Rutgers New Jersey Medical School

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Alpha-gal Syndrome Publications
7
Alpha-gal Syndrome Researchers

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Alpha-gal Syndrome Researchers

Rao S
2 publications ā€¢ h-index: 2
Goyal RM
1 publication ā€¢ h-index: 4
Narakornpichit A
1 publication ā€¢ h-index: 1
Karkra R
1 publication ā€¢ h-index: 2
Al-Khazraji A
1 publication ā€¢ h-index: 1
Shah R
1 publication ā€¢ h-index: 14
Schwartz RA
1 publication ā€¢ h-index: 79

Publications

Understanding Alpha-Gal Syndrome: A Systematic Review and Meta-Analysis of Clinical Manifestations and Outcomes.

Rao S, Rathore SS, Goyal RM, Narakornpichit A, Karkra R, et al.
Neurogastroenterology and motility ā€¢

Alpha-gal syndrome (AGS) is an IgE-mediated hypersensitivity to galactose-Ī±-1,3-galactose, triggered by tick bites. It typically presents with delayed onset allergic or gastrointestinal symptoms after red meat consumption. This study aims to evaluate the prevalence of clinical symptoms and outcomes in AGS patients. A systematic search of PubMed, Embase, and Cochrane Central was conducted to identify studies with at least five AGS patients that utilized alpha-gal IgE for diagnosis and reported symptomatology. A random-effects model calculated pooled prevalence and 95% confidence intervals (CIs) for clinical characteristics of AGS. Of the 739 studies screened, 15 met the inclusion criteria, comprising 1162 AGS patients (57% female). Urticaria was identified as the most prevalent symptom (63.8%, CI: 34.5-88.3, Iā€‰=ā€‰98.8%). At least one gastrointestinal symptom was reported in 69.2% of patients (CI: 49.3-85.9, Iā€‰=ā€‰97.5%), including abdominal pain (58.3%, CI: 36.0-78.9, Iā€‰=ā€‰96.0%), diarrhea (41.7%, CI: 22.3-62.5, Iā€‰=ā€‰93.4%), nausea (39.1%, CI: 29.2-49.6, Iā€‰=ā€‰79.1%), and vomiting (31.1%, CI: 21.9-41.2, Iā€‰=ā€‰70.4%). Tick bite history was recalled by 78.7% (CI: 46.4-98.1; Iā€‰=ā€‰99.1%), and 91.8% (CI: 84.6-96.8; Iā€‰=ā€‰70.3%) had symptom onset ā‰„ā€‰1ā€‰h post red meat intake. Symptomatic improvement was observed in 86.5% (CI: 73.9-95.4, Iā€‰=ā€‰80.9%) of patients, with complete resolution in 42.7% (CI: 26.4-59.8, Iā€‰=ā€‰73.8%). AGS typically presents with delayed onset allergic and GI symptoms after red meat intake, often with tick bite history. Majority of patients report symptomatic improvement on follow-up.

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Meat Allergy: A Ticking Time Bomb.

Shah R, Schwartz RA
American journal of clinical dermatology ā€¢

Food allergies are relatively prevalent, but mammalian meat allergy remains uncommon and represents an important, potentially acute healthcare risk. This risk is partly because both clinicians and the public lack awareness of this serious allergy, which is unique in three important ways: it incurs a delayed reaction, it is induced by a carbohydrate rather than a protein, and it is linked to tick bites. Although various symptoms are possible, its unique presentation means that mammalian meat allergy is often presented to the dermatologist. We review this challenging subject, which is particularly salient considering the unique connection between ticks and mammalian meat allergy, the expanding tick territory, and the dependency by so many on meat products, not only in the diet but also in medications and medical devices.

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