hypersensitivity reactions to antineoplastic agents may lead to discontinuation of first-line treatments. Rapid drug desensitization (RDD) allows for a safe reintroduction in patients who are allergic...
Intraoperative Anaphylaxis in Response to Hemostatic Agents With Protein Derivatives.
Holbert SE, Patel D, Rizk T, et al.·Cureus·
Topical hemostatic agents are commonly used in a wide variety of surgical procedures to assist in hemostasis. However, the use of these agents is not without risk as many contain biologically active a...
View on PubMed →A Case of Pork-cat Syndrome That Developed as Food-dependent Exercise-induced Anaphylaxis.
Shiratsuki R, Chinuki Y, Fukushiro S, et al.·Acta dermato-venereologica·
is missing (Short communication).
Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signaling.
Lin TY, Lu MK, Chang CC·International journal of biological macromolecules·
Poria cocos (Polyporacea), is a fungus used in traditional Chinese medicine. A study of the valuable sulfated polysaccharides (SPS) with the structure and pharmaceutical benefits from the mycelial cul...
Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer.
Krstić Ristivojević M, Grundström J, Apostolović D, et al.·International journal of molecular sciences·
Transepithelial transport of proteins is an important step in the immune response to food allergens. Mammalian meat allergy is characterized by an IgE response against the carbohydrate moiety galactos...
Spatial regulation of alpha-galactosidase activity and its influence on raffinose family oligosaccharides during seed maturation and germination in .
Arunraj R, Skori L, Kumar A, et al.·Plant signaling & behavior·
Alpha-galactosides or Raffinose Family Oligosaccharides (RFOs) are enriched in legumes and are considered as anti-nutritional factors responsible for inducing flatulence. Due to a lack of alpha-galact...
Alpha-gal syndrome: An emerging cause of food and drug allergy.
Rutkowski K, Wagner A, Rutkowski R, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
Alpha-gal syndrome (AGS) describes a wide spectrum of hypersensitivity reactions mediated by specific IgE to the α-gal epitope (galactose-α-1,3-galactose) ubiquitously expressed on glycolipids/glycopr...
Mammalian meat allergy - beyond urticaria?
Schimmel J, Fawaz B, Renzi M, et al.·International journal of dermatology·
Glycolipid-mediated basophil activation in alpha-gal allergy.
Iweala OI, Choudhary SK, Addison CT, et al.·The Journal of allergy and clinical immunology·
Alpha-gal-containing glycolipids activate basophils sensitized with plasma from alpha-gal allergic subjects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-med...
ErbB1-dependent signalling and vesicular trafficking in primary afferent nociceptors associated with hypersensitivity in neuropathic pain.
Mitchell R, Mikolajczak M, Kersten C, et al.·Neurobiology of disease·
Effective analgesic treatment for neuropathic pain remains an unmet need, so previous evidence that epidermal growth factor receptor inhibitors (EGFRIs) provide unexpected rapid pain relief in a clini...
Distinct Pathways Carry Out α and β Galactosylation of Secondary Cell Wall Polysaccharide in Bacillus anthracis.
Chateau A, Oh SY, Tomatsidou A, et al.·Journal of bacteriology·
, the causative agent of anthrax disease, elaborates a secondary cell wall polysaccharide (SCWP) that is required for the retention of surface layer (S-layer) and S-layer homology (SLH) domain protein...
Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients.
Commins SP·Expert review of clinical immunology·
Alpha-gal Syndrome (AGS) is a unique allergy to non-primate mammalian meat (and derived-products) that is associated with tick bites and is due to a specific IgE antibody to the oligosaccharide galact...
Gal d 7-a major allergen in primary chicken meat allergy.
Klug C, Hemmer W, Román-Carrasco P, et al.·The Journal of allergy and clinical immunology·
Poultry meat can induce severe allergic reactions. So far, the molecules causing poultry meat allergy are largely unknown. Our aim was to identify and characterize poultry meat allergens. Profiles of...
Optimization of production conditions of rice α-galactosidase II displayed on yeast cell surface.
Dong M, Gong Y, Guo J, et al.·Protein expression and purification·
The yeast surface displayed rice α-galactosidase II (YSD rice α-Gal II) was generated with the pYD1 vector. The expression and cultural conditions for the improvement of production of YSD rice α-Gal I...
Human Natural Antibodies to Mammalian Carbohydrate Antigens as Unsung Heroes Protecting against Past, Present, and Future Viral Infections.
Galili U·Antibodies (Basel, Switzerland)·
Human natural antibodies to mammalian carbohydrate antigens (MCA) bind to carbohydrate-antigens synthesized in other mammalian species and protect against zoonotic virus infections. Three such anti-MC...
View on PubMed →Gut Microbiota Abrogates Anti-α-Gal IgA Response in Lungs and Protects against Experimental Infection in Poultry.
Mateos-Hernández L, Risco-Castillo V, Torres-Maravilla E, et al.·Vaccines·
Naturally occurring human antibodies (Abs) of the isotypes IgM and IgG and reactive to the galactose-α-1,3-galactose (α-Gal) epitope are associated with protection against infectious diseases, caused...
View on PubMed →Red Meat Allergies after Lone Star Tick () Bites.
Diaz JH·Southern medical journal·
Red meat allergies have followed tick bites on every continent except Antarctica. The sensitizing antigen is galactose-α-1,3-galactose (α-gal), an oligosaccharide constituent of nonprimate blood and m...
Clinical and Serological Characterization of the α-Gal Syndrome-Importance of Atopy for Symptom Severity in a European Cohort.
Kiewiet MBG, Apostolovic D, Starkhammar M, et al.·The journal of allergy and clinical immunology. In practice·
The galactose-α1,3-galactose (α-Gal) syndrome (AGS) is a novel form of food allergy. Patients experience delayed severe allergic reactions after mammalian meat consumption due to IgE antibodies direct...
Anti-Inflammatory Performance of Lactose-Modified Chitosan and Hyaluronic Acid Mixtures in an In Vitro Macrophage-Mediated Inflammation Osteoarthritis Model.
Tarricone E, Mattiuzzo E, Belluzzi E, et al.·Cells·
The development and progression of osteoarthritis (OA) is associated with macrophage-mediated inflammation that generates a broad spectrum of cytokines and reactive oxygen species (ROS). This study in...
A porcine acellular dermal matrix induces human fibroblasts to secrete hyaluronic acid by activating JAK2/STAT3 signalling.
Liu C, Sun J·RSC advances·
Human facial skin undergoes continuous ageing over a lifespan. At present, facial skin rejuvenation is mainly achieved by injecting filling materials. However, conventional materials lack long-term be...
View on PubMed →Regional and temporal awareness of alpha-gal allergy: An infodemiological analysis using Google Trends.
Iglesia EGA, Stone CA, Flaherty MG, et al.·The journal of allergy and clinical immunology. In practice·
Tolerance of porcine pancreatic enzymes despite positive skin testing in alpha-gal allergy.
Stone CA, Choudhary S, Patterson MF, et al.·The journal of allergy and clinical immunology. In practice·
[Red meat allergy].
Marchal O, Allali D·Revue medicale suisse·
The goal of this article is to provide an informative review on allergy to mammalian meat. The main allergen contained in « red meat » is the alpha-gal (galactose-alpha-1,3-galactose) that is found in...
Infection with Inhibits the Production of IgE Antibodies to α-Gal in Humans: Towards a Conceptual Framework of the Hygiene Hypothesis?
Hodžić A, Mateos-Hernández L, Fréalle E, et al.·Vaccines·
α-Gal syndrome (AGS) is a type of anaphylactic reaction to mammalian meat characterized by an immunoglobulin (Ig)E immune response to the oligosaccharide α-Gal (Galα1-3Galβ1-4GlcNAc-R). Tick bites see...
View on PubMed →Tick and Host Derived Compounds Detected in the Cement Complex Substance.
Villar M, Pacheco I, Merino O, et al.·Biomolecules·
Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrob...
On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy.
Platts-Mills TAE, Commins SP, Biedermann T, et al.·The Journal of allergy and clinical immunology·
The mammalian meat allergy known as the "α-Gal syndrome" relates to IgE specific for galactose-α-1,3-galactose (α-Gal), an oligosaccharide that is present in cells and tissues of nonprimate mammals. T...
Diagnostic Challenges in Anaphylaxis.
Lieberman JA, Bingemann TA, Wang J·The journal of allergy and clinical immunology. In practice·
Anaphylaxis is a severe and potentially life-threatening allergic reaction. Since its discovery over 100 years ago, research has led to great strides in describing pathophysiologic mechanisms of anaph...
Topical α-gal nanoparticles accelerate diabetic wound healing.
Kaymakcalan OE, Abadeer A, Goldufsky JW, et al.·Experimental dermatology·
An inadequate response from macrophages, key orchestrators of the wound healing process, has been implicated in the pathophysiology of impaired healing in diabetes. This study explored the utility of...
Global Trends in Anaphylaxis Epidemiology and Clinical Implications.
Turner PJ, Campbell DE, Motosue MS, et al.·The journal of allergy and clinical immunology. In practice·
The true global scale of anaphylaxis remains elusive, because many episodes occur in the community without presentation to health care facilities, and most regions have not yet developed reliable syst...
Evolutionary rate variation among genes involved in galactomannan biosynthesis in .
Ogutu C, Cherono S, Ntini C, et al.·Ecology and evolution·
The endosperm cell walls of mature coffee seeds accumulate large amounts of mannan storage polysaccharides, which serve as nutrient reserve for embryo and contribute to beverage quality. Our study inv...
View on PubMed →In vitro and in vivo biocompatibility study on acellular sheep periosteum for guided bone regeneration.
He J, Li Z, Yu T, et al.·Biomedical materials (Bristol, England)·
This study addresses the fabrication of an extracellular matrix material of the acellular sheep periosteum and the systematic evaluation of its biocompatibility to explore its potential application in...
α-Gal and other recent findings that have informed our understanding of anaphylaxis.
Wilson JM, Platts-Mills TAE·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
To summarize the current understanding of anaphylaxis, with an emphasis on major findings that have been reported within the last 10 years. Queries relating to anaphylaxis, immunoglobulin E (IgE), and...
Patients' Health Information Practices and Perceptions of Provider Knowledge in the Case of the Newly Discovered Alpha-gal Food Allergy.
Flaherty MG, Threats M, Kaplan SJ·Journal of patient experience·
Alpha-gal food allergy is a life-threatening, newly discovered condition with limited presence in authoritative information sources. Sufferers seeking diagnosis are likely to encounter clinicians unfa...
View on PubMed →Characterization of the local wound environment following treatment of chronic leg ulcers with SIS wound matrix.
Hodde JP, Hiles MC, Metzger DW·Journal of tissue viability·
The SIS Wound Matrix (SISWM) has been shown to improve healing of chronic ulcers over standard of care. In this study, we tested the hypothesis that chronic venous ulcers responsive to treatment with...
Chemical structures of oligosaccharides in milks of the American black bear (Ursus americanus americanus) and cheetah (Acinonyx jubatus).
Urashima T, Umewaki M, Taufik E, et al.·Glycoconjugate journal·
The milk oligosaccharides were studied for two species of the Carnivora: the American black bear (Ursus americanus, family Ursidae, Caniformia), and the cheetah, (Acinonyx jubatus, family Felidae, Fel...
Alpha-Gal and Cross-Reactive Carbohydrate Determinants in the N-Glycans of Salivary Glands in the Lone Star Tick, .
Park Y, Kim D, Boorgula GD, et al.·Vaccines·
Ticks are important ectoparasites and vectors of numerous human and animal pathogens. Ticks secrete saliva that contains various bioactive materials to evade the host defense system, and often facilit...
View on PubMed →Diagnosis and Management of Patients with the α-Gal Syndrome.
Platts-Mills TAE, Li RC, Keshavarz B, et al.·The journal of allergy and clinical immunology. In practice·
The galactose-α-1,3-galactose (α-Gal) syndrome has many novel features that are relevant to diagnosis and management. In most cases, the diagnosis can be made on a history of delayed allergic reaction...
Allergenomics of the tick Ixodes ricinus reveals important α-Gal-carrying IgE-binding proteins in red meat allergy.
Apostolovic D, Mihailovic J, Commins SP, et al.·Allergy·
IgE to galactose-α-1,3-galactose wanes over time in patients who avoid tick bites.
Kim MS, Straesser MD, Keshavarz B, et al.·The journal of allergy and clinical immunology. In practice·
A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders.
de la Fuente J, Urra JM, Contreras M, et al.·F1000Research·
Humans evolved by losing the capacity to synthesize the glycan Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), which resulted in the development of a protective response mediated by anti-α-Gal IgM/IgG/IgA antibodi...
The History of Carbohydrates in Type I Allergy.
Hils M, Wölbing F, Hilger C, et al.·Frontiers in immunology·
Although first described decades ago, the relevance of carbohydrate specific antibodies as mediators of type I allergy had not been recognized until recently. Previously, allergen specific IgE antibod...
Alpha-Gal Syndrome in Ophthalmology and Medicine.
Seddon I, Venincasa M, Farber N, et al.·International ophthalmology clinics·
B Cell Responses in the Development of Mammalian Meat Allergy.
Chandrasekhar JL, Cox KM, Erickson LD·Frontiers in immunology·
Studies of meat allergic patients have shown that eating meat poses a serious acute health risk that can induce severe cutaneous, gastrointestinal, and respiratory reactions. Allergic reactions in aff...
Negative Oral Provocation Test With Porcine Pancreatic Enzyme Plus Cofactors Despite Confirmed α-Gal Syndrome.
Eberlein B, Mehlich J, Reidenbach K, et al.·Journal of investigational allergology & clinical immunology·
Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model.
Contreras M, Pacheco I, Alberdi P, et al.·Frontiers in cellular and infection microbiology·
Ticks are arthropod ectoparasite vectors of pathogens and the cause of allergic reactions affecting human health worldwide. In humans, tick bites can induce high levels of immunoglobulin E antibodies...
Prevalence and Impact of Type I Sensitization to Alpha-Gal in Patients Consulting an Allergy Unit.
Fischer J, Huynh HN, Hebsaker J, et al.·International archives of allergy and immunology·
Alpha-gal syndrome is a complex allergy with high clinical relevance regarding mammalian-derived food and drugs and is characterized by the presence of IgE antibodies directed at the carbohydrate gala...
Galactose-α-1,3-galactose (alpha-gal) allergy: first pediatric case in a series of patients in Spain.
Martín-Lázaro J, Núñez-Orjales R, González-Guzmán LA, et al.·Allergologia et immunopathologia·
Allergy to galactose-α-1,3-galactose (alpha-gal) is a peculiar form of food allergy generally manifesting as an anaphylactic reaction hours after mammalian meat consumption, due to the presence of spe...
Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line.
Kim J, Luo H, White W, et al.·mAbs·
The heterogeneity of glycosylation on therapeutic monoclonal antibodies (mAbs) may affect the safety and efficacy of these agents. In particular, glycans of nonhuman origin, such as galactose-alpha-1,...
Alpha-gal antibody due to Lone Star tick bite, a unique case of allergic reaction.
Zhang B, Hauk M, Clyne J·IDCases·
View on PubMed →[Pork-cat syndrome].
·Arerugi = [Allergy]·
Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.
von Döbeln GA, Wagenius G, Holtved E, et al.·Cancer treatment and research communications·
Chemoradiotherapy is standard treatment for localized oesophageal cancer unsuitable for surgery. We aimed to evaluate the efficacy of cetuximab in combination with chemoradiotherapy. This non-randomis...
A BULL IN A PILL SHOP: ALPHA-GAL ALLERGY COMPLICATING TREATMENT OPTIONS FOR POSTPROCEDURAL HYPOTHYROIDISM.
Slayden TA, Shakir MKM, Hoang TD·AACE clinical case reports·
The galactose-alpha-1,3-galactose (alpha-gal) allergy, an IgE-mediated response to nonprimate meat, has a singular pathogenesis linked to tick bites and a delayed allergic presentation, which makes it...
View on PubMed →Anaphylaxis to Bovine Serum Albumin Tissue Adhesive in a Non-Meat-Allergic Patient.
Hilger C, Clark E, Swiontek K, et al.·Journal of investigational allergology & clinical immunology·
Near-fatal anaphylaxis with Kounis syndrome caused by bite: a case report.
Boni E, Incorvaia C·Clinical and molecular allergy : CMA·
The pigeon tick is a temporary parasite of pigeons. It bites during night hours and lies briefly on its prey, as long as it takes the blood meal. When pigeons are not accessible, ticks look for other...
View on PubMed →Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy.
Radwan SS, Gill G, Ghazzal A, et al.·Case reports in cardiology·
Alpha-gal (AG) allergy is an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose found in mammalian meat. Heparin, being derived from porcine intestinal tissue, may have a degree of cross-...
View on PubMed →Determining Effects of Winter Weather Conditions on Adult (Acari: Ixodidae) Survival in Connecticut and Maine, USA.
Linske MA, Williams SC, Stafford KC, et al.·Insects·
The lone star tick ( L.) is native to the United States, with its primary range encompassing the Southeast and portions of the Midwest. It is an aggressive ectoparasite that actively seeks out hosts t...
View on PubMed →Development and characterization of bladder acellular matrix cross-linked by dialdehyde carboxymethyl cellulose for bladder tissue engineering.
Peng X, Yue P, Zhou X, et al.·RSC advances·
In order to address the disadvantage of rapid degradation and serious immune response of bladder acellular matrix (BAM) tissues in clinical application, in this study, oxidized carboxymethyl cellulose...
View on PubMed →Structural investigation of cell wall polysaccharides extracted from wild Finnish mushroom Craterellus tubaeformis (Funnel Chanterelle).
Beltrame G, Trygg J, Rahkila J, et al.·Food chemistry·
Craterellus tubaeformis (Funnel Chanterelle) is among the most abundant wild mushrooms in Finland. Three polysaccharide fractions were sequentially extracted from the fruiting bodies of C. tubaeformis...
Allergy in frequent travelers: the alpha-gal story and the first UK case series.
Harper V, Wagner A, Sowa P, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Relevance of Anti-Galactose-α-1,3-Galactose Antibodies in the Era of Monoclonal Antibodies.
Mangla A, Agarwal N·Journal of oncology practice·
Possible Role of Environmental Factors in the Development of Food Allergies.
Shroba J, Rath N, Barnes C·Clinical reviews in allergy & immunology·
The development of food allergies is thought to involve multiple factors, and it is unclear which conveys the most risk regarding this process. Since food allergy is a chronic disease without a cure a...
Red meat desensitization in a child with delayed anaphylaxis due to alpha-Gal allergy.
Yucel E, Sipahi Cimen S, Varol S, et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
What Does a Red Meat Allergy Have to Do With Anesthesia? Perioperative Management of Alpha-Gal Syndrome.
Dunkman WJ, Rycek W, Manning MW·Anesthesia and analgesia·
Over the past decade, there has been a growing awareness of a new allergic syndrome known as alpha-gal allergy or alpha-gal syndrome, commonly recognized as a red meat allergy. We performed a review o...
The clinical presentation of alpha-gal allergy among pediatric patients with food allergy in southwest Missouri.
Donaldson B, Le MN·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Incidence and Management of Olaratumab Infusion-Related Reactions.
Van Tine BA, Govindarajan R, Attia S, et al.·Journal of oncology practice·
Olaratumab is a human monoclonal immunoglobulin G1 antibody against platelet-derived growth factor receptor-α. We report the nature and frequency of infusion-related reactions (IRRs) with olaratumab i...
Mammalian Meat Allergy Accompanied by Venom Allergy: A Review of 12 Cases.
Kutlu A, Unal D·Iranian journal of allergy, asthma, and immunology·
There has recently been an increase in mammalian meat allergy (MMA) in the Black Sea Region of Turkey. It has been associated with the expansion of tick populations.Tick bites appear to result in sens...
Temporary loss of consciousness during cetuximab treatment of a patient with metastatic colon cancer: a case report.
Fukui T, Suzuki K, Tamaki S, et al.·Surgical case reports·
Anti-epidermal growth factor receptor (EGFR) antibody is widely used for the treatment of patients with metastatic colorectal cancer. Hypomagnesemia is a comparatively frequent adverse event of this d...
View on PubMed →Successful intravenous heparin administration during coronary revascularization surgery in a patient with alpha-gal anaphylaxis history.
Mawhirt SL, Banta E·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Only α-Gal bound to lipids, but not to proteins, is transported across enterocytes as an IgE-reactive molecule that can induce effector cell activation.
Román-Carrasco P, Lieder B, Somoza V, et al.·Allergy·
The oligosaccharide galactose-α-1,3-galactose (α-Gal), present in mammalian proteins and lipids, causes an unusual delayed allergic reaction 3 to 6 hours after ingestion of mammalian meat in individua...
Optimizing detergent concentration and processing time to balance the decellularization efficiency and properties of bioprosthetic heart valves.
Luo Y, Lou D, Ma L, et al.·Journal of biomedical materials research. Part A·
Decellularization treatment has been widely used to decrease the potential immunogenicity and improve the anticalcification properties of bio-derived materials, which may be utilized as an alternative...
Successful desensitization of a patient with cetuximab hypersensitivity: A case report.
Solduzian M, Anvari S, Taghvaye Masoumi H, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Severe hypersensitivity reaction is a dangerous adverse drug reaction in patients receiving cetuximab. It requires drug discontinuation and medical management. A 48-year-old man, previously diagnosed...
Tick Bites Induce Anti-α-Gal Antibodies in Dogs.
Hodžić A, Mateos-Hernández L, Leschnik M, et al.·Vaccines·
Due to the functional inactivation of the gene encoding for the enzyme that is involved in the oligosaccharide galactose-α-1,3-galactose (α-Gal) synthesis, humans and Old-World primates are able to pr...
View on PubMed →Alpha-Gal: A Delayed Onset of Anaphylaxis and Uncovering the Cause.
Berry DC, Britton L, Joseph LM, et al.·Journal of emergency nursing·
The contribution made by skin-infiltrating basophils to the development of alpha-gal syndrome.
Kageyama R, Fujiyama T, Satoh T, et al.·Allergy·
The incidence of infusion reactions associated with monoclonal antibody drugs targeting the epidermal growth factor receptor in metastatic colorectal cancer patients: A systematic literature review and meta-analysis of patient and study characteristics.
Bylsma LC, Dean R, Lowe K, et al.·Cancer medicine·
Systemic cancer therapies may induce infusion reactions (IRs) or hypersensitivities. Metastatic colorectal cancer (mCRC) patients treated with anti-EGFR therapies, including cetuximab and panitumumab,...
Clinical Features and Culprit Food Allergens of Korean Adult Food Allergy Patients: A Cross-Sectional Single-Institute Study.
Lee SC, Kim SR, Park KH, et al.·Allergy, asthma & immunology research·
To investigate the causative allergens and clinical characteristics of Korean adult patients with food allergy (FA). This retrospective, cross-sectional single-institutional study enrolled Korean adul...
View on PubMed →Cetirizine versus diphenhydramine in the prevention of chemotherapy-related hypersensitivity reactions.
Durham CG, Thotakura D, Sager L, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
This study evaluated the role of cetirizine compared to diphenhydramine as premedications for patients receiving paclitaxel, cetuximab, and rituximab infusions. Historically, diphenhydramine has been...
Glycan diversity in the course of vertebrate evolution.
Suzuki N·Glycobiology·
Vertebrates are estimated to have arisen over 500 million years ago in the Cambrian Period. Species that survived the Big Five extinction events at a global scale underwent repeated adaptive radiation...
Hazardous Medications in Children with Egg, Red Meat, Gelatin, Fish, and Cow's Milk Allergy.
Caglayan-Sozmen S, Santoro A, Cipriani F, et al.·Medicina (Kaunas, Lithuania)·
Childhood food allergies are a growing public health problem. Once the offending food allergens have been identified, a strict elimination diet is necessary in treatment or prevention of most of the a...
Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4 T Cell- and MyD88-Dependent Pathways in Mice.
Chandrasekhar JL, Cox KM, Loo WM, et al.·Journal of immunology (Baltimore, Md. : 1950)·
Tick-borne allergies are a growing public health concern and have been associated with the induction of IgE-mediated food allergy to red meat. However, despite the increasing prevalence of tick bite-i...
Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae).
Lima-Barbero JF, Sánchez MS, Cabezas-Cruz A, et al.·Experimental & applied acarology·
Blood-feeding ectoparasites constitute a growing burden for human and animal health, and animal production worldwide. In particular, mites (Acari: Gamasida) of the genera Dermanyssus (Dermanyssidae) a...
Delayed hypersensitivity reaction to mammalian galactose-α-1,3-galactose (α-Gal) after repeated tick bites in a patient from France.
Hodžić A, Mateos-Hernández L, de la Fuente J, et al.·Ticks and tick-borne diseases·
The α-Gal syndrome is a tick-associated and emerging IgE-mediated hypersensitivity reaction directed against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) epitope after red meat intake. Herein, w...
Alpha-gal allergy after a tick bite in Austria.
Pisazka V, Duscher G, Hodžić A, et al.·Wiener klinische Wochenschrift·
Tick bites can cause the alpha-gal syndrome, which is characterized by delayed anaphylactic reactions mainly to red meat and offal due to IgE antibodies against mammalian galactose-alpha-1.3-galactose...
Decellularization as a method to reduce calcification in bovine pericardium bioprosthetic valves.
Collatusso C, Roderjan JG, de Noronha L, et al.·Interactive cardiovascular and thoracic surgery·
Decellularization is an alternative method for processing biological tissues with decreased antigenicity and resistance to calcification. The aim of this study was to characterize the properties of de...
View on PubMed →Alpha-Gal-containing biologics and anaphylaxis.
Chinuki Y, Morita E·Allergology international : official journal of the Japanese Society of Allergology·
Cetuximab, the IgG1 subclass chimeric mouse-human monoclonal antibody biologic that targets the epidermal growth factor receptor (EGFR), is used worldwide for the treatment of EGFR-positive unresectab...
Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.
Dewachter P, Kopac P, Laguna JJ, et al.·British journal of anaesthesia·
This narrative review seeks to distinguish the clinical patterns of pre-existing allergic conditions from other confounding non-allergic clinical entities, and to identify the potential related risks...
Galactose α-1,3-galactose phenotypes: Lessons from various patient populations.
Levin M, Apostolovic D, Biedermann T, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
To review published studies on galactose α-1,3-galactose (α-gal), a carbohydrate epitope found on proteins and lipids in nonprimate mammals and present in foods (particularly organ or fat-rich red mea...
Red meat allergy in children and adults.
Wilson JM, Platts-Mills TAE·Current opinion in allergy and clinical immunology·
To highlight recent advances in our understanding of the clinical features, prevalence, and pathophysiology of red meat allergy. Allergic reactions to red (i.e. mammalian) meat have historically been...
Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma.
Carlsson M, Braddock M, Li Y, et al.·Drug safety·
Tralokinumab is a monoclonal antibody (mAb) that neutralizes interleukin (IL)-13, a cytokine involved in the pathogenesis of asthma. The objectives of this study were to characterize the potential imm...
CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type metastatic colorectal cancer patients: promising findings from a prospective, open-label, randomized, phase III trial.
Shi Y, Li J, Xu J, et al.·Cancer communications (London, England)·
The 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) regimen is the standard first-line treatment for metastatic colorectal cancer (mCRC), however, the optimal second-line regimen for KRAS wild-typ...
An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy.
Cox KM, Commins SP, Capaldo BJ, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
B cells play a critical role in the development and maintenance of food allergy by producing allergen-specific IgE. Despite the importance of B cells in IgE-mediated food allergy, the identity of sIgE...
Validation of PROTIA™ Allergy-Q 64 Atopy® as a Specific IgE Measurement Assay for 10 Major Allergen Components.
Kim SR, Park KH, Lee JH, et al.·Allergy, asthma & immunology research·
Component-resolved diagnostics (CRD) is expected to provide additional diagnostic information in allergic patients. PROTIA™ Allergy-Q 64 Atopy®, a recently developed CRD-based multiplex specific immun...
View on PubMed →Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care.
Mabelane T, Ogunbanjo GA·African journal of primary health care & family medicine·
An allergic reaction to mammalian meat has recently been reported in rural parts of South Africa and throughout other parts of the world. The cause of this allergic reaction is because of an oligosacc...
IgE, α-Gal and atherosclerosis.
Wilson JM, McNamara CA, Platts-Mills TAE·Aging·
The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation.
de la Fuente J, Pacheco I, Villar M, et al.·Parasites & vectors·
This primer focuses on a recently diagnosed tick-borne allergic disease known as the alpha-Gal syndrome (AGS). Tick bites induce in humans high levels of IgE antibodies against the carbohydrate Galα1-...
Insect Sting Anaphylaxis-Or Mastocytosis-Or Something Else?
Golden DBK, Carter MC·The journal of allergy and clinical immunology. In practice·
Insect sting anaphylaxis and mast cell disorders are intertwined in a specific and unusual way. There may be specific subsets of clonal mast cell disorders that are predisposed to sting anaphylaxis. T...
Quantitative and qualitative changes in anti-Neu5Gc antibody response following rabbit anti-thymocyte IgG induction in kidney allograft recipients.
Rousse J, Salama A, Leviatan Ben-Arye S, et al.·European journal of clinical investigation·
Antibodies of non-human mammals are glycosylated with carbohydrate antigens, such as galactose-α-1-3-galactose (α-Gal) and N-glycolylneuraminic acid (Neu5Gc). These non-human carbohydrate antigens are...
Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies.
Sianturi J, Manabe Y, Li HS, et al.·Angewandte Chemie (International ed. in English)·
Cancer treatment with antibodies (Abs) is one of the most successful therapeutic strategies for obtaining high selectivity. In this study, α-gal-Ab conjugates were developed that dramatically increase...
Characterization of the 6-O-acetylated lipoglucuronomannogalactan a novel Cryptococcus neoformans cell wall polysaccharide.
Previato JO, Vinogradov E, Silva MAE, et al.·Carbohydrate research·
Glucuronoxylomannogalactans (GXMGals) are characteristic capsular polysaccharides produced by the opportunistic fungus C. neoformans, which are implicated in cryptococcal virulence, via impairment of...
Recurrent cisplatin hypersensitivity reaction after first exposure: A case report.
Solomon B, Colonna S·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Hypersensitivity reactions to platinum-based chemotherapies are well documented and are often a limiting factor in treating a variety of cancers. Allergy skin testing has been used to determine if rep...
Recall urticaria-A new clinical sign in the diagnosis of alpha-gal syndrome.
Schmidle P, Reidenbach K, Kugler C, et al.·The journal of allergy and clinical immunology. In practice·
Role of Creatine Kinase as an Allergen in Immediate Selective Allergy to Pork Meat.
Barbarroja-Escudero J, Sánchez-González MJ, Pineda F, et al.·Journal of investigational allergology & clinical immunology·
Association between food allergy and ankylosing spondylitis: An observational study.
Niu Q, Wei W, Huang Z, et al.·Medicine·
Food allergies can alter the gut microbiome composition, increasing the risk of conditions such as ankylosing spondylitis (AS).To identify the association between specific allergens and AS, we investi...
Evolution in primates by "Catastrophic-selection" interplay between enveloped virus epidemics, mutated genes of enzymes synthesizing carbohydrate antigens, and natural anti-carbohydrate antibodies.
Galili U·American journal of physical anthropology·
"Catastrophic-selection" is an evolutionary mechanism, by which entire parental-populations are eliminated but very few mutated offspring survive and replace extinct parental-populations. The human na...
A Large Single-Hospital Experience Using Drug Provocation Testing and Rapid Drug Desensitization in Hypersensitivity to Antineoplastic and Biological Agents.
Madrigal-Burgaleta R, Bernal-Rubio L, Berges-Gimeno MP, et al.·The journal of allergy and clinical immunology. In practice·
Large-scale studies of drug provocation testing (DPT) or rapid drug desensitization (RDD) for hypersensitivity to antineoplastics and biologicals are scarce and limited to a few institutions. Our aim...
Could chiggers be contributing to the prevalence of galactose-alpha-1,3-galactose sensitization and mammalian meat allergy?
Stoltz LP, Cristiano LM, Dowling APG, et al.·The journal of allergy and clinical immunology. In practice·
Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat.
Hilger C, Fischer J, Wölbing F, et al.·Current allergy and asthma reports·
The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal i...
Lectin microarray analyses reveal host cell-specific glycan profiles of the hemagglutinins of influenza A viruses.
Hiono T, Matsuda A, Wagatsuma T, et al.·Virology·
Glycan structures on hemagglutinin (HA) of influenza A viruses have been analyzed previously to understand their significance. However, the formerly established methods using mass spectrometry present...
[Diagnostics of alpha-gal syndrome : Current standards, pitfalls and perspectives].
Weins AB, Eberlein B, Biedermann T·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
α-Gal syndrome results from sensitization to the carbohydrate epitope galactose-α-1,3-galactose (α‑gal). The allergen occurs in mammalian meat and innards, but also in other foods and medical products...
α-Gal Syndrome vs Chronic Urticaria.
Pollack K, Zlotoff BJ, Borish LC, et al.·JAMA dermatology·
This cohort study assesses the use of a blood test to distinguish galactose-α-1,3-galactose (α-gal) allergy from chronic urticaria.
IgE to galactose-α-1,3-galactose and the α-Gal syndrome: Insights from basophil activation testing.
Wilson JM, Platts-Mills TAE·The Journal of allergy and clinical immunology·
The basophil activation test differentiates between patients with alpha-gal syndrome and asymptomatic alpha-gal sensitization.
Mehlich J, Fischer J, Hilger C, et al.·The Journal of allergy and clinical immunology·
Galactose-alpha-1,3-galactose (alpha-gal) syndrome is characterized by the presence of serum specific IgE antibodies to alpha-gal and delayed type I allergic reactions to the carbohydrate alpha-gal af...
Anaphylaxis after vaccination in a pediatric patient: further implicating alpha-gal allergy.
Stone CA, Commins SP, Choudhary S, et al.·The journal of allergy and clinical immunology. In practice·
Successful decellularization of thick-walled tissue: Highlighting pitfalls and the need for a multifactorial approach.
Koenig F, Kilzer M, Hagl C, et al.·The International journal of artificial organs·
Decellularization of thick tissue is challenging and varying. Therefore, we tried to establish a multifactorial approach for reliable aortic wall decellularization. Porcine aortic walls were decellula...
Alpha-gal Allergy in a 6-Year-Old Male: A Case Report.
Kinoshita M, Newton S·JNMA; journal of the Nepal Medical Association·
Alpha-gal allergy is a reaction where the immunoglobulin E antibody elicits a response to galactosealpha-1,3-galactose (alpha-gal) which is a mammalian oligosaccharide epitope found in nonprimate mamm...
Alpha gal specific IgE positivity due to tick bites and red meat allergy: the first case report in Turkey.
Keleş Ş, Gündüz M·The Turkish journal of pediatrics·
Keleş Ş, Gündüz M. Alpha gal specific IgE positivity due to tick bites and red meat allergy: the first case report in Turkey. Turk J Pediatr 2019; 61: 615-617. Galactose-alpha-1,3-galactose is a carbo...
No Bull: A Case of Alpha-Gal Syndrome Associated With Buffalo Meat Sensitivity.
Rowane M, Valencia R, Stewart-Bates B, et al.·Allergy & rhinology (Providence, R.I.)·
Alpha (⍺)-gal syndrome (AGS) is an immunoglobulin E (IgE) antibody response against the glycoprotein carbohydrate galactose-⍺-1,3-galactose-β-1-(3)4-N-acetylglucosamine-R (Gal⍺-1,3Galβ1-(3)4GlcNAc-R o...
View on PubMed →Intraoperative anaphylaxis to gelatin-based hemostatic agents: a case report.
Lied GA, Lund KB, Storaas T·Journal of asthma and allergy·
Surgiflo Haemostatic Matrix is an absorbable gelatin matrix hemostatic material that has been widely used in various surgical operations to assist hemostasis. Nonetheless, as biologically active agent...
View on PubMed →Environmental and Molecular Drivers of the α-Gal Syndrome.
Cabezas-Cruz A, Hodžić A, Román-Carrasco P, et al.·Frontiers in immunology·
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab) response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal), which is present in glycoproteins from tick saliva...
Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy.
Crispell G, Commins SP, Archer-Hartman SA, et al.·Frontiers in immunology·
Development of specific IgE antibodies to the oligosaccharide galactose-α-1, 3-galactose (α-gal) following tick bites has been shown to be the source of red meat allergy. In this study, we investigate...
Investigation into the α-Gal Syndrome: Characteristics of 261 Children and Adults Reporting Red Meat Allergy.
Wilson JM, Schuyler AJ, Workman L, et al.·The journal of allergy and clinical immunology. In practice·
Red meat allergy has historically been understood as a rare disease of atopic children, but the discovery of the "α-Gal syndrome," which relates to IgE to the oligosaccharide galactose-α-1,3-galactose...
[PROGNOSIS OF ADULT FOOD ALLERGY CAUSED BY PERCUTANEOUS SENSITIZATION].
Chinuki Y·Arerugi = [Allergy]·
IgE-Mediated Sensitization to Galactose-α-1,3- Galactose (α-Gal) in Urticaria and Anaphylaxis in Spain: Geographical Variations and Risk Factors.
Mateo Borrega MB, Garcia B, Larramendi CH, et al.·Journal of investigational allergology & clinical immunology·
The objectives of this study were to investigate the prevalence of sIgE to galactose-α-1,3-galactose (α-gal) in individuals with acute urticaria or anaphylaxis from different geographical areas of Spa...
Drugs of porcine origin-A risk for patients with α-gal syndrome?
Swiontek K, Morisset M, Codreanu-Morel F, et al.·The journal of allergy and clinical immunology. In practice·
[EARLY CHILDHOOD-ONSET PORK-CAT SYNDROME DUE TO SENSITIZATION BY BOTH CATS AND DOGS -A CASE REPORT].
Yamada S, Matsubara K, Chinuki Y, et al.·Arerugi = [Allergy]·
We present a case of early childhood-onset pork-cat syndrome possibly due to sensitization by both cats and dogs. A 6-year-old girl was referred to our hospital because of repetitive episodes of urtic...
Preliminary assessment of anti-α-Gal IgG and IgM levels in patients with patent Plasmodium vivax infection.
Coelho ZBA, Mourão LC, Rodrigues BCM, et al.·Memorias do Instituto Oswaldo Cruz·
Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and I...
A new look at IgE beyond allergies.
Luker AJ, Lownik JC, Conrad DH, et al.·F1000Research·
Immunoglobulin E (IgE), though constitutively present at low levels, is most commonly studied in atopic disease where it plays a vital role in mast cell degranulation and in initiating a T helper 2 (T...
Glycosylation-dependent antitumor therapeutic monoclonal antibodies.
Zhang Y, Fan C, Zhang L, et al.·Progress in molecular biology and translational science·
The therapeutic market for monoclonal antibodies (MAbs) has grown exponentially since 2000. It is expected that the world-wide market for MAbs could reach $125 billion in 2020. For cancer treatment al...
Pork-cat syndrome revealed after surgery: Anaphylaxis to bovine serum albumin tissue adhesive.
Dewachter P, Jacquenet S, Beloucif S, et al.·The journal of allergy and clinical immunology. In practice·
Purification of Glycosylphosphatidylinositol-Anchored Mucins from Trypanosoma cruzi Trypomastigotes and Synthesis of α-Gal-Containing Neoglycoproteins: Application as Biomarkers for Reliable Diagnosis and Early Assessment of Chemotherapeutic Outcomes of Chagas Disease.
Ortega-Rodriguez U, Portillo S, Ashmus RA, et al.·Methods in molecular biology (Clifton, N.J.)·
Chagas disease (ChD), caused by the protozoan parasite Trypanosoma cruzi, affects millions of people worldwide. Chemotherapy is restricted to two drugs, which are partially effective and may cause sev...
Anaphylactoid hypersensitivity reaction from intra-arterial cetuximab: Clinical considerations and management.
Bardash Y, Tham T, Olson C, et al.·SAGE open medical case reports·
Intra-arterial infusion of drugs shows promising results in terms of safety and efficacy. Intra-arterial cetuximab, a monoclonal antibody treatment, is currently being tested for its use in head and n...
