University of Rochester Medicine

healthcare📍 Rochester, United States
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Alpha-gal Syndrome Publications
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Alpha-gal Syndrome Researchers

Associated Institutions

Strong Memorial Hospital
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Highland Hospital
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Golisano Children's Hospital
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University of Rochester
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Alpha-gal Syndrome Researchers

Publications

American College of Allergy, Asthma and Immunology (ACAAI)/American Academy of Pediatrics (AAP) symposium-What was served in the past year: Food allergy nontreatment.

Bingemann TA
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology •

Food allergies are increasing, with 1 of 13 children in the United States affected. This article discusses articles chosen by the author for inclusion in the American College of Allergy, Asthma and Immunology/American Academy of Pediatrics Symposium Hot Topics in Pediatric Allergy and Immunology, specifically on updates in food allergy nontreatment, and provides a focused review with Podium to Practice Takeaways for each article. Food allergies with delayed presentation of symptoms from the time of exposure, such as food protein-induced enterocolitis syndrome and alpha-gal syndrome (AGS), are highlighted. Both food allergies are increasingly seen by clinicians. Food challenges play an important role in the diagnosis, management, and resolution of these conditions. As such, clinicians should understand the pattern of reaction severity over time in food protein-induced enterocolitis syndrome to assist families in deciding when, where, and how oral food challenges should be scheduled. Regarding AGS, it is imperative that physicians understand risk factors for the development of alpha-gal sensitization and the expected symptomatology. In addition, clinicians need to provide counseling that allows for appropriate but not excessive food avoidance based on allergenicity. Finally, the article addresses the concern that has arisen about the safety of gelatin-containing vaccines in patients with AGS and reports that reactions to gelatin-containing vaccines seem to be rare.

On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy.

Platts-Mills TAE, Commins SP, Biedermann T, van Hage M, Levin M, et al.
The Journal of allergy and clinical immunology •

The mammalian meat allergy known as the "α-Gal syndrome" relates to IgE specific for galactose-α-1,3-galactose (α-Gal), an oligosaccharide that is present in cells and tissues of nonprimate mammals. The recognition of delayed reactions to food derived from mammals in patients with IgE to α-Gal and also the association with tick bites have been increasing worldwide. In 2018, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on this emerging tick-related disease. International experts from the fields of tick biology, allergy, immunology, infectious disease, and dermatology discussed the current state of our understanding of this emerging medical condition. The participants provided suggestions for specific research priorities and for the development of resources to advance our knowledge of the mechanisms, diagnosis, management, and prevention of this allergic disease. This publication is a summary of the workshop and the panel's recommendations are presented herein.