Baker MG, Wong LSY, Konstantinou GN, Nowak-Wegrzyn A
The Journal of allergy and clinical immunology •
In the last century, food allergy has become recognized as an increasingly prevalent and heterogeneous condition. Advances in biomedical technology have revealed complex genetic, environmental, immune, and metabolic pathways underlying the pathogenesis of food-allergic disorders. These findings permit classification of distinct food allergy endotypes with unique pathophysiologic features. In this review, we suggest that these endotypes of food-allergic disorders should be defined on the basis of (1) whether or not the allergic antibody IgE plays an essential role in disease pathogenesis, (2) the molecular features of the allergen (protein vs carbohydrate), and (3) the molecular markers associated with prognosis, severity, or clinical presentation. Beyond these broad categories, additional subtypes with unique mechanistic characteristics are discussed.
Pek CH, Cheong CS, Yap YL, Doggett S, Lim TC, et al.
The Journal of emergency medicine •
Ticks are blood-sucking arachnids that feed on all classes of vertebrates, including humans. Ixodes holocyclus, also known as the Australian Paralysis Tick, is capable of causing a myriad of clinical issues in humans and companion animals, including the transmission of infectious agents, toxin-mediated paralysis, allergic and inflammatory reactions, and mammalian meat allergies in humans. The Australian Paralysis Tick is endemic to Australia, and only two other exported cases have been reported in the literature. We report the third exported case of tick paralysis caused by I. holocyclus, which was imported on a patient into Singapore. We also discuss the clinical course of the patient, the salient points of management, and the proper removal of this tick species. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: With increasing air travel, emergency physicians need to be aware of and to identify imported cases of tick paralysis to institute proper management and advice to the patient. We also describe the tick identification features and proper method of removal of this tick species.