View on PubMed →A Multicenter Phase II Trial of Docetaxel, Cisplatin, and Cetuximab (TPEx) Followed by Cetuximab and Concurrent Radiotherapy for Patients With Local Advanced Squamous Cell Carcinoma of the Head and Neck (CSPOR HN01: ECRIPS Study).
Zenda S, Ota Y, Kiyota N, et al.·Frontiers in oncology·
Induction chemotherapy (IC) is a treatment option for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). However, treatment with docetaxel, cisplatin, and 5-FU (TPF) followed by...
View on PubMed →Predictive values of alpha-gal IgE levels and alpha-gal IgE: Total IgE ratio and oral food challenge-proven meat allergy in a population with a high prevalence of reported red meat allergy.
Mabelane T, Basera W, Botha M, et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
Severe meat allergy with anaphylaxis may be caused by sensitization to alpha-gal. Levels of alpha-gal sensitization that correlate with high risk of meat allergy are currently unknown. We have identif...
Effects of EDC-PEI heparinization on allogeneic vascular antigens and inflammation levels via a rat abdominal aorta transplantation model.
Han F, Tian P, Xia X, et al.·Experimental and therapeutic medicine·
The objective of this study was to investigate the possibility of increasing the remote patency rate of allogeneic vessel transplantation through studying the effects of N-ethyl-N-(3-dimethylaminoprop...
View on PubMed →Distribution analysis of polysaccharides comprised of uronic acid-hexose/hexosamine repeating units in various shellfish species.
Cao C, Song S, Liu B, et al.·Glycoconjugate journal·
Acidic polysaccharides are attractive functional ingredients in shellfish which are consumed as delicious and nutritious foods world widely. In the present study, acidic polysaccharides from 21 specie...
Mammalian meat allergy.
Wong XL, Sebaratnam DF·International journal of dermatology·
Mammalian meat allergy is an allergic reaction mediated by IgE antibodies directed against the mammalian oligosaccharide epitope galactose-α-1,3-galactose. Clinically, it is characterized by a range o...
Ligand binding and retention in snake gourd seed lectin (SGSL). A crystallographic, thermodynamic and molecular dynamics study.
Chandran T, Sivaji N, Surolia A, et al.·Glycobiology·
Snake gourd seed lectin (SGSL) is a non-toxic homolog of type II ribosome-inactivating proteins (RIPs) which contain a catalytic domain and a lectin domain. Isothermal titration calorimetry (ITC) meas...
Analysis of Leishmania mimetic neoglycoproteins for the cutaneous leishmaniasis diagnosis.
de Souza LMB, Thomaz Soccol V, Petterle RR, et al.·Parasitology·
Oligosaccharides are broadly present on Leishmania cell surfaces. They can be useful for the leishmaniases diagnosis and also helpful in identifying new cell markers for the disease. The disaccharide...
Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate.
Luke T, Bennett RS, Gerhardt DM, et al.·The Journal of infectious diseases·
Transchromosomic bovines (Tc-bovines) adaptively produce fully human polyclonal immunoglobulin (Ig)G antibodies after exposure to immunogenic antigen(s). The National Interagency Confederation for Bio...
Phase II study of induction chemotherapy with docetaxel, cisplatin, 5-fluorouracil followed by radioimmunotherapy with cetuximab and intensity-modulated radiotherapy in combination with a carbon ion boost for locally advanced tumors of the oro-, hypopharynx and larynx.
Hauswald H, Jensen AD, Krauss J, et al.·Clinical and translational radiation oncology·
This phase II trial was designed to evaluate efficacy and safety of a highly intensified therapy in locally advanced squamous cell carcinoma of the oro-, hypopharynx and larynx. In this prospective, m...
View on PubMed →The changing face of anaphylaxis in adults and adolescents.
Pattanaik D, Lieberman P, Lieberman J, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Our institution has published serial studies of adults and adolescents with anaphylactic events. The first series was published in 1993 and the last was published in 2006. It was our perception that t...
Recurring acute urticaria and abdominal pain: Consider a diagnosis of alpha-galactose anaphylaxis.
Deschamps Huvier A, Tetart F, Bauvin O, et al.·Annales de dermatologie et de venereologie·
Food urticaria is common and generally benign, and it may be of viral or idiopathic aetiology. A food origin of the allergy is frequently sought but rarely found. Mammalian meat anaphylaxis, or alpha-...
Anti-α-Gal antibodies detected by novel neoglycoproteins as a diagnostic tool for Old World cutaneous leishmaniasis caused by Leishmania major.
Subramaniam KS, Austin V, Schocker NS, et al.·Parasitology·
Outbreaks of Old World cutaneous leishmaniasis (CL) have significantly increased due to the conflicts in the Middle East, with most of the cases occurring in resource-limited areas such as refugee set...
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan.
Kondo M, Goto H, Miyazaki M, et al.·The Journal of dermatology·
Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways.
Chen Y, Liu Y, Sarker MMR, et al.·Carbohydrate polymers·
A novel heteropolysaccharide from Grifola frondosa named GFP-W has been isolated and purified by DEAE Sephadex A-52 chromatography. Gas chromatography, fourier transform infrared spectroscopy, one-dim...
Delayed Anaphylaxis to Mammalian Meat: A Fascinating Disease and Captivating Story.
Abdallah MA, Larson EA·South Dakota medicine : the journal of the South Dakota State Medical Association·
Delayed anaphylaxis to mammalian meat is a newly recognized IgE-mediated syndrome associated with Lone Star tick bites. IgE-mediated anaphylaxis classically occurs within one hour of exposure to the a...
Worsening of Severe Asthma Due to Menstruation and Sensitization to Albumins.
Marques-Mejías MA, Barranco P, Laorden D, et al.·Journal of investigational allergology & clinical immunology·
Specific-IgE to galactose-α-1,3-galactose (alpha-gal) has limited utility in diagnosing meat allergy in a tick-endemic population.
Li J, Fulton RB, O'Connell R, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
[Alpha-Gal-associated delayed red meat anaphylaxis as an occupational disease].
Anemüller W, Mohr M, Brans R, et al.·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
In a 30-year-old chef with recurrent delayed angioedema history as well as the experimental detection of IgE antibodies against galactose-alpha-(1,3)-galactose (alpha-Gal) pointed to alpha-Gal as the...
[Analysis on safety and preliminary efficacy of dose-modified regimen of 5-fluorouracil plus oxaliplatin and irinotecan (FOLFOXIRI) in advanced colorectal cancer].
Cai Y, Deng R, Hu H, et al.·Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·
To evaluate the safety and preliminary efficacy of dose-modified regimen of 5-fluorouracil plus oxaliplatin and irinotecan (mFOLFOXIRI) for patients with advanced colorectal cancer (CRC). Data of 312...
Characterization of Properties and Transglycosylation Abilities of Recombinant α-Galactosidase from Cold-Adapted Marine Bacterium KMM 701 and Its C494N and D451A Mutants.
Bakunina I, Slepchenko L, Anastyuk S, et al.·Marine drugs·
A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, p...
Tick galactosyltransferases are involved in α-Gal synthesis and play a role during Anaplasma phagocytophilum infection and Ixodes scapularis tick vector development.
Cabezas-Cruz A, Espinosa PJ, Alberdi P, et al.·Scientific reports·
The carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) is produced in all mammals except for humans, apes and old world monkeys that lost the ability to synthetize this carbohydrate. Therefore, humans can...
Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity.
Carbone ML, Lulli D, Passarelli F, et al.·International journal of molecular sciences·
Human keratinocytes were recently shown to respond to anti-EGFR (epidermal growth factor receptor) drugs with activation of an interferon-κ-driven autocrine loop, leading to enhanced expression of inn...
Biochemical characterization and immunogenicity of Neureight, a recombinant full-length factor VIII produced by fed-batch process in disposable bioreactors.
Delignat S, Peyron I, El Ghazaly M, et al.·Cellular immunology·
Hemophilia A is a X-linked recessive bleeding disorder consecutive to the lack of circulating pro-coagulant factor VIII (FVIII). The most efficient strategy to treat or prevent bleeding in patients wi...
Correlation of types of food and asthma diagnosis in childhood: A case-control study.
Hallit S, Raherison C, Abou Abdallah R, et al.·The Journal of asthma : official journal of the Association for the Care of Asthma·
: Studies concerning asthma in Lebanon investigated environmental and personal factors but none of them took into account the effect of nutritional habits. Our objective is to assess the effect of nut...
α-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells.
Ristivojević MK, Grundström J, Tran TAT, et al.·Scientific reports·
Red meat allergy is characterized by an IgE response against the carbohydrate galactose-α-1,3-galactose (α-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms...
Discovery of a Potent α-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry.
Elías-Rodríguez P, Pingitore V, Carmona AT, et al.·The Journal of organic chemistry·
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α-galactosidases has been carried out. The combi...
Meat allergy and allergens.
Wilson JM, Platts-Mills TAE·Molecular immunology·
IgE-mediated hypersensitivity to ingested animal products, including both mammalian and avian sources, is increasingly appreciated as an important form of food allergy. Traditionally described largely...
Antibody responses to α-Gal in African children vary with age and site and are associated with malaria protection.
Aguilar R, Ubillos I, Vidal M, et al.·Scientific reports·
Naturally-acquired antibody responses to malaria parasites are not only directed to protein antigens but also to carbohydrates on the surface of Plasmodium protozoa. Immunoglobulin M responses to α-ga...
Immunoprofile of α-Gal- and B-antigen-specific responses differentiates red meat-allergic patients from healthy individuals.
Apostolovic D, Rodrigues R, Thomas P, et al.·Allergy·
The galactose-α-1,3-galactose (α-Gal) epitope is involved in red meat allergy. As α-Gal is structurally similar to the blood group B-antigen, we explored the relationship between the immune responses...
A novel Australian tick () inducing mammalian meat allergy after tick bite.
Kwak M, Somerville C, van Nunen S·Asia Pacific allergy·
Tick-induced mammalian meat allergy has become an emergent allergy world-wide after van Nunen et al. first described the association between tick bites and the development of mammalian meat allergy in...
View on PubMed →Multiple food allergy - unexpected culprits.
Ornelas CIF, Cabral Duarte F, Pereira Dos Santos MCG, et al.·Asia Pacific allergy·
Food allergy has an estimated prevalence of 6%-8% in children. Meat allergy and multiple food allergy due to sensitization to cross-reactive components in infancy is, however, less frequent. A 5-year-...
View on PubMed →Skin Reaction to Cetuximab as a Criterion for Treatment Selection in Head and Neck Cancer.
Strojan P, Zakotnik B, Žumer B, et al.·Anticancer research·
It can be hypothesized that in patients with locally advanced head and neck cancer and prominent cetuximab (CMb)-induced skin rash, immunoradiotherapy would result in a survival advantage over chemora...
IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics-Brief Report.
Wilson JM, Nguyen AT, Schuyler AJ, et al.·Arteriosclerosis, thrombosis, and vascular biology·
Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactos...
Meat reintroduction in a patient with α-gal allergy.
Pelletier T, Alvarez-Arango S, Sameeta FNU, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Galactose-α-1,3-galactose allergy: a rare syndrome and an atypical presentation.
Abreu C, Bartolomé B, Cunha L, et al.·European annals of allergy and clinical immunology·
Allergies to red meat associated with galactose-α-1,3-galactose, commonly known as α-gal, are rare and have only recently been described. At this time, the literature reports only one case documented...
Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: A retrospective cohort study in a single institution.
Hashizume H, Fujiyama T, Umayahara T, et al.·Journal of the American Academy of Dermatology·
Alpha-gal syndrome is a hypersensitivity reaction to red meat mediated by IgE antibody specific to galactose-α-1,3-galactose carbohydrate (alpha-gal). Amblyomma tick bites are associated with this con...
Successful Feasibility Human Trial of a New Self-Expandable Percutaneous Pulmonary Valve (Pulsta Valve) Implantation Using Knitted Nitinol Wire Backbone and Trileaflet α-Gal-Free Porcine Pericardial Valve in the Native Right Ventricular Outflow Tract.
Kim GB, Song MK, Bae EJ, et al.·Circulation. Cardiovascular interventions·
Self-expandable percutaneous pulmonary valve implantation (PPVI) for native right ventricular outflow tract lesions is still in the clinical trial phase. The aim of this study is to present the result...
First-Line Cetuximab Monotherapy in KRAS/NRAS/BRAF Mutation-Negative Colorectal Cancer Patients.
Moiseyenko VM, Moiseyenko FV, Yanus GA, et al.·Clinical drug investigation·
Colorectal carcinomas (CRCs) are sensitive to treatment by anti-epidermal growth factor receptor (EGFR) antibodies only if they do not carry activating mutations in down-stream EGFR targets (KRAS/NRAS...
Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.
Carter MC, Ruiz-Esteves KN, Workman L, et al.·Allergy·
IgE antibodies (Ab) specific to galactose-α-1,3-galactose (alpha-gal) are responsible for a delayed form of anaphylaxis that occurs 3-6 hours after red meat ingestion. In a unique prospective study of...
[A Case of Postoperative Recurrence of Rectal Cancer in Which Desensitization Therapy Was Effective against Oxaliplatin Allergy in L-OHP].
Katagiri M, Miwa K, Shimomura S, et al.·Gan to kagaku ryoho. Cancer & chemotherapy·
The case involved a 44-year-old man who underwent intersphincteric resection and lateral lymph node dissection for rectal cancer. Pathological diagnosis revealed a well-differentiated adenocarcinoma c...
Tick-induced allergies: mammalian meat allergy and tick anaphylaxis.
van Nunen SA·The Medical journal of Australia·
Mammalian meat allergy after tick bites and tick anaphylaxis are the most serious tick-induced allergies. They are often severe, should be largely avoidable and offer fascinating insights into the dev...
The Combinational Use of CRISPR/Cas9 and Targeted Toxin Technology Enables Efficient Isolation of Bi-Allelic Knockout Non-Human Mammalian Clones.
Watanabe S, Sakurai T, Nakamura S, et al.·International journal of molecular sciences·
Recent advances in genome editing systems such as clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease (CRISPR/Cas9) have facilitated genomic modification in...
Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga).
Wold CW, Kjeldsen C, Corthay A, et al.·Carbohydrate polymers·
The aim of this paper was to perform a comprehensive characterization of polysaccharides isolated from the interior (IOI) and exterior (IOE) parts of the fungus Inonotus obliquus. Pre-extraction with...
The differences in the assessments of side effects at an oncology outpatient clinic.
Bayraktar-Ekincioglu A, Kucuk E·International journal of clinical pharmacy·
Background There is a growing interest in the use of targeted and immunotherapies in oncology. However, the assessment of side effects can be different due to interpretation of patients' health status...
A Grapevine-Inducible Gene Vv-α-gal/SIP Confers Salt and Desiccation Tolerance in Escherichia coli and Tobacco at Germinative Stage.
Daldoul S, Amar AB, Gargouri M, et al.·Biochemical genetics·
Grapevine is an important fruit crop cultivated worldwide. Previously, we have reported the characterization of a salt stress-inducible gene Vv-α-gal/SIP isolated from the tolerant grapevine cultivar...
Galactosylation of the Secondary Cell Wall Polysaccharide of Bacillus anthracis and Its Contribution to Anthrax Pathogenesis.
Chateau A, Lunderberg JM, Oh SY, et al.·Journal of bacteriology·
, the causative agent of anthrax disease, elaborates a secondary cell wall polysaccharide (SCWP) that is essential for bacterial growth and cell division. SCWP is comprised of trisaccharide repeats w...
Synthesis of Stachyobifiose Using Bifidobacterial α-Galactosidase Purified from Recombinant Escherichia coli.
Oh SY, Youn SY, Park MS, et al.·Journal of agricultural and food chemistry·
The prebiotic effects of GOS (galactooligosaccharides) are known to depend on the glycosidic linkages, degree of polymerization (DP), and the monosaccharide composition. In this study, a novel form of...
A tick-acquired red meat allergy.
Khoury JK, Khoury NC, Schaefer D, et al.·The American journal of emergency medicine·
Allergic reaction is a common clinical picture in the Emergency Department (ED). Most allergic reactions are from food or drugs. A detailed history is an integral aspect of determining the causative a...
Mammalian meat allergy following a tick bite: a case report.
Jackson WL·Oxford medical case reports·
The alpha-gal allergy is an emerging IgE-mediated reaction against the galactose-alpha-1,3-galactose carbohydrate found in mammalian meats. Patients with this condition will develop anaphylactic sympt...
View on PubMed →Enhanced vascular regeneration with chemically/physically treated bovine/human pericardium in rodents.
van Steenberghe M, Schubert T, Xhema D, et al.·The Journal of surgical research·
Glutaraldehyde-treated pericardia for cardiovascular applications have poor long-term clinical results. The efficacy of a combined physical/chemical treatment to improve pericardium biocompatibility a...
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, et al.·Chest·
Anaphylaxis is a systemic, life-threatening disorder triggered by mediators released by mast cells and basophils activated via allergic (IgE-mediated) or nonallergic (non-IgE-mediated) mechanisms. It...
An unusual case of positive sIgE to Galactose-alpha-1,3-galactose from South Italy.
Uasuf CG, Torina A, Ferrantelli V, et al.·European annals of allergy and clinical immunology·
We report the case of a 38-year-old man who was bitten several times during his life by a tick. He didn't report any previous history of anaphylaxis after the ingestion of red meat. The serum specific...
Meat allergy associated with galactosyl-α-(1,3)-galactose (α-Gal)-Closing diagnostic gaps by anti-α-Gal IgE immune profiling.
Jappe U, Minge S, Kreft B, et al.·Allergy·
Glycoproteins and glycolipids of some mammalian species contain the disaccharide galactosyl-α-(1,3)-galactose (α-Gal). It is known that α-Gal is immunogenic in humans and causes glycan-specific IgG an...
The B antigen protects against the development of red meat allergy.
Brestoff JR, Tesfazghi MT, Zaydman MA, et al.·The journal of allergy and clinical immunology. In practice·
[galactose-α-1,3-galactose (α-gal)].
·Arerugi = [Allergy]·
Natural antibodies - facts known and unknown.
Palma J, Tokarz-Deptuła B, Deptuła J, et al.·Central-European journal of immunology·
In contrast to adaptive antibodies, natural antibodies are present in a non-immunised organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural antibodies, which are dev...
View on PubMed →Aetiology of anaphylaxis in patients referred to an immunology clinic in Colombo, Sri Lanka.
de Silva NR, Dasanayake WMDK, Karunatilake C, et al.·Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·
The aetiology of anaphylaxis differs according to types of foods consumed, fauna and foliage and cultural practices. Although the aetiology of anaphylaxis in Western countries are well known, the caus...
View on PubMed →Cross-Reactive Aeroallergens: Which Need to Cross Our Mind in Food Allergy Diagnosis?
Faber MA, Van Gasse AL, Decuyper II, et al.·The journal of allergy and clinical immunology. In practice·
Secondary food allergies due to cross-reactivity between inhalant and food allergens are a significant and increasing global health issue. Cross-reactive food allergies predominantly involve plant-der...
High incidence of cetuximab-related infusion reactions in head and neck patients.
Palomar Coloma V, Bravo P, Lezghed N, et al.·ESMO open·
Cetuximab is crucial in the management of squamous cell carcinoma of the head and neck of patients. Grade 3-4 cetuximab-induced infusion reactions (CI-IRs) occur in 2% of patients with colorectal canc...
View on PubMed →Diagnosing Meat Allergy After Tick Bite Without Delay.
Kaplan AC, Carson MP·Journal of the American Board of Family Medicine : JABFM·
Galactose-α-1, 3 galactose (α-gal) is a carbohydrate found in mammalian meat. In 2007, it was implicated as a cause of severe hypersensitivity reactions when a study found elevated levels of antibodie...
Outcome of 490 Desensitizations to Chemotherapy Drugs with a Rapid One-Solution Protocol.
Pérez-Rodríguez E, Martínez-Tadeo JA, Pérez-Rodríguez N, et al.·The journal of allergy and clinical immunology. In practice·
Hypersensitivity reactions to chemotherapy drugs are quite frequent. Desensitization for chemotherapy drugs has become an option to maintain first-line therapy in patients who have suffered such react...
Hypersensitivity to Cetuximab After Geographic Relocation.
Baxley AA, Doyin-Lipede OA, Razaq MA·American journal of therapeutics·
IgE to α-Gal in Foresters and Forest Workers From La Rioja, North of Spain.
Venturini M, Lobera T, Sebastián A, et al.·Journal of investigational allergology & clinical immunology·
To investigate the prevalence of and factors associated with the presence of α-gal-specific IgE in a risk group of foresters and forest workers from La Rioja, Spain and in a control group. The study p...
Severe anaphylaxis due to crocodile-meat allergy exhibiting wide cross-reactivity with fish allergens.
Haroun-Díaz E, Blanca-López N, Vázquez de la Torre M, et al.·The journal of allergy and clinical immunology. In practice·
Production of Recombinant Factor VIII in Human Cell Lines.
Fantacini DMC, Picanço-Castro V·Methods in molecular biology (Clifton, N.J.)·
Human cell lines can produce recombinant proteins much more similar to their natural counterpart, compared to other mammalian cell lines, reducing potential immunogenic reactions. Recombinant proteins...
Interstitial lung disease secondary to Cetuximab in bladder cancer: an Oncologist's perspective.
Price L, Glynn P, Zarkar A·BMJ case reports·
A wide variety of cytotoxic medications cause interstitial lung disease (ILD). For the first time, we describe ILD in an 82-year-old woman with muscle invasive bladder cancer 10 days after receiving c...
Prevalence of type I sensitization to alpha-gal in forest service employees and hunters: Is the blood type an overlooked risk factor in epidemiological studies of the α-Gal syndrome?
Cabezas-Cruz A, de la Fuente J, Fischer J, et al.·Allergy·
Galactose-α-1,3-galactose syndrome: an Italian survey.
Villalta D, Cecchi L, Farsi A, et al.·European annals of allergy and clinical immunology·
The term of α-Gal syndrome, which includes the delayed allergy to red meat and the allergic reactions following the administration of cetuximab, is associated to the presence of specific IgE to α-Gal....
Preparation and Biomechanical Properties of an Acellular Porcine Corneal Stroma.
Li Q, Wang H, Dai Z, et al.·Cornea·
To construct an acellular porcine corneal stroma (aPCS) as a human corneal stroma alternative and to further explore its biomechanical properties. A combination of DNA-RNA enzymes and ultrasound techn...
Synthesis of a model trisaccharide for studying the interplay between the anti α-Gal antibody and the trans-sialidase reactions in Trypanosoma cruzi.
Giorgi ME, Lopez R, Agusti R, et al.·Carbohydrate research·
Trypanosoma cruzi, the etiologic agent of Chagas disease, is covered by a dense glycocalix mainly composed by glycoproteins called mucins which are also the acceptors of sialic acid in a reaction cata...
Accurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE.
Sim DW, Lee JS, Park KH, et al.·Molecular nutrition & food research·
IgE against galactose-α-1,3-galactose (α-Gal) causes alpha-gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against c...
Prevalence of type I sensitization to alpha-gal in forest service employees and hunters.
Fischer J, Lupberger E, Hebsaker J, et al.·Allergy·
The production of IgE molecules specific to the carbohydrate galactose-α-1,3-galactose (alpha-gal) is known to induce delayed anaphylaxis against mammalian meat. Tick bites constitute the primary sens...
Mammalian meat allergy and advances in bioprosthetic valve technology.
Hawkins RB, Ghanta RK·The Journal of thoracic and cardiovascular surgery·
When meat allergy meets cardiac surgery: A driver for humanized bioprosthesis.
Ankersmit HJ, Copic D, Simader E·The Journal of thoracic and cardiovascular surgery·
Protein contact dermatitis caused by chicken meat in bird-egg syndrome.
Berbegal L, DeLeon FJ, González I, et al.·Contact dermatitis·
Diagnosis of Life-Threatening Alpha-Gal Food Allergy Appears to Be Patient Driven.
Flaherty MG, Kaplan SJ, Jerath MR·Journal of primary care & community health·
Patients exhibiting life-threatening symptoms associated with the alpha-gal food allergy (delayed urticaria or anaphylaxis due to mammalian meat) are frequently undiagnosed, causing unnecessary emerge...
TPF plus cetuximab induction chemotherapy followed by biochemoradiation with weekly cetuximab plus weekly cisplatin or carboplatin: a randomized phase II EORTC trial.
Specenier PM, Remenar E, Buter J, et al.·Annals of oncology : official journal of the European Society for Medical Oncology·
Our aim was to test the safety of cetuximab added to chemoradiation with either cisplatin or carboplatin after prior induction chemotherapy. Patients with stage III/IV unresectable, squamous cell carc...
Optimized decellularization protocol including α-Gal epitope reduction for fabrication of an acellular porcine annulus fibrosus scaffold.
Wu LC, Kuo YJ, Sun FW, et al.·Cell and tissue banking·
Recent advances in tissue engineering have led to potential new strategies, especially decellularization protocols from natural tissues, for the repair, replacement, and regeneration of intervertebral...
Diagnosis of red meat allergy with antigen-specific IgE tests in serum.
Brestoff JR, Zaydman MA, Scott MG, et al.·The Journal of allergy and clinical immunology·
Mammalian meat allergy: Unexpected danger.
Strickler J·Nursing·
Retrospective analysis of premedication, glucocorticosteroids, and H-antihistamines for preventing infusion reactions associated with cetuximab treatment of patients with head and neck cancer.
Ikegawa K, Suzuki S, Nomura H, et al.·The Journal of international medical research·
Objectives We evaluated infusion-related reactions associated with cetuximab combination chemotherapy comprising an H1-receptor antagonist plus dexamethasone as anti-allergy premedications for patient...
Prolonged Overall Treatment Time and Lack of Skin Rash Negatively Impact Overall Survival in Locally Advanced Head and Neck Cancer Patients Treated with Radiotherapy and Concomitant Cetuximab.
Roman J, Dissaux G, Gouillou M, et al.·Targeted oncology·
Cetuximab, a chimeric monoclonal antibody against EGFR sensitizes tumors to radiotherapy (RT), but is associated with skin and mucosal toxicity. We report outcomes and tolerance of definitive RT in as...
Glycans and glycan-specific IgE in clinical and molecular allergology: Sensitization, diagnostics, and clinical symptoms.
Homann A, Schramm G, Jappe U·The Journal of allergy and clinical immunology·
Glycan-specific IgE antibodies cross-react with highly similar or even identical carbohydrate structures on a variety of different natural allergens, the so-called cross-reactive carbohydrate determin...
Development and Characterization of a Porcine Mitral Valve Scaffold for Tissue Engineering.
Granados M, Morticelli L, Andriopoulou S, et al.·Journal of cardiovascular translational research·
Decellularized scaffolds represent a promising alternative for mitral valve (MV) replacement. This work developed and characterized a protocol for the decellularization of whole MVs. Porcine MVs were...
Acute hypersensitivity reaction to Crotalidae polyvalent immune Fab (CroFab) as initial presentation of galactose-α-1,3-galactose (α-gal) allergy.
Rizer J, Brill K, Charlton N, et al.·Clinical toxicology (Philadelphia, Pa.)·
Crotalidae polyvalent immune Fab antivenom (CroFab), commonly used for the treatment of clinically significant North American crotalinae envenomation, is generally well-tolerated. A novel form of anap...
Fabrication and characterization of a decellularized bovine tendon sheet for tendon reconstruction.
Ning LJ, Jiang YL, Zhang CH, et al.·Journal of biomedical materials research. Part A·
Obtaining a performing decellularized tendon scaffold with proper dimensions and adequate availability is highly desirable. However, the combined study of complete decellularization and detailed chara...
Induced Remodeling of Porcine Tendons to Human Anterior Cruciate Ligaments by α-GAL Epitope Removal and Partial Cross-Linking.
Stone KR, Walgenbach A, Galili U·Tissue engineering. Part B, Reviews·
This review describes a novel method developed for processing porcine tendon and other ligament implants that enables in situ remodeling into autologous ligaments in humans. The method differs from me...
Highly efficient chemoenzymatic synthesis and facile purification of α-Gal pentasaccharyl ceramide Galα3nLcβCer.
Santra A, Li Y, Yu H, et al.·Chemical communications (Cambridge, England)·
A highly efficient chemoenzymatic method for synthesizing glycosphingolipids using α-Gal pentasaccharyl ceramide as an example is reported here. Enzymatic extension of the chemically synthesized lacto...
View on PubMed →Peptidomics of an in vitro digested α-Gal carrying protein revealed IgE-reactive peptides.
Apostolovic D, Krstic M, Mihailovic J, et al.·Scientific reports·
The mammalian carbohydrate galactose-α1,3-galactose (α-Gal) causes a novel form of food allergy, red meat allergy, where patients experience severe allergic reactions several hours after red meat cons...
Red meat allergy induced by tick bites: A Norwegian case report.
Arslan Lied G·European annals of allergy and clinical immunology·
Food allergies, especially delayed hypersensitivity reactions, are often challenging for both patients and clinicians. Here, we report the case of a 64-year-old man who had allergic reactions six hour...
Retrospective evaluation of concomitant cetuximab and radiotherapy tolerance for locoregional advanced head and neck squamous cell carcinoma treatment in patients unfit for platinum-based chemotherapy.
Rambeau A, Gervais R, De Raucourt D, et al.·European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·
Radiotherapy associated with cetuximab (Cet-RT) is an alternative treatment to platinum-based chemoradiotherapy in locally advanced head and neck carcinoma (LAHNC). Reviews suggest that the use of cet...
Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat.
Cabezas-Cruz A, Mateos-Hernández L, Chmelař J, et al.·Trends in parasitology·
Tick-induced allergy to red meat is associated with anti-α-Gal IgE antibody levels. We propose that tick salivary prostaglandin E2 triggers antibody class switching in mature B cells, increasing the l...
[Characterization of N-glycosylation in an anti-EGFR monoclonal antibody produced by different expression systems].
Wang C, Guo H·Sheng wu gong cheng xue bao = Chinese journal of biotechnology·
The use of mammalian expression systems results in a remarkable heterogeneity of mAb products, generally due to post-translational modifications, and glycosylation is a critical post-translation modif...
Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.
Ali M, Kaltenbrun E, Anderson GR, et al.·Nature communications·
KRAS mutations drive resistance to targeted therapies, including EGFR inhibitors in colorectal cancer (CRC). Through genetic screens, we unexpectedly find that mutant HRAS, which is rarely found in CR...
Management of infusion reactions associated with cetuximab treatment: A case report.
Ohshita N, Ichimaru Y, Gamoh S, et al.·Molecular and clinical oncology·
Cetuximab is a drug targeting the epidermal growth factor receptor, which is indicated for the treatment of unresectable advanced or recurrent head and neck or colorectal cancer. Cetuximab also enhanc...
View on PubMed →Food Allergy in South Africa.
Gray CL·Current allergy and asthma reports·
Whilst food allergy seems to have increased significantly in many developed countries in the past few decades, quality data on the burden of food allergy in many developing countries is scanty. Until...
Enhanced vascular biocompatibility of decellularized xeno-/allogeneic matrices in a rodent model.
van Steenberghe M, Schubert T, Guiot Y, et al.·Cell and tissue banking·
Glutaraldehyde preservation is the gold standard for cardiovascular biological prosthesis. However, secondary calcifications and the absence of tissue growth remain major limitations. Our study assess...
Roles of Glycoproteins in the Diagnosis and Differential Diagnosis of Chronic and Latent Keshan Disease.
Wang S, Fan Z, Zhou B, et al.·Molecules (Basel, Switzerland)·
We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent Keshan disease (CKD and LKD), and screen the lectins as indicators of significant differences in glycoproteins...
Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism.
Stone CA, Hemler JA, Commins SP, et al.·The Journal of allergy and clinical immunology·
A patient with alpha-gal allergy presented with anaphylaxis after receiving zoster vaccine. Subsequent testing of selected vaccines revealed the presence of alpha-gal allergen in MMR and zoster vaccin...
Alpha-gal is a possible target of IgE-mediated reactivity to antivenom.
Fischer J, Eberlein B, Hilger C, et al.·Allergy·
Antivenoms are mammalian immunoglobulins with the ability to neutralize snake venom components and to mitigate the progression of toxic effects. Immediate hypersensitivity to antivenoms often occurs d...
Anaphylactic Reactions to Novel Foods: Case Report of a Child With Severe Crocodile Meat Allergy.
Ballardini N, Nopp A, Hamsten C, et al.·Pediatrics·
Availability of "exotic" foods is steadily increasing. In this report, we describe the first case of anaphylaxis to crocodile meat. The patient was a 13-year-old boy with severe immunoglobulin E-media...
Delayed Anaphylaxis to Mammalian Meat Following Tick Exposure and Its Impact on Anesthetic Management for Cardiac Surgery: A Case Report.
Kleiman AM, Littlewood KE, Groves DS·A & A case reports·
Hypersensitivity reactions to mammalian meat following tick exposure are increasing in prevalence and provide a unique challenge to anesthesiologists. The reactions, including anaphylaxis, are delayed...
Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite.
Mateos-Hernández L, Villar M, Moral A, et al.·Oncotarget·
Tick-borne infectious diseases and allergies are a growing problem worldwide. Tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens,...
Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases.
Cabezas-Cruz A, Mateos-Hernández L, Alberdi P, et al.·Experimental & molecular medicine·
The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility t...
[Alpha-Gal in therapeutics : More relevant than thought?].
Wedi B·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
Utility of serum anti-cetuximab immunoglobulin E levels to identify patients at a high risk of severe hypersensitivity reaction to cetuximab.
Dupont B, Mariotte D, Dugué AE, et al.·British journal of clinical pharmacology·
Cetuximab is an anti-epidermal growth factor receptor antibody used for the treatment of metastatic colorectal cancer and head and neck cancer. Hypersensitivity reactions (HSRs) are associated with ce...
Inhibition of cyclodextrins on α-galactosidase.
Yao D, Zhu Z, Cai H, et al.·Food chemistry·
This work successfully investigated the effects of different influential factors and hydrophobic cavities of cyclodextrins (CDs) on α-galactosidase (α-Gal) by detecting α-Gal activity. The highest inh...
The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy.
Kollmann D, Nagl B, Ebner C, et al.·Allergy·
IgG to galactose-α-1,3-galactose (α-gal) are highly abundant natural antibodies (Ab) in humans. α-Gal-specific IgE Ab cause a special form of meat allergy characterized by severe systemic reactions 3-...
What's eating you? lone star tick (Amblyomma americanum).
Reynolds HH, Elston DM·Cutis·
, also known as the lone star tick, is found in much of the eastern United States. Since the mid-20th century, the lone star tick has been implicated in human disease. Today, remains an important vec...
Food allergy to the carbohydrate galactose-alpha-1,3-galactose (alpha-gal): four case reports and a review.
Bircher AJ, Hofmeier KS, Link S, et al.·European journal of dermatology : EJD·
Until recently, food allergies to mammalian meats have been considered to be very rare. The observation that patients not previously exposed to the monoclonal chimeric antibody cetuximab suffered from...
Decellularization and Characterization of Porcine Superflexor Tendon: A Potential Anterior Cruciate Ligament Replacement.
Jones G, Herbert A, Berry H, et al.·Tissue engineering. Part A·
The porcine superflexor tendon (SFT) was identified as having appropriate structure and properties for development of a decellularized device for use in anterior cruciate ligament reconstruction. SFTs...
Unraveling the target genes of RIN transcription factor during tomato fruit ripening and softening.
Li L, Wang X, Zhang X, et al.·Journal of the science of food and agriculture·
The RIN transcription factor is one of the MADS box family members and predominantly controls fruit ripening. In this study, effort was made to demonstrate the regulation network of RIN transcription...
Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor.
Gagarinov IA, Li T, Toraño JS, et al.·Journal of the American Chemical Society·
Progress in glycoscience is hampered by a lack of well-defined complex oligosaccharide standards that are needed to fabricate the next generation of microarrays, to develop analytical protocols to det...
Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity?
Wilson JM, Schuyler AJ, Schroeder N, et al.·Current allergy and asthma reports·
Galactose-α-1,3-galactose (α-gal) is a carbohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the 'alpha-gal syndrome,' hig...
Genes Required for Bacillus anthracis Secondary Cell Wall Polysaccharide Synthesis.
Oh SY, Lunderberg JM, Chateau A, et al.·Journal of bacteriology·
The secondary cell wall polysaccharide (SCWP) is thought to be essential for vegetative growth and surface (S)-layer assembly in Bacillus anthracis; however, the genetic determinants for the assembly...
IgE reactivity to α-Gal in relation to Lyme borreliosis.
Tjernberg I, Hamsten C, Apostolovic D, et al.·PloS one·
An association between tick bites, the development of immunoglobulin E (IgE) antibodies to galactose-α-1, 3-galactose (α-Gal) and red meat allergy has recently been reported. Here we wanted to elucida...
[The alpha-gal syndrome: an allergic reaction to mammalian meat secondary to a tick bite].
Berends AMA, Oude Elberink JN·Nederlands tijdschrift voor geneeskunde·
Here we present the case of a 68-year-old patient with alpha-gal syndrome. This is a delayed-onset allergic reaction, characteristically occurring 2-6 hours after ingestion of mammalian meat products....
Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies.
Kralickova P, Kuhnova J, Soucek O, et al.·Journal of immunology research·
Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galact...
Immunity to α-Gal: The Opportunity for Malaria and Tuberculosis Control.
Cabezas-Cruz A, de la Fuente J·Frontiers in immunology·
View on PubMed →Bovine Amniotic Fluid: A New and Occupational Source of Galactose-α-1,3-Galactose.
Nuñez-Orjales R, Martin-Lazaro J, Lopez-Freire S, et al.·Journal of investigational allergology & clinical immunology·
Structural and immunochemical relatedness suggests a conserved pathogenicity motif for secondary cell wall polysaccharides in Bacillus anthracis and infection-associated Bacillus cereus.
Kamal N, Ganguly J, Saile E, et al.·PloS one·
Bacillus anthracis (Ba) and human infection-associated Bacillus cereus (Bc) strains Bc G9241 and Bc 03BB87 have secondary cell wall polysaccharides (SCWPs) comprising an aminoglycosyl trisaccharide re...
Development and characterisation of a low-concentration sodium dodecyl sulphate decellularised porcine dermis.
Helliwell JA, Thomas DS, Papathanasiou V, et al.·Journal of tissue engineering·
The aim of this study was to adapt a proprietary decellularisation process for human dermis for use with porcine skin. Porcine skin was subject to: sodium chloride (1 M) to detach the epidermis, tryps...
View on PubMed →Rare drug allergies: Review on prevalence and test procedures.
Treudler R, Simon JC·Allergologie select·
This paper gives a review on rare hypersensitivity reactions (including allergies) to drugs. Pathogenesis, allergy tests and possible therapeutic options are discussed by presenting examples out of th...
View on PubMed →First-dose anaphylaxis to infliximab: a case of mammalian meat allergy.
Chitnavis M, Stein DJ, Commins S, et al.·The journal of allergy and clinical immunology. In practice·
Current Knowledge and Management of Hypersensitivity Reactions to Monoclonal Antibodies.
Picard M, Galvão VR·The journal of allergy and clinical immunology. In practice·
Hypersensitivity reactions (HSRs) to monoclonal antibodies (mAbs) are increasingly frequent as this class of therapeutic agents is rapidly expanding. Immediate and nonimmediate HSRs have been reported...
Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins.
Xia L, Schrump DS, Gildersleeve JC·Cell chemical biology·
Whole-cell cancer vaccines are a promising strategy for treating cancer, but the characteristics of a favorable immune response are not fully understood. New insights could enable development of bette...
View on PubMed →Virus-like Particle Display of the α-Gal Epitope for the Diagnostic Assessment of Chagas Disease.
Brito CR, McKay CS, Azevedo MA, et al.·ACS infectious diseases·
The α-Gal antigen [Galα(1,3)Galβ(1,4)GlcNAcα] is an immunodominant epitope displayed by infective trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas disease. A virus-like particl...
Effect of linkage on the location of reducing and nonreducing sugars bound to jacalin.
Abhinav KV, Sharma K, Surolia A, et al.·IUBMB life·
The crystal structures of jacalin complexed with Gal α-(1,4) Gal and Gal α-(1,3) Gal β-(1,4) Gal have been determined with the primary objective of exploring the effect of linkage on the location of r...
Low rate of cetuximab hypersensitivity reactions in Northeast Tennessee: An Appalachian effect?
Adams CB, Street DS, Crass M, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Cetuximab is a monoclonal antibody with a known risk of hypersensitivity reactions. Early studies showed hypersensitivity reaction rates of 3%, but there appears to be a higher incidence in the southe...
Cross-reactivity to fish and chicken meat - a new clinical syndrome.
Kuehn A, Codreanu-Morel F, Lehners-Weber C, et al.·Allergy·
Fish is one of the most allergenic foods. While clinical cross-reactivity among different fishes is a widely accepted feature of fish allergy, associations with other food allergies are not well under...
Hypersensitivity reaction caused by folinic acid administration: a case report and literature review.
Florit-Sureda M, Conde-Estévez D, Vidal J, et al.·Journal of chemotherapy (Florence, Italy)·
5-Fluorouracil (5-FU) is combined with folinic acid (FA) for enhancing its cytotoxic effects in the colon cancer chemotherapy treatment. Folinic acid has rarely been involved in hypersensitivity react...
Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes.
Wu Z, Liu Y, Ma C, et al.·Organic & biomolecular chemistry·
Glycans play diverse roles in a wide range of biological processes. Research on glycan-binding events is essential for learning their biological and pathological functions. However, the functions of t...
Clinical characteristics of adverse events associated with therapeutic monoclonal antibodies in Korea.
Sim DW, Park KH, Park HJ, et al.·Pharmacoepidemiology and drug safety·
The use of monoclonal antibodies (mAbs) is increasing in various clinical fields. Although mAb safety must be demonstrated prior to approval, targeted pharmacovigilance is essential for the recognitio...
Rare Cause of Facial Palsy: Case Report of Tick Paralysis by Ixodes Holocyclus Imported by a Patient Travelling into Singapore from Australia.
Pek CH, Cheong CS, Yap YL, et al.·The Journal of emergency medicine·
Ticks are blood-sucking arachnids that feed on all classes of vertebrates, including humans. Ixodes holocyclus, also known as the Australian Paralysis Tick, is capable of causing a myriad of clinical...
Acne during adolescence did not predict skin rash reaction to cetuximab.
Bar-Sela G, Avgush S, Kaidar-Person O, et al.·Anti-cancer drugs·
Cetuximab, a monoclonal antibody, is a part of the treatment for metastatic colorectal cancer. The most common side effect of cetuximab is skin rash, which has a similar distribution to acne vulgaris...
Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge.
Steinke JW, Pochan SL, James HR, et al.·The Journal of allergy and clinical immunology·
Determination of metabolic changes that occur following the development of and after red meat challenge in alpha-gal allergic individuals will aid in biomarkers for patient identification and targeted...
Synthesis, self-assembly, and immunological activity of α-galactose-functionalized dendron-lipid amphiphiles.
Trant JF, Jain N, Mazzuca DM, et al.·Nanoscale·
Nanoassemblies presenting multivalent displays of biologically active carbohydrates are of significant interest for a wide array of biomedical applications ranging from drug delivery to immunotherapy....
Recombinant Mucin-Type Fusion Proteins with a Galα1,3Gal Substitution as Clostridium difficile Toxin A Inhibitors.
Cherian RM, Jin C, Liu J, et al.·Infection and immunity·
The capability of a recombinant mucin-like fusion protein, P-selectin glycoprotein ligand-1/mouse IgG2b (PSGL-1/mIgG2b), carrying Galα1,3Galβ1,4GlcNAc determinants to bind and inhibit Clostridium diff...
Antibody complement-mediated hemolytic studies with kodecytes reveal that human complement utilized in the classical pathway is more stable than generally accepted.
Perry H, Bovin N, Henry S·Transfusion·
Complement has significant status in the field of transfusion medicine. The accepted stability profile of complement is based on historical studies of diluted human serum hemolyzing rabbit heterophile...
The CD25-binding antibody Daclizumab High-Yield Process has a distinct glycosylation pattern and reduced antibody-dependent cell-mediated cytotoxicity in comparison to Zenapax®.
Ganguly B, Balasa B, Efros L, et al.·mAbs·
The CD25-binding antibody daclizumab high-yield process (DAC HYP) is an interleukin (IL)-2 signal modulating antibody that shares primary amino acid sequence and CD25 binding affinity with Zenapax®, a...
Top Ten Facts You Should Know about "Alpha-gal, the Newly Described Delayed Red Meat Allergy.
Ramey K, Stewart PH·Journal of the Mississippi State Medical Association·
Invited Commentary: Alpha-Gal Allergy: Tip of the Iceberg to a Pivotal Immune Response.
Commins SP·Current allergy and asthma reports·
The syndrome of delayed allergic reactions to the carbohydrate galactose-alpha-1,3-galactose ("alpha-gal") has become increasingly recognized in allergy and immunology clinics regionally throughout th...
Anti EGFR therapy in the treatment of non-metastatic head and neck squamous cell carcinoma: The current evidence.
Benson R, Mallick S, Julka PK, et al.·Journal of the Egyptian National Cancer Institute·
Head and neck squamous cell carcinoma (HNSCC) accounts for a large oncologic burden in the developing countries. In patients with locally advanced head and neck cancer multimodality treatment is warra...
Impact of oral consumption of heat-treated Bacteroides xylanisolvens DSM 23964 on the level of natural TFα-specific antibodies in human adults.
Ulsemer P, Toutounian K, Kressel G, et al.·Beneficial microbes·
It is now generally accepted that the human body exists in close synergy with the gut microbiome and that this cross-talk plays an essential role in human health and disease. One facet from the many i...
Control of vector-borne infectious diseases by human immunity against α-Gal.
Cabezas Cruz A, Valdés JJ, de la Fuente J·Expert review of vaccines·
High rate of galactose-alpha-1,3-galactose sensitization in both eosinophilic esophagitis and patients undergoing upper endoscopy.
Burk CM, Beitia R, Lund PK, et al.·Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·
Eosinophilic esophagitis (EoE) is an antigen/allergy-mediated chronic inflammatory condition. The rapid rise in the number of cases of EoE suggests an as-yet undiscovered environmental trigger. This s...
Premature Bioprosthetic Aortic Valve Degeneration Associated with Allergy to Galactose-Alpha-1,3-Galactose.
Hawkins RB, Frischtak HL, Kron IL, et al.·Journal of cardiac surgery·
We present the cases of two patients with bioprosthetic aortic valves who developed an allergy to alpha-gal. Each had premature degeneration of their bioprosthesis and demonstrated rapidly increasing...
Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study.
Chakraborty S, Filippi CG, Wong T, et al.·Journal of neuro-oncology·
Objective To establish a maximum tolerated dose of superselective intraarterial cerebral infusion (SIACI) of Cetuximab after osmotic disruption of the blood-brain barrier (BBB) with mannitol, and exam...
IgE in the diagnosis and treatment of allergic disease.
Platts-Mills TAE, Schuyler AJ, Erwin EA, et al.·The Journal of allergy and clinical immunology·
Traditionally, the concept of allergy implied an abnormal response to an otherwise benign agent (eg, pollen or food), with an easily identifiable relationship between exposure and disease. However, th...
Using the galactose-α-1,3-galactose enzyme-linked immunosorbent assay to predict anaphylaxis in response to cetuximab.
Weiss J, Grilley Olson J, Deal AM, et al.·Cancer·
Cetuximab is a monoclonal antibody against epidermal growth factor receptor with activity against head and neck cancer and colorectal cancer. Anaphylaxis in response to cetuximab is a significant clin...
The safety of monoclonal antibodies for treatment of colorectal cancer.
Berger MD, Lenz HJ·Expert opinion on drug safety·
Monoclonal antibodies such as bevacizumab, ramucirumab, cetuximab and panitumumab play an important role in the treatment of metastatic colorectal cancer (mCRC). With the introduction of these drugs c...
A novel approach to predict cetuximab-induced hypersensitivity reaction: detection of drug-specific IgE on basophils.
Iwamoto T, Okamoto A, Ishinaga H, et al.·Cancer medicine·
Cetuximab is remarkable for the relatively high rate and severity of hypersensitivity reactions (HR) being reported in the literature. Screening for cetuximab-specific IgE in serum via immunoassay has...
Two galactose-α-1,3-galactose carrying peptidases from pork kidney mediate anaphylactogenic responses in delayed meat allergy.
Hilger C, Fischer J, Swiontek K, et al.·Allergy·
Serum IgE antibodies directed at galactose-α-1,3-galactose (α-Gal) are associated with a novel form of delayed anaphylaxis occurring upon consumption of red meat or innards. Pork kidney is known as th...
Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment.
Iweala OI, Burks AW·Current allergy and asthma reports·
Food allergy is defined as an IgE-mediated hypersensitivity response to ingested food with allergic symptoms ranging from urticaria to life-threatening anaphylaxis. Food allergy is thought to develop...
Amblyomma sculptum tick saliva: α-Gal identification, antibody response and possible association with red meat allergy in Brazil.
Araujo RN, Franco PF, Rodrigues H, et al.·International journal for parasitology·
The anaphylaxis response is frequently associated with food allergies, representing a significant public health hazard. Recently, exposure to tick bites and production of specific IgE against α-galact...
Haemaphysalis longicornis tick bites are a possible cause of red meat allergy in Japan.
Chinuki Y, Ishiwata K, Yamaji K, et al.·Allergy·
Recent studies revealed that Amblyomma or Ixodes tick bites may cause red meat allergy, in which galactose-α-1,3-galactose (α-Gal) is a major IgE-binding epitope. The incidence of red meat allergy is...
Chemoradiotherapy with FOLFOX plus cetuximab in locally advanced oesophageal cancer: The GERCOR phase II trial ERaFOX.
Lledo G, Huguet F, Chibaudel B, et al.·European journal of cancer (Oxford, England : 1990)·
To determine efficacy and toxicity of radiation therapy combined with oxaliplatin, 5-fluorouracil, and folinic acid (FOLFOX) and cetuximab in patients with locally advanced oesophageal cancer. Patient...
Complete Remission of Squamous Cell Carcinoma After Treatment With Panitumumab in a Patient With Cetuximab-Induced Anaphylaxis.
Marti A, Fauconneau A, Ouhabrache N, et al.·JAMA dermatology·
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose.
Bum-Erdene K, Leffler H, Nilsson UJ, et al.·Scientific reports·
Galectin-4 is a tandem-repeat galectin with two distinct carbohydrate recognition domains (CRD). Galectin-4 is expressed mainly in the alimentary tract and is proposed to function as a lipid raft and...
Uptake of Marasmius oreades agglutinin disrupts integrin-dependent cell adhesion.
Juillot S, Cott C, Madl J, et al.·Biochimica et biophysica acta·
Fruiting body lectins have been proposed to act as effector proteins in the defense of fungi against parasites and predators. The Marasmius oreades agglutinin (MOA) is a lectin from the fairy ring mus...
High prevalence of sIgE to Galactose-α-1,3-galactose in rural pre-Alps area: a cross-sectional study.
Villalta D, Pantarotto L, Da Re M, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody.
Yu C, Gao K, Zhu L, et al.·Scientific reports·
Two non-human glycan epitopes, galactose-α-1,3-galactose (α-gal) and Neu5Gc-α-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAb...
Factors Affecting Anti-Glycan IgG and IgM Repertoires in Human Serum.
Muthana SM, Gildersleeve JC·Scientific reports·
Serum anti-glycan antibodies play important roles in many immune processes and are of particular interest as biomarkers for many diseases. Changes in anti-glycan antibodies can occur with the onset of...
Delayed immediate-type hypersensitivity to red meat and innards: current insights into a novel disease entity.
Fischer J, Biedermann T·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·
The development of component-resolved diagnostics instead of whole extracts has brought about major advances in recent years. Particularly remarkable has been the identification of new disease entitie...
Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
Commins SP, Jerath MR, Cox K, et al.·Allergology international : official journal of the Japanese Society of Allergology·
IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen...
Combination of cytokine-induced killer and dendritic cells pulsed with antigenic α-1,3-galactosyl epitope-enhanced lymphoma cell membrane for effective B-cell lymphoma immunotherapy.
Qiu Y, Yun MM, Dong X, et al.·Cytotherapy·
Refractory B-cell lymphomas are difficult to successfully treat with current chemotherapeutic regimens; however, immunotherapy may be an effective form of treatment for these patients. Fourteen refrac...
Localizing Carbohydrate Binding Sites in Proteins Using Hydrogen/Deuterium Exchange Mass Spectrometry.
Zhang J, Kitova EN, Li J, et al.·Journal of the American Society for Mass Spectrometry·
The application of hydrogen/deuterium exchange mass spectrometry (HDX-MS) to localize ligand binding sites in carbohydrate-binding proteins is described. Proteins from three bacterial toxins, the B su...
The red meat allergy syndrome in Sweden.
Apostolovic D, Tran TA, Starkhammar M, et al.·Allergo journal international·
In the last decade, a novel type of food allergy presenting with severe allergic reactions several hours after consumption of red meat has been recognized. The allergic responses are due to IgE antibo...
View on PubMed →Update on the bird-egg syndrome and genuine poultry meat allergy.
Hemmer W, Klug C, Swoboda I·Allergo journal international·
Allergy to poultry meat is rare and affects both children and adults. The prevalence of poultry meat allergy is unknown, but presumably is similar to that of red meat allergy. There is no close relati...
View on PubMed →Clinical spectrum of α-Gal syndrome: from immediate-type to delayed immediate-type reactions to mammalian innards and meat.
Fischer J, Yazdi AS, Biedermann T·Allergo journal international·
The term α-Gal syndrome describes a novel IgE-mediated immediate-type allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Its classification as a syndrome is proposed on the basis of its cl...
View on PubMed →Rapid Drug Desensitization with Biologics: A Single-Center Experience with Four Biologics.
Bavbek S, Kendirlinan R, Çerçi P, et al.·International archives of allergy and immunology·
Rapid drug desensitization (RDD) induces a temporary tolerance to biologics which induce hypersensitivity reactions (HSRs). Data are limited regarding the use of RDD outside the USA. Our purpose was t...
Vaginal Capsules: An Unsuspected Probable Source of Exposure to α-Gal.
Vidal C, Méndez-Brea P, López-Freire S, et al.·Journal of investigational allergology & clinical immunology·
Coping with cross-reactive carbohydrate determinants in allergy diagnosis.
Altmann F·Allergo journal international·
A relevant proportion of allergy diagnosis is accomplished by in vitro determination of specific immunglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycoprot...
View on PubMed →Successful Desensitization to Cetuximab in a Patient With a Positive Skin Test to Cetuximab and Specific IgE to Alpha-gal.
García-Menaya JM, Cordobés-Durán C, Gómez-Ulla J, et al.·Journal of investigational allergology & clinical immunology·
On the Automatic Decellularisation of Porcine Aortae: A Repeatability Study Using a Non-Enzymatic Approach.
O'Connor Mooney R, Davis NF, Hoey D, et al.·Cells, tissues, organs·
To investigate the repeatability of automatic decellularisation of porcine aortae using a non-enzymatic approach, addressing current limitations associated with other automatic decellularisation proce...
Allergy to Red Meat: A Diagnosis Made by the Patient and Confirmed by an Assay for IgE Antibodies Specific for Alpha-1,3-Galactose.
Kaloga M, Kourouma S, Kouassi YI, et al.·Case reports in dermatology·
We report the first case of allergy to red meat observed in Ivory Coast. A 49-year-old male presented with pruritus. The diagnosis of allergy to red meat was confirmed by an assay for IgE antibodies s...
View on PubMed →α-Gal-a new clue for anaphylaxis in mastocytosis.
Roenneberg S, Böhner A, Brockow K, et al.·The journal of allergy and clinical immunology. In practice·
Phase I study of cetuximab in combination with 5-fluorouracil, mitomycin C and radiotherapy in patients with locally advanced anal cancer.
Leon O, Guren MG, Radu C, et al.·European journal of cancer (Oxford, England : 1990)·
5-fluorouracil (5FU) and mitomycin C (MMC)-based chemoradiotherapy (CRT) is standard treatment for anal squamous cell carcinoma. In this phase I study cetuximab was added and the primary aim was to de...
The common food additive carrageenan and the alpha-gal epitope.
Tobacman JK·The Journal of allergy and clinical immunology·
Echocardiographic evaluation of pre-diagnostic development in young relatives genetically predisposed to hypertrophic cardiomyopathy.
Jensen MK, Havndrup O, Christiansen M, et al.·The international journal of cardiovascular imaging·
Identification of the first echocardiographic manifestations of hypertrophic cardiomyopathy may be important for clinical management and our understanding of the pathogenesis. We studied the developme...
Red meat allergic patients have a selective IgE response to the α-Gal glycan.
Apostolovic D, Tran TA, Sánchez-Vidaurre S, et al.·Allergy·
Galactose-α-1,3-galactose (α-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against α-Gal report severe allergic symptoms 3-6 h after consumption...
Fifty-six-year-old man with anaphylaxis: A novel delayed food hypersensitivity reaction.
Wagner KD, Bell MC, Pesek RD, et al.·The Journal of the Arkansas Medical Society·
Anaphylaxis and urticaria are commonly seen in both primary care and allergy clinics. Foods, drugs, and insects are frequent culprits for immediate reactions; however, the trigger for recurring and/or...
Delayed red meat allergy: clinical ramifications of galactose-α-1,3-galactose sensitization.
Stewart PH, McMullan KL, LeBlanc SB·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Regulation of the Immune Response to α-Gal and Vector-borne Diseases.
Cabezas-Cruz A, Mateos-Hernández L, Pérez-Cruz M, et al.·Trends in parasitology·
Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE...
Alpha-gal anaphylaxis: the first case report in Italy.
Calamari AM, Poppa M, Villalta D, et al.·European annals of allergy and clinical immunology·
We report the case of a 55-year-old man who went into anaphylactic shock six hours after eating a meal containing meat. He reported having had several tick bites in months before the reaction. The ser...
Chemical Synthesis of a Glycopeptide Derived from Skp1 for Probing Protein Specific Glycosylation.
Chinoy ZS, Schafer CM, West CM, et al.·Chemistry (Weinheim an der Bergstrasse, Germany)·
Skp1 is a cytoplasmic and nuclear protein, best known as an adaptor of the SCF family of E3-ubiquitin ligases that label proteins for their degradation. Skp1 in Dictyostelium is posttranslationally mo...
Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein.
McCue J, Kshirsagar R, Selvitelli K, et al.·Biologicals : journal of the International Association of Biological Standardization·
Recombinant factor VIII Fc fusion protein (rFVIIIFc) is a long-acting coagulation factor approved for the treatment of hemophilia A. Here, the rFVIIIFc manufacturing process and results of studies eva...
Re: development of a next-generation tissue valve using a glutaraldehyde-fixed porcine aortic valve treated with decellularization, α-galactosidase, space filler, organic solvent and detoxification.
Parolari A, Songia P, Myasoedova V, et al.·European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·
[Assessment Method of Remnant α-1, 3-galactosyle Epitopes in Animal Tissue-derived Biomaterials].
Shan Y, Xu L, Ke L, et al.·Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi·
The aim of this study was to establish an assessment method for determining α-Gal (α-1, 3-galactosyle) epitopes contained in animal tissue or animal tissue-derived biological materials with ELISA inhi...
Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer.
Kristian SA, Hwang JH, Hall B, et al.·Journal of molecular medicine (Berlin, Germany)·
The ever-increasing threat of multi-drug resistant bacterial infections has spurred renewed interest in alternative approaches to classical antibiotic therapy. In contrast to other mammals, humans do...
Tissue-engineered mitral valve: morphology and biomechanics †.
Iablonskii P, Cebotari S, Tudorache I, et al.·Interactive cardiovascular and thoracic surgery·
The present study aimed at developing tissue-engineered mitral valves based on cell-free ovine mitral allografts. The ovine mitral valves (OMVs) (n = 46) were harvested in the local slaughter house. T...
Development of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen.
Jiang ZM, Luo W, Wen Q, et al.·Journal of translational medicine·
The invariant natural killer T (iNKT) cell has been shown to play a central role in early stages immune responses against Mycobacterium tuberculosis (Mtb) infection, which become nonresponsive (anergi...
Anaphylaxis to the carbohydrate side chain alpha-gal.
Platts-Mills TA, Schuyler AJ, Tripathi A, et al.·Immunology and allergy clinics of North America·
In 2007, the monoclonal antibody cetuximab caused severe hypersensitivity reactions during the first infusion in a region of the southeastern United States. Investigation of pretreatment sera establis...
Construction of a shuttle vector based on the small cryptic plasmid pJY33 from Weissella cibaria 33.
Park JY, Jeong SJ, Sa HD, et al.·Plasmid·
A cryptic plasmid, pJY33, from Weissella cibaria 33 was characterized. pJY33 was 2365 bp in size with a GC content of 41.27% and contained two putative open reading frames (ORFs). orf1 encoded a putat...
A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer.
Chen JS, Hsu C, Chiang NJ, et al.·Annals of oncology : official journal of the European Society for Medical Oncology·
Previous clinical trials have not proved that adding epidermal growth factor receptor inhibitors to chemotherapy confers a survival benefit for patients with advanced biliary tract cancer (ABTC). Whet...
Hypersensitivity and tumor lysis syndrome associated with cetuximab treatment: should we be afraid?
Cihan S, Atasoy A, Yildirim Y, et al.·Tumori·
The majority of the chemotherapy agents in use today cause various infusion reactions, from mild flushing to life-threatening events. The frequency of the reported hypersensitivity reactions induced b...
Delayed Anaphylaxis Involving IgE to Galactose-alpha-1,3-galactose.
Platts-Mills TA, Schuyler AJ, Hoyt AE, et al.·Current allergy and asthma reports·
Hypersensitivity in the allergic setting refers to immune reactions, stimulated by soluble antigens that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. As the numb...
Diagnostic and experimental food challenges in patients with nonimmediate reactions to food.
Tripathi A, Commins SP, Heymann PW, et al.·The Journal of allergy and clinical immunology·
Safe administration of a gelatin-containing vaccine in an adult with galactose-α-1,3-galactose allergy.
Pinson ML, Waibel KH·Vaccine·
Immunoglobulin (Ig) E antibodies to galactose-α-1,3-galactose (α-Gal) are associated with delayed anaphylaxis to mammalian food products and gelatin-based foods (Commins et al., J Allergy Clin Immunol...
The alpha-gal story: lessons learned from connecting the dots.
Steinke JW, Platts-Mills TA, Commins SP·The Journal of allergy and clinical immunology·
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal, and therefore establishing its cause is pivotal to long-term risk management. Our recent work has identified a nove...
Anti-Gal IgM, IgA and IgG natural antibodies in childhood.
Hamanova M, Chmelikova M, Nentwich I, et al.·Immunology letters·
The target for the most abundant xenoreactive natural antibodies in humans is the α-Gal epitope. Anti-Gal could provide natural immune defense against pathogens that express the α-Gal epitope. Anti-Ga...
Allergy to furry animals: New insights, diagnostic approaches, and challenges.
Konradsen JR, Fujisawa T, van Hage M, et al.·The Journal of allergy and clinical immunology·
The prevalence of allergy to furry animals has been increasing, and allergy to cats, dogs, or both is considered a major risk factor for the development of asthma and rhinitis. An important step forwa...
Autoactivation of pancreatic trypsinogen is controlled by carbohydrate-specific interaction.
Ogawa H, Kusumi I, Ogata A, et al.·FEBS letters·
Activation of bovine pancreatic trypsinogen (BPTG) by trypsin (BPT) was found to be inhibited by d GalN/GalNAc at pH 5.5, the pH of secretory granules in the pancreas. Binding studies with biotinylate...
Pathogenesis, newly recognized etiologies, and management of idiopathic anaphylaxis.
Kuhlen JL, Virkud YV·Discovery medicine·
Idiopathic anaphylaxis (IA) is a life-threatening allergic disease and the most common diagnosis given to patients following an anaphylactic event. The inability of the healthcare provider and the pat...
Tick bite-related meat allergy as a cause of chronic urticaria, angioedema, and anaphylaxis in endemic areas.
Ghahramani GK, Temprano J·International journal of dermatology·
[Delayed anaphylaxis after ingestion of meat. Carbohydrate epitope galactose-α-1,3-galactose as cause of severe anaphylactic reactions].
Soemantri SP, Höxtermann S, Holz-Larose R, et al.·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
The correlation between anaphylaxis after consumption of meat and the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) was first described in oncologic patients treated with cetuximab. An associ...
Delayed Anaphylaxis to Red Meat Associated With Specific IgE Antibodies to Galactose.
Wen L, Zhou J, Yin J, et al.·Allergy, asthma & immunology research·
A novel delayed anaphylactic reaction to red meat, associated with tick bites and IgE antibodies against galactose-α-1, 3-galactose (α-gal), was reported in 2009 in the US, Australia and Europe. In th...
View on PubMed →Carbohydrates as food allergens.
Soh JY, Huang CH, Lee BW·Asia Pacific allergy·
The literature supports the notion that carbohydrate epitopes, on their own, do not contribute significantly to the induction of allergic reactions. They bind weakly to IgE antibodies and have been te...
View on PubMed →Tick-induced allergies: mammalian meat allergy, tick anaphylaxis and their significance.
van Nunen S·Asia Pacific allergy·
Serious tick-induced allergies comprise mammalian meat allergy following tick bites and tick anaphylaxis. Mammalian meat allergy is an emergent allergy, increasingly prevalent in tick-endemic areas of...
View on PubMed →Biomechanical properties of hybrid heart valve prosthesis utilizing the pigs that do not express the galactose-α-1,3-galactose (α-Gal) antigen derived tissue and tissue engineering technique.
Wilczek P, Lesiak A, Niemiec-Cyganek A, et al.·Journal of materials science. Materials in medicine·
The aim of the study was to estimate the biomechanical properties of heart valves conduit derived from transgenic pigs to determine the usefulness for the preparation of tissue-engineered heart valves...
Carbohydrates as allergens.
Commins SP·Current allergy and asthma reports·
Complex carbohydrates are effective inducers of Th2 responses, and carbohydrate antigens can stimulate the production of glycan-specific antibodies. In instances where the antigen exposure occurs thro...
A combination of targeted toxin technology and the piggyBac-mediated gene transfer system enables efficient isolation of stable transfectants in nonhuman mammalian cells.
Sato M, Inada E, Saitoh I, et al.·Biotechnology journal·
Isolation of cells harboring exogenous DNA is typically achieved by the introduction of plasmids, but its efficiency remains still low. In this study, we developed a novel strategy to obtain stable tr...
A retrospective analysis of cross-reacting cetuximab IgE antibody and its association with severe infusion reactions.
Maier S, Chung CH, Morse M, et al.·Cancer medicine·
Severe infusion reactions (SIRs) at rates of 5% or less are known side effects of biological agents, including mAbs such as cetuximab. There are currently no prospectively validated risk factors to ai...
Mammalian meat allergy: a diagnostic challenge.
Biedermann T, Fischer J, Yazdi A·Allergo journal international·
View on PubMed →Vesicles from different Trypanosoma cruzi strains trigger differential innate and chronic immune responses.
Nogueira PM, Ribeiro K, Silveira AC, et al.·Journal of extracellular vesicles·
Trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas Disease, shed extracellular vesicles (EVs) enriched with glycoproteins of the gp85/trans-sialidase (TS) superfamily and other α...
View on PubMed →Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria.
Maurer M, Church MK, Metz M, et al.·International archives of allergy and immunology·
Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic reactions including urticaria, gastrointestinal symptoms or anaphylaxis....
Panitumumab: A safe option for oncologic patients sensitized to galactose-α-1,3-galactose.
Caponetto P, Biedermann T, Yazdi AS, et al.·The journal of allergy and clinical immunology. In practice·
Allergic hypersensitivity to red meat induced by tick bites: a French case report.
Guillier A, Fauconneau A, De Barruel F, et al.·European journal of dermatology : EJD·
Exercise-induced anaphylaxis after consumption of red meat in a patient with IgE antibodies specific for galactose-alpha-1,3-galactose.
Knight ME, Wyatt K, James HC·The journal of allergy and clinical immunology. In practice·
Anaphylaxis to medications containing meat byproducts in an alpha-gal sensitized individual.
Muglia C, Kar I, Gong M, et al.·The journal of allergy and clinical immunology. In practice·
IgE reactivity to carbohydrate moieties of glycoproteins in wheat allergy.
Song TW, Hong JY, Lee KE, et al.·Allergy and asthma proceedings·
Carbohydrate moieties of different glycoproteins, such as cross-reactive carbohydrate determinants (CCDs) and galactose α-1,3-galactose, can induce IgE reactivity with varied clinical significance. In...
Hypersensitivity to biological agents-updated diagnosis, management, and treatment.
Galvão VR, Castells MC·The journal of allergy and clinical immunology. In practice·
Biological agents are used in the treatment of neoplastic, autoimmune, and inflammatory diseases and their clinical applications are becoming broader. Following their increased utilization, hypersensi...
Gut microbiota elicits a protective immune response against malaria transmission.
Yilmaz B, Portugal S, Tran TM, et al.·Cell·
Glycosylation processes are under high natural selection pressure, presumably because these can modulate resistance to infection. Here, we asked whether inactivation of the UDP-galactose:β-galactoside...
Detection of high levels of anti-α-galactosyl antibodies in sera of patients with Old World cutaneous leishmaniasis: a possible tool for diagnosis and biomarker for cure in an elimination setting.
Al-Salem WS, Ferreira DM, Dyer NA, et al.·Parasitology·
In the Kingdom of Saudi Arabia (KSA), Old World cutaneous leishmaniasis (CL) is mainly caused by Leishmania major and Leishmania tropica parasites. Diagnosis of CL is predominately made by clinicians,...
The choice of mammalian cell host and possibilities for glycosylation engineering.
Butler M, Spearman M·Current opinion in biotechnology·
Non-human mammalian cells such as CHO have been used predominantly for the production of biopharmaceuticals including monoclonal antibodies (Mabs). Although the glycosylation profile of these products...
Incidence of cetuximab-related infusion reactions in oncology patients treated at the University of North Carolina Cancer Hospital.
Keating K, Walko C, Stephenson B, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
The primary purpose of this study was to determine the rate of infusion reactions to cetuximab in oncology patients treated at the University of North Carolina Cancer Hospital. Secondarily, we sought...
High-affinity carbohydrate binding by trimeric benzoboroxoles measured on carbohydrate arrays.
Claes D, Memmel E, Holzapfel M, et al.·Chembiochem : a European journal of chemical biology·
Carbohydrates are involved in a wide range of biological processes of pharmaceutical relevance. The selective recognition of carbohydrates is therefore of great interest in biology and medicine. In th...
Risk factors associated with hypersensitivity reactions to cetuximab: anti-cetuximab IgE detection as screening test.
Dupont B, Mariotte D, Clarisse B, et al.·Future oncology (London, England)·
To describe the factors associated with a high risk of a hypersensitivity reaction to cetuximab. We retrospectively studied a cohort of patients living in Normandy (France) treated with cetuximab. Amo...
Anaphylaxis to succinylated gelatin in a patient with a meat allergy: galactose-α(1, 3)-galactose (α-gal) as antigenic determinant.
Uyttebroek A, Sabato V, Bridts CH, et al.·Journal of clinical anesthesia·
Specific immunoglobulin E (sIgE) antibodies towards the galactose-α(1,3)-galactose (α-gal) moieties may elicit life-threatening and fatal anaphylactic reactions. Patients sensitized to α-gal moieties...
Function characterization of a glyco-engineered anti-EGFR monoclonal antibody cetuximab in vitro.
Yi CH, Ruan CP, Wang H, et al.·Acta pharmacologica Sinica·
To evaluate the biochemical features and activities of a glyco-engineered form of the anti-human epidermal growth factor receptor monoclonal antibody (EGFR mAb) cetuximab in vitro. The genes encoding...
Development and characterization of acellular porcine pulmonary valve scaffolds for tissue engineering.
Luo J, Korossis SA, Wilshaw SP, et al.·Tissue engineering. Part A·
Currently available replacement heart valves all have limitations. This study aimed to produce and characterize an acellular, biocompatible porcine pulmonary root conduit for reconstruction of the rig...
Immunoproteomics of processed beef proteins reveal novel galactose-α-1,3-galactose-containing allergens.
Apostolovic D, Tran TA, Hamsten C, et al.·Allergy·
Red meat allergy presents a novel form of food allergy with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate α-Gal epitope. Food preparation and processing...
Galactose-alpha-1,3-galactose sensitization is a prerequisite for pork-kidney allergy and cofactor-related mammalian meat anaphylaxis.
Fischer J, Hebsaker J, Caponetto P, et al.·The Journal of allergy and clinical immunology·
Risk factors for and pre-medications to prevent cetuximab-induced infusion reactions in patients with squamous cell carcinoma of the head and neck.
Touma W, Koro SS, Ley J, et al.·Oral oncology·
Cetuximab, a chimeric monoclonal antibody, is the only targeted therapy approved for squamous cell carcinoma of the head and neck (SCCHN). Infusion reactions (IRs) occur in 6-18% of patients pre-medic...
Genogroup IV and VI canine noroviruses interact with histo-blood group antigens.
Caddy S, Breiman A, le Pendu J, et al.·Journal of virology·
Human noroviruses (HuNV) are a significant cause of viral gastroenteritis in humans worldwide. HuNV attaches to cell surface carbohydrate structures known as histo-blood group antigens (HBGAs) prior t...
Screening of hepatocyte proteins binding with C‑terminally truncated surface antigen middle protein of hepatitis B virus (MHBst167) by a yeast two‑hybrid system.
Li ZQ, Linghu E, Jun W, et al.·Molecular medicine reports·
The function of middle hepatitis B surface protein C‑terminally truncated at amino acid position 167 (MHBst167) is not currently clear. This study aimed to screen and identify the proteins that intera...
A randomized phase 2 trial of gemcitabine/cisplatin with or without cetuximab in patients with advanced urothelial carcinoma.
Hussain M, Daignault S, Agarwal N, et al.·Cancer·
Epidermal growth factor receptor overexpression is associated with poor outcomes in urothelial carcinoma (UC). Cetuximab (CTX) exhibited an antitumor effect in in vivo UC models. The efficacy of gemci...
[IgE-induced anaphylactic reaction after eating lamb meat].
Johansen KL, Rasmussen K·Ugeskrift for laeger·
This article presents the case of a 54-year-old male, who was admitted to hospital after suffering a severe anaphylactic reaction after tasting a spoonful of chili con carne and four months later afte...
IgE antibodies specific to alpha-gal: an example of clinically relevant cross-reactive anti-carbohydrate antibodies.
Rispens T·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
Phytase properties and locations in tissues of transgenic pigs secreting phytase in the saliva.
Forsberg CW, Meidinger RG, Murray D, et al.·Journal of animal science·
A transgenic Cassie (CA) line of Yorkshire (YK) pigs was developed using a transgene composed of the mouse parotid secretory protein promoter linked to the Escherichia coli phytase gene integrated in...
IgE antibodies to alpha-gal in the general adult population: relationship with tick bites, atopy, and cat ownership.
Gonzalez-Quintela A, Dam Laursen AS, Vidal C, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
The carbohydrate alpha-gal epitope is present in many animal proteins, including those of red meat and animal immunoglobulins, such as cat IgA. Systemic anaphylaxis to the alpha-gal epitope has recent...
Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells.
Sheridan RT, Hudon J, Hank JA, et al.·Chembiochem : a European journal of chemical biology·
Immunotherapy is a promising strategy for targeting tumors. One emerging approach is to harness the immune effector functions of natural antibodies to destroy tumor cells. Dinitrophenyl (DNP) and the...
Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose.
Commins SP, James HR, Stevens W, et al.·The Journal of allergy and clinical immunology·
In 2009, we reported a novel form of delayed anaphylaxis to red meat related to serum IgE antibodies to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Although patients were remarkably...
Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.
Haji-Ghassemi O, Müller-Loennies S, Saldova R, et al.·The Journal of biological chemistry·
The structure of the antigen binding fragment of mAb S25-26, determined to 1.95 Å resolution in complex with the Chlamydiaceae family-specific trisaccharide antigen Kdo(2→8)Kdo(2→4)Kdo (Kdo = 3-deoxy-...
CD1d expressed in mast cell surface enhances IgE production in B cells by up-regulating CD40L expression and mediator release in allergic asthma in mice.
Hong GU, Kim NG, Kim TJ, et al.·Cellular signalling·
Mast cells play important roles via FcεRI-mediated activation in allergic asthma. A nonpolymorphic MHC I-like molecule CD1d, which is mainly expressed in APCs, presents glycolipid Ag to iTCR on iNKT c...
Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)- and ErbB family-targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC).
Cohen RB·Cancer treatment reviews·
Overexpression of the epidermal growth factor receptor (EGFR) is a common characteristic of head and neck squamous cell carcinomas (HNSCC). Cetuximab is a chimeric anti-EGFR monoclonal antibody (mAb)...
Novel human renal proximal tubular cell line for the production of complex proteins.
Fliedl L, Manhart G, Kast F, et al.·Journal of biotechnology·
Human host cell lines for the production of biopharmaceutical proteins are of interest due to differences in the glycosylation patterns of human and animal cell lines. Specifically, sialylation, which...
A case of tick-bite-induced red meat allergy.
Wuerdeman MF, Harrison JM·Military medicine·
Delayed hypersensitivity disorders and food allergies are often challenging for the clinician and patient alike. A recent discovery of an IgE antibody specific to galactose-α-1,3-galactose, which is a...
Structure analysis of a bioactive heteropolysaccharide from Schisandra chinensis (Turcz.) Baill.
Zhao T, Mao G, Zhang M, et al.·Carbohydrate polymers·
Our previous study revealed that Schisandra polysaccharide (SCPP11) exerted excellent antitumor and immunomodulatory activities. In this investigation, the structure of SCPP11 was elucidated. The resu...
Characterization and site-directed mutagenesis of an α-galactosidase from the deep-sea bacterium Bacillus megaterium.
Xu H, Qin Y, Huang Z, et al.·Enzyme and microbial technology·
A novel gene (BmelA) (1323bp) encoding an α-galactosidase of 440 amino acids was cloned from the deep-sea bacterium Bacillus megaterium and the protein was expressed in Escherichia coli BL21 (DE3) wit...
Structural documentation of glycan epitopes: sequential mass spectrometry and spectral matching.
Ashline DJ, Hanneman AJ, Zhang H, et al.·Journal of the American Society for Mass Spectrometry·
Documenting mass spectral data is a fundamental aspect of accepted protocols. In this report, we contrast MS(n) sequential disassembly spectra obtained from natural and synthetic glycan epitopes. The...
Skin prick test and basophil reactivity to cetuximab in patients with IgE to alpha-gal and allergy to red meat.
Michel S, Scherer K, Heijnen IA, et al.·Allergy·
Severe hypersensitivity reactions to red meat with delay of several hours in patients with IgE to alpha-gal (galactose-alpha-1,3-galactose) have been reported. The diagnosis of meat allergy is difficu...
Characterization of α-galacto-oligosaccharides formed via heterologous expression of α-galactosidases from Lactobacillus reuteri in Lactococcus lactis.
Wang Y, Black BA, Curtis JM, et al.·Applied microbiology and biotechnology·
α-Galacto-oligosaccharides (α-GOS) are produced by transgalactosylation reactions of α-galactosidase (α-Gal) or by conversion of raffinose family oligosaccharides by levansucrase. Similarly to β-GOS,...
Dermatologic toxicities to targeted cancer therapy: shared clinical and histologic adverse skin reactions.
Curry JL, Torres-Cabala CA, Kim KB, et al.·International journal of dermatology·
Dermatologic toxicities (DT) to targeted cancer therapy may present as inflammatory dermatoses, keratoses, and as benign and malignant squamous proliferations. Published reports of DT with cancer ther...
Drug allergens and food--the cetuximab and galactose-α-1,3-galactose story.
Berg EA, Platts-Mills TA, Commins SP·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
A novel form of food allergy has been described that initially became apparent from IgE reactivity with the drug cetuximab. Ongoing work regarding the etiology, distribution, clinical management, and...
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA·The Journal of allergy and clinical immunology·
This review focuses on advances and updates in the epidemiology, pathogenesis, diagnosis, and treatment of food allergy over the past 3 years since our last comprehensive review. On the basis of numer...
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2013.
Sicherer SH, Leung DY·The Journal of allergy and clinical immunology·
This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2013. Stud...
Laminin γ-1 and collagen α-1 (VI) chain are galactose-α-1,3-galactose-bound allergens in beef.
Takahashi H, Chinuki Y, Tanaka A, et al.·Allergy·
Sensitization to the carbohydrate galactose-α-1,3-galactose (α-Gal) has been reported in patients with beef allergy. However, the proteins responsible for this allergy have not yet been identified. Th...
The effect of treatment with α-glycosidases from Bacteroides fragilis on the survival of rat erythrocytes in the circulation.
Li SB, Gao HW, Ji SP, et al.·Blood transfusion = Trasfusione del sangue·
It has been demonstrated recently that α1,3-galactosidase from Bacteroides fragilis can efficiently convert human group B red blood cells (RBC) to group O cells. In addition, in vitro data indicated t...
Allergy to galactose-alpha-1,3-galactose: Clinical features and the diagnostic value of cetuximab.
Martínez Arcediano A, Audicana Berasategui MT, Longo Areso N, et al.·Journal of investigational allergology & clinical immunology·
Porcine or bovine valve replacement in 3 patients with IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose.
Mozzicato SM, Tripathi A, Posthumus JB, et al.·The journal of allergy and clinical immunology. In practice·
Assessment of skin-related toxicity in patients with metastatic colorectal cancer treated with cetuximab.
Pacek A, Kozioł M, Püsküllüoğlu M, et al.·Acta dermatovenerologica Croatica : ADC·
Monoclonal antibodies (mAbs) blocking the epidermal growth factor receptor (EGFR) pathway, such as cetuximab, have been widely used in recent years for the treatment of metastatic colorectal cancer (m...
Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test.
Dupont B, Mariotte D, Moldovan C, et al.·Clinical Medicine Insights. Oncology·
Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted b...
View on PubMed →Allergy to red meat in adulthood: a case report.
Carrapatoso I, Bartolomé Zavala B, Ribeiro F, et al.·Journal of investigational allergology & clinical immunology·
The androgen receptor remains a key player in metastatic hormone-refractory prostate cancer. Implications for new treatments.
Nemes A, Tomuleasa C, Kacso G·Journal of B.U.ON. : official journal of the Balkan Union of Oncology·
Metastatic castration-resistant prostate cancer (mCRPC) shows a number of adaptive mechanisms that facilitate continued androgen receptor (AR) dependent tumor growth. In this article we reviewed the s...
Delayed anaphylaxis to red meat masquerading as idiopathic anaphylaxis.
Tripathi A, Commins SP, Heymann PW, et al.·The journal of allergy and clinical immunology. In practice·
Anaphylaxis is traditionally recognized as a rapidly developing combination of symptoms that often includes hives and hypotension or respiratory symptoms. Furthermore, when a specific cause is identif...
Idiopathic anaphylaxis.
Greenberger PA, Lieberman P·The journal of allergy and clinical immunology. In practice·
Idiopathic anaphylaxis is a perplexing problem that accounts for approximately 30% to 60% of cases of anaphylaxis in ambulatory adults and perhaps 10% of cases in children. Advances in our knowledge o...
Idiopathic anaphylaxis.
Lieberman PL·Allergy and asthma proceedings·
Idiopathic anaphylaxis is not uncommon and can be found in as many as 60% of patients referred to an allergist for anaphylactic events. It is an extremely frustrating condition for patients because th...
First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprosthesis (by Naso et al.).
Byrne GW, McGregor CG·Xenotransplantation·
Investigation of the effect of sugar stereochemistry on biologically relevant lyotropic phases from branched-chain synthetic glycolipids by small-angle X-ray scattering.
Zahid NI, Conn CE, Brooks NJ, et al.·Langmuir : the ACS journal of surfaces and colloids·
Synthetic branched-chain glycolipids are suitable as model systems in understanding biological cell membranes, particularly because certain natural lipids possess chain branching. Herein, four branche...
Red meat allergy in Sweden: association with tick sensitization and B-negative blood groups.
Hamsten C, Tran TAT, Starkhammar M, et al.·The Journal of allergy and clinical immunology·
Lectin-reactive anti-α-gal in patients with Crohn's disease: correlation with clinical phenotypes.
Safaie P, Ham M, Kuang P, et al.·Inflammatory bowel diseases·
Patients with inflammatory bowel disease have higher proportions of immunoglobulin G (IgG) antibodies lacking N-galactose, also called agalactosyl IgG, in their serum. Such agalactosyl IgGs have been...
Emerging antigens involved in allergic responses.
Platts-Mills TA, Commins SP·Current opinion in immunology·
New allergic diseases can 'emerge' because of exposure to a novel antigen, because the immune responsiveness of the subject changes, or because of a change in the behavior of the population. Novel ant...
N-/O-glycosylation analysis of human FVIIa produced in the milk of transgenic rabbits.
Chevreux G, Faid V, Scohyers JM, et al.·Glycobiology·
Human coagulation factor VIIa is a glycoprotein that promotes haemostasis through activation of the coagulation cascade extrinsic pathway. Most haemophilia A/B patients with inhibitors are treated by...
Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken.
de Geus ED, Tefsen B, van Haarlem DA, et al.·Molecular immunology·
To increase our understanding of the interaction between avian influenza virus and its chicken host, we identified receptors for putative avian influenza virus (AIV) glycan determinants on chicken den...
Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis.
Chan RW, Karamanska R, Van Poucke S, et al.·Influenza and other respiratory viruses·
Swine have been regarded as intermediate hosts in the spread of influenza from birds to humans but studies of the sialylated glycans that comprise their respiratory tract have not been extensively stu...
Synthesis of nucleotide sugars and α-galacto-oligosaccharides by recombinant Escherichia coli cells with trehalose substrate.
Ryu SI, Lee SB·Enzyme and microbial technology·
Useful nucleoside diphosphate (NDP)-sugars and α-galacto-oligosaccharides were synthesized by recombinant Escherichia coli whole cells and compared to those produced by enzyme-coupling. Production yie...
Multicenter phase II trial to investigate safety and efficacy of gemcitabine combined with cetuximab as adjuvant therapy in pancreatic cancer (ATIP).
Fensterer H, Schade-Brittinger C, Müller HH, et al.·Annals of oncology : official journal of the European Society for Medical Oncology·
To investigate whether addition of cetuximab to standard adjuvant chemotherapy with gemcitabine improves outcome in pancreatic cancer, specifically whether the rate of disease-free survival (DFS) at 1...
[Urticaria. Sometimes IgE-mediated?].
Wieczorek D, Langhorst J, Kapp A, et al.·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
There are specific diagnostic recommendations for approaching chronic spontaneous urticaria, physical urticaria and special forms of urticaria. They include the detection of subclinical viral and bact...
Cetuximab hypersensitivity infusion reactions: Incidence and risk factors.
Hopps S, Medina P, Pant S, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Cetuximab is a chimeric mouse-human (30:70) IgG1 monoclonal antibody that competitively inhibits the binding of epidermal growth factor. Cetuximab is generally well tolerated; however, hypersensitivit...
Structure of the capsular polysaccharides and lipopolysaccharides from Haemophilus parasuis strains ER-6P (serovar 15) and Nagasaki (serovar 5).
Perry MB, MacLean LL, Gottschalk M, et al.·Carbohydrate research·
Haemophilus parasuis is a Gram-negative bacterium from the family Pasteurellaceae and a swine pathogen. H. parasuis is found in the upper respiratory tract of piglets and produces Glässer's disease, a...
Tick bites and red meat allergy.
Commins SP, Platts-Mills TA·Current opinion in allergy and clinical immunology·
A novel form of anaphylaxis has been described that is due to IgE antibody (Ab) directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). Ongoing work regarding...
Feasibility of 6-month maintenance cetuximab after adjuvant concurrent chemoradiation plus cetuximab in squamous cell carcinoma of the head and neck.
Matuschek C, Bölke E, Belka C, et al.·Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·
Close resection margins < 5 mm (CM) or extra capsular extent at the lymph nodes (ECE) impair the prognosis of patients with squamous cell cancer of the head and neck (SCCHN) scheduled for adjuvant rad...
A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure-related gene 6.
Mitsui S, Hidaka C, Furihata M, et al.·Biochemical and biophysical research communications·
A serine protease, motopsin (prss12), plays a significant role in cognitive function and the development of the brain, since the loss of motopsin function causes severe mental retardation in humans an...
Delayed mammalian meat-induced anaphylaxis confirmed by skin test to cetuximab.
Lee JH, Kim JH, Kim TH, et al.·The Journal of dermatology·
Cetuximab infusion reactions: French pharmacovigilance database analysis.
Grandvuillemin A, Disson-Dautriche A, Miremont-Salamé G, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
To compare characteristics of patients exhibiting cetuximab infusion reactions or another adverse drug reaction related to cetuximab and to identify factors associated with the severity of cetuximab i...
Galactose-α-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children.
Kennedy JL, Stallings AP, Platts-Mills TA, et al.·Pediatrics·
Despite a thorough history and comprehensive testing, many children who present with recurrent symptoms consistent with allergic reactions elude diagnosis. Recent research has identified a novel cause...
Coupling reactions of trehalose synthase from Pyrococcus horikoshii: cost-effective synthesis and anti-adhesive activity of α-galactosyl oligosaccharides using a one-pot three-enzyme system with trehalose.
Ryu SI, Woo JB, Lee SB·Bioresource technology·
A new sugar nucleotide cycling (SNC) process was established in a one-pot three enzyme-coupled reaction using disaccharide trehalose. Trehalose synthase from Pyrococcus horikoshii could be applied to...
Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.
Hamsten C, Starkhammar M, Tran TA, et al.·Allergy·
Patients with IgE antibodies against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed asso...
Structure and biosynthetic locus of the lipopolysaccharide outer core produced by Pasteurella multocida serovars 8 and 13 and the identification of a novel phospho-glycero moiety.
Harper M, St Michael F, Vinogradov E, et al.·Glycobiology·
Pasteurella multocida strains are classified into 16 Heddleston serovars on the basis of the lipopolysaccharide (LPS) antigens expressed on the surface of the bacteria. The LPS structure and the corre...
Phosphatidylserine exposure and surface sugars in two Leishmania (Viannia) braziliensis strains involved in cutaneous and mucocutaneous leishmaniasis.
Farias LH, Rodrigues AP, Silveira FT, et al.·The Journal of infectious diseases·
Phosphatidylserine (PS) and surface carbohydrates (SC) are known as virulence factors that may contribute to the different clinical symptoms ranging from self-healing cutaneous leishmaniasis lesions t...
Preparation of immunogen-reduced and biocompatible extracellular matrices from porcine liver.
Park KM, Park SM, Yang SR, et al.·Journal of bioscience and bioengineering·
Decellularized biologic matrices are plausible biomedical materials for the bioengineering in liver transplantation. However, one of the concerns for safe medical application is the lack of objective...
Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal).
Commins SP, Platts-Mills TA·Current allergy and asthma reports·
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to lon...
A peculiar cause of anaphylaxis: no more steak? The journey to discovery of a newly recognized allergy to galactose-alpha-1,3-galactose found in mammalian meat.
Wolver SE, Sun DR, Commins SP, et al.·Journal of general internal medicine·
In recent years, a newly recognized allergic disease has been uncovered, and seemingly idiopathic causes of anaphylaxis now have an explanation. Individuals bitten by the lone star tick may develop Ig...
Mechanism of the glycosylation step catalyzed by human α-galactosidase: a QM/MM metadynamics study.
Pan XL, Liu W, Liu JY·The journal of physical chemistry. B·
The enzyme α-galactosidase (α-GAL), a member of glycoside hydrolase family 27, catalyzes the removal of a nonreducing terminal α-galactose residue from polysaccharides, glycolipids, and glycopeptides....
A patient experiencing anaphylaxis and urticaria, in some cases preceded by ingestion of red meat.
Lieberman P, Commins SP·The journal of allergy and clinical immunology. In practice·
Penetrance of hypertrophic cardiomyopathy in children and adolescents: a 12-year follow-up study of clinical screening and predictive genetic testing.
Jensen MK, Havndrup O, Christiansen M, et al.·Circulation·
The penetrance of hypertrophic cardiomyopathy (HCM) during childhood and adolescence has been only sparsely described. We studied the penetrance of HCM and the short- and long-term outcomes of clinica...
Characterisation of the post-translational modifications of a novel, human cell line-derived recombinant human factor VIII.
Kannicht C, Ramström M, Kohla G, et al.·Thrombosis research·
Host cell lines used for recombinant protein expression differ in their ability to perform post-translational modifications (PTMs). The currently available recombinant human FVIII (rhFVIII) products a...
Gelatin-containing sweets can elicit anaphylaxis in a patient with sensitization to galactose-α-1,3-galactose.
Caponetto P, Fischer J, Biedermann T·The journal of allergy and clinical immunology. In practice·
The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection.
Onsten TG, Callegari-Jacques SM, Goldani LZ·The open AIDS journal·
To analyze the frequency of and odds for and against HIV infection based on ABO blood type in a large sample of blood donors. Coevolution between pathogens and hosts may explain the ABO system of poly...
View on PubMed →Sensitization to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal): experience in a Flemish case series.
Ebo DG, Faber M, Sabato V, et al.·Acta clinica Belgica·
Recent observations have disclosed that the galactose-alpha (1,3)-galactose (alpha-gal) moiety of non-primate glycoproteins can constitute a target for meat allergy. To describe adults with allergic r...
Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection.
Lamontagne A, Long RE, Comunale MA, et al.·PloS one·
Using comparative glycoproteomics, we have previously identified a glycoprotein that is altered in both amount and glycosylation as a function of liver cirrhosis. The altered glycoprotein is an agalac...
Structural features of a polysaccharide from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.
Fu J, Huang L, Zhang H, et al.·Journal of Asian natural products research·
A polysaccharide Astragalus polysaccharide (APS) was obtained from the boiling water extract of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. The results of gas chromatography (...
IgE production to α-gal is accompanied by elevated levels of specific IgG1 antibodies and low amounts of IgE to blood group B.
Rispens T, Derksen NI, Commins SP, et al.·PloS one·
IgE antibodies to gal-α-1,3-gal-β-1,4-GlcNAc (α-gal) can mediate a novel form of delayed anaphylaxis to red meat. Although IgG antibodies to α-gal (anti-α-gal or anti-Gal) are widely expressed in huma...
A decrease in galectin-1 (Gal-1) levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid arthritis.
Xibillé-Friedmann D, Bustos Rivera-Bahena C, Rojas-Serrano J, et al.·Scandinavian journal of rheumatology·
Several studies have confirmed that galectin-1 (Gal-1) plays a role in controlling the immune response because of its pro-apoptotic effect. Although studies based on a rheumatoid arthritis (RA) mouse...
Specific detection of N-glycolylneuraminic acid and Galα1-3Gal epitopes of therapeutic antibodies by partial-filling capillary electrophoresis.
Yagi Y, Kakehi K, Hayakawa T, et al.·Analytical biochemistry·
The oligosaccharide structure is very important in biopharmaceuticals because of its effects on protein function, including efficacy and half-life. N-glycolylneuraminic acid (Neu5Gc) and Galα1-3Gal (α...
Histologic Characteristics and Mechanical Properties of Bovine Pericardium Treated with Decellularization and α-Galactosidase: A Comparative Study.
Min BJ, Kim YJ, Choi JW, et al.·The Korean journal of thoracic and cardiovascular surgery·
Bioprostheses for cardiovascular surgery have limitations in their use following as calicification. α-galactosidase epitope is known as a stimulant of immune response and then shows a progressing calc...
View on PubMed →Quantitative structural characterization of local N-glycan microheterogeneity in therapeutic antibodies by energy-resolved oxonium ion monitoring.
Toyama A, Nakagawa H, Matsuda K, et al.·Analytical chemistry·
Site-specific characterization of glycoform heterogeneity currently requires glycan structure assignment and glycopeptide quantification in two independent experiments. We present here a new method co...
Identification of novel α1,3-galactosyltransferase and elimination of α-galactose-containing glycans by disruption of multiple α-galactosyltransferase genes in Schizosaccharomyces pombe.
Ohashi T, Fujiyama K, Takegawa K·The Journal of biological chemistry·
The oligosaccharides from fission yeast Schizosaccharomyces pombe contain large amounts of D-galactose (Gal) in addition to D-mannose (Man), in contrast to the budding yeast Saccharomyces cerevisiae....
Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis.
Nairn AV, Aoki K, dela Rosa M, et al.·The Journal of biological chemistry·
The abundance and structural diversity of glycans on glycoproteins and glycolipids are highly regulated and play important roles during vertebrate development. Because of the challenges associated wit...
Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells.
Yoshida R, Vavken P, Murray MM·The Knee·
Rupture of ACL is a common injury. While the current surgical treatments are effective, many patients still suffer from precocious osteoarthritis, and there is an increasing interest in bioengineering...
A perspective on new immune adjuvant principles: Reprogramming inflammatory states to permit clearance of cancer cells and other age-associated cellular pathologies.
Prendergast GC, Metz R·Oncoimmunology·
Aging entails the accumulation of neoantigens comprised of aggregated, oxidized, mutated and misfolded biomolecules, including advanced-glycation end projects (AGEs). There is evidence that the immune...
View on PubMed →A phase I study of concurrent chemoradiotherapy and cetuximab for locally advanced esophageal cancer.
Holländer C, Baeksgaard L, Sorensen M, et al.·Anticancer research·
To determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of concurrent chemoradiotherapy and cetuximab in patients with non-resectable locally advanced esophageal cancer. Esca...
Levansucrase and sucrose phoshorylase contribute to raffinose, stachyose, and verbascose metabolism by lactobacilli.
Teixeira JS, McNeill V, Gänzle MG·Food microbiology·
Raffinose family oligosaccharides (RFOs) in food are considered anti-nutritional factors. This study elucidated the role of α-galactosidase (α-Gal), levansucrase, and sucrose phosphorylase for convers...
HIV inhibition by CD4 and CCR5-derived glycopeptides.
Perdomo MF, Sällberg M, Vahlne A·AIDS research and human retroviruses·
We have previously proposed a method by which natural antibodies can be redirected toward a known pathogen. We could show that CD4-derived peptides coupled to the galα1,3gal sugar moiety, a specificit...
α-N-Linked glycopeptides: conformational analysis and bioactivity as lectin ligands.
Marcelo F, Cañada FJ, André S, et al.·Organic & biomolecular chemistry·
Natural N-glycosylation involves a β-anomeric linkage connecting the sugar to one asparagine residue of the protein. We herein report NMR- and modelling-based data on glycomimetics containing α-glycos...
Structural and biomechanical characterizations of porcine myocardial extracellular matrix.
Wang B, Tedder ME, Perez CE, et al.·Journal of materials science. Materials in medicine·
Extracellular matrix (ECM) of myocardium plays an important role to maintain a multilayered helical architecture of cardiomyocytes. In this study, we have characterized the structural and biomechanica...
Anaphylaxis: current state of knowledge for the modern physician.
Rutkowski K, Dua S, Nasser S·Postgraduate medical journal·
Anaphylaxis is a severe, potentially fatal, hypersensitivity reaction of rapid onset. It may trigger life-threatening cardiopulmonary compromise, often with skin and mucosal changes such as urticaria...
Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies.
Argiris A, Feinstein TM, Wang L, et al.·Investigational new drugs·
Combined inhibition of epidermal growth factor receptor (EGFR) and Src family kinases (SFK) may lead to improved therapeutic effects. We evaluated the combination of dasatinib, an inhibitor of SFK and...
Glycomolecule modifications in the seminiferous epithelial cells and in the acrosome of post-testicular spermatozoa in the alpaca.
Parillo F, Verini Supplizi A, Mancuso R, et al.·Reproduction in domestic animals = Zuchthygiene·
A lectin histochemical investigation of the seminiferous epithelium and acrosomes of spermatozoa present in the efferent ductules and epididymal regions was carried out in the alpaca. The histochemica...
A phase I study of cetuximab in combination with gemcitabine and radiation for locally advanced pancreatic cancer.
Chakravarthy AB, Tsai CJ, O'Brien N, et al.·Gastrointestinal cancer research : GCR·
Cetuximab is a monoclonal antibody against the epidermal growth factor receptor (EGFR). The primary goal of this phase I study was to determine the maximum tolerated dose (MTD) and dose-limiting toxic...
View on PubMed →Structural characterization of N-linked oligosaccharides on monoclonal antibody Nimotuzumab through process development.
Montesino R, Calvo L, Vallin A, et al.·Biologicals : journal of the International Association of Biological Standardization·
Nimotuzumab (TheraCIM, CIMAher, h-R3, humanized anti-EGF-R antibody), monoclonal antibody (mAb) manufactured at the Center of Molecular Immunology (Havana, Cuba) is currently being tested in several c...
Potential of healing a transected anterior cruciate ligament with genetically modified extracellular matrix bioscaffolds in a goat model.
Fisher MB, Liang R, Jung HJ, et al.·Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·
Biological augmentation to heal a torn anterior cruciate ligament (ACL) has gained significant interest. This study examined the potential advantages of using extracellular matrix (ECM) bioscaffolds f...
Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia.
Austarheim I, Christensen BE, Hegna IK, et al.·Carbohydrate polymers·
The bark of Cola cordifolia used in Malian traditional medicine contains unusual types of polysaccharides with immunomodulating activities. We report for the first time on the structure of a polymer d...
Ultrasensitive capillary electrophoretic analysis of potentially immunogenic carbohydrate residues in biologics: galactose-α-1,3-galactose containing oligosaccharides.
Szabo Z, Guttman A, Bones J, et al.·Molecular pharmaceutics·
With the recent growth of the global monoclonal antibody market, ultrasensitive techniques are required for rapid analysis of possible immunogenic residues, such as galactose-α-1,3-galactose (α-1,3-Ga...
[A case of advanced colon cancer with peritoneal dissemination effectively treated with modified FOLFOX6 chemotherapy].
Tanaka K, Hirai K, Ogawa H, et al.·Gan to kagaku ryoho. Cancer & chemotherapy·
A 50-year-old woman was diagnosed with ascending colon cancer with bilateral ovarian metastases, carcinomatous peritonitis, and carcinomatous pleurisy. Nine courses of mFOLFOX6 treatment resulted in t...
Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose.
Mullins RJ, James H, Platts-Mills TA, et al.·The Journal of allergy and clinical immunology·
We have observed patients clinically allergic to red meat and meat-derived gelatin. We describe a prospective evaluation of the clinical significance of gelatin sensitization, the predictive value of...
Safety and efficacy of cetuximab combined with chemotherapy in Chinese patients with advanced non-small cell lung cancer.
Si X, Zhang L·Thoracic cancer·
The aim of this study was to evaluate safety and efficacy of cetuximab combined with chemotherapy in Chinese patients with advanced non-small cell lung cancer (NSCLC). A retrospective analysis of cl...
View on PubMed →Quantifying ligand binding to large protein complexes using electrospray ionization mass spectrometry.
El-Hawiet A, Kitova EN, Arutyunov D, et al.·Analytical chemistry·
An electrospray ionization mass spectrometry (ESI-MS) method for quantifying protein-ligand complexes that cannot be directly detected by ESI-MS is described. The proxy protein ESI-MS method combines...
Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose.
Morisset M, Richard C, Astier C, et al.·Allergy·
Carbohydrate-specific IgE antibodies present on nonprimate mammalian proteins were incriminated recently in delayed meat anaphylaxis. The aim of this study was to explore whether anaphylaxis to mammal...
Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: synthesis and biological properties.
Thomann JS, Monneaux F, Creusat G, et al.·European journal of medicinal chemistry·
A more complete understanding of the mechanism of action of TLR agonists has fueled the investigation of new synthetic immunoadjuvants. In this context, we designed and synthesized glycolipids of the...
Reviewing α-Gal in valve immunology.
Mangold A, Ankersmit HJ·European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·
Anti-alpha-Gal antibody titres remain unaffected by the consumption of fermented milk containing Lactobacillus casei in healthy adults.
Mangold A, Hercher D, Hlavin G, et al.·International journal of food sciences and nutrition·
Alpha-Gal is a glycoconjugate present on cell membranes of non-primate mammals and bacteria, but not in humans, who display anti-Gal antibodies (ABs) in high titres. Probiotics contain bacterial strai...
[Delayed appearance of symptoms in immediate hypersensitivity: type I sensitization to galactose-α-1,3-galactose].
Biedermann T, Röcken M·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
Delayed immediate-type allergy to innards and red meat can be mediated by IgE antibodies to galactose-α-1, 3-galactose (α-Gal). Apart from humans and Old World apes, α-Gal is ubiquitously expressed in...
[Update on meat allergy. α-Gal: a new epitope, a new entity?].
Jappe U·Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·
The association between the carbohydrate galactose-[alpha]-1,3-galactose (α-Gal) and anaphylaxis was first documented after severe hypersensitivity reactions to cetuximab, a chimeric mouse-human IgG1...
Terminal galactosylation of glycoconjugates in Plasmodium falciparum asexual blood stages and Trypanosoma brucei bloodstream trypomastigotes.
Ramasamy R, Field MC·Experimental parasitology·
There is definitive biochemical evidence for the presence of terminal α-galactosyl residues (α-gal) in the N-linked oligosaccharides and glycophosphatidylinositol anchors (GPI anchors) of the variant...
Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.
Commins SP, Kelly LA, Rönmark E, et al.·American journal of respiratory and critical care medicine·
IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give ris...
Anaphylactic reactions to oligosaccharides in red meat: a syndrome in evolution.
Saleh H, Embry S, Nauli A, et al.·Clinical and molecular allergy : CMA·
While most allergic responses to food are directed against protein epitopes and occur within 30 minutes of ingesting the allergen, recent studies suggest that delayed reactions may occur, sometimes me...
View on PubMed →Analysis of nonhuman N-glycans as the minor constituents in recombinant monoclonal antibody pharmaceuticals.
Maeda E, Kita S, Kinoshita M, et al.·Analytical chemistry·
Minor N-linked glycans containing N-glycolylneuraminic acid residues and/or α-Gal epitopes (i.e., galactose-α1,3-galactose residues) have been reported to be present in recombinant monoclonal antibody...
Purification and characterization of a thermostable α-galactosidase from Thielavia terrestris NRRL 8126 in solid state fermentation.
Saad RR, Fawzi EM·Acta biologica Hungarica·
Several seeds and husks of some plants belonging to leguminosae, Graminae, Compositae and Palmae were evaluated as carbon substrates to produce α-galactosidase (α-Gal) by the thermophilic fungus, Thie...
Acidic α-galactosidase is the most abundant nectarin in floral nectar of common tobacco (Nicotiana tabacum).
Zha HG, Flowers VL, Yang M, et al.·Annals of botany·
To date, most floral nectarins (nectar proteins) are reported to function in nectar defence, particularly for insect-pollinated outcrossing species. We compared nectarin composition and abundance in s...
Determinants of food allergy.
Masilamani M, Commins S, Shreffler W·Immunology and allergy clinics of North America·
Food allergy is an emerging epidemic in the United States and the Western world. The determination of factors that make certain foods allergenic is still not clearly understood. Only a tiny fraction o...
Anticalcification effects of decellularization, solvent, and detoxification treatment for genipin and glutaraldehyde fixation of bovine pericardium.
Lim HG, Kim SH, Choi SY, et al.·European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·
Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve substitutes. The objective of this study was to evaluate the anticalcification effect of decellularization...
Fatal infusion reactions to cetuximab: role of immunoglobulin e-mediated anaphylaxis.
Pointreau Y, Commins SP, Calais G, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
Allergy to monoclonal antibodies: cutting-edge desensitization methods for cutting-edge therapies.
Hong DI, Bankova L, Cahill KN, et al.·Expert review of clinical immunology·
Monoclonal antibodies are important therapeutic tools, but their usefulness is limited in patients who experience acute infusion reactions, most of which are consistent with type I hypersensitivity re...
The indoor air and asthma: the role of cat allergens.
Kelly LA, Erwin EA, Platts-Mills TA·Current opinion in pulmonary medicine·
The objective is to discuss recent progress in our understanding of the role of the indoor environment in asthma, focusing on the special role of cat allergens. Sensitization to Fel d 1 is the dominan...
The expression and distribution of α-Gal gene in various species ocular surface tissue.
Shao Y, Yu Y, Pei CG, et al.·International journal of ophthalmology·
To examine the α-Gal gene expression and distribution in the different species/genus and developing phase animal ocular surface tissue. α-Gal binding assay were carried out on various animal eye secti...
View on PubMed →Safety profiles of current antiangiogenic therapies for metastatic colorectal cancer.
Fuloria J·OncoTargets and therapy·
The biological agents approved for the treatment of patients with metastatic colorectal cancer - bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor A, along with cetuxi...
View on PubMed →Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation.
Ghaderi D, Zhang M, Hurtado-Ziola N, et al.·Biotechnology & genetic engineering reviews·
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic glycoproteins. Today, these molecules play a major role in the treatment of various diseases, and include...
Characterization of a new α-galactosyl-binding lectin from the mushroom Clavaria purpurea.
Lyimo B, Funakuma N, Minami Y, et al.·Bioscience, biotechnology, and biochemistry·
A galactose specific lectin (CpL) was purified from the Clavaria purpurea mushroom by affinity chromatography. CpL agglutinated only trypsin-treated rabbit erythrocytes. On enzyme linked lectin sorben...
Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab.
Wadlow RC, Hezel AF, Abrams TA, et al.·The oncologist·
Cetuximab and panitumumab are monoclonal antibodies that target the epidermal growth factor receptor (EGFR) and are approved for the treatment of patients with KRAS wild-type meta-static colorectal ca...
Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3- galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells.
Qiu Y, Xu MB, Yun MM, et al.·World journal of gastroenterology·
To evaluate the safety and clinical efficacy of a new immunotherapy using both α-Gal epitope-pulsed dendritic cells (DCs) and cytokine-induced killer cells. Freshly collected hepatocellular carcinoma...
Oxaliplatin, irinotecan and cetuximab in advanced gastric cancer. A multicenter phase II trial (Gastric-2) of the Arbeitsgemeinschaft Medikamentose Tumortherapie (AGMT).
Wöll E, Greil R, Eisterer W, et al.·Anticancer research·
Patients suffering from advanced gastric cancer still have a poor prognosis and treatment options are limited. In our previous phase II trial (AGMT-Gastric-1), we showed that the combination of oxalip...
Anti-Gal titers in healthy adults and inflammatory bowel disease patients.
Mangold A, Lebherz D, Papay P, et al.·Transplantation proceedings·
ALPHA-GAL is a glycoconjugate present on cell membranes of mammals and bacteria but not humans who display anti-Gal antibodies (AB) in high titers provoked by the commensal gut flora. In the present s...
The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts.
Böer U, Lohrenz A, Klingenberg M, et al.·Biomaterials·
Decellularized equine carotid arteries (dEAC) may represent a reasonable alternative to alloplastic materials in vascular replacement therapy. Acellularity of the matrix is standardly evaluated by DNA...
Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis.
Bouchahda M, Macarulla T, Liedo G, et al.·Medical oncology (Northwood, London, England)·
Cetuximab was approved using a weekly schedule, alone or in combination with chemotherapy (CT). However, many CT regimens in metastatic colorectal cancer (CRC) are delivered every 2 weeks (q2wks). Pre...
Delayed mammalian meat-induced anaphylaxis due to galactose-α-1,3-galactose in 5 European patients.
Nuñez R, Carballada F, Gonzalez-Quintela A, et al.·The Journal of allergy and clinical immunology·
Differences in both prevalence and titre of specific immunoglobulin E among children with asthma in affluent and poor communities within a large town in Ghana.
Stevens W, Addo-Yobo E, Roper J, et al.·Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·
Reports from several African countries have noted an increasing prevalence of asthma in areas of extensive urbanization. To investigate the relevance of allergen-specific sensitization and body mass i...
Characterization of novel glycolipid antigens with an α-galactose epitope in lactobacilli detected with rabbit anti-Lactobacillus antisera and occurrence of antibodies against them in human sera.
Iwamori M, Sakai A, Minamimoto N, et al.·Journal of biochemistry·
Anti-Lactobacillus johnsonii (LJ) antisera generated by immunization of rabbits with LJ reacted with glyceroglycolipids in LJ, i.e. dihexaosyl diacylglycerol (DH-DG), trihexaosyl DG (TH-DG) and tetrah...
Crystal structure of α-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding.
Fredslund F, Hachem MA, Larsen RJ, et al.·Journal of molecular biology·
Lactobacillus acidophilus NCFM is a probiotic bacterium known for its beneficial effects on human health. The importance of α-galactosidases (α-Gals) for growth of probiotic organisms on oligosacchari...
Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity.
Wohlschlager T, Butschi A, Zurfluh K, et al.·The Journal of biological chemistry·
Fruiting body lectins have been proposed to act as effector proteins in the defense of fungi against parasites and predators. The Marasmius oreades agglutinin (MOA) is a Galα1,3Gal/GalNAc-specific lec...
Immediate post-operative hypersensitivity reaction to Cetuximab in patients preoperatively treated by the monoclonal antibody: what's wrong?
Delaunoit T·Acta gastro-enterologica Belgica·
Necitumumab in the treatment of advanced non-small cell lung cancer: translation from preclinical to clinical development.
Dienstmann R, Felip E·Expert opinion on biological therapy·
Treatment outcomes in unselected patients with advanced NSCLC remain disappointing with platinum-based chemotherapy. The addition of monoclonal antibodies targeting EGFR to standard first-line therapy...
Specificity analysis of the C-type lectin from rattlesnake venom, and its selectivity towards Gal- or GalNAc-terminated glycoproteins.
Young NM, van Faassen H, Watson DC, et al.·Glycoconjugate journal·
The rattlesnake (Crotalus atrox) venom lectin is a readily-prepared decameric C-type lectin, specific for Gal and GalNAc. Glycan microarray analysis showed it reacted with a wide range of glycans, chi...
Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains.
Lammerts van Bueren JJ, Rispens T, Verploegen S, et al.·Nature biotechnology·
pH-responsive polysaccharide-based polyelectrolyte complexes as nanocarriers for lysosomal delivery of therapeutic proteins.
Giannotti MI, Esteban O, Oliva M, et al.·Biomacromolecules·
Nanopharmaceutics composed of a carrier and a protein have the potential to improve the activity of therapeutical proteins. Therapy for lysosomal diseases is limited by the lack of effective protein d...
Deep vein and artery thrombosis associated with cetuximab-based chemoradiotherapy.
Gupta D, Shukla P, Bisht SS, et al.·Indian journal of pharmacology·
Molecular targeted agents have lower hematological toxicity. However, specific side-effects such as allergic rashes, skin reactions and high cost limit their use. We report a case of 35-year-old male...
View on PubMed →Epidermal growth factor receptor inhibition augments the expression of MHC class I and II genes.
Pollack BP, Sapkota B, Cartee TV·Clinical cancer research : an official journal of the American Association for Cancer Research·
Diverse immune-related effects occur with the use of epidermal growth factor receptor inhibitors (EGFRI). In addition to the cutaneous inflammation induced by EGFRIs, these agents have been associated...
Development and characterization of a full-thickness acellular porcine cornea matrix for tissue engineering.
Du L, Wu X·Artificial organs·
Our aim was to produce a natural, acellular matrix from porcine cornea for use as a scaffold in developing a tissue-engineered cornea replacement. Full-thickness, intact porcine corneas were decellula...
Secondary cell wall polysaccharides from Bacillus cereus strains G9241, 03BB87 and 03BB102 causing fatal pneumonia share similar glycosyl structures with the polysaccharides from Bacillus anthracis.
Forsberg LS, Choudhury B, Leoff C, et al.·Glycobiology·
Secondary cell wall polysaccharides (SCWPs) are important structural components of the Bacillus cell wall and contribute to the array of antigens presented by these organisms in both spore and vegetat...
Incidence and predictors of cetuximab hypersensitivity reactions in a North Carolina academic medical center.
Hansen NL, Chandiramani DV, Morse MA, et al.·Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·
Previous research has indicated a high incidence of cetuximab hypersensitivity reactions in the southern US. This study documents the incidence of hypersensitivity reactions in North Carolina, and exp...
N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells.
Korekane H, Korekane A, Yamaguchi Y, et al.·Glycoconjugate journal·
Extracellular superoxide dismutase (EC-SOD), the major SOD isoenzyme in biological fluids, is known to be N-glycosylated and heterogeneous as was detected in most glycoproteins. However, only one N-gl...
The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
Commins SP, James HR, Kelly LA, et al.·The Journal of allergy and clinical immunology·
In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (alpha-gal). Most of these patients had to...
Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study.
Farley J, Sill MW, Birrer M, et al.·Gynecologic oncology·
The purpose of this study was to evaluate the safety and efficacy of cetuximab (C225), an antibody that inhibits epidermal growth factor receptor (EGFR) activity, with cisplatin and to explore associa...
Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α 1,3-galactose.
Arkestål K, Sibanda E, Thors C, et al.·The Journal of allergy and clinical immunology·
The carbohydrate epitope galactose-α 1,3-galactose (α-Gal) is abundantly expressed on nonprimate mammalian proteins. We have recently shown that α-Gal is responsible for the IgE binding to cat IgA, a...
Rapid recruitment and activation of macrophages by anti-Gal/α-Gal liposome interaction accelerates wound healing.
Wigglesworth KM, Racki WJ, Mishra R, et al.·Journal of immunology (Baltimore, Md. : 1950)·
Macrophages are pivotal in promoting wound healing. We hypothesized that topical application of liposomes with glycolipids that carry Galα1-3Galβ1-4GlcNAc-R epitopes (α-gal liposomes) on wounds may ac...
Documentation of fatty acid profiles in lamb meat and lamb-based infant foods.
Nudda A, McGuire MK, Battacone G, et al.·Journal of food science·
Lamb meat, when used in the weaning diet of children, is presumed to have a lower allergenicity than other forms of red meat. In children with atopic dermatitis and multiple food hypersensitivities, c...
The pathogenic fungus Paracoccidioides brasiliensis exports extracellular vesicles containing highly immunogenic α-Galactosyl epitopes.
Vallejo MC, Matsuo AL, Ganiko L, et al.·Eukaryotic cell·
Exosome-like vesicles containing virulence factors, enzymes, and antigens have recently been characterized in fungal pathogens, such as Cryptococcus neoformans and Histoplasma capsulatum. Here, we des...
Novel tissue-derived biomimetic scaffold for regenerating the human nucleus pulposus.
Mercuri JJ, Gill SS, Simionescu DT·Journal of biomedical materials research. Part A·
Numerous scaffold formulations have been investigated to support the regeneration of nucleus pulposus (NP) tissue for use as an early-stage therapy for intervertebral disc degeneration. Particular att...
Concurrent cetuximab and radiotherapy after docetaxel-cisplatin induction chemotherapy in stage III NSCLC: satellite--a phase II study from the Swedish Lung Cancer Study Group.
Hallqvist A, Wagenius G, Rylander H, et al.·Lung cancer (Amsterdam, Netherlands)·
Several attempts to increase the locoregional control in locally advanced lung cancer including concurrent chemotherapy, accelerated fractionation and dose escalation have been made during the last ye...
Possible case of levofloxacin-induced thrombocytopenia.
Salloum R, Liu CY, Weise AM·American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·
A possible case of levofloxacin-induced thrombocytopenia is reported. A 73-year-old Caucasian woman with stage IV squamous cell cancer of the oral cavity arrived at the hospital with a 6-day history o...
First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD).
Sastre J, Aranda E, Grávalos C, et al.·Critical reviews in oncology/hematology·
to evaluate the efficacy and safety of first-line single-agent cetuximab in fit elderly patients with metastatic colorectal cancer, as well as potential molecular predictive factors for efficacy. pati...
2nd Charles Richet et Jules Héricourt workshop: therapeutic antibodies and anaphylaxis; May 31-June 1, 2011, Tours, France.
Daguet A, Watier H·mAbs·
The Charles Richet and Jules Héricourt workshops honor the memory of Jules Héricourt (1850-1938) and Charles Richet (1850-1935) who described the principle of serotherapy in 1888 and made the very fir...
How to manage hypersensitivity reactions to biological agents?
Barbaud A, Granel F, Waton J, et al.·European journal of dermatology : EJD·
Biological agents induce cutaneous adverse drug reactions (CADR) different from those observed with xenobiotics. Type alpha is the cytokine release syndrome, type beta are hypersensitivity reactions a...
Identification of allergens in chicken meat allergy.
González-Mancebo E, Pastor C, González-de-Olano D, et al.·Journal of investigational allergology & clinical immunology·
Anti-cetuximab IgE ELISA for identification of patients at a high risk of cetuximab-induced anaphylaxis.
Mariotte D, Dupont B, Gervais R, et al.·mAbs·
Cetuximab, a chimeric mouse-human IgG1 monoclonal antibody against the epidermal growth factor receptor, has proven effective in the treatment of metastatic colorectal cancer and squamous cell carcino...
Safety and efficacy of panitumumab therapy after progression with cetuximab: experience at two institutions.
Saif MW, Kaley K, Chu E, et al.·Clinical colorectal cancer·
Cetuximab therapy has been effectively combined with cytotoxic chemotherapy in the first-, second-, and third-line treatment settings. In general, treatment with cetuximab is well tolerated, though it...
Cetuximab and radiation for primary and recurrent squamous cell carcinoma of the head and neck (SCCHN) in the elderly and multi-morbid patient: a single-centre experience.
Jensen AD, Bergmann ZP, Garcia-Huttenlocher H, et al.·Head & neck oncology·
Chemoradiotherapy for head and neck cancer (SCCHN) is challenging in elderly, multi-morbid patients. Radioimmunotherapy (RIT) with cetuximab provides an option to enhance efficacy of radiotherapy with...
Enhancement of plant and bacterial lectin binding affinities by three-dimensional organized cluster glycosides constructed on helical poly(phenylacetylene) backbones.
Otsuka I, Blanchard B, Borsali R, et al.·Chembiochem : a European journal of chemical biology·
A series of poly(phenylacetylene)s bearing diverse saccharide pendants--N-acetyl-D-glucosamine, D-lactose, and N-acetyl-D-neuraminic acid--were synthesized by rhodium-mediated polymerizations of the c...
Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins.
Bosques CJ, Collins BE, Meador JW, et al.·Nature biotechnology·
Different patterns of toxicity after sequential administration of two anti-EGFR monoclonal antibodies.
López-Gómez M, Gómez-Raposo C, Sereno M, et al.·Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·
A 40-year-old woman with liver metastasis resulting from colorectal adenocarcinoma suffered from a severe hypersensitivity reaction to cetuximab. She also experienced grade 3 skin toxicity. The admini...
The role of natural killer T cells in costimulation blockade-based mixed chimerism.
Nierlich PN, Klaus C, Bigenzahn S, et al.·Transplant international : official journal of the European Society for Organ Transplantation·
Distinct lymphocyte populations have been identified that either promote or impede the establishment of chimerism and tolerance through allogeneic bone marrow transplantation (BMT). Natural killer T (...
Phase I trial of dose-escalated cisplatin with concomitant cetuximab and hyperfractionated-accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck.
Kuhnt T, Sandner A, Wendt T, et al.·Annals of oncology : official journal of the European Society for Medical Oncology·
Cetuximab is active in the treatment of squamous cell carcinoma of the head and neck (SCCHN), enhancing both radiotherapy and chemotherapy effects. This phase I study was designed to investigate the s...
Effects of trichostatin A on in vitro development and transgene function in somatic cell nuclear transfer embryos derived from transgenic Clawn miniature pig cells.
Himaki T, Yokomine TA, Sato M, et al.·Animal science journal = Nihon chikusan Gakkaiho·
The present study was carried out to examine the effects of post-activation treatment of trichostatin A (TSA), a histone deacetylase inhibitor, on in vitro development and transgene function of somati...
Bovine norovirus: carbohydrate ligand, environmental contamination, and potential cross-species transmission via oysters.
Zakhour M, Maalouf H, Di Bartolo I, et al.·Applied and environmental microbiology·
Noroviruses (NoV) are major agents of acute gastroenteritis in humans and the primary pathogens of shellfish-related outbreaks. Previous studies showed that some human strains bind to oyster tissues t...
Carbohydrate-mediated binding and induction of acrosomal exocytosis in a boar sperm-somatic cell adhesion model.
Clark GF, Zimmerman S, Lafrenz DE, et al.·Biology of reproduction·
The molecular basis underlying the binding of spermatozoa to their homologous eggs and the subsequent induction of acrosomal exocytosis remain a major unresolved issue in mammalian fertilization. Nove...
Expression of prostate glycoconjugates in the stallion and castrated horse.
Parillo F, Mancuso R, Vullo C, et al.·Reproduction in domestic animals = Zuchthygiene·
This work was undertaken to determine the glycoconjugates secreted by the epithelium of the prostate in the intact stallion and castrated horse using lectin histochemical procedures in conjunction wit...
The American Society for Virology--29th Annual Meeting.
Minieri Arroyo J·IDrugs : the investigational drugs journal·
The American Society for Virology 29th Annual Meeting, held in Bozeman, MT, USA, included topics covering new vaccine technologies, delivery methods and treatments in the field of virology. This confe...
Phase II trial of FOLFOX6, bevacizumab, and cetuximab in the first-line treatment of metastatic colorectal cancer.
Spigel DR, Greco FA, Waterhouse D, et al.·Clinical advances in hematology & oncology : H&O·
To examine FOLFOX/bevacizumab/cetuximab in the first-line treatment of metastatic colorectal cancer (mCRC). Randomized phase II trial aimed at achieving a 60% objective response rate (ORR). Due to fre...
Clinical and economic impact of infusion reactions in patients with colorectal cancer treated with cetuximab.
Foley KA, Wang PF, Barber BL, et al.·Annals of oncology : official journal of the European Society for Medical Oncology·
Systemic agents in cancer treatment were often associated with possible infusion reactions (IRs). This study estimated the incidence of IRs requiring medical intervention and assessed the clinical and...
Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart Valves.
Sierad LN, Simionescu A, Albers C, et al.·Cardiovascular engineering and technology·
Heart valve tissue engineering requires biocompatible and hemocompatible scaffolds that undergo remodeling and repopulation, but that also withstand harsh mechanical forces immediately following impla...
View on PubMed →A retrospective, multicenter study of the tolerance of induction chemotherapy with docetaxel, Cisplatin, and 5-Fluorouracil followed by radiotherapy with concomitant cetuximab in 46 cases of squamous cell carcinoma of the head and neck.
Buiret G, Combe C, Favrel V, et al.·International journal of radiation oncology, biology, physics·
To investigate, in a multicenter study, the tolerance of induction chemotherapy (ICT) and external radiotherapy (ERT) with concomitant cetuximab in the treatment of patients with squamous cell carcino...
Safety and efficacy of panitumumab following cetuximab: retrospective review of the Memorial Sloan-Kettering experience.
Power DG, Shah MA, Asmis TR, et al.·Investigational new drugs·
There are two highly selective antibodies to the epidermal growth factor receptor (EGFR) now available for use in metastatic colorectal cancer (mCRC). In KRAS wild type patients, cetuximab (Cmab)-an I...
Phase II study of cetuximab, docetaxel, and gemcitabine in patients with previously untreated advanced non-small-cell lung cancer.
Spigel DR, Greco FA, Thompson DS, et al.·Clinical lung cancer·
Targeting epidermal growth factor receptors (EGFRs) has been a novel strategy in treating non-small-cell lung cancer (NSCLC). This multicenter, community-based trial was designed to examine the role o...
Brief report: a new profile of terminal N-acetyllactosamines glycans on pig red blood cells and different expression of alpha-galactose on Sika deer red blood cells and nucleated cells.
Tan Y, Gong F, Li S, et al.·Glycoconjugate journal·
It has been reported that: (1) large variations were found in the number of sialic acid (SA) capped with N-acetyllactosamines (SA-Galbeta1-4GlcNAc-R) and alpha-Gal epitopes (Galalpha1-3Galbeta1-4GlcNA...
Pharmacogenetic application in personalized cancer treatment.
Kristyanto H, Utomo AR·Acta medica Indonesiana·
Pharmacogenetic is broadly understood as study or clinical testing of genetic variations that contribute to differing response to drugs. In cancer treatment, applications of pharmacogenetic cover thre...
Panitumumab: a new frontier of target therapy for the treatment of metastatic colorectal cancer.
Addeo R, Caraglia M, Cerbone D, et al.·Expert review of anticancer therapy·
Panitumumab is a fully human monoclonal IgG(2) antibody targeting the EGF receptor (EGFR). This agent represents a new class of drug owing to its fully human nature, and no need for premedication and...
Sugar acetates as CO2-philes: molecular interactions and structure aspects from absorption measurement using quartz crystal microbalance.
Ma SL, Wu YT, Hurrey ML, et al.·The journal of physical chemistry. B·
Sugar acetates, recognized as attractive CO(2)-philic compounds, have potential uses as pharmaceutical excipients, controlled release agents, and surfactants for microemulsion systems in CO(2)-based p...
View on PubMed →Chemical characterisation of polysaccharides from Lilium davidii.
Zhang J, Gao Y, Zhou X, et al.·Natural product research·
Lilium davidii var. unicolor Salisb is known for its esculent and exceptionally sweet bulbs. This article reports the isolation and purification of a non-starch polysaccharide from the bulb tissues. T...
A phase II study of cetuximab, capecitabine and radiotherapy in neoadjuvant treatment of patients with locally advanced resectable rectal cancer.
Velenik V, Ocvirk J, Oblak I, et al.·European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·
Neoadjuvant chemoradiotherapy (CRT) reduces local tumor recurrence in locally advanced rectal cancer (LARC). This phase II study assessed neoadjuvant cetuximab with capecitabine-based CRT in LARC. Pat...
Incorporating new data on colorectal cancer into nursing practice.
Viale PH·Clinical journal of oncology nursing·
Treatment for colorectal cancer (CRC) has seen major advances, resulting in longer survival times for many patients. New data about improvements can appear daily in the form of updated journal article...
Vaccination-induced IgG response to Galalpha1-3GalNAc glycan epitopes in lambs protected against Haemonchus contortus challenge infection.
van Stijn CM, van den Broek M, Vervelde L, et al.·International journal for parasitology·
Lambs vaccinated with Haemonchus contortus excretory/secretory (ES) glycoproteins in combination with the adjuvant Alhydrogel are protected against H. contortus challenge infection. Using glycan micro...
Metabolic engineering of Agrobacterium sp. strain ATCC 31749 for production of an alpha-Gal epitope.
Ruffing AM, Chen RR·Microbial cell factories·
Oligosaccharides containing a terminal Gal-alpha1,3-Gal moiety are collectively known as alpha-Gal epitopes. alpha-Gal epitopes are integral components of several medical treatments under development,...
Allergenicity of carbohydrates and their role in anaphylactic events.
Commins SP, Platts-Mills TA·Current allergy and asthma reports·
The IgE response to pollen allergens often includes IgE antibodies specific for glycosylation motifs on the pollen proteins. These oligosaccharides are present on many different species and are known...
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009.
Sicherer SH, Leung DY·The Journal of allergy and clinical immunology·
This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects, as well as advances in allergic skin disease that were reported in the...
Structural investigation of an antibacterial polysaccharide from Streptomyces virginia H03.
He F, Yang Y, Yang G, et al.·Zeitschrift fur Naturforschung. C, Journal of biosciences·
The chemical structure of a polysaccharide from the broth of cultured Streptomyces virginia H03 was investigated. There might be 1-->2 and 1-->4 and no 1-->6 glycosidic linkages in the polysaccharide...
Managing cetuximab hypersensitivity-infusion reactions: incidence, risk factors, prevention, and retreatment.
George TJ, Laplant KD, Walden EO, et al.·The journal of supportive oncology·
Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody approved by the US Food and Drug Administration for the treatment of colorectal (CRC) and head and neck (H&N) cancers....
Cetuximab given every 2 weeks plus irinotecan is an active and safe option for previously treated patients with metastatic colorectal cancer.
Roca JM, Alonso V, Pericay C, et al.·Chemotherapy·
We gathered data from multiple institutions on the cetuximab regimen of patients with metastatic colorectal cancer. 126 patients from 19 centers were included from July 2006 to July 2007 in this prosp...
[Efficacy of cetuximab combined with chemotherapy on advanced colorectal cancer: a report of 53 cases].
Guo GF, Xia LP, Zhang B, et al.·Ai zheng = Aizheng = Chinese journal of cancer·
Studies showed that cetuximab combined with chemotherapy was effective on advanced colorectal cancer (ACRC) in recent years, however, few reports based on large case cohort are available in China. Thi...
Successful desensitization with cetuximab after an infusion reaction to panitumumab in patients with metastatic colorectal cancer.
Saif MW, Syrigos KI, Hotchkiss S, et al.·Cancer chemotherapy and pharmacology·
Cetuximab and panitumumab are chimeric and fully human monoclonal antibodies, respectively, against epidermal growth factor receptor used in the treatment of metastatic colorectal cancer (mCRC). Incid...
Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab.
Jacquenet S, Moneret-Vautrin DA, Bihain BE·The Journal of allergy and clinical immunology·
Prenatal and childhood Mediterranean diet and the development of asthma and allergies in children.
Chatzi L, Kogevinas M·Public health nutrition·
To discuss current evidence about the relation between prenatal and childhood Mediterranean diet, and the development of asthma and allergies in children. Review of the literature. Four recent studies...
Allergic reactions during allergy skin testing with food allergens.
Pitsios C, Dimitriou A, Kontou-Fili K·European annals of allergy and clinical immunology·
Skin testing is a reliable and safe way to diagnose IgE-mediated allergies, with rare side-effects. Two cases of systemic allergic reactions during skin testing to food allergens are hereby reported....
Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature.
James E, Waldron-Lynch MG, Saif MW·Anti-cancer drugs·
Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 have been proven to predict a drastically increased lifetime risk of breast and ovarian cancers in the individuals who carry them. A nu...
Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada.
Anderson LN, Cotterchio M, Gallinger S·Cancer causes & control : CCC·
Pancreatic adenocarcinoma has one of the worst survival rates of all the cancers. Established risk factors for this malignancy are smoking, body mass index (BMI) and family history of pancreatic cance...
Glycoprofile of the different cell types present in the mucosa of the horse guttural pouches.
Parillo F, Arias MP, Supplizi AV·Tissue & cell·
Histochemical characterization of the equine guttural pouches was performed using lectins combined with sialidase digestion and deglycosylation pre-treatments. The goblet cells contained O- and N-link...
Structural analysis of N-glycans from gull egg white glycoproteins and egg yolk IgG.
Suzuki N, Su TH, Wu SW, et al.·Glycobiology·
We previously showed that the expression of (Gal alpha 1-4Gal)-bearing glycoproteins among birds is related to their phylogeny. However, precise structures of (Gal alpha 1-4Gal)-containing N-glycans w...
Meat allergy.
Restani P, Ballabio C, Tripodi S, et al.·Current opinion in allergy and clinical immunology·
This review summarizes the scientific evidence on meat allergy, an unusual disorder, whose prevalence in some European countries (such as Italy) may be increasing. Data reported in this review underli...
An association between tick bite reactions and red meat allergy in humans.
Van Nunen SA, O'Connor KS, Clarke LR, et al.·The Medical journal of Australia·
Twenty-five patients living in a tick-endemic region of Sydney, New South Wales developed red meat allergy after experiencing large local reactions to tick bites. This represents a potentially novel c...
Clinical presentation and diagnosis of meat allergy in Switzerland and Southern Germany.
Theler B, Brockow K, Ballmer-Weber BK·Swiss medical weekly·
The aim of this study was to investigate the clinical characteristics of meat allergy, to validate the routine diagnostic tools and to compare our results with data from the literature. We recruited w...
The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA.
Grönlund H, Adédoyin J, Commins SP, et al.·The Journal of allergy and clinical immunology·
Successful re-challenge with panitumumab in patients who developed hypersensitivity reactions to cetuximab: report of three cases and review of literature.
Saif MW, Peccerillo J, Potter V·Cancer chemotherapy and pharmacology·
Monoclonal antibodies (MAbs) targeting epidermal growth factor receptor (EGFR) are effective in treatment of metastatic colorectal cancer (mCRC). Cetuximab, a chimeric MAb targets EGFR. Even with prem...
A phase 2 study of cetuximab in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced nonsmall cell lung cancer.
Kim ES, Mauer AM, William WN, et al.·Cancer·
Cetuximab in combination with docetaxel was examined in chemotherapy-refractory/resistant patients with advanced nonsmall-cell lung cancer (NSCLC) to determine response rate, survival, safety, and pha...
Cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: a multicentre phase II study.
Kullmann F, Hollerbach S, Dollinger MM, et al.·British journal of cancer·
Targeting the epidermal growth factor receptor pathway in pancreatic cancer seems to be an attractive therapeutic approach. This study assessed the efficacy of cetuximab plus the combination of gemcit...
Six cases of treatment with panitumumab in patients with severe hypersensitivity reactions to cetuximab.
Nielsen DL, Pfeiffer P, Jensen BV·Annals of oncology : official journal of the European Society for Medical Oncology·
The ductus epididymis of the alpaca: immunohistochemical and lectin histochemical study.
Parillo F, Verini Supplizi A, Macrì D, et al.·Reproduction in domestic animals = Zuchthygiene·
Our objective was to characterize epithelial cells lining the epididymal duct (caput, corpus, cauda) of the alpaca using AE1/AE3 cytokeratin antibodies and a battery of different lectins: Con-A, UEA-I...
Glycocomposition of the apocrine interdigital gland secretions in the fallow deer (Dama dama).
Parillo F, Diverio S·Research in veterinary science·
The secretions of the tubular interdigital glands were investigated by conventional (Periodic-Acid Schiff, Alcian-Blue at different pH, Low Iron Diamine and High Iron Diamine) and lectin (Con-A, UEA-I...
Targeting colorectal cancer with anti-epidermal growth factor receptor antibodies: focus on panitumumab.
Williams KJ, Lockhart AC·OncoTargets and therapy·
The tumor biology targeted therapies have improved outcomes in colorectal cancer (CRC). The epidermal growth factor receptor (EGFR) inhibitors represent one of these successful strategies. EGFR is fre...
View on PubMed →Computationally and experimentally derived general rules for fragmentation of various glycosyl bonds in sodium adduct oligosaccharides.
Suzuki H, Kameyama A, Tachibana K, et al.·Analytical chemistry·
Mechanisms of fragmentation of glycosyl bond linkages in various saccharides were investigated by using computational calculations to find general rules of fragmentation of sodiated oligosaccharides i...
Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose.
Commins SP, Satinover SM, Hosen J, et al.·The Journal of allergy and clinical immunology·
Carbohydrate moieties are frequently encountered in food and can elicit IgE responses, the clinical significance of which has been unclear. Recent work, however, has shown that IgE antibodies to galac...
Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer.
Bertolini F, Chiara S, Bengala C, et al.·International journal of radiation oncology, biology, physics·
Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced colorectal cancer, and its incor...
Glycosylation specific for adhesion molecules in epidermis and its receptor revealed by glycoform-focused reverse genomics.
Uematsu R, Shinohara Y, Nakagawa H, et al.·Molecular & cellular proteomics : MCP·
Glycosylation of proteins greatly affects their structure and function, but traditional genomics and transcriptomics are not able to precisely capture tissue- or species-specific glycosylation pattern...
Pharmacogenetics: implementing personalized medicine.
Mini E, Nobili S·Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases·
Pharmacogenetics and pharmacogenomics have been widely recognized as fundamental steps toward personalized medicine. They deal with genetically determined variants in how individuals respond to drugs,...
View on PubMed →Immunohistochemical and lectin histochemical analysis of the alpaca efferent ducts.
Parillo F, Magi GE, Diverio S, et al.·Histology and histopathology·
An immunohistochemical and lectin histochemical study of the efferent ducts was performed in the alpaca. Two types of epithelium, consisting of principal and ciliated cells, were detected on the basis...
Cytotoxic T lymphocyte responses to transgene product, not adeno-associated viral capsid protein, limit transgene expression in mice.
Siders WM, Shields J, Kaplan J, et al.·Human gene therapy·
The use of adeno-associated viral (AAV) vectors for gene replacement therapy is currently being explored in several clinical indications. However, reports have suggested that input capsid proteins fro...
Gateways to clinical trials.
Tomillero A, Moral MA·Methods and findings in experimental and clinical pharmacology·
(-)-Gossypol; Alemtuzumab, Amlodipine, Anakinra, Azacitidine; Bazedoxifene acetate, Belinostat, Bevacizumab, BI-201335, BI-2536, Biphasic insulin aspart, Bortezomib; Cetuximab, CNTO-328, Custirsen sod...
Identification of alpha Gal as the major target for human anti-pig antibodies.
Cooper DK·Xenotransplantation·
Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase.
Tumbale P, Jamaluddin H, Thiyagarajan N, et al.·Glycobiology·
Complex glycans have important roles in biological recognition processes and considerable pharmaceutical potential. The synthesis of novel glycans can be facilitated by engineering glycosyltransferase...
Synthesis of novel fructooligosaccharides by substrate and enzyme engineering.
Beine R, Moraru R, Nimtz M, et al.·Journal of biotechnology·
Fructooligosaccharides (FOSs) and polyfructosides (PSs) have received particular attention due to its beneficial effects as prebiotics. Here we report the synthesis of a new class of fructooligosaccha...
Results of a phase II trial of cetuximab plus capecitabine/irinotecan as first-line therapy for patients with advanced and/or metastatic colorectal cancer.
Cartwright T, Kuefler P, Cohn A, et al.·Clinical colorectal cancer·
XELIRI (capecitabine/irinotecan) is effective and well tolerated in metastatic colorectal cancer (mCRC). Cetuximab is active in mCRC alone or with chemotherapy. This study evaluated cetuximab plus XEL...
Tissue engineering small-diameter vascular grafts: preparation of a biocompatible porcine ureteric scaffold.
Derham C, Yow H, Ingram J, et al.·Tissue engineering. Part A·
This study aimed to investigate a biocompatible, biomechanically functional, small-diameter (<6 mm) scaffold for tissue engineering a vascular graft using acellular porcine ureters. Porcine ureters we...
Experimental and theoretical studies of sodium cation interactions with D-arabinose, xylose, glucose, and galactose.
Heaton AL, Armentrout PB·The journal of physical chemistry. A·
The binding of Na (+) to arabinose (Ara), xylose (Xyl), glucose (Glc), and galactose (Gal) is examined in detail by studying the collision-induced dissociation (CID) of the four sodiated monosaccharid...
New source of α-d-galactosidase: Germinating coffee beans.
Shen W, Jin Z, Xu X, et al.·Food chemistry·
Enzyme activities of α-Gal from dormant and germinating coffee beans (Coffea arabica) were studied and compared to develop one new source of α-d-galactosidase (α-Gal). During the germination, enzyme a...
View on PubMed →Reduction of soybean oligosaccharides and properties of alpha-D-galactosidase from Lactobacillus curvatus R08 and Leuconostoc mesenteroides [corrected] JK55.
Yoon MY, Hwang HJ·Food microbiology·
This study was undertaken to investigate the potential for reducing non-digestive oligosaccharides (NDO) in soy foods, as well as the influence of exogenous conditions on intracellular alpha-galactosi...
Galactose residues on the lipooligosaccharide of Moraxella catarrhalis 26404 form the epitope recognized by the bactericidal antiserum from conjugate vaccination.
Yu S, Xie H, Datta A, et al.·Infection and immunity·
Lipooligosaccharide (LOS) from Moraxella catarrhalis has the potential to elicit bactericidal antibodies against the pathogen. We generated LOS-based conjugate vaccines that elicited bactericidal anti...
Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile.
Dingle T, Wee S, Mulvey GL, et al.·Glycobiology·
The biological and ligand-binding properties of recombinant C-terminal cell-binding domains (CBDs) and subdomains of the two large exotoxins, Toxin A (TcdA) and Toxin B (TcdB) expressed by Clostridium...
Production of alpha 1,3-galactosyltransferase gene-deficient pigs by somatic cell nuclear transfer: a novel selection method for gal alpha 1,3-Gal antigen-deficient cells.
Fujimura T, Takahagi Y, Shigehisa T, et al.·Molecular reproduction and development·
The objective of the present study was to isolate alpha 1,3-galactosyltransferase (GalGT)-gene double knockout (DKO) cells using a novel simple method of cell selection method. To obtain GalGT-DKO cel...
A phase II study of cetuximab/paclitaxel/carboplatin for the initial treatment of advanced-stage ovarian, primary peritoneal, or fallopian tube cancer.
Konner J, Schilder RJ, DeRosa FA, et al.·Gynecologic oncology·
Determine the safety and efficacy of cetuximab plus paclitaxel and carboplatin as initial treatment of stage III/IV ovarian cancer. An initial intravenous [IV] dose of cetuximab (400 mg/m(2)) was admi...
6-sulfo sialyl Lewis X is the common receptor determinant recognized by H5, H6, H7 and H9 influenza viruses of terrestrial poultry.
Gambaryan AS, Tuzikov AB, Pazynina GV, et al.·Virology journal·
Influenza A viruses of domestic birds originate from the natural reservoir in aquatic birds as a result of interspecies transmission and adaptation to new host species. We previously noticed that infl...
Structural analysis of alpha-Gal and new non-Gal carbohydrate epitopes from specific pathogen-free miniature pig kidney.
Kim YG, Gil GC, Harvey DJ, et al.·Proteomics·
The major barrier in transplantation of pig organs into humans is the presence of surface carbohydrate antigens (e.g., the Gal alpha 1-3 Gal beta 1-4GlcNAc-R (alpha-Gal) epitope) expressed on pig endo...
Synthesis and in vitro evaluation of alpha-GalCer epimers.
Trappeniers M, Goormans S, Van Beneden K, et al.·ChemMedChem·
alpha-GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d-mediated stimulation. Because Th1 and Th2 cyt...
Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.
Arnold DF, Misbah SA·The New England journal of medicine·
Managing premedications and the risk for reactions to infusional monoclonal antibody therapy.
Chung CH·The oncologist·
Monoclonal antibodies-including rituximab, alemtuzumab, trastuzumab, bevacizumab, cetuximab, and panitumumab-have improved the treatment of various malignancies. Although generally better tolerated wi...
Targeting colorectal cancer with human anti-EGFR monoclonocal antibodies: focus on panitumumab.
Kim GP, Grothey A·Biologics : targets & therapy·
The human anti-epidermal growth factor receptor (EGFR) monoclonal antibody, panitumumab, represents a significant advance in the treatment of colorectal cancer. The strategy to target this receptor is...
View on PubMed →Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer.
Jean GW, Shah SR·Pharmacotherapy·
Treatment of metastatic colorectal disease has evolved over the last decade. Two epidermal growth factor receptor (EGFR) monoclonal antibodies--cetuximab and panitumumab--have been developed in an eff...
Biweekly cetuximab and irinotecan as third-line therapy in patients with advanced colorectal cancer after failure to irinotecan, oxaliplatin and 5-fluorouracil.
Pfeiffer P, Nielsen D, Bjerregaard J, et al.·Annals of oncology : official journal of the European Society for Medical Oncology·
Standard weekly cetuximab and irinotecan (CetIri) is an effective regimen in heavily pretreated patients with advanced colorectal cancer (ACRC). Inspired by a pharmacokinetic study demonstrating no di...
Molecular and antigenic characterization of a Streptococcus oralis coaggregation receptor polysaccharide by carbohydrate engineering in Streptococcus gordonii.
Yoshida Y, Yang J, Peaker PE, et al.·The Journal of biological chemistry·
The coaggregation receptor polysaccharides (RPS) of Streptococcus oralis and related species are recognized by lectin-like adhesins on other members of the oral biofilm community and by RPS-specific a...
Decreased specific antibody responses to alpha-Gal-conjugated antigen in animals with preexisting high levels of natural antibodies binding alpha-Gal residues.
Parmentier HK, De Vries Reilingh G, Lammers A·Poultry science·
High levels of natural antibodies (NAb) binding the alpha-Gal residue (Galalpha1-3Galbeta1-4GlcNAc) are found in poultry (and humans), which is probably reflected by high levels of natural agglutinati...
Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.
Chung CH, Mirakhur B, Chan E, et al.·The New England journal of medicine·
Cetuximab, a chimeric mouse-human IgG1 monoclonal antibody against the epidermal growth factor receptor, is approved for use in colorectal cancer and squamous-cell carcinoma of the head and neck. A hi...
Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: a Gynecologic Oncology Group study.
Secord AA, Blessing JA, Armstrong DK, et al.·Gynecologic oncology·
This phase II trial assessed the activity and tolerability of cetuximab (C225, Erbitux) in combination with carboplatin in patients with relapsed platinum-sensitive ovarian or primary peritoneal carci...
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis.
Mehta AS, Long RE, Comunale MA, et al.·Journal of virology·
Hepatitis B and C viruses are major causative agents of liver fibrosis, cirrhosis, and liver cancer. Using comparative glycoproteomics, we identified a glycoprotein that is altered both in amount and...
Cetuximab with concurrent chemoradiation for esophagogastric cancer: assessment of toxicity.
Safran H, Suntharalingam M, Dipetrillo T, et al.·International journal of radiation oncology, biology, physics·
To determine the feasibility and toxicity of the addition of cetuximab with paclitaxel, carboplatin, and radiation for patients with esophagogastric cancer on a Phase II study. Patients with locoregio...
Efficacy and skin toxicity management with cetuximab in metastatic colorectal cancer: outcomes from an oncologic/dermatologic cooperation.
Racca P, Fanchini L, Caliendo V, et al.·Clinical colorectal cancer·
The aim of this study was to investigate the efficacy of the combination of irinotecan/cetuximab and to plan related skin toxicity management with an oncologic/dermatologic team. Thirty-four patients...
Accelerated proliferation and abnormal differentiation of epidermal keratinocytes in endo-beta-galactosidase C transgenic mice.
Misawa M, Watanabe S, Ihara S, et al.·Glycobiology·
Transgenic (TG) mice that have systemically expressed endo-beta-galactosidase C (EndoGalC) have rough and flaky skin. This skin phenotype is detectable around 5 days postnatal and becomes obscure by 2...
Lectin histochemistry of the endothelium of blood vessels in the mammalian integument, with remarks on the endothelial glycocalyx and blood vessel system nomenclature.
Meyer W, Godynicki S, Tsukise A·Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·
Based on sensitive light and electron microscopical lectin histochemistry, the distribution of saccharide residues is demonstrated in endothelial cells and/or the walls of integumental blood vessels o...
Comparability and monitoring immunogenic N-linked oligosaccharides from recombinant monoclonal antibodies from two different cell lines using HPLC with fluorescence detection and mass spectrometry.
Kilgore BR, Lucka AW, Patel R, et al.·Methods in molecular biology (Clifton, N.J.)·
One of the most important structural features of recombinant monoclonal antibodies produced in mammalian cells is the N-linked oligosaccharide profile. These profiles impact recombinant therapeutics i...
Expression of alpha-galactosidase gene from Leuconostoc mesenteroides SY1 in Leuconostoc citreum.
Park JY, Jeong SJ, Lee AR, et al.·Journal of microbiology and biotechnology·
A 2.5 kb aga gene encoding alpha-galactosidase (alpha- Gal) from Leuconostoc mesenteroides SY1 was cloned into pSJE, an E. coli-Leuconostoc shuttle vector. The recombinant plasmid, pSJEaga, was introd...
Successful desensitization protocol for hypersensitivity reactions caused by oxaliplatin.
Rosique-Robles D, Vicent Verge JM, Borrás-Blasco J, et al.·International journal of clinical pharmacology and therapeutics·
To report the successful desensitization of a patient with a hypersensitivity reaction to oxaliplatin. A 57-year-old woman with metastatic colon cancer was receiving oxaliplatin, fluorouracil and leuc...
High incidence of cetuximab-related infusion reactions in Tennessee and North Carolina and the association with atopic history.
O'Neil BH, Allen R, Spigel DR, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
To confirm the anecdotal observation that patients in North Carolina (NC) and Tennessee (TN) treated with cetuximab experience hypersensitivity reactions (HSR) at a much higher rate than are reported...
Analysis of protein-linked glycosylation in a sperm-somatic cell adhesion system.
Sutton-Smith M, Wong NK, Khoo KH, et al.·Glycobiology·
Murine sperm initiate fertilization by binding to the specialized extracellular matrix of their complementary eggs, known as the zona pellucida. On the basis of data reported in this study, mouse sper...
Management and preparedness for infusion and hypersensitivity reactions.
Lenz HJ·The oncologist·
Like nearly all systemic cancer therapies, monoclonal antibodies are associated with hypersensitivity reactions. This article reviews the characteristics and management of hypersensitivity reactions t...
The C-terminal sequence from common bugle leaf galactan:galactan galactosyltransferase is a non-sequence-specific vacuolar sorting determinant.
Tapernoux-Lüthi EM, Schneider T, Keller F·FEBS letters·
The Ajuga reptans L. galactan:galactan galactosyltransferase (ArGGT) is a vacuolar enzyme that synthesizes long-chain raffinose family oligosaccharides (RFOs), the major storage carbohydrates of this...
Unexpected immunoresponse to Gal and APA antigens in diabetic type 1 patients receiving neonatal pig islets after 6 years.
Valdés-González RA, Dorantes LM, Garibay GN, et al.·Journal of clinical immunology·
Cotransplantation of porcine islets and Sertoli cells into preimplanted subcutaneous devices improve metabolic control in type 1 diabetic patients, and survive grafted for more than 4 years. We report...
Incidence and management of cutaneous toxicities associated with cetuximab.
Saif MW, Kim R·Expert opinion on drug safety·
Cetuximab is a human/mouse chimeric monoclonal antibody that binds to the EGF receptor, competitively inhibiting ligand binding, and inducing receptor dimerization and downregulation. Cetuximab has be...
Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat.
Fullmer JM, Riedl M, Williams FG, et al.·The Journal of comparative neurology·
The isolectin B4 (IB4) stains a subset of small and medium-sized dorsal root ganglion (DRG) neurons by binding to terminal alpha-galactose on glycoproteins and glycolipids. The enzymes alpha(1,3)galac...
Selective tumor cell targeting using low-affinity, multivalent interactions.
Carlson CB, Mowery P, Owen RM, et al.·ACS chemical biology·
This report highlights the advantages of low-affinity, multivalent interactions to recognize one cell type over another. Our goal was to devise a strategy to mediate selective killing of tumor cells,...
[Screening proteins in hepatocytes interacting with the middle surface protein of hepatitis B virus using the yeast-two hybrid technique].
Li ZQ, Ma YJ, Cheng J·Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·
To screen proteins in hepatocytes interacting with hepatitis B virus surface antigen middle protein (MHBs) with yeast-two hybrid technique for studying the biological functions of MHBs. Polymerase cha...
Expression of rice (Oryza sativa L. var. Nipponbare) alpha-galactosidase genes in Escherichia coli and characterization.
Li S, Kim WD, Kaneko S, et al.·Bioscience, biotechnology, and biochemistry·
Two putative alpha-galactosidase genes from rice (Oryza sativa L. var. Nipponbare) belonging to glycoside hydrolase family 27 were cloned and expressed in Escherichia coli. These enzymes showed alpha-...
Bifunctional ligands that target cells displaying the alpha v beta3 integrin.
Owen RM, Carlson CB, Xu J, et al.·Chembiochem : a European journal of chemical biology·
Strategies to eliminate tumor cells have long been sought. We envisioned that a small molecule could be used to decorate the offending cells with immunogenic carbohydrates and evoke an immune response...
Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the Gal alpha1-3Galbeta1-4GlcNAc-R (alpha-Gal) epitope.
Hewitt Z, Priddle H, Thomson AJ, et al.·Stem cells (Dayton, Ohio)·
Although undifferentiated human embryonic stem cells (hESCs) are tumorigenic, this capacity is lost after differentiation, and hESCs are being widely investigated for applications in regenerative medi...
Safety and efficacy of cetuximab-chemotherapy combination in Saudi patients with metastatic colorectal cancer.
Ibrahim EM, Zeeneldin AA, Al-Gahmi AM, et al.·Indian journal of cancer·
Cetuximab-based combination chemotherapy (CBCC) proved safe and effective as second-line strategy for metastatic colorectal cancer (mCRC). This prospective phase-II study was designed to assess the ef...
Examination of basement membrane components associated with the bovine seminiferous tubule basal lamina.
Glattauer V, Irving-Rodgers HF, Rodgers RJ, et al.·Reproduction, fertility, and development·
Immunohistology has been used to examine the distribution of certain components of the basement membrane (BM) associated with bovine spermatogonial germ cells that are located within the seminiferous...
Serum levels of anti-alphaGalactosyl antibodies predict survival and peritoneal dialysis-related enteric peritonitis rates in patients undergoing renal replacement therapy.
Fontán MP, Máñez R, Rodríguez-Carmona A, et al.·American journal of kidney diseases : the official journal of the National Kidney Foundation·
Anti-Galalpha1-3Gal antibodies (anti-alphaGal) represent a significant fraction of natural antibodies and were implicated in several disease states, yet their origin and physiological significance rem...
Profiling terminal N-acetyllactosamines of glycans on mammalian cells by an immuno-enzymatic assay.
Ogawa H, Galili U·Glycoconjugate journal·
Profiling of carbohydrate structures on cell membranes has been difficult to perform because of the complexity and the variations of such structures on cell surface glycans. This study presents a nove...
Screening of genes for proteins interacting with the PS1TP5 protein of hepatitis B virus: probing a human leukocyte cDNA library using the yeast two-hybrid system.
Zhang JK, Zhao LF, Cheng J, et al.·Chinese medical journal·
The hepatitis B virus (HBV) genome includes S, C, P and X regions. The S region is divided into four subregions of pre-pre-S, pre-S1, pre-S2 and S. PS1TP5 (human gene 5 transactivated by pre-S1 protei...
Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin.
Natchiar SK, Srinivas O, Mitra N, et al.·Acta crystallographica. Section D, Biological crystallography·
Crystal structures of peanut lectin complexed with Galbeta1-3Gal, methyl-T-antigen, Galbeta1-6GalNAc, Galalpha1-3Gal and Galalpha1-6Glc and that of a crystal grown in the presence of Galalpha1-3Galbet...
A thermostable alpha-galactosidase from Lactobacillus fermentum CRL722: genetic characterization and main properties.
Carrera-Silva EA, Silvestroni A, LeBlanc JG, et al.·Current microbiology·
Alpha-galactosidase (alpha-Gal) enzyme, which is encoded by the melA gene hydrolyzes alpha-1,6 galactoside linkages found in sugars, such as raffinose and stachyose. These alpha-galacto-oligosaccharid...
The structure of the major cell wall polysaccharide of Bacillus anthracis is species-specific.
Choudhury B, Leoff C, Saile E, et al.·The Journal of biological chemistry·
In this report we describe the structure of the polysaccharide released from Bacillus anthracis vegetative cell walls by aqueous hydrogen fluoride (HF). This HF-released polysaccharide (HF-PS) was iso...
Protein glycosylation in Parelaphostrongylus tenuis--first description of the Galalpha1-3Gal sequence in a nematode.
Duffy MS, Morris HR, Dell A, et al.·Glycobiology·
The white-tailed deer is the definitive host of the parasitic nematode Parelaphostrongylus tenuis. This parasite also infects a wide variety of domesticated livestock, causing a debilitating neurologi...
Activation of murine CD4+ and CD8+ T lymphocytes leads to dramatic remodeling of N-linked glycans.
Comelli EM, Sutton-Smith M, Yan Q, et al.·Journal of immunology (Baltimore, Md. : 1950)·
Differentiation and activation of lymphocytes are documented to result in changes in glycosylation associated with biologically important consequences. In this report, we have systematically examined...
Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues.
Marková V, Smetana K, Jeníková G, et al.·International journal of molecular medicine·
Galectin-4 and its homologue galectin-6 are members of the tandem-repeat subfamily of monomer divalent galectins. Expression of mouse galectin-4 and galectin-6 by RT-PCR using primers designed to dist...
Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation.
Wu AM, Singh T, Wu JH, et al.·Glycobiology·
Cell-surface glycans are functional docking sites for tissue lectins such as the members of the galectin family. This interaction triggers a wide variety of responses; hence, there is a keen interest...
Carbohydrate recognition by Clostridium difficile toxin A.
Greco A, Ho JG, Lin SJ, et al.·Nature structural & molecular biology·
Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-G...
The galactophilic lectin (PA-IL, gene LecA) from Pseudomonas aeruginosa. Its binding requirements and the localization of lectin receptors in various mouse tissues.
Kirkeby S, Hansen AK, d'Apice A, et al.·Microbial pathogenesis·
The opportunistic pathogen Pseudomonas aeruginosa contains lectins of which one of them, PA-IL (gene lecA), shows preference for alpha-galactosylated glycans. The bacterial lectin is probably importan...
Biological activity of Bifidobacterium longum in response to environmental pH.
Garro MS, Aguirre L, Savoy de Giori G·Applied microbiology and biotechnology·
The influence of environmental pH on biological activity of Bifidobacterium longum CRL 849 grown in MRS-raffinose was evaluated. At pH 6.0, 5.5 and 5.0, raffinose was completely consumed by this micro...
Cetuximab and irinotecan as third-line therapy in advanced colorectal cancer patients: a single centre phase II trial.
Vincenzi B, Santini D, Rabitti C, et al.·British journal of cancer·
The epidermal growth factor receptor (EGFR), which participates in signalling pathways that are deregulated in cancer cells, is frequently mutated in colorectal-cancer cells. Cetuximab is a monoclonal...
Carbohydrate-protein interactions by "clicked" carbohydrate self-assembled monolayers.
Zhang Y, Luo S, Tang Y, et al.·Analytical chemistry·
A Huisgen 1,3-dipolar cycloaddition "click chemistry" was employed to immobilize azido sugars (mannose, lactose, alpha-Gal) to fabricate carbohydrate self-assembled monolayers (SAMs) on gold. This fab...
Natural anti-Gal and Salmonella-specific antibodies in bile and plasma of hens differing in diet efficiency.
Cotter PF, Van Eerden E·Poultry science·
Specific anti-Salmonella enteritidis (SE) and natural anti-alpha-gal epitope (Galalpha1-3Galbeta-1-4GlcNAc-R; anti-Gal) antibodies were measured in plasma sample pools and individual bile specimens ob...
Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: a pilot phase II study of a new combined-modality paradigm.
Pfister DG, Su YB, Kraus DH, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
Cetuximab is a chimeric monoclonal antibody that targets the epidermal growth factor receptor. Cetuximab has activity in squamous cell carcinoma and enhances both chemotherapy and radiotherapy. We con...
Current status of cetuximab for the treatment of patients with solid tumors.
Frieze DA, McCune JS·The Annals of pharmacotherapy·
To review the pharmacology, pharmacokinetics, clinical evidence, and safety, as well as the potential directions for use, of the epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab....
Characterisation of an alpha-galactosidase with potential relevance to ripening related texture changes.
Soh CP, Ali ZM, Lazan H·Phytochemistry·
alpha-Galactosidase (EC 3.2.1.22) from ripe papaya (Carica papaya L.) fruit was fractionated by a combination of ion exchange and gel filtration chromatography into three forms, viz., alpha-galactosid...
Carbohydrate recognition factors of the lectin domains present in the Ricinus communis toxic protein (ricin).
Wu JH, Singh T, Herp A, et al.·Biochimie·
Ricin (RCA60) is a potent cytotoxic protein with lectin domains, contained in the seeds of the castor bean Ricinus communis. It is a potential biohazard. To corroborate the biological properties of ri...
Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies.
Zhang W, Gordon M, Lenz HJ·Annals of medicine·
The standard treatment of metastatic colorectal cancer (mCRC) is combination of 5- fluorouracil/folinic acid with irinotecan or oxaliplatin-based chemotherapy. Epidermal growth factor receptor (EGFR)...
Re-treatment with cetuximab in patients with severe hypersensitivity reactions to cetuximab. Two case reports.
Nielsen DL, Pfeiffer P, Jensen BV·Acta oncologica (Stockholm, Sweden)·
Binding of T-antigen disaccharides to Artocarpus hirsuta lectin and jacalin are energetically different.
Gaikwad SM, Khan MI·Photochemistry and photobiology·
The thermodynamics of binding of Me-alpha(-GalNAc, Gal-beta-1-3GalNAc-alpha-O-Me (T-antigen-alpha), Gal-beta-1-3GalNAc and Gal-alpha-1-6Glc (mellibiose) to Artocarpus hirsuta lectin was studied using...
Cutaneous reactions to chemotherapy and their management.
Wyatt AJ, Leonard GD, Sachs DL·American journal of clinical dermatology·
International data from 2002 report 10.9 million new cases of cancer and 6.7 million cancer deaths. Chemotherapy is an essential component in the multidisciplinary management of most cancers. Cutaneou...
Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer.
Robert F, Blumenschein G, Herbst RS, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
This multicenter, open-label, phase I/IIa study was undertaken to establish the safety/toxicity profile of cetuximab in combination with gemcitabine and carboplatin in patients with chemotherapy-naïve...
Cetuximab: new drug. Metastatic colorectal cancer: an inappropriate evaluation.
·Prescrire international·
(1) In patients with metastatic colorectal cancer initially treated with irinotecan combination therapy, second-line therapy with a combination of fluorouracil, folinic acid and oxaliplatin resulted i...
[Cloning and expression of alpha-D-galactosidase from coffee bean (Coffea liberica & Coffea canephora)].
Liang SY, Zheng XQ·Yi chuan = Hereditas·
Alpha-D-galactosidase (alpha-Gal,E.C. 3.2.1.22) is an exo-glycosidase. The enzyme isolated from coffee beans has been well characterized. It has high activity in hydrolyzing the terminal alpha-D-galac...
Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck.
Herbst RS, Arquette M, Shin DM, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
This multicenter phase II study was undertaken to define the efficacy and safety of cetuximab, an antiepidermal growth factor receptor chimeric human and murine monoclonal antibody, administered with...
Lectinochemical studies on the binding properties of a toxic lectin (ricin) isolated from the seeds of Ricinus communis.
Wu AM, Wu JH, Singh T, et al.·Chang Gung medical journal·
Ricin (RCA2 or RCA60) is a highly toxic heterodimeric protein found in the seeds of the castor plant Ricinus communis. It is a potential biohazard. In the present study, the fine specificity of ricin...
The role of cetuximab in the treatment of squamous cell cancer of the head and neck.
Burtness B·Expert opinion on biological therapy·
The epidermal growth factor receptor (EGFR) is a member of the HER family of tyrosine kinase growth factor receptors. Binding to EGFR by its natural ligands, mainly epidermal growth factor (EGF) or tr...
Lactobacillus fermentum CRL 722 is able to deliver active alpha-galactosidase activity in the small intestine of rats.
LeBlanc JG, Piard JC, Sesma F, et al.·FEMS microbiology letters·
alpha-galactooligosaccharides (alpha-GOS) found in legumes such as soybeans can cause gastrointestinal disorders since mammals lack alpha-galactosidase (alpha-Gal) in the small intestine which is nece...
Effect of long-term culture on the expression of antigens and adhesion molecule in single porcine pancreatic endocrine cells.
Edamura K, Nasu K, Iwami Y, et al.·Xenotransplantation·
Changes in the expression of galactose (Gal) alpha1-3Gal, swine lymphocyte antigen (SLA) class II and intracellular adhesion molecule (ICAM)-1 of single porcine pancreatic endocrine (PE) cells during...
Reducing Gal expression on the pig organ - a retrospective review.
Ezzelarab M, Cooper DK·Xenotransplantation·
The rejection caused by the presence of Galalpha1,3Gal (Gal) on the pig vascular endothelium and of natural anti-Gal antibodies in human blood has recently been prevented by the breeding of pigs that...
Molecular epidemiological study on pre-X region of hepatitis B virus and identification of hepatocyte proteins interacting with whole-X protein by yeast two-hybrid.
Yang Q, Cheng J, Dong J, et al.·World journal of gastroenterology·
To identify the pre-X region in hepatitis B virus (HBV) genome and to study the relationship between the genotype and the pre-X region. To investigate the biological function of whole-X (pre-X plus X)...
Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer.
Wong SF·Clinical therapeutics·
Cetuximab is a recombinant human/mouse chimeric epidermal growth factor receptor (EGFR) monoclonal antibody. It was approved by the US Food and Drug Administration in February 2004 to be used in combi...
Analyses of Pseudomonas aeruginosa lectin binding to alpha-galactosylated glycans.
Kirkeby S, Moe D·Current microbiology·
The specificity and binding capacity of the galactophilic lectin from the Gram negative bacterium Pseudomonas aeruginosa (PA-IL) was determined by solid phase measurements using galactosylated neoglyc...
Anti-pig antibody adsorption efficacy of {alpha}-Gal carrying recombinant P-selectin glycoprotein ligand-1/immunoglobulin chimeras increases with core 2 {beta}1, 6-N-acetylglucosaminyltransferase expression.
Liu J, Gustafsson A, Breimer ME, et al.·Glycobiology·
We have previously described the construction of a P-selectin glycoprotein ligand-1-mouse immunoglobulin Fc fusion protein, which when transiently coexpressed with the porcine alpha1,3 galactosyltrans...
[A prompt method to quantitative assay of alpha-Gal on pig cell surface without injury].
Zeng LY, Li ST, Zhang J, et al.·Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition·
To develop a method for quantitative assay of alpha-Gal on pig cell surface. After centrifugation of the anticoagulated blood samples, the white blood cell layer was collected for addition of FITC-BSI...
An unusual pattern of meat allergy.
Bourne HC, Restani P, Moutzouris M, et al.·Allergy·
[The role RNA interference of alpha1, 3GT plays in resistance to complement mediated cytotoxicity of porcine endothelial cells].
Zhu M, Xia ZX, Wang SS, et al.·Zhonghua yi xue za zhi·
To evaluate whether RNA interference can protect porcine endothelial cells from complement mediated cytotoxicity. Immortalized porcine aortic endothelial cells of the line PED were cultured and transf...
Structural basis for the energetics of jacalin-sugar interactions: promiscuity versus specificity.
Arockia Jeyaprakash A, Jayashree G, Mahanta SK, et al.·Journal of molecular biology·
Jacalin, a tetrameric lectin, is one of the two lectins present in jackfruit (Artocarpus integrifolia) seeds. Its crystal structure revealed, for the first time, the occurrence of the beta-prism I fol...
The bacterial flora of alpha-Gal knockout mice express the alpha-Gal epitope comparable to wild type mice.
Dahl K, Kirkeby S, d'Apice AF, et al.·Transplant immunology·
The human genome possesses pseudogenes for the enzyme alpha1,3 galactosyltransferase and hence, human cells and tissues do not express the Galalpha terminated trisaccharide structure Galalpha1-3Galbet...
Full NMR assignment and revised structure for the capsular polysaccharide from Streptococcus pneumoniae type 15B.
Jones C, Lemercinier X·Carbohydrate research·
The capsular polysaccharide from Streptococcus pneumoniae Type 15B is a component of the 23-valent polysaccharide vaccine against pneumococcal disease. We report full NMR assignments for the native an...
Biochemical and molecular characterization of alpha-D-galactosidase from coffee beans.
Marraccini P, Rogers WJ, Caillet V, et al.·Plant physiology and biochemistry : PPB·
Alpha-D-Galactosidase (alpha-Gal; EC 3.2.1.22) is one of three principal enzymes involved in the modification or degradation of plant cell wall galactomannans. In the present paper it is shown that al...
Asthma and allergic diseases in schoolchildren: third cross-sectional survey in the same primary school in Ankara, Turkey.
Demir AU, Karakaya G, Bozkurt B, et al.·Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·
We investigated prevalence and determinants of asthma and allergic diseases in a cross-sectional survey of schoolchildren aged 6-14 in 2002. This was the third of a series of cross-sectional surveys,...
Identification of allergens responsible for canine cutaneous adverse food reactions to lamb, beef and cow's milk.
Martín A, Sierra MP, González JL, et al.·Veterinary dermatology·
Lamb, beef and cow's milk are common causes of cutaneous adverse food reactions in dogs. The aim of this study was to identify the proteins responsible for cutaneous adverse reactions to these foods....
A four-component one-pot synthesis of alpha-Gal pentasaccharide.
Wang Y, Huang X, Zhang LH, et al.·Organic letters·
A four-component one-pot sequential synthesis of alpha-Gal pentasaccharide 2 with minimal protecting group manipulations in a very short period of time is described in this paper. [structure: see text...
View on PubMed →Reduction of non-digestible oligosaccharides in soymilk: application of engineered lactic acid bacteria that produce alpha-galactosidase.
LeBlanc JG, Silvestroni A, Connes C, et al.·Genetics and molecular research : GMR·
Human consumption of soy-derived products has been limited by the presence of non-digestible oligosaccharides (NDO), such as the alpha-galactooligosaccharides raffinose and stachyose. Most mammals, in...
EGFR inhibition in NSCLC: the emerging role of cetuximab.
Herbst RS·Journal of the National Comprehensive Cancer Network : JNCCN·
Epidermal growth factor receptor expression has been shown to contribute to the growth and survival of tumor cells via several mechanisms. High levels of this expression are common in patients with no...
Structural analysis of the lipopolysaccharide derived core oligosaccharides of Actinobacillus pleuropneumoniae serotypes 1, 2, 5a and the genome strain 5b.
Michael FS, Brisson JR, Larocque S, et al.·Carbohydrate research·
The structures of the core oligosaccharides of the lipopolysaccharides (LPS) from Actinobacillus pleuropneumoniae serotypes 1, 2, 5a and 5b were elucidated. The LPS's were subjected to a variety of de...
Effect of pH on Lactobacillus fermentum growth, raffinose removal, alpha-galactosidase activity and fermentation products.
LeBlanc JG, Garro MS, Savoy de Giori G·Applied microbiology and biotechnology·
In this study, the behaviour of Lactobacillus fermentum CRL 722 and CRL 251 were evaluated under different pH conditions (pH 6.0, 5.5, 5.0, 4.5) and without pH control. Growth was similar under all co...
The structure of the carbohydrate backbone of the lipopolysaccharide of Pectinatus frisingensis strain VTT E-79104.
Vinogradov E, Li J, Sadovskaya I, et al.·Carbohydrate research·
The structure of the carbohydrate backbone of the lipopolysaccharide from Pectinatus frisingensis strain VTT E-79104 was analyzed using chemical degradations, NMR spectroscopy, mass spectrometry, and...
Phylogenetic expression of Galalpha1-4Gal on avian glycoproteins: glycan differentiation inscribed in the early history of modern birds.
Suzuki N, Laskowski M, Lee YC·Proceedings of the National Academy of Sciences of the United States of America·
Glycoproteins containing Galalpha1-4Gal (galabiose) had been rarely found in vertebrates, except in a few species of birds and amphibians. We had previously reported that pigeon (Columba livia) egg wh...
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.
Saltz LB, Meropol NJ, Loehrer PJ, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
To evaluate the antitumor activity and toxicity of single-agent cetuximab in patients with chemotherapy-refractory colorectal cancer whose tumors express the epidermal growth factor receptor. Phase II...
Design and synthesis of alpha Gal-conjugated peptide T20 as novel antiviral agent for HIV-immunotargeting.
Naicker KP, Li H, Heredia A, et al.·Organic & biomolecular chemistry·
An efficient chemo-enzymatic synthesis of alpha Gal-conjugated peptide T20 as novel HIV-immuno-targeting agent is described. The synthesis involves chemo-enzymatic preparation of maleimide-functionali...
Isolation and characterization of a heat-resistant beef allergen: myoglobin.
Fuentes MM, Palacios R, Garcés M, et al.·Allergy·
Meat allergy is rarely reported. Most of the described cases are sensitizations to bovine serum albumin. The aim of the study was to describe a case of allergy to a new meat allergen and, after its ch...
Reduction of anti-Galalpha1,3Gal antibodies by infusion of types 2 and 6 gal trisaccharides conjugated to poly-L-lysine.
Kuwaki K, Knosalla C, Moran K, et al.·Xenotransplantation·
To investigate the specificity of anti-Galalpha1,3Gal (Gal) antibodies (Abs) with respect to Gal oligosaccharides of types 2 and 6, eight baboons received an intravenous infusion of either a poly-l-ly...
Facile preparation of the alpha-Gal-recognizing Griffonia simplicifolia I-B4 isolectin.
Winter HC, Goldstein IJ·Carbohydrate research·
The B4 isolectin from Griffonia simplicifolia is of great utility as a reagent for the identification of alpha-D-galactopyranosyl end groups. Its separation from isolectins containing A subunits has b...
Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coli.
Cavallone D, Malagolini N, Monti A, et al.·The Journal of biological chemistry·
Tamm-Horsfall glycoprotein (THP), the most abundant protein in mammalian urine, has been implicated in defending the urinary tract against infections by type 1-fimbriated Escherichia coli. Recent expe...
The neutralization of pseudorabies virus by anti-alpha-galactocyl natural antibody in normal serum.
Hayashi S, Ogawa S, Takashima Y, et al.·Virus research·
Pseudorabies virus (PrV), a member of herpesviridae alphaherpes subfamily, can infect human cells in vitro. However, the transmission to Old World primates including humans is strongly restricted. In...
Reduction of alpha-galactooligosaccharides in soyamilk by Lactobacillus fermentum CRL 722: in vitro and in vivo evaluation of fermented soyamilk.
LeBlanc JG, Garro MS, Silvestroni A, et al.·Journal of applied microbiology·
Consumption of soya-derived products has been hampered by the presence of alpha-galactooligosaccharides (alpha-GOS) because mammals lack pancreatic alpha-galactosidase (alpha-Gal) which is necessary f...
Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans.
Dell A, Chalabi S, Easton RL, et al.·Proceedings of the National Academy of Sciences of the United States of America·
Murine sperm initiate fertilization by binding to the outer covering of the egg known as the murine zona pellucida (mZP). This binding is thought to require the interaction of O-glycans linked to a sp...
Roles of individual enzyme-substrate interactions by alpha-1,3-galactosyltransferase in catalysis and specificity.
Zhang Y, Swaminathan GJ, Deshpande A, et al.·Biochemistry·
The retaining glycosyltransferase, alpha-1,3-galactosyltransferase (alpha3GT), is mutationally inactivated in humans, leading to the presence of circulating antibodies against its product, the alpha-G...
N-glycan structures of pigeon IgG: a major serum glycoprotein containing Galalpha1-4 Gal termini.
Suzuki N, Khoo KH, Chen CM, et al.·The Journal of biological chemistry·
We had shown previously that all major glycoproteins of pigeon egg white contain Galalpha1-4Gal epitopes (Suzuki, N., Khoo, K. H., Chen, H. C., Johnson, J. R., and Lee, Y. C. (2001) J. Biol. Chem. 276...
Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells.
Kawahara T, Ohdan H, Zhao G, et al.·Journal of immunology (Baltimore, Md. : 1950)·
Peritoneal cavity B-1 cells are believed to produce IgM natural Abs. We have used alpha1,3-galactosyltransferase-deficient (GalT(-/-)) mice, which, like humans, produce IgM natural Abs against the car...
pH-dependent aggregation of oligomeric Artocarpus hirsuta lectin on thermal denaturation.
Gaikwad SM, Islam Khan M·Biochemical and biophysical research communications·
The pH dependence of the activity, aggregation, and secondary structure of Artocarpus hirsuta lectin was studied using intrinsic and extrinsic fluorescence, light scattering, and circular dichroism. T...
[Inhibitors of epidermal growth factor receptor and colorectal cancer].
Adenis A, Peyrat JP·Bulletin du cancer·
Colorectal cancers (CRC) express the epidermal growth factor receptor (EGF-R), a type I transmembrane receptor with tyrosine kinase activity. EGF-R signaling inhibition is a promising target for cance...
Transplantation of cultured human corneal endothelial cells.
Amano S·Cornea·
To investigate the feasibility of corneal reconstruction utilizing cultured human corneal endothelial cells (HCECs). We cultivated HCECs using culture dishes pre-coated with bovine corneal endothelial...
Down-regulating alpha-galactosidase enhances freezing tolerance in transgenic petunia.
Pennycooke JC, Jones ML, Stushnoff C·Plant physiology·
Alpha-galactosidase (alpha-Gal; EC 3.2.1.22) is involved in many aspects of plant metabolism, including hydrolysis of the alpha-1,6 linkage of raffinose oligosaccharides during deacclimation. To exami...
The structure of the rough-type lipopolysaccharide from Shewanella oneidensis MR-1, containing 8-amino-8-deoxy-Kdo and an open-chain form of 2-acetamido-2-deoxy-D-galactose.
Vinogradov E, Korenevsky A, Beveridge TJ·Carbohydrate research·
The LPS from Shewanella oneidensis strain MR-1 was analysed by chemical methods and by NMR spectroscopy and mass spectrometry. The LPS contained no polysaccharide O-chain, and its carbohydrate backbon...
Enhanced production of alpha-galactosyl epitopes by metabolically engineered Pichia pastoris.
Shao J, Hayashi T, Wang PG·Applied and environmental microbiology·
A metabolically engineered Pichia pastoris strain was constructed that harbored three heterologous enzymes: an S11E mutated sucrose synthase from Vigna radiata, a truncated UDP-glucose C4 epimerase fr...
Studying the interaction of alpha-gal carbohydrate antigen and proteins by quartz-crystal microbalance.
Zhang Y, Telyatnikov V, Sathe M, et al.·Journal of the American Chemical Society·
The interaction of alpha-galacosyl antigen and its binding protein (anti-Gal antibody) has been studied by quartz crystal microbalance through a SAM immobilization technique which overcomes the nonspe...
Synthetic potential of molluscan sulfatases for the library synthesis of regioselectively O-sulfonated D-galacto-sugars.
Uzawa H, Nishida Y, Sasaki K, et al.·Chembiochem : a European journal of chemical biology·
The substrate specificities of three molluscan sulfatases (E.C. 3.1.6.1; snail, abalone, and limpet origins) were investigated with assorted p-nitrophenyl (pNP) di-O-sulfonated beta-D-galactopyranosid...
Sequential one-pot glycosylations using 1-hydroxyl and 1-thiodonors.
Codée JD, van den Bos LJ, Litjens RE, et al.·Organic letters·
[reaction: see text] A novel sequential glycosylation procedure is described that combines the use of 1-hydroxyl and thiodonors. The Ph(2)SO/Tf(2)O-mediated dehydrative condensation of 1-hydroxyl dono...
Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways.
Taylor SG, McKenzie IF, Sandrin MS·Glycobiology·
The important xenoepitope Galalpha(1,3)Gal was thought to be exclusively synthesized by a single alpha(1,3)galactosyltransferase. However, the cloning of the distant family member rat iGb3 synthase, w...
Binding profile of Artocarpus integrifolia agglutinin (Jacalin).
Wu AM, Wu JH, Lin LH, et al.·Life sciences·
Artocarpus integrifolia agglutinin (Jacalin) from the seeds of jack fruits has attracted considerable attention for its diverse biological activities and has been recognized as a Galbeta1-->3GalNAc (T...
Specificity of human anti-NOR antibodies, a distinct species of "natural" anti-alpha-galactosyl antibodies.
Duk M, Westerlind U, Norberg T, et al.·Glycobiology·
Natural anti-NOR antibodies are common in human sera and agglutinate human erythrocytes of a rare NOR phenotype. The NOR phenotype-related antigens are unique neutral glycosphingolipids recognized by...
Human NKT cells express granulysin and exhibit antimycobacterial activity.
Gansert JL, Kiessler V, Engele M, et al.·Journal of immunology (Baltimore, Md. : 1950)·
Human NKT cells are a unique subset of T cells that express an invariant V alpha 24 TCR that recognizes the nonclassical Ag-presenting molecule CD1d. Activation of NKT cells is greatly augmented by th...
Tolerance induction to a mammalian blood group-like carbohydrate antigen by syngeneic lymphocytes expressing the antigen.
Ogawa H, Yin DP, Shen J, et al.·Blood·
Tolerance induction to transplantation-associated carbohydrate antigens, such as blood group A or B and the alpha-gal epitope (Gal(alpha)1-3Gal(beta)1-4GlcNAc-R), is of clinical significance. This stu...
Anti-allergic effect of Perilla frutescens and its active constituents.
Makino T, Furuta Y, Wakushima H, et al.·Phytotherapy research : PTR·
The leaves of Perilla frutescens Britton (Labiatae) are one of the most popular garnishes in Japan, used as an antidote for fi sh and crab meat allergy or as a food colorant. The present study was con...
Suitability of binary mixtures of water with aprotic solvents to turn hydroxyl protons of carbohydrate ligands into conformational sensors in NOE and transferred NOE experiments.
Siebert HC, André S, Vliegenthart JF, et al.·Journal of biomolecular NMR·
The structural analysis of protein-carbohydrate interactions is essential for the long-range aim to sort out entropic/ enthalpic factors in the binding process. Of conspicuous clinical interest, this...
Assessment in mice of the therapeutic potential of tailored, multivalent Shiga toxin carbohydrate ligands.
Mulvey GL, Marcato P, Kitov PI, et al.·The Journal of infectious diseases·
The therapeutic potential of 2 soluble multivalent receptor-based inhibitors of Shiga toxin (Stx) 1 and Stx2 was determined in mice. One of these, Starfish, protected mice when it was injected subcuta...
Meat allergy and cross-reactivity with hamster epithelium.
Cisteró-Bahíma A, Enrique E, San Miguel-Moncín MM, et al.·Allergy·
A quantitative assay of alpha-GAL expressed on pig blood cells.
Zeng L, Li Y, Cheng J, et al.·Transplantation proceedings·
Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.
Li K, Wang L, Cheng J, et al.·World journal of gastroenterology·
To investigate the interaction between hepatitis C virus core protein and translin protein and its role in the pathogenensis of hepatocellular carcinoma and lymphoma. With the components of the yeast...
Cloning and functional expression of alkaline alpha-galactosidase from melon fruit: similarity to plant SIP proteins uncovers a novel family of plant glycosyl hydrolases.
Carmi N, Zhang G, Petreikov M, et al.·The Plant journal : for cell and molecular biology·
Raffinose and stachyose are ubiquitous galactosyl-sucrose oligosaccharides in the plant kingdom which play major roles, second only to sucrose, in photoassimilate translocation and seed carbohydrate s...
Carbohydrate structural units in glycoproteins and polysaccharides as important ligands for Gal and GalNAc reactive lectins.
Wu AM·Journal of biomedical science·
Glycoproteins (gps) contain many carbohydrate epitopes or crypto-glycotopes for Gal and GalNAc reactive lectins. They are present on the cell surface and function as receptors in various life processe...
Anti-gal A/B, a novel anti-blood group antibody identified in recipients of abo-incompatible kidney allografts.
Galili U, Ishida H, Tanabe K, et al.·Transplantation·
The most prevalent anticarbohydrate antibodies in human serum are anti-Gal interacting specifically with the alpha-gal epitope (Galalpha1-3Galbeta1-4GlcNAc-R) and anti-blood group antibodies interacti...
[Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein].
Li K, Wang L, Cheng J, et al.·Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology·
To clone the unknown gene of hepatocyte protein interacting with hepatitis C virus core protein. Using the yeast dual hybrid system 3, bait plasmids of hepatitis C virus core were constructed. After i...
[Transplantation of corneal endothelial cells].
Amano S·Nippon Ganka Gakkai zasshi·
Though conventional corneal transplantation has achieved great success, it still has several drawbacks including limited availability of donor corneas, recurrent allograft rejection, and subsequent gr...
A complete alpha1,3-galactosyltransferase gene is present in the human genome and partially transcribed.
Lantéri M, Giordanengo V, Vidal F, et al.·Glycobiology·
The synthesis of Galalpha1-3Gal-terminated oligosaccharides (alpha-Gal) epitopes has been interrupted during the course of evolution, starting with Old World primates. Partial sequences similar to the...
Characterization of the melA locus for alpha-galactosidase in Lactobacillus plantarum.
Silvestroni A, Connes C, Sesma F, et al.·Applied and environmental microbiology·
Alpha-galactosides are abundant sugars in legumes such as soy. Because of the lack of alpha-galactosidase (alpha-Gal) in the digestive tract, humans are unable to digest these sugars, which consequent...
Effect of dietary supplementation with alpha-galactosidase preparation and stachyose on growth performance, nutrient digestibility and intestinal bacterial populations of piglets.
Pan B, Li D, Piao X, et al.·Archiv fur Tierernahrung·
Two experiments were conducted to investigate the effect of dietary supplementation with alpha-galactosidase preparation and stachyose on growth performance, nutrient digestibility and intestinal bact...
Crystal structure of the jacalin-T-antigen complex and a comparative study of lectin-T-antigen complexes.
Jeyaprakash AA, Geetha Rani P, Banuprakash Reddy G, et al.·Journal of molecular biology·
Thomsen-Friedenreich antigen (Galbeta1-3GalNAc), generally known as T-antigen, is expressed in more than 85% of human carcinomas. Therefore, proteins which specifically bind T-antigen have potential d...
Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase.
Boix E, Zhang Y, Swaminathan GJ, et al.·The Journal of biological chemistry·
Bovine alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the synthesis of the alpha-galactose (alpha-Gal) epitope, the target of natural human antibodies. It represents a family of enzymes, includi...
Engraftment of genetically modified bone marrow cells in sensitized hosts.
Bracy J, Iacomini J·Molecular therapy : the journal of the American Society of Gene Therapy·
Expression of retrovirally transduced genes in bone marrow-derived cells can be used to establish stable long-term B- and T-cell tolerance. To determine whether preexisting antibodies may prohibit the...
Expeditious syntheses of two carbohydrate-linked cisplatin analogs.
Chen Y, Janczuk A, Chen X, et al.·Carbohydrate research·
The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and alpha-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-alpha-Gal trisaccharide int...
Cloning, expression, and characterization of the Galalpha 1,3Gal high affinity lectin from the mushroom Marasmius oreades.
Kruger RP, Winter HC, Simonson-Leff N, et al.·The Journal of biological chemistry·
The purification and unique carbohydrate binding properties, including blood group B-specific agglutination and preferential binding to Galalpha1,3Gal-containing sugar epitopes, of the Marasmius oread...
Synthesis and characterization of a novel glycopolymer with protective activity toward human anti-alpha-Gal antibodies.
Vetere A, Donati I, Campa C, et al.·Glycobiology·
An efficient and rapid synthesis of the derivative of the biocompatible polymer poly(styrene co-maleic acid) with Linear B disaccharide (Galili antigen) was achieved. The oligosaccharide portion was o...
Alterations in serum anti-alpha-galactosyl antibodies in patients with Crohn's disease and ulcerative colitis.
D'Alessandro M, Mariani P, Lomanto D, et al.·Clinical immunology (Orlando, Fla.)·
Anti-galactosyl alpha1-3-galactosyl (anti-Gal) is a natural serum antibody abundantly produced in humans in response to immune stimulation by enteric bacteria. Marked elevation of its titer has been d...
Expression of ABO or related antigenic carbohydrates on viral envelopes leads to neutralization in the presence of serum containing specific natural antibodies and complement.
Preece AF, Strahan KM, Devitt J, et al.·Blood·
No definitive biologic function has been associated with the human ABO histo-blood group polymorphism, or any other terminal carbohydrate differences within or between closely related species. We have...
The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme.
Milland J, Russell SM, Dodson HC, et al.·The Journal of biological chemistry·
It is currently under debate whether the mechanism of Golgi retention of different glycosyltransferases is determined by sequences in the transmembrane, luminal, or cytoplasmic domains or a combinatio...
Characterization of the recognition of blood group B trisaccharide derivatives by the lectin from Marasmius oreades using frontal affinity chromatography-mass spectrometry.
Rempel BP, Winter HC, Goldstein IJ, et al.·Glycoconjugate journal·
A novel lectin from the mushroom Marasmius oreades (MOA) has been shown to bind to human blood group B oligosaccharides [1]. In the present work we examine the binding of a series of analogues of the...
A role for arabinogalactan proteins in gibberellin-induced alpha-amylase production in barley aleurone cells.
Suzuki Y, Kitagawa M, Knox JP, et al.·The Plant journal : for cell and molecular biology·
Arabinogalactan proteins (AGPs) are plant proteoglycans that have been implicated in plant growth and development. The possible involvement of AGPs in the action of gibberellin (GA), a class of plant...
Expression of alpha-gal epitopes on HeLa cells transduced with adenovirus containing alpha1,3galactosyltransferase cDNA.
Deriy L, Chen ZC, Gao GP, et al.·Glycobiology·
Alpha1,3galactosyltransferase (alpha1,3GT) synthesizes alpha-gal epitopes (Gal(alpha)1-3Galbeta1-4GlcNAc-R) on glycoconjugates in nonprimate mammals but not in humans. Transduction of alpha1,3GT gene...
Protective effect of Linomide on TNF-alpha-induced hepatic injury.
Klintman D, Hedlund G, Thorlacius H·Journal of hepatology·
Linomide is an immunomodulator that ameliorates several autoimmune and inflammatory diseases. We assessed the effect of Linomide on microvascular perfusion failure, leukocyte recruitment and hepatocel...
Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.
Bühler L, Awwad M, Treter S, et al.·Transplantation·
In an attempt to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, we have infused high-dose porcine peripheral blood progenitor cells (PBPC) into baboons...
Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug".
Chen X, Liu Z, Zhang J, et al.·Chembiochem : a European journal of chemical biology·
A metabolic pathway engineered Escherichia coli strain (superbug) containing one plasmid harboring an artificial gene cluster encoding all the five enzymes in the biosynthetic pathway of Galalpha l,3L...
Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade.
Bühler L, Deng S, O'Neil J, et al.·Xenotransplantation·
The aim of the present study was to assess the survival of adult porcine islets transplanted into baboons receiving either (I) conventional triple drug immunosuppressive therapy or (2) a non-myeloabla...
Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion.
Klintman D, Schramm R, Menger MD, et al.·Journal of hepatology·
This study was designed to examine the role of selectins and CD18 in leukocyte recruitment in hepatic injury induced by tumor necrosis factor-alpha (TNF-alpha) and galactosamine (Gal) in vivo. Intravi...
Expression pattern of glycoconjugates in rat retina as analysed by lectin histochemistry.
Cho EY, Choi HL, Chan FL·The Histochemical journal·
The present study sought to characterize the expression and distribution of complex glycoconjugates in the rat retina by lectin histochemistry, using a panel of 21 different lectins with different car...
[Effect of coordinational germanium compounds on enzyme synthesis and activity].
Seĭfullina II, Martsinko EE, Batrakova OA, et al.·Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993)·
Germanium complexes (IV) with succinic (H2Suc), oxyethyliminodiacetic (H2Oeida) and iminodisuccinic (H4Ids) acids as well as homo- and heteroligand germanium complexes (IV)--products of interaction of...
Structure of a neutral glycosphingolipid recognized by human antibodies in polyagglutinable erythrocytes from the rare NOR phenotype.
Duk M, Reinhold BB, Reinhold VN, et al.·The Journal of biological chemistry·
NOR is a rare inheritable polyagglutination phenomenon that has been described in two families. Our recent studies on these erythrocytes showed they contained at least two unique neutral glycosphingol...
Chemo-enzymatic synthesis of the Galili epitope Gal(alpha)(1-->3)Galbeta(1-->4)GlcNAc on a homogeneously soluble PEG polymer by a multi-enzyme system.
Brinkmann N, Malissard M, Ramuz M, et al.·Bioorganic & medicinal chemistry letters·
The alpha-Gal trisaccharide Gal(alpha)(1-->3)Galbeta(1-->4)GlcNAc 11 was synthesized on a homogeneously soluble polymeric support (polyethylene glycol, PEG) by use of a multi-enzyme system consisting...
Phase I study of anti--epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer.
Robert F, Ezekiel MP, Spencer SA, et al.·Journal of clinical oncology : official journal of the American Society of Clinical Oncology·
To evaluate the safety, pharmacokinetics, and efficacy of a chimeric anti-epidermal growth factor receptor monoclonal antibody, cetuximab, in combination with radiation therapy (RT) in patients with a...
Isolation and characterization of major glycoproteins of pigeon egg white: ubiquitous presence of unique N-glycans containing Galalpha1-4Gal.
Suzuki N, Khoo KH, Chen HC, et al.·The Journal of biological chemistry·
Ovotransferrin (POT), two ovalbumins (POA(hi) and POA(lo)), and ovomucoid (POM) were isolated from pigeon egg white (PEW). Unlike their chicken egg white counterparts, PEW glycoproteins contain termin...
Adenovirus-mediated expression of pig alpha(1, 3) galactosyltransferase reconstructs Gal alpha(1, 3) gal epitope on the surface of human tumor cells.
Xing L, Xia GH, Fei J, et al.·Cell research·
Gal alpha(1, 3) Gal (gal epitope) is a carbohydrate epitope and synthesized in large amount by alpha(1, 3) galactosyltransferase [alpha(1, 3) GT] enzyme on the cells of lower mammalian animals such as...
Chemoenzymatic synthesis of neoglycopeptides: application to an alpha-Gal-terminated neoglycopeptide.
Ramos D, Rollin P, Klaffke W·The Journal of organic chemistry·
A novel methodology for the enzymatic preparation from suitably derivatized oligosaccharides of N-linked neoglycopeptides using the microbial glutaminyl-peptide gamma-glutamyl transferase, transglutam...
Specificity and mechanism of metal ion activation in UDP-galactose:beta -galactoside-alpha -1,3-galactosyltransferase.
Zhang Y, Wang PG, Brew K·The Journal of biological chemistry·
UDP-galactose:beta-galactosyl-alpha1,3-galactosyltransferase (alpha3GT) catalyzes the synthesis of galactosyl-alpha-1,3-beta-galactosyl structures in mammalian glycoconjugates. In humans the gene for...
[Fatal anaphylaxis after eating wild boar meat in a patient with pork-cat syndrome].
Drouet M, Sabbah A, Le Sellin J, et al.·Allergie et immunologie·
Crossed allergy between pork and cat epithelia was described by us in 1994. It is due to serum albumin. Nowadays, other bio-chemical observations allow "completion" of the syndrome by extension of the...
Functional characteristics of a protective monoclonal antibody against serotype A and C lipooligosaccharides from Moraxella catarrhalis.
Hu WG, Chen J, McMichael JC, et al.·Infection and immunity·
A monoclonal antibody (MAb), designated MAb 8E7 (immunoglobulin G3), specific for Moraxella catarrhalis lipooligosaccharide (LOS) was evaluated for its functional activity in vitro and in a mouse mode...
Red blood cell antigens responsible for inherited types of polyagglutination.
Lisowska E, Duk M·Advances in experimental medicine and biology·
The three described types on inheritable polyagglutination are related to altered carbohydrate structures in glycoproteins or/and glycolipds on the erythrocyte surface. HEMPAS, a condition causing ane...
Expression of binding properties of Gal/GalNAc reactive lectins by mammalian glycotopes (an updated report).
Wu AM·Advances in experimental medicine and biology·
Expression of the binding properties of Gal/GalNAc specific lectins, based on the affinity of decreasing order of mammalian glycotopes (determinants) rather than monosaccharide inhibition pattern, is...
Enzymatic digestion of alpha-gal antigens in pig organs by in vivo infusion of endo-beta-galactosidase C.
Kobayashi T, Yokoyama I, Liu D, et al.·Transplantation proceedings·
Detection of elicited antiporcine antibodies by FACS and Galalpha1-3Gal-specific ELISA in cynomolgus recipients after porcine kidney transplantation.
Kunz R, Loss M, Schröder C, et al.·Transplantation proceedings·
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast.
Ashida H, Tamaki H, Fujimoto T, et al.·Archives of biochemistry and biophysics·
Alpha-N-acetylgalactosaminidase (alpha-GalNAc-ase; EC 3.2.1.49) is an exoglycosidase specific for the hydrolysis of terminal alpha-linked N-acetylgalactosamine in various sugar chains. The cDNA, nagA,...
Adenovirus-mediated expression of antisense RNA transcripts complementary to pig alpha(1,3) galactosyltransferase mRNA inhibits expression of Gal alpha(1,3) Gal epitope.
Xing L, Xia GH, Bai XF, et al.·Acta pharmacologica Sinica·
To examine the effects of the expression of antisense RNA transcripts complementary to the pig alpha(1,3) galactosyltransferase [alpha(1,3)GT]mRNA on the expression of Gal alpha(1,3) Gal structure (ga...
Sesonal changes in acid glycosidases from gander testes.
Dzugan M, Droba M, Droba B·Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology·
The goal of this study was to assess the contributions of the most important acid glycosidases to the processes connected with testes involution (in the summer) and spermatogenesis during the reproduc...
Changing the donor cofactor of bovine alpha 1, 3-galactosyltransferase by fusion with UDP-galactose 4-epimerase. More efficient biocatalysis for synthesis of alpha-Gal epitopes.
Chen X, Liu Z, Wang J, et al.·The Journal of biological chemistry·
Two fusion enzymes consisting of uridine diphosphogalactose 4-epimerase (UDP-galactose 4-epimerase, EC ) and alpha1, 3-galactosyltransferase (EC ) with an N-terminal His(6) tag and an intervening thre...
Adenovirus-mediated expression of human secretor type alpha(1,2) fucosyltransferase reduces level of Gal alpha(1,3)Gal epitope.
Xing L, Xia GH, Fei J, et al.·Acta pharmacologica Sinica·
To test the potential of human secretor type alpha(1, 2) fucosyltransferase [Se alpha(1,2)FT] to downregulate the expression of Gal alpha(1,3)Gal epitope (gal epitope) in cultured cell lines. Expressi...
Meat allergy: investigation of potential allergenic proteins in beef.
Han GD, Matsuno M, Ito G, et al.·Bioscience, biotechnology, and biochemistry·
The potential allergenic proteins in beef were investigated. The sera of ten beef-allergic patients suffering from atopic dermatitis and having a positive RAST score to beef, aged 3-18 years, were obt...
A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli.
Foo LY, Lu Y, Howell AB, et al.·Journal of natural products·
Three proanthocyanidin trimers possessing A-type interflavanoid linkages, epicatechin-(4beta-->6)-epicatechin-(4beta-->8, 2beta-->O-->7)-epicatechin (4), epicatechin-(4beta-->8, 2beta-->O-->7)-epicate...
Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 320 aphereses in baboons.
Watts A, Foley A, Awwad M, et al.·Xenotransplantation·
Anti-Galalpha1-3Gal (Gal) antibodies (Gal Ab) contribute to the rejection of porcine organs transplanted into primates. Extracorporeal immunoadsorption (EIA) has been developed to eliminate Gal Ab fro...
Ultrastructural identification of cells expressing Galalpha1-3Gal antigen in cultured fetal porcine isletlike cell clusters.
Strokan V, Bennet W, Mölne J, et al.·Transplantation proceedings·
Human monocytes bind to ligands on porcine endothelium containing the gal alpha (1,3)-Gal antigen.
Kwiatkowski P, Artrip JH, Michler RE, et al.·Transplantation proceedings·
alpha-Gal and beta-Gal are preferentially expressed on porcine cardiac microvascular endothelium.
Chen RH, Kadner A, Mitchell RN, et al.·Transplantation proceedings·
Recombinant Galalpha1,3Gal-substituted mucin/immunoglobulin chimeras: a superior absorber of anti-pig antibodies.
Liu J, Holgersson J·Transplantation proceedings·
Differential expression of alpha-Gal epitopes on pig and mouse organs.
Tanemura M, Galili U·Transplantation proceedings·
Chemical characterization of milk oligosaccharides of the polar bear, Ursus maritimus.
Urashima T, Yamashita T, Nakamura T, et al.·Biochimica et biophysica acta·
Two trisaccharides, three tetrasaccharides, two pentasaccharides, one hexasaccharide, one heptasaccharide, one octasaccharide and one decasaccharide were isolated from polar bear milk samples by chlor...
Terminal glycosylation of bovine uroplakin III, one of the major integral-membrane glycoproteins of mammalian bladder.
Malagolini N, Cavallone D, Wu XR, et al.·Biochimica et biophysica acta·
Uroplakin III (UPIII) is one of the major transmembrane glycoproteins exposed at the luminal face of mammalian bladder. We investigated the terminal glycosylation of bovine UPIII in order to ascertain...
The significance of chicken meat allergy without sensitization to egg proteins.
Liccardi G, Szepfalusi Z, Noschese P, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Defining the carbohydrate specificities of aplysia gonad lectin exhibiting a peculiar D-galacturonic acid affinity.
Wu AM, Song SC, Chen YY, et al.·The Journal of biological chemistry·
Aplysia gonad lectin (AGL), which has been shown to stimulate mitogenesis in human peripheral lymphocytes, to suppress tumor cells, and to induce neurite outgrowth and improve cell viability in cultur...
The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro.
Foo LY, Lu Y, Howell AB, et al.·Phytochemistry·
Ethyl acetate extracts of Sephadex LH20-purified proanthocyanidins of American cranberry (Vaccinium macrocarpon Ait.) exhibited potent biological activity by inhibiting adherence of uropathogenic isol...
Lectin histochemical detection of sulfoglycans in the zona pellucida of mammalian antral oocytes.
Parillo F, Fagioli O, Dall'Aglio C, et al.·Acta histochemica·
Sulphated esters are important to increase effectiveness of specific biological activities of carbohydrates. Biochemical studies revealed the presence of distinct sulphated glycoproteins in mammal zon...
Specificity and prevalence of natural bovine anti-alpha galactosyl (Galalpha1-6Glc or Galalpha1-6Gal) antibodies.
Ni Y, Powell R, Turner DD, et al.·Clinical and diagnostic laboratory immunology·
Immunity against the carbohydrate components of microorganisms mediated by antibodies is an important part of host defenses. Humans and closely related primates, but not other mammals, possess natural...
Regioselective synthesis of p-nitrophenyl glycosides of beta-D-galactopyranosyl-disaccharides by transglycosylation with beta-D-galactosidases.
Zeng X, Yoshino R, Murata T, et al.·Carbohydrate research·
The beta-D-galactosidase from porcine liver induced regiospecific transglycosylation of beta-D-galactose from beta-D-Gal-OC6H4NO2-o to OH-6 of, respectively, p-nitrophenyl glycoside acceptors of Gal,...
In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice.
Ohdan H, Yang YG, Swenson KG, et al.·Transplantation·
It has been reported that T-cell depletion by in vivo treatment with monoclonal antibodies results in polyclonal B-cell activation. However, its effects on B cells responding to Galalpha1,3Gal (Gal) e...
Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen.
Medina E, Paglia P, Rohde M, et al.·European journal of immunology·
We evaluated whether immune responses stimulated by Salmonella vaccine carriers can be modulated by using different promoters to drive antigen expression. Mice were orally immunized with strains trans...
Differential expression of alpha-GAL epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on pig and mouse organs.
Tanemura M, Maruyama S, Galili U·Transplantation·
Expression of the alpha-gal epitope in mice can be completely eliminated by disruption of the alpha1,3 galactosyltransferase gene. As an initial step for assessing the feasibility of this approach in...
The carboxyl terminus of coffee bean alpha-galactosidase is critical for enzyme activity.
Maranville E, Zhu A·Archives of biochemistry and biophysics·
The role of the carboxyl (C)-terminal region of coffee bean alpha-galactosidase (alpha-GAL) has been studied by expressing C-terminal deletion mutants in the methylotrophic yeast strain Pichia pastori...
Increased galectin-3 expression in gastric cancer: correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation.
Baldus SE, Zirbes TK, Weingarten M, et al.·Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·
Galectin-3 represents an endogenous galactoside-binding lectin which may be involved in tumor cell adhesion and proliferation. In order to evaluate its biological significance in human gastric cancer,...
IgE antibody response to vertebrate meat proteins including tropomyosin.
Ayuso R, Lehrer SB, Tanaka L, et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·
Although meat is a main source of proteins in western diets, little information is available regarding allergy to vertebrate meats or the allergens implicated in these reactions. To evaluate the in vi...
Enzyme-assisted synthesis of disaccharides to inhibit binding of human anti-alpha Gal antibody.
Haga I, Satake M, Ohrui H, et al.·Transplantation proceedings·
Further characterization of the combining sites of Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4).
Wu AM, Wu JH, Chen YY, et al.·Glycobiology·
Bandeiraea (Griffonia) simplicifolia lectin-I, isolectin A(4)(GS I-A(4)), which is cytotoxic to the human colon cancer cell lines, is one of two lectin families derived from its seed extract. It conta...
Chemical characterization of milk oligosaccharides of the Japanese black bear, Ursus thibetanus japonicus.
Urashima T, Sumiyoshi W, Nakamura T, et al.·Biochimica et biophysica acta·
Two trisaccharides, two tetrasaccharides, one penta-, one hexa-, two hepta-, one deca- and two undeca-saccharides were isolated from several Japanese black bear milk samples by chloroform/methanol ext...
Bacteria targeted by human natural antibodies using alpha-Gal conjugated receptor-specific glycopolymers.
Li J, Zacharek S, Chen X, et al.·Bioorganic & medicinal chemistry·
Synthesis of polymerizable beta-lactosyl, Galalpha1-->3Gal and alpha-mannosyl acrylamide derivatives with either a hydrophobic aromatic spacer or a hydrophilic biocompatible oligoethoxyl spacer was ac...
Characterization of the substrate specificity of alpha1,3galactosyltransferase utilizing modified N-acetyllactosamine disaccharides.
Stults CL, Macher BA, Bhatti R, et al.·Glycobiology·
alpha1,3galactosyltransferase (alpha1,3GalT) catalyzes the synthesis of a range of glycoconjugates containing the Galalpha1,3Gal epitope which is recognized by the naturally occurring human antibody,...
Chemoenzymatic synthesis of the Salmonella group E1 core trisaccharide using a recombinant beta-(1-->4)-mannosyltransferase.
Zhao Y, Thorson JS·Carbohydrate research·
The chemical synthesis of the bacterial O-antigen from Salmonella serogroup E1, 3-O-(4-O-beta-D-mannopyranosyl-alpha-L-rhamnopyranosyl)-alpha-D-galactos e, presents a particular challenge because it c...
Effects of 3alpha- and 3beta-galactosylated alpha-galactosylceramides on the immune system.
Sakai T, Morita M, Matsunaga N, et al.·Bioorganic & medicinal chemistry letters·
We compared effects of alpha-galactosylceramide (alpha-GalCer) and its 3alpha- or 3beta-galactosylated derivatives on the proliferation of murine spleen cells. The 3alpha-galactosylated alpha-GalCer s...
Glycoconjugates of the rat ciliary body epithelium: a lectin histochemical and protein blotting study.
Chan FL, Poon HK, Huang Y, et al.·The Histochemical journal·
The present study sought to identify and partially characterize the glycoconjugates specific to the double-layered ciliary body epithelium of the rat eye by lectin histochemistry and lectin blottings....
Targeted expression of toxic genes directed by pituitary hormone promoters: a potential strategy for adenovirus-mediated gene therapy of pituitary tumors.
Lee EJ, Anderson LM, Thimmapaya B, et al.·The Journal of clinical endocrinology and metabolism·
Pituitary adenomas cause clinical manifestations because of mass effects and excess hormone production. This group of tumors represents a tractable target for gene therapy because they are rarely meta...
Molecular cloning and characterization of the pig secretor type alpha 1,2fucosyltransferase (FUT2).
Cohney S, Mouhtouris E, McKenzie IF, et al.·International journal of molecular medicine·
The existence of at least two distinct alpha 1,2fucosyltransferases has been postulated for many years, and recently confirmed in humans with the cloning of the human and rabbit secretor type alpha 1,...
All accessible epitopes in the Salmonella lipopolysaccharide core are associated with branch residues.
Nnalue NA·Infection and immunity·
Antisera generated against each of the nine known chemotypes of Salmonella lipopolysaccharide (LPS) core were characterized in order to delineate cross-reactive epitopes and define the bases for their...
High-level porcine endothelial cell expression of alpha(1,2)-fucosyltransferase reduces human monocyte adhesion and activation.
Kwiatkowski P, Artrip JH, Edwards NM, et al.·Transplantation·
Monocyte binding to and activation by human endothelium requires a number of interactions, including those involving sialylated endothelial cell ligands. As porcine endothelial cell transfection with...
Complement and anti-alpha-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum.
Agrawal RS, Karhu K, Laukkanen J, et al.·Gene therapy·
Many retroviral vectors for hematopoietic cell and other clinical gene therapy are derived from murine packaging cell lines. The exposure of these retroviruses and packaging cell lines to adult human...
Comparative study of glycoconjugates of the rat prostatic lobes by lectin histochemistry.
Chan FL, Ho SM·The Prostate·
The rat prostate gland is composed of several distinct lobes: the ventral, lateral, dorsal, and anterior (also called the coagulating gland). Each prostatic lobe is different in its morphology, secret...
Modulation of alpha gal epitope expression on porcine cells.
Sandrin MS, McKenzie IF·Sub-cellular biochemistry·
Enterotoxin A of Clostridium difficile and alpha-Gal epitopes.
Pothoulakis C·Sub-cellular biochemistry·
alpha-Gal epitopes on viral glycoproteins.
Rother RP, Galili U·Sub-cellular biochemistry·
Evolution of alpha 1,3galactosyltransferase and of the alpha-Gal epitope.
Galili U·Sub-cellular biochemistry·
Sustained decrease of serum anti-galactose alpha 1-3-galactose antibodies in baboons by removing aerobic gram-negative bacteria from the bowel.
Manez R, Diaz I, Centeno A, et al.·Transplantation proceedings·
Glycoconjugate expression during early mouse oculogenesis.
Buse E, Seifert H·The Histochemical journal·
The carbohydrate side-chain of glycoconjugates can show a developmentally regulated expression pattern. In order to analyse these changes during the development of the eye, 13 lectins were used to rev...
Inhibitory effect of alpha(1,2) fucosyltransferase recombinant adenoviral vector on alpha Gal expression.
Nagasaka T, Hayashi S, Tachi Y, et al.·Transplantation proceedings·
Cloning and high-level expression of alpha-galactosidase cDNA from Penicillium purpurogenum.
Shibuya H, Nagasaki H, Kaneko S, et al.·Applied and environmental microbiology·
The cDNA coding for Penicillium purpurogenum alpha-galactosidase (alphaGal) was cloned and sequenced. The deduced amino acid sequence of the alpha-Gal cDNA showed that the mature enzyme consisted of 4...
Two novel isoneolacto-undecaglycosylceramides carrying Galalpha1-->3Lewis(x) on the 6-linked antenna and N-acetylneuraminic acidalpha2-->3 or Galactose alpha1-->3 on the 3-linked antenna, expressed in porcine kidney.
Bouhours D, Liaigre J, Lemoine J, et al.·Glycoconjugate journal·
Three sialosylated and three neutral glycosphingolipids sharing a common iso-neolacto core were isolated from porcine kidney cortex. They were purified by preparative HPTLC, and were characterized by...
Expression of Gal alpha(1,3)gal on neonatal porcine islet beta-cells and susceptibility to human antibody/complement lysis.
Rayat GR, Rajotte RV, Elliott JF, et al.·Diabetes·
Neonatal porcine pancreases may be a potential source of islets for transplantation into patients with type 1 diabetes; however, whether these cellular grafts will be susceptible to damage by human na...
Heat treatment modifies the allergenicity of beef and bovine serum albumin.
Fiocchi A, Restani P, Riva E, et al.·Allergy·
The effect of heat on the allergenicity of beef and bovine serum albumin was investigated among 10 toddlers skin prick test (SPT)-positive to raw and cooked beef. The meat-allergy diagnosis was confir...
Differential expression of Galalpha1,3Gal epitope in polymeric and monomeric IgM secreted by mouse myeloma cells deficient in alpha2, 6-sialyltransferase.
Smilovich D, Malagolini N, Fagioli C, et al.·Glycobiology·
IgM are glycoproteins secreted by plasma cells as (mu2L2)5+J or (mu2L2)6 polymers. In most species, mu- and J-chains bear five and one N -glycans, respectively. Here we compare the terminal glycosylat...
Alpha-galactosidase transgenic mouse: heterogeneous gene expression and posttranslational glycosylation in tissues.
Ishii S, Kase R, Sakuraba H, et al.·Glycoconjugate journal·
We produced six transgenic mouse lines expressing human alpha-galactosidase (alpha-Gal) in order to evaluate its posttranslational modification. Among them, serum alpha-Gal activity increased 3000-fol...
Evaluation of the Galalpha1-3Gal epitope as a host modification factor eliciting natural humoral immunity to enveloped viruses.
Welsh RM, O'Donnell CL, Reed DJ, et al.·Journal of virology·
Human sera contain high levels of natural antibody (Ab) to Galalpha1-3Gal, a terminal glycosidic structure expressed on the surface of cells of mammals other than Old World primates. Incorporation of...
Monoclonal antibodies to the epitope alpha-Gal-(1-4)-beta-Gal-(1- of Moraxella catarrhalis LPS react with a similar epitope in type IV pili of Neisseria meningitidis.
Rahman M, Jonsson AB, Holme T·Microbial pathogenesis·
Murine monoclonal antibodies (MAbs) against the A, B and C LPS serotypes of M. catarrhalis were generated and their binding specificity was examined in an enzyme-linked immunosorbent assay (ELISA). Tw...
Structural characterization of the oligosaccharides of a human monoclonal anti-lipopolysaccharide immunoglobulin M.
Leibiger H, Kersten B, Albersheim P, et al.·Glycobiology·
The oligosaccharide side chains of a human anti-lipopolysaccharide IgM produced by a human-human-mouse heterohybridoma were analyzed at each of its five conserved N-glycosylation sites. This antibody...
Modification at C6 of the terminal galactosyl residues of cobra venom factor abolishes anti-alpha-Gal antibody immunoreactivity without affecting functional activity.
Gowda DC·Biochemical and biophysical research communications·
The N-linked oligosaccharides of cobra venom factor (CVF) contain unique terminal alpha-galactosylated Lewis X structures. We have previously shown that CVF immobilized on nylon membranes binds natura...
Gal alpha(1,3)Gal expression on neonatal porcine islet cells and susceptibility to human antibody/complement lysis.
Rayat GR, Rajotte RV, Elliott JF, et al.·Transplantation proceedings·
MUC1 cross-reactive Gal alpha(1,3)Gal antibodies in humans switch immune responses from cellular to humoral.
Apostolopoulos V, Osinski C, McKenzie IF·Nature medicine·
Successful tumor immunotherapy with peptides requires the induction of cytotoxic T lymphocytes (CTLs) rather than antibodies. Mice immunized with mannan conjugated to MUC1, a peptide found in large am...
Characterization of a polyclonal anti-Galalpha1-3Gal antibody from chicken.
Bouhours JF, Richard C, Ruvoen N, et al.·Glycoconjugate journal·
A polyclonal antibody was raised against the Galalpha1-3Gal carbohydrate epitope, which is expressed by all mammals (except man and the closest primate species) by immunizing hens with rabbit erythroc...
Reactivity of chagasic antigal antibodies with noninfected cells treated with Trypanosoma cruzi secreted/excreted antigens.
Yokoyama-Yasunaka JK, Piazza RM, Umezawa ES, et al.·Journal of clinical laboratory analysis·
Here, we show that antigal antibodies from Chagas' disease patients react with noninfected host cells previously treated with antigens secreted by the trypomastigote forms of Trypanosoma cruzi. With t...
Acceptor hydroxyl group mapping for calf thymus alpha-(1-->3)-galactosyltransferase and enzymatic synthesis of alpha-D-Galp-(1-->3)-beta-D-Galp-(1-->4)-beta D-GlcpNAc analogs.
Sujino K, Malet C, Hindsgaul O, et al.·Carbohydrate research·
The epitope of the acceptor substrate for alpha-(1-->3)-galactosyltransferase from calf thymus has been mapped by using a series of mono-deoxygenated and mono-O-alkylated Type II (beta-D-Ga1p-(1-->4)-...
Human alternative complement pathway-mediated lysis of rabbit erythrocytes is enhanced by natural anti-Galalpha1-3Gal antibodies.
Tomlinson S, Nussenzweig V·Journal of immunology (Baltimore, Md. : 1950)·
Human serum is effective at lysing unsensitized rabbit erythrocytes due to activation of the alternative complement pathway. Hemolysis is known to be enhanced by the addition of human IgG. We demonstr...
Secretion of alpha1,3-galactosyltransferase by cultured cells and presence of enzyme in animal sera.
Cho SK, Yeh JC, Cummings RD·Glycoconjugate journal·
Glycosyltransferases are normally synthesized as membrane-anchored proteins. However, we recently found that the murine enzyme UDP-Gal:Gal beta1 -->4GLcNAc (Gal to Gal) alpha1,3 galactosyltransferase...
Epitopes of the P-fimbrial adhesin of E. coli cause different urinary tract infections.
Roberts JA, Kaack MB, Baskin G, et al.·The Journal of urology·
This is a study of the interaction of the tip protein of P-fimbriae E. coli, its specific urothelial adhesin, and urothelial receptors for the adhesin. This tip protein has several epitopes that adher...
FUT-175, a synthetic inhibitor of the complement pathway, protects against the inactivation of infectious retroviruses by human serum.
Miyao Y, Ikenaka K, Kishima H, et al.·Human gene therapy·
Serum-induced inactivation of retroviruses is the most critical limitation for in vivo gene transfer therapy. To solve this problem, we searched for reagents that protect retroviruses from inactivatio...
Expression and characterization of a lactosaminoglycan-carrying glycoprotein of Zajdela hepatoma cell surface--structural analysis of the carbohydrate moiety.
Goulut-Chassaing C, Bourrillon R·European journal of biochemistry·
In poorly differentiated hepatoma cells, a glycoprotein carrying lactosaminoglycans is identified, and the structure of its glycan moiety is proposed. After membrane solubilization, protein fractionat...
Removal of anti-Gal alpha (1,3)Gal antibodies diminishes the cytotoxic effect of primate xenoreactive antibodies on rat endothelial cells.
Azimzadeh A, Anegon I, Thibaudeau K, et al.·Transplantation proceedings·
Meat allergy: III--Proteins involved and cross-reactivity between different animal species.
Restani P, Fiocchi A, Beretta B, et al.·Journal of the American College of Nutrition·
Although relatively infrequent, meat allergy represents a serious problem for children both because it is generally associated with intolerance to other protein sources and because of the suggested ro...
Cloning of anti-Gal Fabs from combinatorial phage display libraries: structural analysis and comparison of Fab expression in pComb3H and pComb8 phage.
Wang L, Radic MZ, Siegel D, et al.·Molecular immunology·
Anti-Gal is the most abundant natural antibody in humans. It interacts specifically with the carbohydrate epitope Gal alpha1-3Galbeta1-4GlcNAc-R (termed the alpha-galactosyl epitope). In an attempt to...
Structural characterization of the N-glycans from Echinococcus granulosus hydatid cyst membrane and protoscoleces.
Khoo KH, Nieto A, Morris HR, et al.·Molecular and biochemical parasitology·
Infection by the tapeworm Echinococcus granulosus in the intermediate host results in the development of a hydatid cyst which contains the protoscoleces within a fluid-filled cavity enclosed by the bi...
Gene transfer and expression of human alpha-galactosidase from mouse muscle in vitro and in vivo.
Novo FJ, Górecki DC, Goldspink G, et al.·Gene therapy·
Lysosomal storage disorders are amenable to treatment by enzyme replacement. Genetic modification of muscle via direct injection of expression vectors might represent an alternative method of providin...
Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians.
Candore G, Di Lorenzo G, Mansueto P, et al.·Mechanisms of ageing and development·
In the present study we have investigated the prevalence of organ-specific and non organ-specific autoantibodies in 26 healthy centenarians (6 men, 20 women; age range 101-106 years), using as control...
[Does the pork/cat syndrome constitute a predisposition to heparin allergy?].
Drouet M, Le Sellin J, Sabbah A·Allergie et immunologie·
Observations are reported of two heparin-allergic patients (in one case, urticaria and in the other urticaria and asthma). These two patients show a curious association of the pork/cat syndrome, previ...
Reduction of metastatic properties of BL6 melanoma cells expressing terminal fucose(alpha)1-2-galactose after alpha1,2-fucosyltransferase cDNA transfection.
Gorelik E, Xu F, Henion T, et al.·Cancer research·
We reported previously that transfection of BL6 melanoma cells that do not express the alpha1,3-galactosyltransferase (alpha1,3GT) gene with the alpha1,3GT cDNA resulted in synthesis and expression of...
Natural human anti-Gal alpha(1,3)Gal antibodies react with human mucin peptides.
Sandrin MS, Vaughan HA, Xing PX, et al.·Glycoconjugate journal·
We have recently demonstrated that both antibodies to Gal alpha(1,3)Gal, and the Gal alpha(1,3)Gal binding lectin (IB4), bind a synthetic peptide (DAHWESWL), there being a similar recognition of carbo...
Immobilization of reducing sugars as toxin binding agents.
Nilsson UJ, Heerze LD, Liu YC, et al.·Bioconjugate chemistry·
A simple and economical procedure for the attachment of reducing sugars to aminated solid supports has been developed. Reaction of the amino groups on the solid support with p-nitrophenyl chloroformat...
Apheresis and column absorption for specific removal of Gal-alpha-1,3 Gal natural antibodies in a pig-to-baboon model.
Kozlowski T, Fuchimoto Y, Monroy R, et al.·Transplantation proceedings·
Reduction of alpha-Gal epitopes in transgenic pig by introduction of human alpha 1-2 fucosyltransferase.
Koike C, Katayama A, Kadomatsu K, et al.·Transplantation proceedings·
Effect of antisense ribozyme to alpha (1,3)galactosyl transferase gene on the expression of Gal alpha (1,3)Gal epitope.
Hayashi S, Nagasaka T, Koike C, et al.·Transplantation proceedings·
Capillary isoelectric focusing-electrospray ionization mass spectrometry for transferrin glycoforms analysis.
Yang L, Tang Q, Harrata AK, et al.·Analytical biochemistry·
On-line capillary isoelectric focusing (CIEF)-electrospray ionization mass spectrometry (ESIMS) as a two-dimensional separation system is employed for high-resolution analysis of bovine serum apotrans...
Extracorporeal ("ex vivo") connection of pig kidneys to humans. II. The anti-pig antibody response.
Rydberg L, Björck S, Hallberg E, et al.·Xenotransplantation·
Pig kidneys were extracorporeally "ex vivo" connected to the circulation of two volunteer male dialysis patients (Breimer et al., this issue). The patients were pretreated by daily plasmapheresis for...
View on PubMed →Influence of Carbohydrates on the alpha-Galactosidase Activity of Lactobacillus fermentum.
Garro MS, de Valdez GF, Oliver G, et al.·Current microbiology·
The influence of soybean galactosaccharides (stachyose, raffinose, melibiose) as well as galactose and glucose on the synthesis and activity of alpha-galactosidase (alpha-gal) from Lactobacillus ferme...
View on PubMed →Gluconoylated and glycosylated polylysines as vectors for gene transfer into cystic fibrosis airway epithelial cells.
Kollen WJ, Midoux P, Erbacher P, et al.·Human gene therapy·
To provide an alternative to viral vectors for the transfer of genes into airway epithelial cells in cystic fibrosis (CF), a novel set of substituted polylysines were employed. Polylysine was partiall...
Characterization of the specificities of human blood group H gene-specified alpha 1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha 1,2-L-fucosylation of Gal and alpha 1,6-L-fucosylation of asparagine-linked GlcNAc.
Chandrasekaran EV, Jain RK, Larsen RD, et al.·Biochemistry·
The assembly of complex structures bearing the H determinant was examined by characterizing the specificities of a cloned blood group H gene-specified alpha 1,2-L-fucosyltransferase (FT) toward a vari...
Effect of antisense ribozyme to pig alpha (1,3) galactosyl transferase gene on the expression of Gal alpha (1,3)Gal epitope.
Hayashi S, Nagasaka T, Namii Y, et al.·Transplantation proceedings·
Potent inhibition of human and baboon anti-alpha Gal antibodies by a subfraction of oligosaccharides derived from porcine stomach mucin.
Li S, Neethling FA, Yeh JC, et al.·Transplantation proceedings·
Identification and characterization of a peptide mimeotope of galactose alpha 1,3 galactose.
Kooyman DL, McClellan SB, Parker WR, et al.·Transplantation proceedings·
Converting alpha-Gal epitope of pig into H antigen.
Koike C, Hayashi S, Yokoyama I, et al.·Transplantation proceedings·
The effect of plasmapheresis and deoxyspergualin or cyclophosphamide treatment on anti-porcine Gal-alpha (1,3)-Gal antibody titres in humans.
Gannedahl G, Tufveson G, Sundberg B, et al.·Transplantation proceedings·
Identification and characterization of a galactosyl peptide mimetic. Implications for use in removing xenoreactive anti-A Gal antibodies.
Kooyman DL, McClellan SB, Parker W, et al.·Transplantation·
Gal alpha 1,3 Gal is thought to be the major antigenic epitope present on pig tissues to which XNAs bind. Removal of antibodies directed against that structure may be critical to the success of pig to...
Characterization of recombinant alpha-galactosidase for use in seroconversion from blood group B to O of human erythrocytes.
Zhu A, Leng L, Monahan C, et al.·Archives of biochemistry and biophysics·
Alpha-Galactosidase (alpha-GAL) purified from green coffee bean cleaves the terminal galactose residues from the surface of group B erythrocytes, thereby converting these cells serologically to group...
Enhancement of antigen presentation of influenza virus hemagglutinin by the natural human anti-Gal antibody.
Galili U, Repik PM, Anaraki F, et al.·Vaccine·
Immunogenicity of inactivated virus or subviral vaccines may be enhanced by complexing with an IgG antibody. Such antibody would increase the uptake, processing and presentation of the vaccine's antig...
Tissue distribution of Gal alpha(1,3)Gal epitope in heart, kidney, and liver of pig and mouse.
Hayashi S, Katayama A, Nagasaka T, et al.·Transplantation proceedings·
Bacterial enzymes can add galactose alpha 1,3 to human erythrocytes and creates a senescence-associated epitope.
Hamadeh RM, Jarvis GA, Zhou P, et al.·Infection and immunity·
Humans have abundant circulating anti-alpha (1,3-di)-galactosyl (alpha Gal) antibodies (anti-Gal). Anti-Gal has been implicated in the clearance of senescent human erythrocytes (RBCs). The nature of t...
Sensitization of cells and retroviruses to human serum by (alpha 1-3) galactosyltransferase.
Takeuchi Y, Porter CD, Strahan KM, et al.·Nature·
Mammalian C-type retroviruses are inactivated by human serum, following triggering of the classical complement cascade. This may have inhibited transmission to humans of C-type oncoviruses from other...
Associations of blood group-related antigens to FEV1, wheezing, and asthma.
Kauffmann F, Frette C, Pham QT, et al.·American journal of respiratory and critical care medicine·
Discordant results have been observed regarding the associations of chronic obstructive pulmonary diseases with secretor, Lewis, and ABO histo-blood groups, which are defined by glycosyltransferases....
Abnormal expression of galactosyl(alpha 1-->3) galactose epitopes in squamous cells of the uterine cervix infected by human papillomavirus.
Tremont-Lukats IW, Avila JL, Tapia F, et al.·Pathobiology : journal of immunopathology, molecular and cellular biology·
This study describes the presence of alpha-galactosyl epitopes on 12 cervical biopsy samples with features of human papillomavirus infection (HPV) and different stages of cervical intraepithelial neop...
A possible role for the alpha 1-->3 galactosyl epitope and the natural anti-gal antibody in oncogenesis.
Gollogly L, Castronovo V·Neoplasma·
Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->...
The reducing end of alpha Gal oligosaccharides contributes to their efficiency in blocking natural antibodies of human and baboon sera.
Neethling FA, Joziasse D, Bovin N, et al.·Transplant international : official journal of the European Society for Organ Transplantation·
Synthetic galactosyl oligosaccharides were tested for their ability to inhibit the cytotoxic reaction of human and baboon natural antibodies on PK15 cells in culture. Methyl-alpha-Gal gave weak inhibi...
Anti-Gal binds to pili of Neisseria meningitidis: the immunoglobulin A isotype blocks complement-mediated killing.
Hamadeh RM, Estabrook MM, Zhou P, et al.·Infection and immunity·
alpha 1,3-Galactosyl antibodies (anti-Gal) are ubiquitous natural human serum and secretory polyclonal antibodies that bind to terminal galactose-alpha 1,3-galactose (alpha-galactosyl) residues. Serum...
Direct analysis of enzymatic reactions of oligosaccharides in human serum using matrix-assisted laser desorption ionization mass spectrometry.
Whittal RM, Palcic MM, Hindsgaul O, et al.·Analytical chemistry·
Matrix-assisted laser desorption ionization mass spectrometry has been developed for direct mass analysis of enzymatic reaction products of oligosaccharides in human blood serum without the use of ext...
A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel penta-antennary N-glycan chains with a bisecting N-acetylglucosaminyl residue.
Taguchi T, Kitajima K, Muto Y, et al.·Glycobiology·
A novel carbohydrate-rich sialoglycopeptide of apparent molecular mass approximately 6 kDa was isolated from the fertilized eggs of Fundulus heteroclitus (euryhaline killi fish). This glycopeptide is...
Optimizing production of human monoclonal IgG antibodies by in vitro-primed human PBMC: influence of CD56+ NK cell depletion.
Puhlmann CM, Anderer FA·Hybridoma·
Freshly isolated human peripheral blood mononuclear cells (PBMC) were immunomagnetically depleted of CD56+ cells. When these CD56- PBMC populations were cultured in the presence of autologous donor se...
The hydrophobic mannoside Man alpha 1-6Man alpha 1-S-(CH2)7-CH3 acts as an acceptor for the UDP-Gal:glycosylphosphatidylinositol anchor alpha 1,3-galactosyltransferase of Trypanosoma brucei.
Pingel S, Field RA, Güther ML, et al.·The Biochemical journal·
The variant surface glycoproteins (VSGs) of Trypanosoma brucei are attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) membrane anchor. This anchor contains the core sequence etha...
Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.
Wang L, Radic MZ, Galili U·Journal of immunology (Baltimore, Md. : 1950)·
Anti-Gal is the most abundant natural Ab known in humans. It interacts specifically with the carbohydrate structure Gal alpha 1-3 Gal beta 1-4GlcNAc-R (termed the alpha-galactosyl epitope), constitute...
Meat allergy: II--Effects of food processing and enzymatic digestion on the allergenicity of bovine and ovine meats.
Fiocchi A, Restani P, Riva E, et al.·Journal of the American College of Nutrition·
This study was designed to evaluate whether peptic treatment of BSA and OSA affects their allergenicity and to evaluate the effect of technological treatments of meat for infant feeding on the allerge...
Meat allergy: I--Specific IgE to BSA and OSA in atopic, beef sensitive children.
Fiocchi A, Restani P, Riva E, et al.·Journal of the American College of Nutrition·
The use of lamb meat products has been suggested as an alternative diet for polyallergic children, although until now this clinical practice has not been supported by in-depth biochemical/immunologica...
Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure.
Essani NA, Fisher MA, Farhood A, et al.·Hepatology (Baltimore, Md.)·
Neutrophil-induced liver injury during endotoxemia is dependent on the adhesion molecule Mac-1 (CD11b/CD18) on neutrophils. The potential involvement of its counterreceptor, intercellular adhesion mol...
Primary structure of acidic oligosaccharide-alditols derived from the jelly coat of Ambystoma tigrinum. Occurrence of oligosaccharides with fucosyl(alpha 1-5)[fucosyl(alpha 1-4)]-3-deoxy-D-glycero-D-galacto- nonulosonic acid and fucosyl (alpha 1-2) galactosyl (alpha 1-3)-N- acetylgalactosamine sequences.
Maes E, Plancke Y, Deplace F, et al.·European journal of biochemistry·
Eleven O-glycosidic carbohydrate units derived from the jelly coat of Ambystoma tigrinum were analyzed by 1H-NMR spectroscopy. As previously shown for four other amphibian species, the glycans display...
Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive natural antibodies.
Holzknecht ZE, Platt JL·Journal of immunology (Baltimore, Md. : 1950)·
Rejection of an organ transplanted into a phylogenetically disparate recipient may be initiated by the binding of xenoreactive natural Abs of the recipient to Ags expressed on donor endothelium leadin...
Cyclic analogues of Thr6-bradykinin, N epsilon-Lys-bradykinin and endo-Lys8a-vespulakinin 1.
Gobbo M, Biondi L, Filira F, et al.·International journal of peptide and protein research·
Syntheses are described of the endo-Lys8a-vespulakinin 1 and of cyclo-Thr6- and cyclo-N epsilon-Lys-bradykinin. The linear peptides covering the entire sequences of endo-Lys8a-VSK-1 and Thr6-BK, and t...
Identification of a novel glycosaminoglycan core-like molecule. II. Alpha-GalNAc-capped xylosides can be made by many cell types.
Salimath PV, Spiro RC, Freeze HH·The Journal of biological chemistry·
The accompanying article (Manzi, A., Salimath, P. V., Spiro, R. C., Keifer, P. A., and Freeze, H. H. (1995) J. Biol. Chem. 270, 9154-9163) reported the complete structure of a novel molecule made by h...
Identification of a novel glycosaminoglycan core-like molecule. I. 500 MHz 1H NMR analysis using a nano-NMR probe indicates the presence of a terminal alpha-GalNAc residue capping 4-methylumbelliferyl-beta-D-xylosides.
Manzi A, Salimath PV, Spiro RC, et al.·The Journal of biological chemistry·
beta-Xylosides compete with endogenous proteoglycan core proteins and act as alternate acceptors for synthesizing protein-free glycosaminoglycan chains. Their assembly on these alternate acceptors uti...
Identification of tyrosine 108 in coffee bean alpha-galactosidase as an essential residue for the enzyme activity.
Zhu A, Wang ZK, Goldstein J·Biochimica et biophysica acta·
The cDNA for coffee bean alpha-galactosidase (alpha-Gal) has been cloned and expressed in a baculovirus expression system. An early study of coconut alpha-Gal by chemical modification suggested that o...
[Levels of anti-Gal antibodies in persons infected and non-infected with Trypanosoma cruzi. Probably induced by bacteria and by the parasite].
González J, Ramírez C, Seguel X, et al.·Boletin chileno de parasitologia·
Antibodies levels against Gal alpha 1,3 Gal epitopes were studied in 407 human sera (92 chagasic and 315 non-chagasic), by means of hemagglutination with rabbit erytrocytes reactivity of serum having...
Synthesis of alpha-D-galactopyranosyl-linked oligosaccharides containing the alpha-Gal-->beta-Gal-->GlcNAc sequence employing methyl-2,3,4,6-tetra-O-(4-methoxybenzyl)-1-thio-beta-D-galactopyranosid e as an efficient glycosyl donor.
Reddy GV, Jain RK, Bhatti BS, et al.·Carbohydrate research·
Synthesis of two trisaccharides and a tetrasaccharide, namely, alpha-Gal-(1-->3)-beta-Gal-(1-->3)-GlcNAc-beta-OBn (6), alpha-Gal-(1-->3)-beta-Gal-(1-->4)-GlcNAc-beta-OBn (9) and alpha-Gal-(1-->3)-beta...
[The pork-cat syndrome: effect of sensitization to cats on sensitization to pork meat. Apropos of a case].
Drouet M, Lauret MG, Sabbah A·Allergie et immunologie·
A patient who presented with exercise-induced anaphylaxis, linked with a food allergy to pork meat (VP), about three years ago became allergic to VP though effort was necessary to trigger the anaphyla...
[The pork-cat syndrome: RAST inhibition test with Feld One].
Sabbah A, Rousseau C, Lauret MG, et al.·Allergie et immunologie·
This work confirms that the common allergen in subjects who are doubly sensitized to cat and pork is quite different from that of subjects who are mono-sensitized to cat. The common protein is Albumin...
Isolation and characterization of novel mucin-like glycoproteins from cobra venom.
Gowda DC, Davidson EA·The Journal of biological chemistry·
A high molecular weight, heavily glycosylated protein fraction was isolated from cobra venom. It consists of mucin-like glycoproteins (designated as cobra venom mucin) in noncovalent association with...
A new cancer-associated antigen defined by a monoclonal antibody against a synthetic carbohydrate chain.
Yamashita Y, Chung YS, Sawada T, et al.·International journal of cancer·
Carbohydrate antigens can be designed by referring to previously defined carbohydrate structures. We have generated a novel monoclonal antibody (MAb) (F1 alpha-75) against an artificially designed ant...
Confirmation of a major target epitope of human natural IgG and IgM anti-pig antibodies: terminal galactose alpha -1,3-galactose.
Cairns T, Karlsson E, Holgersson J, et al.·Transplantation proceedings·
Enzymatic removal from various tissues of the galactose alpha 1,3-galactose target antigens of human antispecies antibodies.
Cairns T, Hammelmann W, Gray D, et al.·Transplantation proceedings·
Cell surface laminin-like substances and laminin-related carbohydrates of rat ascites hepatoma AH7974 and its variants with different lung-colonizing potential.
Kawaguchi T, Ono T, Wakabayashi H, et al.·Clinical & experimental metastasis·
Rat ascites hepatoma AH7974 cells strongly expressed antilaminin antibody-reactive substances (laminin-like substances) and Griffonia simplicifolia isolectin B4 (GS)-reactive carbohydrate (alpha-D-gal...
[The pork-cat syndrome or crossed allergy between pork meat and cat epithelia (1)].
Drouet M, Boutet S, Lauret MG, et al.·Allergie et immunologie·
This work is a study of the frequency of the association between sensitivity to pork meat and cat epithelia. Comparison with a reference population that was not sensitized to pork meat, shows that thi...
[The pork-cat syndrome or crossed allergy between pork meat and cat epithelia (2)].
Sabbah A, Lauret MG, Chène J, et al.·Allergie et immunologie·
Is there a port-cat syndrome in food allergy? Many clinical observations have revealed a frequent association between allergy to cat epithelia in subjects who have allergy to pork meat. This second pa...
Retinoic acid enhances adhesiveness, laminin and integrin beta 1 synthesis, and retinoic acid receptor expression in F9 teratocarcinoma cells.
Ross SA, Ahrens RA, De Luca LM·Journal of cellular physiology·
The teratocarcinoma-derived F9 cells respond to retinoic acid (RA) and RA plus dibutyrylcyclic adenosine monophosphate (dcAMP) by differentiating into endoderm cells, which elaborate a laminin and typ...
Glycosphingolipids of rat T cells. Predominance of asialo-GM1 and GD1c.
Nohara K, Nakauchi H, Spiegel S·Biochemistry·
Glycosphingolipids play an important role in the immune response, yet their compositions in T and B cells which mediate cellular and humoral immunity, respectively, have not been elucidated. In this s...
Cloning and functional expression of a cDNA encoding coffee bean alpha-galactosidase.
Zhu A, Goldstein J·Gene·
Purified coffee bean alpha-galactosidase (alpha Gal) has been used for removing terminal alpha-galactose residues from the glyco-conjugates at the red cell surface, in studies of blood group conversio...
Immunoreactivity and function of oligosaccharides in cobra venom factor.
Gowda DC, Petrella EC, Raj TT, et al.·Journal of immunology (Baltimore, Md. : 1950)·
Cobra venom factor (CVF) is the nontoxic C-activating glycoprotein in cobra venom. It is a structural and functional analogue of complement component C3. Previous work has established that the major o...
Effect of antigen on the glycoconjugate profile of tracheal secretions and the epithelial glycocalyx in allergic sheep.
Mariassy AT, Abraham WM, Wanner A·The Journal of allergy and clinical immunology·
To characterize the glycoconjugate composition of tracheal secretions and the apical glycocalyx of the tracheal epithelium under baseline conditions and after antigen challenge, sheep allergic to Asca...
Synthesis of allyl 3-deoxy- and 4-deoxy-beta-D-galactopyranoside and simultaneous preparations of Gal(1-->2)- and Gal(1-->3)-linked disaccharide glycosides.
Lee RT, Lee YC·Carbohydrate research·
Syntheses of galactose derivatives that are useful in probing the binding specificity of galactose-specific lectins are reported. These include allyl 3-deoxy- and 4-deoxy-beta-D-xylo-hexopyranoside an...
Human monoclonal anti-Rh antibodies produced by human-mouse heterohybridomas express the Gal alpha 1-3 Gal epitope.
Montaño RF, Romano EL·Human antibodies and hybridomas·
The presence of the Gal alpha 1-3 Gal structure (Gal epitope) in the carbohydrate component of fifteen human monoclonal antibodies with specificity for the Rh blood group factor and produced by human-...
Use of Trypanosoma cruzi purified glycoprotein (GP57/51) or trypomastigote-shed antigens to assess cure for human Chagas' disease.
Gazzinelli RT, Galvao LM, Krautz G, et al.·The American journal of tropical medicine and hygiene·
With the exception of assays for the detection of antibodies promoting complement-mediated lysis of Trypanosoma cruzi, serologic tests have generally failed to assess the effectiveness of chemotherapy...
Isogenic P-fimbrial deletion mutants of pyelonephritogenic Escherichia coli: the role of alpha Gal(1-4) beta Gal binding in virulence of a wild-type strain.
Mobley HL, Jarvis KG, Elwood JP, et al.·Molecular microbiology·
Escherichia coli strains causing acute pyelonephritis often express multiple fimbrial types and haemolysin, which may contribute to their ability to adhere to, and interact with, kidney epithelial cel...
Antibodies against terminal galactosyl alpha(1-3) galactose epitopes in patients with idiopathic myelofibrosis.
Leoni P, Rupoli S, Salvi A, et al.·British journal of haematology·
Sera from patients with myelofibrosis were analysed for circulating antibodies against an antigenic determinant characterized by two molecules of galactose in alpha 1-3 linkage (anti-Gal antibodies)....
The role of a repetitive DNA motif (5'-CAAT-3') in the variable expression of the Haemophilus influenzae lipopolysaccharide epitope alpha Gal(1-4)beta Gal.
High NJ, Deadman ME, Moxon ER·Molecular microbiology·
Haemophilus influenzae lipopolysaccharide (LPS) contains structures, defined by monoclonal antibodies, which undergo phase variation. This investigation reports the nucleotide sequence of lic2A, which...
Control of IgG/Fc glycosylation: a comparison of oligosaccharides from chimeric human/mouse and mouse subclass immunoglobulin Gs.
Lund J, Takahashi N, Nakagawa H, et al.·Molecular immunology·
Oligosaccharide profiles were obtained for chimeric mouse-human antibodies corresponding to each of the human IgG subclasses 1-4, and mouse IgG2b antibodies each expressed in the mouse J558L cell line...
[Cleavage of O-glycosyl bonds in glycopeptides].
Ibatullin FM, Neustroev KN, Golubev AM, et al.·Biokhimiia (Moscow, Russia)·
The possibility of cleavage of the alpha-bond between mannose (or galactose) and serine (or threonine) in the presence of alpha-mannosidase and alpha-galactosidase has been studied. Using model compou...
Carbohydrate antigen expression in murine embryonic stem cells and embryos. I. Lacto and neo-lacto determinants.
Brown DG, Warren VN, Påhlsson P, et al.·The Histochemical journal·
A comparative study of lacto- and neo-lacto series carbohydrate antigens between the undifferentiated and differentiated derivatives of the embryonic stem (ES) cell line E14 and expression in the earl...
A monoclonal IgM kappa from a blood group B individual with specificity for alpha-galactosyl epitopes on partially hydrolyzed blood group B substance.
Nickerson KG, Liao J, Kabat EA·Carbohydrate research·
We have characterized a human monoclonal IgM kappa, designated IgMDON, from a blood group B individual. IgMDON is specific for alpha-galactosyl residues on blood group B substance; its fine specificit...
Comparative study of active absorption by the intestine and disposition of anomers of sugar-conjugated compounds.
Mizuma T, Ohta K, Hayashi M, et al.·Biochemical pharmacology·
Active absorption in the intestine and metabolism of the beta- and alpha-anomers of the glucoside and galactoside of p-nitrophenol (p-NP) were studied to find a more suitable prodrug for poorly absorb...
Characterization of serum lysosomal enzymatic activities. III. Effect of infectious influenza in Egyptian equines.
Abdalla MA, Taleb ZA, Ebid MH·DTW. Deutsche tierarztliche Wochenschrift·
An outbreak of infectious influenza was recognized in Menofeia governorate in October 1989. Eight naturally influenza infected as well as 8 healthy control horses, mules and donkeys were selected for...
Effect of a pmr 1 disruption and different signal sequences on the intracellular processing and secretion of Cyamopsis tetragonoloba alpha-galactosidase by Saccharomyces cerevisiae.
Harmsen MM, Langedijk AC, van Tuinen E, et al.·Gene·
We fused the yeast-derived sequences encoding the invertase, acid phosphatase and alpha-factor pre- and prepro-signal peptides (SP) to the Cyamopsis tetragonoloba (guar plant) alpha-galactosidase(alph...
Glycosylation of human IgG subclass and mouse IgG2b heavy chains secreted by mouse J558L transfectoma cell lines as chimeric antibodies.
Lund J, Takahashi N, Hindley S, et al.·Human antibodies and hybridomas·
Oligosaccharide profiles for monoclonal chimeric mouse-human and mouse IgG2b antibodies produced in the mouse J558L cell line have been determined. These chimeric antibodies share the same mouse light...
Immunologic aspects of scleroderma.
Needleman BW·Current opinion in rheumatology·
Recent investigations of immunologic events in systemic sclerosis focus on the identification of which immune system cells are participating in the disease process, what antigens are stimulating the T...
[Structural heterochromatin and X-chromosome inactivation].
Zakiian SM, Nesterova TB·Genetika·
Our previous studies on the expression of the G6PD and alpha-GAL genes from the X chromosome of inter-specific hybrids of voles of the Microtus genus have demonstrated an unusual pattern of X-inactiva...
Substrate specificity of the Trypanosoma cruzi trans-sialidase.
Vandekerckhove F, Schenkman S, Pontes de Carvalho L, et al.·Glycobiology·
Trypanosoma cruzi trypomastigotes acquire sialic acid (SA) from host glycoconjugates by means of a plasma membrane-associated trans-sialidase (TS). Here we study the substrate specificity of TS, which...
Enzymatic transfer of a preassembled trisaccharide antigen to cell surfaces using a fucosyltransferase.
Srivastava G, Kaur KJ, Hindsgaul O, et al.·The Journal of biological chemistry·
The Lewis alpha (1-->3/4)-fucosyltransferase (Le-FucT) is known to fucosylate both Type I (beta Gal(1-->3) beta GlcNAc) and Type II (beta Gal(1-->4) beta GlcNAc) sequences even when these are sialylat...
Nerve-induced secretion of glycoconjugates from cat submandibular glands: a correlative study with lectin probes on tissues and saliva.
Winston DC, Proctor GB, Garrett JR, et al.·The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·
Horseradish peroxidase-conjugated lectins were used on tissue sections to localize the main secretory glycoproteins in cat submandibular glands and on Western blots to evaluate their movement into sal...
Characterization of a natural human antibody with anti-galactosyl(alpha 1-2)galactose specificity that is present at high titers in chronic Trypanosoma cruzi infection.
Avila JL, Rojas M, Velazquez-Avila G·The American journal of tropical medicine and hygiene·
An antibody reactive with the galactosyl(alpha 1-2)galactose [gal(alpha 1-2)gal] epitope was characterized in human sera by enzyme-linked immunosorbent assay, red blood cell (RBC) and laminin absorpti...
A novel ganglioside expressed by mouse hematopoietic cell lines.
Shimamura M, Oku M, Yamagata T·The Journal of biological chemistry·
Mouse progenitor T cell-derived cell lines were established by fusion of cells of hematopoietic organs such as bone marrow and fetal liver with T lymphoma (BW5147) to determine their characteristic ce...
Parasitic oligosaccharide residues recognized by patients with mucocutaneous and localized cutaneous leishmaniasis.
Avila JL, Rojas M, Rodas A, et al.·The American journal of tropical medicine and hygiene·
Humoral immune responses were studied in 118 Venezuelan patients with either active mucocutaneous (MCL) or localized cutaneous leishmaniasis (LCL). Most patients had elevated antibody levels to the si...
Characterization of serum lysosomal enzymatic activities. II. Effect of lumpy skin disease in Egyptian cows.
Abdalla MA, Gawad SM·DTW. Deutsche tierarztliche Wochenschrift·
Clinical findings and lysosomal enzymes (LYE) in eight lumpy skin diseases (LSD) cows and same number of healthy ones were reported in Tal-El Baker village and Tal Alkabir centre, Ismailia province, E...
Rapid isolation of human plasma anti-alpha-galactoside antibody using sugar-specific binding to guar galactomannan or agarose.
Jaison PL, Appukuttan PS·Indian journal of biochemistry & biophysics·
A method of purifying the naturally occurring antibody to alpha-galactoside moiety (anti-alpha-Gal) in human plasma by a single-step affinity chromatography on cross-linked guar galactomannan (CLGG) o...
Age and serotype dependent binding of K88 fimbriae to porcine intestinal receptors.
Willemsen PT, de Graaf FK·Microbial pathogenesis·
The porcine small intestine contains several polypeptides that could function as receptors for K88-positive Escherichia coli. The mucus fraction contained three proteins with molecular weights of 25,...
Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces.
Hamadeh RM, Jarvis GA, Galili U, et al.·The Journal of clinical investigation·
One percent of circulating IgG in humans recognizes galactose alpha 1,3 galactose residues (anti-Gal) and is synthesized in response to stimulation by enteric bacteria. In this study, we found that th...
Euonymus europaeus lectin as an endothelial and epithelial marker in canine tissues.
Roussel F, Dalion J, Wissocq JC·Laboratory animals·
The Euonymus europaeus agglutinin (EEA) is an endothelial marker in mammalia. In canine tissues, 4 types of endothelial cells (general, nervous, arterial, hepatic) were identified by the presence of t...
The spectrum of incomplete N-linked oligosaccharides synthesized by endothelial cells in the presence of brefeldin A.
Sampath D, Varki A, Freeze HH·The Journal of biological chemistry·
Previous studies in many cell lines have shown that Brefeldin A (BFA) inhibits the forward movement of newly synthesized glycoconjugates by fusing the cis-, medial-, and trans-Golgi compartments with...
Structure of the Escherichia coli 0104 polysaccharide and its identity with the capsular K9 polysaccharide.
Kogan G, Jann B, Jann K·FEMS microbiology letters·
The 0104 antigen (lipopolysaccharide, LPS) of Escherichia coli has an acidic O specific polysaccharide. From the aqueous phase of a phenol water extraction of E. coli O104: K-, a fraction was obtained...
[Synthesis of spaced trisaccharides with blood group A and B specificity, their fragments, and structural analogs].
Korchagina EIu, Bovina NV·Bioorganicheskaia khimiia·
Trisaccharides GalNAc alpha 1----3(Fuc alpha 1----2)Gal and Gal alpha 1----3(Fuc alpha 1----2)Gal, which are the determinant fragments of the human blood group specific antigens A and B, respectively,...
Enzyme-linked immunosorbent assays for the measurement of blood group A and B glycosyltransferase activities.
Keshvara LM, Newton EM, Good AH, et al.·Glycoconjugate journal·
ELISA assays have been developed for alpha(1-3)N-acetylgalactosaminyltransferase (blood group A transferase) and alpha(1-3)galactosyltransferase (blood group B transferase) activities. In these assays...
American Leishmania spp. and Trypanosoma cruzi: galactosyl alpha(1-3) galactose epitope localization by colloidal gold immunocytochemistry and lectin cytochemistry.
Bretaña A, Avila JL, Contreras-Bretaña M, et al.·Experimental parasitology·
Patients with Chagas' disease or different clinical forms of leishmaniasis (cutaneous or visceral) have elevated galactosyl alpha (1-3)galactose antibodies. Using colloidal gold immunocytochemistry--m...
Molecular basis of recognition by the glycoprotein hormone-specific N-acetylgalactosamine-transferase.
Smith PL, Baenziger JU·Proceedings of the National Academy of Sciences of the United States of America·
Lutropin (LH) bears asparagine-linked oligosaccharides terminating with the unique sequence SO4-4GalNAc beta 1-4GlcNAc beta 1-2Man alpha, whereas follitropin (FSH) bears oligosaccharides terminating p...
Galactose alpha 1-3 galactose and anti-alpha galactose antibody in normal and pathological pregnancies.
Christiane Y, Aghayan M, Emonard H, et al.·Placenta·
The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumo...
Antibodies against terminal galactosyl (alpha 1-3) galactose epitopes in systemic sclerosis (scleroderma).
Gabrielli A, Candela M, Pisani E, et al.·Clinical and experimental rheumatology·
Sera from 224 patients with systemic sclerosis (scleroderma) were analyzed for circulating antibodies against an antigenic determinant characterized by two molecules of galactose in alpha 1-3 linkage....
Molecular mimicry between Trypanosoma cruzi and host nervous tissues.
Avila JL·Acta cientifica venezolana·
Increasing evidence suggests that in Chagas' disease chronic-phase pathology is autoimmune in nature. There are at least two nonexclusive explanations for the generation of autoimmunity in Chagas dise...
Antibodies to mouse laminin in patients with systemic sclerosis (scleroderma) recognize galactosyl (alpha 1-3)-galactose epitopes.
Gabrielli A, Candela M, Ricciatti AM, et al.·Clinical and experimental immunology·
Employing radioimmunoinhibition assays with distinct oligosaccharides as inhibitors, this study demonstrates that the epitope recognized on mouse laminin by sera from patients with systemic sclerosis...
Investigation of Shiga-like toxin binding to chemically synthesized oligosaccharide sequences.
Armstrong GD, Fodor E, Vanmaele R·The Journal of infectious diseases·
Shiga-like toxin (SLT)-I and SLT-II/IIc bound to Synsorbs containing synthetic alpha Gal(1-4)beta Gal (P1 disaccharide), alpha Gal(1-4)beta GlcNAc (P1 trisaccharide), or alpha Gal(1-4)beta Gal(1-4)bet...
Glycoinositol phospholipids from American Leishmania and Trypanosoma spp: partial characterization of the glycan cores and the human humoral immune response to them.
Avila JL, Rojas M, Acosta A·Journal of clinical microbiology·
The glycoinositol phospholipid (GIPL) profiles of American Leishmania spp. (L. mexicana and L. braziliensis), Leishmania donovani, and American Trypanosoma spp. (T. cruzi and T. rangeli) were compared...
Gene sequences suggest inactivation of alpha-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys.
Galili U, Swanson K·Proceedings of the National Academy of Sciences of the United States of America·
The glycosylation enzyme alpha-1,3-galactosyltransferase (alpha 1,3GT; UDPgalactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase, EC 2.4.1.151) displays a unique patt...
Direct lysis of Trypanosoma cruzi: a novel effector mechanism of protection mediated by human anti-gal antibodies.
Gazzinelli RT, Pereira ME, Romanha A, et al.·Parasite immunology·
Anti-gal antibodies directed against a carbohydrate epitope present in mouse laminin (galactosyl alpha 1-3 galactose) and detected in high levels in sera from patients in the acute phase of Chagas dis...
Cloning, sequence and chromosomal location of a MEL gene from Saccharomyces carlsbergensis NCYC396.
Turakainen H, Korhola M, Aho S·Gene·
Yeast strains producing alpha-galactosidase (alpha Gal) are able to use melibiose as a carbon source during growth or fermentation. We cloned a MEL gene from Saccharomyces carlsbergensis NCYC396 throu...
Antibodies against galactosyl (alpha 1----3) galactose in connective tissue diseases.
Gabrielli A, Leoni P, Danieli G, et al.·Arthritis and rheumatism·
[Heterochromatin as a factor influencing X-chromosome inactivation in hybrids of the common vole (Microtinae, Rodentia)].
Zakiian SM, Nesterova TB, Cheriaukene OV, et al.·Genetika·
Expression of X-linked genes for G6PD and alpha-GAL was studied in female interspecific hybrids of Microtus. The G6PD and alpha-GAL isozymes of Microtus arvalis were found to predominate in all cases...
Comparison of serum anti-band 3 and anti-Gal antibody binding to density-separated human red blood cells.
Sorette MP, Galili U, Clark MR·Blood·
This study examines the quantitative relationship between two natural serum antibodies, anti-band 3 and anti-alpha-galactosyl (anti-Gal), in their capacity to bind to human red blood cell (RBC) popula...
A monoclonal antibody for terminal beta-galactose. Use in analysis of glycosphingolipids.
Kalisiak A, Oosterwijk E, Minniti JG, et al.·Glycoconjugate journal·
A monoclonal antibody (mAb 8281) specific for the terminal beta-galactose (beta Gal) of glycosphingolipids (GSL) and glycoproteins was produced from mice immunized with lipid extract from fresh acute...
Studies of the binding activity of phage G13 to synthetic trisaccharides analogous to binding structures in Salmonella typhimurium and Escherichia coli C core saccharide. Correlation between conformation and binding activity.
Bruse GW, Wollin R, Oscarson S, et al.·Journal of molecular recognition : JMR·
Phage G13 binds to the carbohydrate part of lipopolysaccharides from rough mutants of Salmonella and Escherichia coli as the first event of infection. Equilibrium dialysis inhibition studies with nati...
Distribution of carbohydrates recognized by the lectins Euonymus europaeus and concanavalin A in monoxenic and heteroxenic trypanosomatids.
Gazzinelli RT, Romanha AJ, Fontes G, et al.·The Journal of protozoology·
We observed a wide distribution of the carbohydrate epitopes galactosyl alpha(1-3)galactose (gal alpha1-3 gal), alpha-glucoside and alpha-mannoside in mono- and heteroxenic trypanosomatids by using fl...
The alpha-galactosyl epitope on human normal and autoimmune thyroid cells.
Thall A, Etienne-Decerf J, Winand RJ, et al.·Autoimmunity·
As much as 1% of circulating IgG in man (the natural anti-Gal antibody) is directed against the alpha-galactosyl epitope, with the structure Gal alpha 1----3Gal beta 1----4GlcNAc-R. The alpha-galactos...
Subcompartment sugar residues of gastric surface mucous cells studied with labeled lectins.
Ihida K, Tsuyama S, Kashio N, et al.·Histochemistry·
We examined the intracellular localization of sugar residues of the rat gastric surface mucous cells in relation to the functional polarity of the cell organellae using preembedding method with severa...
A unique fucoganglioside with blood group B determinant in rat spleen.
Nohara K, Suzuki M, Inagaki F, et al.·Journal of biochemistry·
A unique fucoganglioside was isolated from rat spleen and characterized by compositional analysis, methylation analysis, exoglycosidase treatment, negative ion fast atom bombardment (FAB) mass spectro...
Recognition by the glycoprotein hormone-specific N-acetylgalactosaminetransferase is independent of hormone native conformation.
Smith PL, Baenziger JU·Proceedings of the National Academy of Sciences of the United States of America·
Some members of the glycoprotein hormone family [luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and free alpha subunit] bear unique asparagine-linked oligosaccharides with the terminal s...
Identification of novel gangliosides containing lactosaminyl-GM1 structure from rat spleen.
Nohara K, Suzuki M, Inagaki F, et al.·The Journal of biological chemistry·
Two novel monosialogangliosides were isolated from rat spleen. The structures of the gangliosides (shown below, where NeuNGc is N-glycolylneuraminic acid) were characterized by compositional analysis,...
Synthesis of O-glycosylated tuftsins by utilizing threonine derivatives containing an unprotected monosaccharide moiety.
Filira F, Biondi L, Cavaggion F, et al.·International journal of peptide and protein research·
Synthesis is described of four tuftsin derivatives containing a D-glucopyranosyl or a D-galactopyranosyl unit covalently linked to the hydroxy side chain function of the threonine residue through eith...
A galactosyl(alpha 1-3)mannose epitope on phospholipids of Leishmania mexicana and L. braziliensis is recognized by trypanosomatid-infected human sera.
Avila JL, Rojas M·Journal of clinical microbiology·
An immunoglobulin M antibody reactive with galactosyl(alpha 1-3)mannose [Gal(alpha 1-3)Man] residues present on phospholipids extracted from Leishmania mexicana and L. braziliensis was found to be pre...
Three-dimensional structure of the oligosaccharide terminus of globotriaosylceramide and isoglobotriaosylceramide in solution. A rotating-frame NOE study using hydroxyl groups as long-range sensors in conformational analysis by 1H-NMR spectroscopy.
Poppe L, Dabrowski J, von der Lieth CW, et al.·European journal of biochemistry·
Spatial structures of the oligosaccharide parts of globotriaosylceramide, Gal(alpha 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer (Cer = ceramide) and isoglobotriaosylceramide, Gal(alpha 1-3)Gal(beta 1-4)Glc(beta...
Topography of the combining region of a Thomsen-Friedenreich-antigen-specific lectin jacalin (Artocarpus integrifolia agglutinin). A thermodynamic and circular-dichroism spectroscopic study.
Mahanta SK, Sastry MV, Surolia A·The Biochemical journal·
Thermodynamic analysis of carbohydrate binding by Artocarpus integrifolia (jackfruit) agglutinin (jacalin) shows that, among monosaccharides, Me alpha GalNAc (methyl-alpha-N-acetylgalactosamine) is th...
The N-linked carbohydrate chain of the 85-kilodalton glycoprotein from Trypanosoma cruzi trypomastigotes contains sialyl, fucosyl and galactosyl (alpha 1-3)galactose units.
Couto AS, Gonçalves MF, Colli W, et al.·Molecular and biochemical parasitology·
The structure of the N-linked oligosaccharide of the 85-kDa surface glycoprotein (Tc-85) from the infective trypomastigote form of Trypanosoma cruzi was investigated. Tc-85 metabolically labeled with...
Binding of the blood group-reactive lectins to human adult kidney specimens.
Laitinen L, Juusela H, Virtanen I·The Anatomical record·
The binding of a panel of blood group-reactive lectins to frozen sections of human kidney was studied with a special emphasis on reactivity with endothelia and basement membranes. The blood group A-re...
Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer.
Larsen RD, Rajan VP, Ruff MM, et al.·Proceedings of the National Academy of Sciences of the United States of America·
We have developed a genetic approach to isolate cloned cDNA sequences that determine expression of cell surface oligosaccharide structures and their cognate glycosyltransferases. A cDNA library was co...
Effects of ozone on lamb tracheal mucosa. Quantitative glycoconjugate histochemistry.
Mariassy AT, Sielczak MW, McCray MN, et al.·The American journal of pathology·
Whether or not the previously reported O3-induced abnormality in the postnatal development of tracheal secretory function in lambs is accompanied by changes in epithelial cell populations and their gl...
Identification of a soluble UDP-Gal: Gal (beta 1-4)Glc (or GlcNAc) (alpha 1-3) galactosyltransferase of bovine colostrum.
Hosomi O, Takeya A·Nihon juigaku zasshi. The Japanese journal of veterinary science·
A soluble UDP-Gal: Gal (alpha 1-3) galactosyltransferase was first detected in bovine colostrum and this enzyme activity was simply assayed by using rho-nitrophenyl-beta-lactoside (Gal(beta 1-4)Glc-C6...
Significant increase in the antibody to Gal alpha 1-3Gal structure in sera of patients with hepatocellular carcinoma after transcatheter arterial embolization.
Kashiwagi M, Ikeda Y, Iwamori M, et al.·Cancer research·
Sera from the patients with chronic liver diseases and hepatocellular carcinoma (HCC) were tested for reactivity with neutral glycosphingolipids extracted from rabbit liver plasma membrane by enzyme-l...
High antibody levels against mouse laminin with specificity for galactosyl-(alpha 1-3)galactose in patients with inner ear diseases.
Klein R, Timpl R, Zanetti FR, et al.·The Annals of otology, rhinology, and laryngology·
Sera of 413 patients with inner ear diseases were examined for ELISA binding to mouse laminin and compared to a normal group. Strongly enhanced antilaminin antibody reactions were observed in a large...
Novel isoglobo-neolacto-series hybrid glycolipid detected by a monoclonal antibody is a rat colon tumor-associated antigen.
Thurin J, Brodin T, Bechtel B, et al.·Biochimica et biophysica acta·
Isoglobotetraosylceramide (GalNAc(beta 1-3)Gal(alpha 1-3)Gal(beta 1-4)Glc (beta 1-1)Cer), the major glycolipid species in dimethylhydrazine-induced rat tumors of colorectal origin, was not detected in...
N-linked oligosaccharide changes with oncogenic transformation require sialylation of multiantennae.
Santer UV, DeSantis R, Hård KJ, et al.·European journal of biochemistry·
Glycopeptides derived from NIH 3T3 fibroblasts and these cells transformed by transfection with human DNA containing oncogene H-ras were analyzed by 500-MHz 1H-NMR spectroscopy and binding to immobili...
Differential expression of galactose and N-acetylgalactosamine residues during fetal development and postnatal maturation of rat glomeruli as revealed with lectin conjugates.
Laitinen L, Lehtonen E, Virtanen I·The Anatomical record·
A battery of fluorochrome- or peroxidase-coupled lectins, reacting with alpha- or beta-galactose (Gal), terminal N-acetylgalactosamine (GalNAc), or Gal-(beta 1-3)-GalNAc residues, was used to study th...
A pituitary N-acetylgalactosamine transferase that specifically recognizes glycoprotein hormones.
Smith PL, Baenziger JU·Science (New York, N.Y.)·
The glycoprotein hormones lutropin (LH) and follitropin (FSH), which have common alpha-subunits but hormone-specific beta-subunits, are both synthesized in the gonadotroph. However, they bear Asn-link...
Poly-N-acetyllactosamines synthesized by cultured Ehrlich carcinoma cells: application of endo-beta-galactosidase C for analysis of the terminal structure.
Kamada Y, Muramatsu H, Kawata M, et al.·Journal of biochemistry·
Poly-N-acetyllactosamines were prepared from Ehrlich carcinoma cells cultured in the presence of [14C]galactose. Methylation analysis indicated that 31% of the galactose was in the non-reducing end. O...
Persistence of elevated levels of galactosyl-alpha(1-3)galactose antibodies in sera from patients cured of visceral leishmaniasis.
Avila JL, Rojas M, García L·Journal of clinical microbiology·
Using rabbit erythrocyte-derived neutral glycosphingolipids enriched for a ceramide pentasaccharide as the antigen, we detected elevated anti-galactosyl-alpha(1-3)galactose (anti-G alpha G) antibody l...
Characterization of a major neutral glycolipid in PC12 cells as III3Gal alpha-globotriaosylceramide by the method for determining glycosphingolipid saccharide sequence with endoglycoceramidase.
Shimamura M, Hayase T, Ito M, et al.·The Journal of biological chemistry·
Neutral glycolipids in PC12 cells were examined. A major neutral glycosphingolipid, isolated from a chloroform/methanol extract of the cells, was found to contain only galactose and glucose at a ratio...
[The distribution of 4 genes (alpha GAL, PGK-1, HPRT and G6PD) on the X chromosome of the American mink (Mustela vison)].
Zhdanova NS, Pak SD, Nesterova TB, et al.·Genetika·
The segregation of X-linked markers (alpha GAL, PGK-1, HPRT and G6PD) was analysed in hybrids between gamma ray-irradiated mink fibroblasts and Chinese hamster cells, or between mink cells and mouse h...
Accumulation of a globo-series glycolipid having Gal alpha 1-3Gal in PC12h pheochromocytoma cells.
Ariga T, Yu RK, Scarsdale JN, et al.·Biochemistry·
In a previous paper, we reported the presence of globoside as a major neutral glycolipid in PC12 pheochromocytoma cells [Ariga, T., Macala, L. J., Saito, M., Margolis, R. K., Greene, L. A., Margolis,...
Identification of carbohydrate structures that are possible receptors for Neisseria gonorrhoeae.
Stromberg N, Deal C, Nyberg G, et al.·Proceedings of the National Academy of Sciences of the United States of America·
Different strains and isogenic variants of Neisseria gonorrhoeae were assayed for their ability to bind glycolipids extracted from various sources. Among a large number of reference glycolipids, bindi...
Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin.
Baenziger JU, Green ED·Biochimica et biophysica acta·
Luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) from pituitary and chorionic gonadotropin (CG) from placenta are a family of closely related glycopro...
Expression of cellular glycoconjugates in transfilter-induced metanephric mesenchyme.
Laitinen L, Virtanen I, Saxén L, et al.·The Anatomical record·
Expression of glycoconjugates during transfilter-induced differentiation of metanephric mesenchyme was studied by using fluorochrome- and peroxidase-coupled lectins. All cells in the uninduced metanep...
Serological activity against galactosyl-alpha(1-3)galactose in sera from patients with several kinetoplastida infections.
Avila JL, Rojas M, Towbin H·Journal of clinical microbiology·
Using rabbit erythrocyte-derived neutral glycosphingolipids enriched for a defined ceramide pentasaccharide as antigens, we have detected elevated anti-galactosyl-alpha(1-3)galactose (anti-G alpha G)...
Pathogenesis of urinary tract infections--amoxicillin induces genital Escherichia coli colonization.
Herthelius BM, Hedström KG, Möllby R, et al.·Infection·
The aim of this study was to examine whether a vaginal Escherichia coli colonization, mimicking the one seen in UTI-prone females, could be induced by amoxicillin administration. In adult cynomolgus m...
Anti-laminin and specific antibodies in acute Chagas disease.
Gazzinelli R, Galvão LM, Dias JC, et al.·Transactions of the Royal Society of Tropical Medicine and Hygiene·
A striking increase of anti-laminin antibodies contrasting with low levels of anti-Trypanosoma cruzi antibodies was detected by enzyme-linked immunosorbent assay in sera of 16 patients at the acute ph...
Circulating antibodies to mouse laminin in Chagas disease, American cutaneous leishmaniasis, and normal individuals recognize terminal galactosyl(alpha 1-3)-galactose epitopes.
Towbin H, Rosenfelder G, Wieslander J, et al.·The Journal of experimental medicine·
Sera from patients with American cutaneous leishmaniasis and Chagas disease and from monkeys infected with either Trypanosoma cruzi or Trypanosoma rhodesiense show, in RIAs, strong binding to mouse la...
Comparison of inhibitory effect of galactose analogs on the binding and cytotoxicity of an anti-globotriaosylceramide monoclonal antibody coupled or not coupled to pokeweed antiviral protein.
Junqua S, Wils P, Mishal Z, et al.·European journal of immunology·
The results described here provided an example of a human IgM monoclonal antibody against a tumor-associated glycolipid and of the unusual properties of its corresponding immunotoxin (IT). The monoclo...
Monoclonal antibodies and synthetic tumor-associated glycoconjugates in the study of the expression of Thomsen-Friedenreich-like and Tn-like antigens on human cancers.
Longenecker BM, Willans DJ, MacLean GD, et al.·Journal of the National Cancer Institute·
Synthetic carbohydrate haptens, which are conjugated to carrier human serum albumin molecules [synthetic tumor-associated glycoconjugates (S-TAGs)], were used to immunize mice for monoclonal antibody...
Purification and characterization of fish surface mucin.
Datta S, Datta SC·The Italian journal of biochemistry·
Fish surface mucin from Pampus argenteus was extracted with different organic solvents and the residue passed through Sephadex G-200. The major peak was purified by DEAE-Cellulose chromatography and f...
Human anti-alpha-galactosyl IgG reduces the lung colonization by murine MO4 cells.
Castronovo V, Foidart JM, Li Vecchi M, et al.·Invasion & metastasis·
The lung colonization of MO4 cells, a highly malignant murine cell line, is strongly reduced in syngeneic C3H/He mice by a prior incubation with anti-alpha-galactosyl antibody (alpha-Gal Ab), a natura...
Production of oligosaccharide-binding monoclonal antibodies of diverse specificities by immunization with purified tumor-associated glycolipids inserted into liposomes with lipid A.
Brodin T, Thurin J, Strömberg N, et al.·European journal of immunology·
Two species of neutral glycosphingolipids purified from rat colon carcinoma tissue, isoglobotetraosylceramide [GalNAc(beta 1----3)Gal(alpha 1----3)Gal(beta 1----3)Glc(beta 1----1)Cer] and a related 6-...
Asialogangliosides as differentiation markers of rat erythropoietic and granulopoietic cells in rat bone marrow. Flow cytometric analysis of rat bone marrow cells using anti-asialoganglioside antibodies.
Kimura H, Taki T, Hoshi S, et al.·Cell structure and function·
Flow cytometric analysis using anti-glycolipid antiserum was used on rat bone marrow cells to determine the relation between the glycolipid species expressed on cell surfaces and cell differentiation....
Sugar binding properties of the melibiose permease in Escherichia coli membrane vesicles. Effects of Na+ and H+ concentrations.
Damiano-Forano E, Bassilana M, Leblanc G·The Journal of biological chemistry·
The substrate binding reaction of the melibiose carrier was analyzed by studying [3H]p-nitrophenyl-alpha-D-galactopyranoside (Np alpha Gal) binding to de-energized membrane vesicles from Escherichia c...
Studies on the endogenous galactose-binding lectin during early development of the embryo of Xenopus laevis.
Harris H, Zalik SE·Journal of cell science·
Embryos of the frog Xenopus laevis at cleavage, blastula, gastrula and neurula stages contain a galactose-specific lectin. Extracts of gastrula embryos show the highest specific activity for this lect...
The occurrence of glycosphingolipids containing mannose in the sea-water bivalve, Meretrix lusoria (Hamaguri).
Sugita M, Nakae H, Yamamura T, et al.·Journal of biochemistry·
Total neutral and acidic glycosphingolipids were prepared from whole tissues of the sea-water bivalve, Meretrix lusoria, and the former preparation was further fractionated into subgroups by silicic a...
Analysis of the inducible MEL1 gene of Saccharomyces carlsbergensis and its secreted product, alpha-galactosidase (melibiase).
Sumner-Smith M, Bozzato RP, Skipper N, et al.·Gene·
We have determined both the nucleotide sequence of the MEL1 gene of Saccharomyces carlsbergensis and the N-terminal amino acid (aa) sequence of its extracellular gene product, alpha-galactosidase (mel...
Anaphylaxis to Antivenom in a Patient With Asymptomatic Alpha-Gal IgE Antibodies: A Case Report.
Bryant JS, Scott MD, Gerardo CJ, et al.·Advanced emergency nursing journal
Snakebite envenoming affects an estimated 10,000 people annually in the United States. Two FDA-approved antivenoms, ANAVIP® (equine F(ab') 2 ) and CroFab® (ovine Fab), are standard treatments. However...
Alpha-Gal Syndrome: A Growing Health Care Concern.
Silbernagel TJ, Bullard ZT·Critical care nursing quarterly
Alpha-gal syndrome is a serious, potentially life-threatening allergic reaction to mammalian products that has been linked to the lone star tick. Early recognition and management of alpha-gal syndrome...
Alpha-Gal Syndrome: A New Etiology for Periorbital Edema.
Avila SA, Wojno T·Ophthalmic plastic and reconstructive surgery
Alpha-gal syndrome is characterized by an IgE-mediated hypersensitivity response to the carbohydrate galactose-alpha-1,3-galactose. It can manifest as both an immediate drug allergy to pharmaceuticals...
Anaphylaxis to Antivenom in a Patient With Asymptomatic Alpha- Gal IgE Antibodies: A Case Report.
·Advanced emergency nursing journal
View on PubMed →